Reference code: | PT/FB/BL-2014-495.05 |
Location: | BF-GMS
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Title:
| Validation study of the Alzheimer’s disease assessment scale–cognitive subscale (ADAS-Cog) for the Portuguese patients with mild cognitive impairment and Alzheimer’s disease
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Publication year: | 2018
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URL:
| https://www.tandfonline.com/doi/full/10.1080/13854046.2018.1454511
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Abstract/Results: | ABSTRACT:
OBJECTIVE:
The Alzheimer’s disease assessment scale–Cognitive Subscale (ADAS-Cog) is a battery to assess cognitive performance in Alzheimer’s disease (AD) and was developed according to the core characteristics of cognitive decline in AD: memory, language, praxis, constructive ability, and orientation. The aim of this study was to explore the diagnostic accuracy and discriminative capacity of the ADAS-Cog for Mild Cognitive Impairment (MCI) and AD, using cut-off points for the Portuguese population. METHOD:
The European Portuguese version of the ADAS-Cog was administrated to 650 participants, divided into a control group (n = 210), an MCI group (n = 240), and an AD group (n = 200). The clinical groups fulfilled standard international diagnostic criteria. Controls were healthy cognitive participants actively integrated in the community. The neuropsychological assessment protocol included the ADAS-Cog, the Mini Mental State Examination (MMSE), the Montreal Cognitive Assessment (MoCA), and the Adults and Older Adults Functional Assessment Inventory (IAFAI).
RESULTS: The ADAS-Cog revealed good psychometric indicators, and the total scores were significantly different between the three groups (p < .001: Control < MCI < AD). The optimal cut-off points established were: MCI > 9 points (AUC = .835; sensitivity = 58% and specificity = 91%) and AD > 12 points (AUC = .996; sensitivity = 94% and specificity = 98%).
CONCLUSIONS: Our findings confirmed the capacity of the ADAS-Cog total score to identify cognitive impairment in AD patients, with poor sensitivity for MCI, in a Portuguese cohort.
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Accessibility: | Document exists in file
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Copyright/Reproduction:
| By permission
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Language:
| eng
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Author:
| Nogueira, J.
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Secondary author(s):
| Freitas, S., Duro, D., Almeida, J., Santana, I.
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Document type:
| Article
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Number of reproductions:
| 1
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Percentiles:
| 6
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Reference:
| Nogueira, J., Freitas, S., Duro, D., Almeida, J., & Santana, I. (2018). Validation study of the Alzheimer’s disease assessment scale–cognitive subscale (ADAS-Cog) for the Portuguese patients with mild cognitive impairment and Alzheimer’s disease. Clinical Neuropsychologist, 32(Supplement 1), 46-59. https://doi.org/10.1080/13854046.2018.1454511
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2-year Impact Factor: | 2.006|2018
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Times cited: | 22|2024-02-09
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Indexed document: | Yes
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Quartile: | Q3
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Keywords: | ADAS-Cog / Neuropsychological assessment / Mild cognitive impairment / Alzheimer’s disease / Dementia
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