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084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

2005-01

2008-11

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Document

Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

2008

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.01
Location:	Arquivo PCA - Pasta 19/2004
Title:	Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Publication year:	2008
URL:	http://www.bial.com/imagem/Bolsa8404_21022014.pdf
Abstract/Results:	ABSTRACT: The studies performed in grant 84/04 "THE CONSCIOUSNESS OF PAIN" led to significant advances in our understanding of the neurobiological mechanisms that induce cognitive alterations under chronic pain conditions. Our studies have introduced for the first time the use of complex cognitive tasks in animal models of chronic pain. The relevance of our studies is notorious not only from the quality of the scientific publications in which we have reported our results, but also from the impact that these studies have achieved in the Pain Research scientific community as inferred by the many invitations to present our results in international meetings. Specifically, in this Project we have: 1 – developed for the first time a cognitive task for emotional decision making under ambiguity – the Rodent Gambling Task – that is sensitive to prefrontal and amygdalar functioning just like is observed in the human brain; 2 – demonstrated that prefrontal executive function assessed in our decision-making task is impaired in chronic pain animals, and that this pain-induced impairment is as severe as after a prefrontal lesion; 3 – demonstrated that chronic pain changes the neurochemical balance of dopamine and serotonin in the prefrontal cortex, amygdala, hippocampus, and ventral striatum; 4 – demonstrated that chronic pain impairs working memory without affecting preformance dependent on long-term memory. 5 – demonstrated that chronic pain impairs attentional processing, without affecting choice impulsivity as some authors had previously suggested; 6 – developed a novel software for acquition of behavioral animal data and control of experimental arenas that was freely available for download by the neuroscience community.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Notes:	The final report contains in attachment articles published and/or submitted for publication
Author:	Galhardo, V.
Document type:	Final report
Number of reproductions:	1
Indexed document:	No
Keywords:	Psychophysiology / Pain / Cognitive processes / Emotion and motivation / Brain structure and function / Assessment
Final report - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Document

5.35 – Ascending pathways: Anatomy and physiology

2008

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - 5.35 – Ascending pathways: Anatomy and physiology

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.02
Location:	Arquivo PCA - Pasta 19/2004
Title:	5.35 – Ascending pathways: Anatomy and physiology
Publication year:	2008
URL:	http://www.sciencedirect.com/science/article/pii/B9780123708809001778
Abstract/Results:	ABSTRACT: Nociceptive information traveling from the periphery in primary sensory neurons is transmitted to second-order neurons located at the spinal cord and cranial sensory nuclei. From this first relay, various pathways distribute nociceptive input through higher processing centers, so that pain is ultimately perceived in its multiple dimensions and adequate adaptive responses are generated. Although these ascending pathways are believed to terminate in the cortex with one or several relay stations in their way, the term ‘nociceptive ascending pathways’ is normally used in a restricted sense to designate the neuronal tracts that connect the spinal cord with supraspinal regions, each pathway being named from the brain area at which it terminates. About 20 nociceptive ascending pathways have been uncovered so far, which terminate at multiple sites, from the upper spinal cord up to the thelencephalon. There are subtle differences between the various pathways as to the laminar location and morphology of the spinal neurons of origin, although the latter aspect has been addressed only sporadically. Data on the spinal location of the ascending tracts point to the lack of clear segregation in their way to the brain. As to their neurochemical architecture, our present knowledge is still scarce and thus far from allowing a neurochemical-based pathway characterization. The data collected on the response properties of the neurons of origin of most pathways do not reveal major differences between them. High-threshold, wide-dynamic-range, and low-threshold neurons always participate albeit in different proportions, and, whenever investigated, inputs from skin, viscera, and deep tissues converge onto the same pathway. The multitude of ascending nociceptive pathways, together with the subtleness of the anatomical and physiological aspects that separate them as to their origin at the spinal cord, makes difficult to attribute a particular functional meaning to each one. A tentative way of unraveling the role of each pathway in nociceptive processing has been the elucidation of the connections established by the target. There is, however, a fundamental need to further investigate the functional specificity of each pathway and in which way the compound organization of the nociceptive system contributes to the processing of the various pain states.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Lima, D.
Document type:	Book chapter
Number of reproductions:	1
Reference:	Lima, D. (2008). 5.35 - Ascending Pathways: Anatomy and Physiology. In R. H. Masland, T. D. Albright, P. Dallos, D. Oertel, S. Firestein, G. K. Beauchamp, M. C. Bushnell, A. I. Basbaum, J. H. Kaas & E. P. Gardner (Eds.), The Senses: A Comprehensive Reference (pp. 477-526). New York: Academic Press. https://doi.org/10.1016/B978-012370880-9.00177-8
Indexed document:	Yes
Keywords:	Amygdala / Ascending system / Dorsal reticular nucleus / Globus pallidus / Hypothalamus / Infralimbic cortex / Nociceptive pathways / Nucleus tractus solitarii / Parabrachial nuclei / Periaqueductal gray / Rostral ventromedial medulla / Septal complex / Spinal cord / Thalamus / Ventrolateral reticular formation

Document

Thalamus, dynamics of nociception

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Thalamus, dynamics of nociception

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.03
Location:	Arquivo PCA - Pasta 19/2004
Title:	Thalamus, dynamics of nociception
Publication year:	2006
URL:	http://link.springer.com/referenceworkentry/10.1007%2F978-3-540-29805-2_4452
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Galhardo, V.
Document type:	Book chapter
Number of reproductions:	1
Reference:	Galhardo, V. (2006). Thalamus, dynamics of nociception. In R. F. Schmidt & W. D. Willis (Eds.), Encyclopedia of pain (pp. 2444-2446). New York, NY: Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_4452
Indexed document:	No
Keywords:	Thalamic plasticity / Thalamic reorganization / Sensitization
Thalamus, dynamics of nociception

Document

Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats

2007

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.04
Location:	Arquivo PCA - Pasta 19/2004
Title:	Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats
Publication year:	2007
URL:	http://www.sciencedirect.com/science/article/pii/S0306452206016629
Abstract/Results:	ABSTRACT: Neurobiological mechanisms of decision-making have been shown to be modulated by a number of frontal brain regions. Among those areas, the orbitofrontal cortex (OFC) is thought to play an important role in the decision of behavioral actions when faced with alternative options of ambiguous outcome. Here we present a novel neurobehavioral task to study affective decision-making in the rat, based on evaluation of consecutive choices between two levers associated with rewards of different value and probability. Two groups of animals were studied; a sham control group (n=6) and an OFC-lesioned group (n=7). In the first 30 trials both groups had similar preference patterns but at the end of the 90 trials of the task both groups developed specific preferences. The control group systematically preferred the lever associated with smaller but more reliable rewards (low risk lever) while the OFC lesion group preferred the high risk lever (index of preference of 0.21±0.21 vs. -0.45±0.10; t-test, P<0.05). Analysis of choice persistence (i.e. choosing the same lever in consecutive trials) suggests that the OFC-lesioned group became less sensitive to risk, seeking large rewards irrespective of their success probability.
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Pais-Vieira, M.
Secondary author(s):	Lima, D., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Pais-Vieira, M., Lima, D., & Galhardo, V. (2007). Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats. Neuroscience, 145(1), 225-231. https://doi.org/10.1016/j.neuroscience.2006.11.058
2-year Impact Factor:	3.352\|2007
Times cited:	66\|2025-02-04
Indexed document:	Yes
Quartile:	Q2
Keywords:	Uncertainty / Gambling / Reward / Persistence / Quinolinic acid
Orbitofrontal cortex lesions disrupt risk assessment in a novel serial decision-making task for rats

Document

Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain

2009

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.05
Location:	Arquivo PCA - Pasta 19/2004
Title:	Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain
Publication year:	2009
URL:	http://www.sciencedirect.com/science/article/pii/S0306452209005909
Abstract/Results:	ABSTRACT: Forced choice between alternative options of unpredictable outcome is a complex task that requires continual update of the value associated with each option. Prefrontal areas such as the orbitofrontal cortex (OFC) have been shown to play a major role in performance on ambiguous decision-making tasks with substantial risk component, broadly named as “gambling tasks.” We have recently demonstrated that rats display complex decision-making behavior in a rodent gambling task based on serial choices between rewards of different value and probability. This rodent task retains many of the key characteristics of the human Iowa Gambling Task (IGT), and performance in this novel task is also disrupted by OFC or amygdalar lesioning. In the present study we addressed if rat models of chronic pain would have impaired performance in this gambling task, since it is already known that the IGT response patterns of human pain patients are comparable to individuals with OFC lesions. We found that animals with a monoarthritic inflammatory model of chronic pain systematically preferred the lever associated with larger but infrequent rewards. In addition, we measured the neurochemical content of the OFC, amygdala and nucleus accumbens using HPLC, and found that in prolonged chronic pain animals there was a decrease in the tonic levels of dopamine, DOPAC (3,4-hydroxyphenyl-acetic acid) and 5-HIAA (5-hydroxyindole-3-acetic acid) in the OFC. This is the first report of the effect of chronic pain in rat decision-making processes and supports the notion that pain may have profound effects on the functioning of the reward-aversion circuitry relevant to strategic planning.
Accessibility:	Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Pais-Vieira, M.
Secondary author(s):	Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Pais-Vieira, M., Mendes-Pinto, M. M., Lima, D., & Galhardo, V. (2009). Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain. Neuroscience, 161(3), 671-679. https://doi.org/10.1016/j.neuroscience.2009.04.011
2-year Impact Factor:	3.292\|2009
Times cited:	95\|2025-02-07
Indexed document:	Yes
Quartile:	Q2
Keywords:	Orbitofrontal cortex / Uncertainty / Monoarthritis / Reward / Gambling
Cognitive impairment of prefrontal-dependent decision-making in rats after the onset of chronic pain

Document

Sustained attention deficits in rats with chronic inflammatory pain

2009

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Sustained attention deficits in rats with chronic inflammatory pain

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.06
Location:	Arquivo PCA - Pasta 19/2004
Title:	Sustained attention deficits in rats with chronic inflammatory pain
Publication year:	2009
URL:	http://www.sciencedirect.com/science/article/pii/S0304394009009835
Abstract/Results:	ABSTRACT: Attentional deficits are a common clinical manifestation in chronic pain patients. The causes for this impairment are not clear, and explanations range from distraction caused by painful feelings to pain-induced putative alterations of brain regions related to attention processing. However, none of these explanations have been experimentally tested and few studies have addressed this issue in animal models. In this study we compared sustained attention in the 5-choice serial reaction time task (5-CSRTT) in rats before and after chronic pain. Persistent pain was induced by intra-articular injection of Complete Freund's Adjuvant and the development of monoarthritis was accessed by sensitivity to von Frey filaments. Results showed that after the induction of persistent pain, animals presented more errors in accuracy and more omissions in the task trials. When the same animals were studied with two different doses of carprofen (5 and 10 mg/kg), the performance was not altered, despite the analgesic effect of the drug. The persistence of attentional impairment during transient analgesia suggests that distraction due to painful stimuli is not the main cause for attentional deficits and that permanent alteration of neurobiological mechanisms of attention should follow chronic pain.
Accessibility:	Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Pais-Vieira, M.
Secondary author(s):	Lima, D., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Pais-Vieira, M., Lima, D., & Galhardo, V. (2009). Sustained attention deficits in rats with chronic inflammatory pain. Neuroscience Letters, 463(1), 98-102. https://doi.org/10.1016/j.neulet.2009.07.050
2-year Impact Factor:	1.925\|2009
Times cited:	53\|2025-02-07
Indexed document:	Yes
Quartile:	Q3
Keywords:	Cognitive deficit / Monoarthritis / Complete Freund's Adjuvant / 5-choice serial reaction time task / Executive function
Sustained attention deficits in rats with chronic inflammatory pain

Document

Forebrain pain mechanisms

2009

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Forebrain pain mechanisms

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.07
Location:	Arquivo PCA - Pasta 19/2004
Title:	Forebrain pain mechanisms
Publication year:	2009
URL:	http://www.sciencedirect.com/science/article/pii/S0165017308001537
Abstract/Results:	ABSTRACT: Emotional–affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain areas outside the traditional pain processing network contribute critically to emotional–affective responses and cognitive deficits related to pain. These brain areas include different nuclei of the amygdala and certain prefrontal cortical areas. Their roles in various aspects of pain will be discussed. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Supporting data from preclinical studies in neuropathic pain models will be presented. Neuroimaging analysis provides evidence for plastic changes in the pain processing brain network. Results of clinical studies in neuropathic pain patients suggest that neuroimaging may help determine mechanisms of altered brain functions in pain as well as monitor the effects of pharmacologic interventions to optimize treatment in individual patients. Recent progress in the analysis of higher brain functions emphasizes the concept of pain as a multidimensional experience and the need for integrative approaches to determine the full spectrum of harmful or protective neurobiological changes in pain.
Accessibility:	Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Neugebauer, V.
Secondary author(s):	Galhardo, V., Maione, S., Mackey, S. C.
Document type:	Article
Number of reproductions:	1
Reference:	Neugebauer, V., Galhardo, V., Maione, S., Mackey, S. C. (2009). Forebrain pain mechanisms. Brain Research Reviews, 60(1), 226-242. https://doi.org/10.1016/j.brainresrev.2008.12.014
2-year Impact Factor:	9.432\|2009
Times cited:	272\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Pain / Emotion / Cognition / Decision-making / Amygdala / Prefrontal cortex

Document

OpenControl: A free opensource software for video tracking and automated control of behavioral mazes

2007

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - OpenControl: A free opensource software for video tracking and automated control of behavioral mazes

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.07
Location:	Arquivo PCA - Pasta 19/2004
Title:	OpenControl: A free opensource software for video tracking and automated control of behavioral mazes
Publication year:	2007
URL:	http://www.sciencedirect.com/science/article/pii/S0165027007003329
Abstract/Results:	ABSTRACT: Operant animal behavioral tests require the interaction of the subject with sensors and actuators distributed in the experimental environment of the arena. In order to provide user independent reliable results and versatile control of these devices it is vital to use an automated control system. Commercial systems for control of animal mazes are usually based in software implementations that restrict their application to the proprietary hardware of the vendor. In this paper we present OpenControl: an opensource Visual Basic software that permits a Windows-based computer to function as a system to run fully automated behavioral experiments. OpenControl integrates video-tracking of the animal, definition of zones from the video signal for real-time assignment of animal position in the maze, control of the maze actuators from either hardware sensors or from the online video tracking, and recording of experimental data. Bidirectional communication with the maze hardware is achieved through the parallel-port interface, without the need for expensive AD-DA cards, while video tracking is attained using an inexpensive Firewire digital camera. OpenControl Visual Basic code is structurally general and versatile allowing it to be easily modified or extended to fulfill specific experimental protocols and custom hardware configurations. The Visual Basic environment was chosen in order to allow experimenters to easily adapt the code and expand it at their own needs.
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Aguiar, P.
Secondary author(s):	Mendonça, L., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Aguiar, P., Mendonça, L., & Galhardo, V. (2007). OpenControl: A free opensource software for video tracking and automated control of behavioral mazes. Journal of Neuroscience Methods, 166(1), 66-72. https://doi.org/10.1016/j.jneumeth.2007.06.020
2-year Impact Factor:	1.884\|2007
Times cited:	57\|2025-02-04
Indexed document:	Yes
Quartile:	Q3
Keywords:	Automated control / Behavior tests / Opensource software
OpenControl: a free opensource software for video tracking and automated control of behavioral mazes

Document

Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.08
Location:	Arquivo PCA - Pasta 19/2004
Title:	Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons
Publication year:	2006
URL:	http://www.sciencedirect.com/science/article/pii/S0304394006000231
Abstract/Results:	ABSTRACT: Somatosensory deep dorsal horn spinal neurons were previously shown to present in vitro a bistable state of activity in which a fixed firing rate is maintained over prolonged periods in the absence of stimulation. Those periods of enhanced spinal spontaneous discharge may play a role in the genesis or maintenance of hyperalgesic states, where episodes of durable spontaneous pain are commonly reported. Here we show in vivo that a small percentage of deep spinal neurons (4% of the recorded population) are capable of rapidly shifting between low-frequency and high-frequency levels of spontaneous activity. At least one of the transitions between the two states was induced by stimulation of the receptive field, making this an interesting and unique case in which stable firing rates are switched-on or -off by somatosensory stimuli.
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Monteiro, C.
Secondary author(s):	Lima, D., Galhardo, V.
Document type:	Article
Number of reproductions:	1
Reference:	Monteiro, C., Lima, D., & Galhardo, V. (2006). Switching-on and -off of bistable spontaneous discharges in rat spinal deep dorsal horn neurons. Neuroscience Letters, 398(3), 258-63. https://doi.org/10.1016/j.neulet.2006.01.008
2-year Impact Factor:	2.092\|2006
Times cited:	5\|2025-02-04
Indexed document:	Yes
Quartile:	Q3
Keywords:	Strychnine / Formalin / Pain / Oscillations / Multielectrode extracellular recordings

Document

Recent advances in basic neurosciences and brain disease: from synapses to behavior

2006

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Recent advances in basic neurosciences and brain disease: from synapses to behavior

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.09
Location:	Arquivo PCA - Pasta 19/2004
Title:	Recent advances in basic neurosciences and brain disease: from synapses to behavior
Publication year:	2006
URL:	http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769477/
Abstract/Results:	ABSTRACT: Understanding basic neuronal mechanisms hold the hope for future treatment of brain disease. The 1st international conference on synapse, memory, drug addiction and pain was held in beautiful downtown Toronto, Canada on August 21–23, 2006. Unlike other traditional conferences, this new meeting focused on three major aims: (1) to promote new and cutting edge research in neuroscience; (2) to encourage international information exchange and scientific collaborations; and (3) to provide a platform for active scientists to discuss new findings. Up to 64 investigators presented their recent discoveries, from basic synaptic mechanisms to genes related to human brain disease. This meeting was in part sponsored by Molecular Pain, together with University of Toronto (Faculty of Medicine, Department of Physiology as well as Center for the Study of Pain). Our goal for this meeting is to promote future active scientific collaborations and improve human health through fundamental basic neuroscience researches. The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29–31, 2007).
Accessibility:	Document does not exist in file
Language:	eng
Author:	Bi, G.-Q.
Secondary author(s):	Bolshakov, V., Bu, G., Cahill, C., Chen, Z.-F., Collingridge, G., Cooper, R., Coorssen, J. R., El-Husseini, A., Galhardo, V., Gan, W. -B., Gu, J., Inoue, K., Isaac, J., Iwata, K., Jia, Z., Kaang, B. -K., Kawamata, M., Kida, S., Klann, E., Kohno, T., Li, M., Li, X. -J., MacDonald, J., Nader, K., Nguyen, P., Oh, U., Ren, K., Roder, J., Salter, M., Song, W., Sugita, S., Tang, S. -J., Tao, Y., Wang, Y., Woo, N., Woodin, M., Yan, Z., Yoshimura, M., Xu, M., Xu, Z. , Zhang, X., Zhen, M., Zhuo, M.
Document type:	Article
Number of reproductions:	1
Reference:	Bi, G.-Q., Bolshakov, V., Bu, G., Cahill, C., Chen, Z.-F., Collingridge, G., . . . Zhuo, M. (2006). Recent advances in basic neurosciences and brain disease: from synapses to behavior. Molecular Pain, 2(1), 38-51. https://doi.org/10.1186/1744-8069-2-38
2-year Impact Factor:	4.127\|2007
Impact factor notes:	Impact factor computed since 2007
Times cited:	2\|2025-02-04
Indexed document:	Yes
Quartile:	Q1
Keywords:	Psychophysiology / Pain
Recent advances in basic neurosciences and brain disease: from synapses to behavior

Document

Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

2010

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.10
Location:	Arquivo PCA - Pasta 19/2004
Title:	Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
Publication year:	2010
URL:	http://www.ncbi.nlm.nih.gov/pubmed/20392966
Abstract/Results:	ABSTRACT; Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo, patch-clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Further, pharmacologic inhibition (with a CRF1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting synaptic inhibition was glutamate-driven. The results are consistent with a model of BLA-driven feed-forward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Accessibility:	Document does not exist in file
Language:	eng
Related objects:	PT/FB/BL-2008-126.11
Author:	Ji, G.
Secondary author(s):	Sun, H., Fu, Y., Li, Z., Galhardo, V., Neugebauer, V.
Document type:	Article
Number of reproductions:	1
Reference:	Ji, G., Sun, H., Fu, Y., Li, Z., Galhardo, V., & Neugebauer, V. (2010). Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. Journal of Neuroscience, 30(15), 5451-5464. https://doi.org/10.1523/JNEUROSCI.0225-10.2010
2-year Impact Factor:	7.271\|2010
Times cited:	317\|2025-02-07
Indexed document:	Yes
Quartile:	Q1
Keywords:	Amygdala / Prefrontal cortex / Pain / Anxiety / Decision-making / Central sensitization / Synaptic plasticity
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

Document

Learning impairments and dopaminergic changes in monoarthritic rats

2008

BIAL Foundation Archive
- BIAL Grants
  - 2004 Grants
    - 084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
      - Learning impairments and dopaminergic changes in monoarthritic rats

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.11
Location:	Arquivo PCA - Pasta 19/2004
Title:	Learning impairments and dopaminergic changes in monoarthritic rats
Publication year:	2008
Accessibility:	Document exists in file (in attachment to the final report)
Copyright/Reproduction:	By permission
Language:	eng
Author:	Pais-Vieira, M.
Secondary author(s):	Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:	Unpublished document
Number of reproductions:	1
Reference:	Pais-Vieira, M., Mendes-Pinto, M., Lima, D., & Galhardo, V. (2008). Learning impairments and dopaminergic changes in monoarthritic rats [Unpublished document].
Indexed document:	No
Keywords:	Monoarthritis / Complete Freund's adjuvant / Dopamine / Hippocampus / Orbitofrontal cortex / Learning / Working memory / Reference memory
Learning impairments and dopaminergic changes in monoarthritic rats

Document

A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]

2010

BIAL Foundation Archive

BIAL Grants

2004 Grants

084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2004
Location:	Arquivo PCA - Pastas 1 a 25/2004
Title:	2004 Grants
Start date:	2005-01 - 2012-09
Dimension/support:	25 caixas de arquivo

Reference code:	PT/FB/BL-2004-084
Location:	Arquivo PCA - Pastas 19 a 20/2004
Title:	084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration:	2005-01 - 2008-11
Researcher(s):	Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s):	IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents:	Contents: Bursary agreement Application form Correspondence Financial report and expenditure documents Progress reports Final report
Language:	eng / por
Related objects:	PT/FB/BL-2008-126
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:	1
Keywords:	Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code:	PT/FB/BL-2004-084.12
Location:	Arquivo PCA - Pasta 19/2004
Title:	A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]
Publication year:	2010
URL:	http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results:	ABSTRACT: Uncovering the roles of the orbitofrontal cortex and the amygdala in rewardbased decision-making strategies has relied heavily in studies using discrete brain lesions. However, chronic pain patients also display risk-prone behavior even in the absence of discrete brain lesions. The main objective of this project was to study how chronic pain affects brain areas critical for reward processing. For this we developed a novel Rodent Gambling Task in which naïve animals make consecutive choices between two levers that attribute rewards of different value and probability. After a prolonged training phase in which both levers give the same reward, in the probe trial we maintain one lever at 1 food pellet with 80% probability of reward - low risk lever – while the other lever gives 3 pellets but at only 30% probability – high risk lever. We found that control animals start the task with a preference for the high-risk lever, but progressively shift to the low-risk option, while animals with orbitofrontal or amigdalar lesions, and animals with chronic pain prefer the high-risk lever. Since no brain lesion is caused by the model of chronic pain, we performed an HPLC analysis and found a decrease in the levels of dopamine and serotonin at the OFC, with no significant changes in the amygdala. We extended these findings by chronically implanting multielectrodes and recording 96 neurons in awake-behaving animals performing four sessions of the RGT before and after induction of pain. We found that the neuronal instantaneous firing rate was correlated with the probability of choosing a specific lever in the majority of the recorded neurons. Moreover, we found that the fraction of risk-sensitive neurons recorded in each session predicted the overall behavioural risk-bias of the animal. This project demonstrated that chronic pain changes the reward-aversion circuitry and that these changes are crucial for setting individual levels of risk preference. PUBLICATIONS: Pais-Vieira M et al (2009) Neuroscience, 161: 671-679. Neugebauer V et al (2009) Brain Research Reviews, 60: 226-242. Pais-Vieira M et al (2007) Neuroscience, 145: 225-231.
Accessibility:	Document does not exist in file
Language:	eng
Author:	Galhardo, V.
Secondary author(s):	Lima, D., Pais-Vieira, M., Monteiro, C.
Document type:	Conference abstract
Number of reproductions:	1
Reference:	Galhardo, V., Lima, D., Pais-Vieira, M., & Monteiro, C. (2010). A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 190). Porto: Fundação Bial.
Indexed document:	No
Keywords:	Pain / Multielectrode neurophysiology / Prefrontal cortex / Reward
A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa [Similar decision-making impairment in orbitofrontal cortex lesioned and chronic pain animals in a risk assessment task]