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Document5.35 – Ascending pathways: Anatomy and physiology2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.02
Location: Arquivo PCA - Pasta 19/2004
Title:
5.35 – Ascending pathways: Anatomy and physiology
Publication year: 2008
URL:
http://www.sciencedirect.com/science/article/pii/B9780123708809001778
Abstract/Results: ABSTRACT:
Nociceptive information traveling from the periphery in primary sensory neurons is transmitted to second-order neurons located at the spinal cord and cranial sensory nuclei. From this first relay, various pathways distribute nociceptive input through higher processing centers, so that pain is ultimately perceived in its multiple dimensions and adequate adaptive responses are generated. Although these ascending pathways are believed to terminate in the cortex with one or several relay stations in their way, the term ‘nociceptive ascending pathways’ is normally used in a restricted sense to designate the neuronal tracts that connect the spinal cord with supraspinal regions, each pathway being named from the brain area at which it terminates. About 20 nociceptive ascending pathways have been uncovered so far, which terminate at multiple sites, from the upper spinal cord up to the thelencephalon.
There are subtle differences between the various pathways as to the laminar location and morphology of the spinal neurons of origin, although the latter aspect has been addressed only sporadically. Data on the spinal location of the ascending tracts point to the lack of clear segregation in their way to the brain. As to their neurochemical architecture, our present knowledge is still scarce and thus far from allowing a neurochemical-based pathway characterization. The data collected on the response properties of the neurons of origin of most pathways do not reveal major differences between them. High-threshold, wide-dynamic-range, and low-threshold neurons always participate albeit in different proportions, and, whenever investigated, inputs from skin, viscera, and deep tissues converge onto the same pathway.
The multitude of ascending nociceptive pathways, together with the subtleness of the anatomical and physiological aspects that separate them as to their origin at the spinal cord, makes difficult to attribute a particular functional meaning to each one. A tentative way of unraveling the role of each pathway in nociceptive processing has been the elucidation of the connections established by the target. There is, however, a fundamental need to further investigate the functional specificity of each pathway and in which way the compound organization of the nociceptive system contributes to the processing of the various pain states.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Document type:
Book chapter
Number of reproductions:
1
Reference:
Lima, D. (2008). 5.35 - Ascending Pathways: Anatomy and Physiology. In R. H. Masland, T. D. Albright, P. Dallos, D. Oertel, S. Firestein, G. K. Beauchamp, M. C. Bushnell, A. I. Basbaum, J. H. Kaas & E. P. Gardner (Eds.), The Senses: A Comprehensive Reference (pp. 477-526). New York: Academic Press. doi: 10.1016/B978-012370880-9.00177-8
Indexed document: Yes
Keywords: Amygdala / Ascending system / Dorsal reticular nucleus / Globus pallidus / Hypothalamus / Infralimbic cortex / Nociceptive pathways / Nucleus tractus solitarii / Parabrachial nuclei / Periaqueductal gray / Rostral ventromedial medulla / Septal complex / Spinal cord / Thalamus / Ventrolateral reticular formation

DocumentForebrain pain mechanisms2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.07
Location: Arquivo PCA - Pasta 19/2004
Title:
Forebrain pain mechanisms
Publication year: 2009
URL:
http://www.sciencedirect.com/science/article/pii/S0165017308001537
Abstract/Results: ABSTRACT:
Emotional–affective and cognitive dimensions of pain are less well understood than nociceptive and nocifensive components, but the forebrain is believed to play an important role. Recent evidence suggests that subcortical and cortical brain areas outside the traditional pain processing network contribute critically to emotional–affective responses and cognitive deficits related to pain. These brain areas include different nuclei of the amygdala and certain prefrontal cortical areas. Their roles in various aspects of pain will be discussed. Biomarkers of cortical dysfunction are being identified that may evolve into therapeutic targets to modulate pain experience and improve pain-related cognitive impairment. Supporting data from preclinical studies in neuropathic pain models will be presented. Neuroimaging analysis provides evidence for plastic changes in the pain processing brain network. Results of clinical studies in neuropathic pain patients suggest that neuroimaging may help determine mechanisms of altered brain functions in pain as well as monitor the effects of pharmacologic interventions to optimize treatment in individual patients. Recent progress in the analysis of higher brain functions emphasizes the concept of pain as a multidimensional experience and the need for integrative approaches to determine the full spectrum of harmful or protective neurobiological changes in pain.
Accessibility: Document exists in file (previous version submitted for publication/ in attachment to the final report)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Neugebauer, V.
Secondary author(s):
Galhardo, V., Maione, S., Mackey, S. C.
Document type:
Article
Number of reproductions:
1
Reference:
Neugebauer, V., Galhardo, V., Maione, S., Mackey, S. C. (2009). Forebrain pain mechanisms. Brain Research Reviews, 60(1), 226-242. doi: 10.1016/j.brainresrev.2008.12.014
2-year Impact Factor: 9.432|2009
Times cited: 248|2022-07-12
Indexed document: Yes
Quartile: Q1
Keywords: Pain / Emotion / Cognition / Decision-making / Amygdala / Prefrontal cortex

DocumentCognitive impairment in pain through amygdala-driven prefrontal cortical deactivation2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.10
Location: Arquivo PCA - Pasta 19/2004
Title:
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20392966
Abstract/Results: ABSTRACT;
Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo, patch-clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Further, pharmacologic inhibition (with a CRF1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting synaptic inhibition was glutamate-driven. The results are consistent with a model of BLA-driven feed-forward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2008-126.11
Author: Ji, G.
Secondary author(s):
Sun, H., Fu, Y., Li, Z., Galhardo, V., Neugebauer, V.
Document type:
Article
Number of reproductions:
1
Reference:
Ji, G., Sun, H., Fu, Y., Li, Z., Galhardo, V., & Neugebauer, V. (2010). Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation. Journal of Neuroscience, 30(15), 5451-5464. doi: 10.1523/JNEUROSCI.0225-10.2010
2-year Impact Factor: 7.271|2010
Times cited: 261|2022-07-12
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Prefrontal cortex / Pain / Anxiety / Decision-making / Central sensitization / Synaptic plasticity

Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation

DocumentFinal report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.01
Location: Arquivo PCA - Pasta 10/2006
Title:
Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Publication year: 2010
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Learning / Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning

Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning

DocumentTime determines the neural circuit underlying associative fear learning2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.02
Location: Arquivo PCA - Pasta 10/2006
Title:
Time determines the neural circuit underlying associative fear learning
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246300/pdf/fnbeh-05-00089.pdf
Abstract/Results: ABSTRACT:
Ultimately associative learning is a function of the temporal features and relationships between experienced stimuli. Nevertheless how time affects the neural circuit underlying this form of learning remains largely unknown. To address this issue, we used single-trial auditory trace fear conditioning and varied the length of the interval between tone and foot-shock. Through temporary inactivation of the amygdala, medial prefrontal-cortex (mPFC), and dorsal-hippocampus in rats, we tested the hypothesis that different temporal intervals between the tone and the shock influence the neuronal structures necessary for learning. With this study we provide the first experimental evidence showing that temporarily inactivating the amygdala before training impairs auditory fear learning when there is a temporal gap between the tone and the shock. Moreover, imposing a short interval (5 s) between the two stimuli also relies on the mPFC, while learning the association across a longer interval (40 s) becomes additionally dependent on a third structure, the dorsal-hippocampus. Thus, our results suggest that increasing the interval length between tone and shock leads to the involvement of an increasing number of brain areas in order for the association between the two stimuli to be acquired normally. These findings demonstrate that the temporal relationship between events is a key factor in determining the neuronal mechanisms underlying associative fear learning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Guimarãis, M.
Secondary author(s):
Gregório, A., Cruz, A., Guyon, N., Moita, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Guimarãis, M., Gregório, A., Cruz, A., Guyon, N., & Moita, M. (2011). Time determines the neural circuit underlying associative fear learning. Frontiers in Behavioral Neuroscience, 5: 89. doi: 10.3389/fnbeh.2011.00089
2-year Impact Factor: 4.758|2012
Impact factor notes: Impact factor computed since 2012
Times cited: 35|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

Time determines the neural circuit underlying associative fear learning

Time determines the neural circuit underlying associative fear learning

DocumentThe outcome of elderly patients with cognitive complaints but normal neuropsychological tests2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.07
Location: Arquivo PCA - Pasta 21/2006
Title:
The outcome of elderly patients with cognitive complaints but normal neuropsychological tests
Publication year: 2010
URL:
http://iospress.metapress.com/content/n007j334322x0634/
Abstract/Results: ABSTRACT:
Elderly patients may present with prominent cognitive complaints and have performances in neuropsychological tests within the normal range for the age and education, and thus do not fulfill the criteria for mild cognitive impairment (MCI). There is insufficient evidence to support the clinical decision in these cases ("pre-MCI"). Forty-three subjects, 11 controls, 15 "pre-MCI," and 17 MCI, were followed for about three and half years with neuropsychological testing and magnetic resonance imaging including volumetric measurements of the hippocampus and amygdala. Two of the "pre-MCI" subjects suffered cognitive and functional deterioration and were diagnosed with dementia. Although the "pre-MCI" subjects as a group had no significant deterioration in neuropsychological tests, they suffered a decline in the total hippocampal volume (P=0.04) along the follow-up time. In contrast, all control subjects remained stable and had no volumetric decreases. As expected, MCI patients underwent significant deterioration in several neuropsychological tests, often progressed to Alzheimer's disease, and showed decreases both in total hippocampal and amygdalar volumes. Elderly people presenting with cognitive complaints may be in an initial phase of a degenerative disorder and should be followed clinically, even if they have normal neuropsychological tests.
Accessibility: Document does not exist in file
Language:
eng
Author:
Nunes, T.
Secondary author(s):
Fragata, I., Ribeiro, F., Palma, T., Maroco, J., Cannas, J., Secca, M., Menezes, C., Carmo, I., Cunha, G., Castelo-Branco, M., Guerreiro, M., Mendonça, A.
Document type:
Article
Number of reproductions:
1
Reference:
Nunes, T., Fragata, I., Ribeiro, F., Palma, T., Maroco, J., ... Mendonça, A. (2010). The outcome of elderly patients with cognitive complaints but normal neuropsychological tests. Journal of Alzheimer´s disease, 19(1), 137-145. doi: 10.3233/JAD-2010-1210
2-year Impact Factor: 4.261|2010
Times cited: 27|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Aging / Alzheimer's disease / Amygdala / Dementia / Hippocampus / Magnetic resonance imaging / Mild cognitive impairment (MCI) / Pre-MCI / Volumetry

DocumentHow do we learn to associate events separate in time: a study using trace auditory fear conditioning2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.04
Location: Arquivo PCA - Pasta 10/2006
Title:
How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Ultimately associative learning is a function of the temporal features and relationships between experienced stimuli. Nevertheless how time affects the neural circuit underlying this form of learning remains largely unknown. To address this issue, we used single-trial auditory trace fear conditioning and varied the length of the interval between tone and foot-shock. Through temporary inactivation of the amygdala, medial-prefrontal cortex (mPFC) and dorsal-hippocampus in rats, we tested the hypothesis that different temporal intervals between the tone and the shock influence the neuronal structures necessary for learning.
METHODS:
Rats were implanted with bilateral cannulae targeting dorsal hippocampus, lateral amygdala or mPFC, under stereotaxic surgery. Muscimol, a GABAa agonist that efficiently shuts down activity, was infused into the targeted region just prior to the trace fear conditioning session. Rats in teh control group received infusions of the vehicle solution. The next day all rats were tested for their fear of the tone in a distinct environment. Freezing was used as a measure of fear.
RESULTS:
We show for the first time that the amygdala is critically involved in the acquisition of auditory fear learning when there is a temporal gap between the tone and the shock. Moreover, imposing a short interval (5 s) between the two stimuli also recruits the medial pre-frontal cortex (mPFC), while learning the association across a longer interval (40 s) becomes additionally dependent on a third structure, the dorsal-hippocampus.
CONCLUSION:
Thus, our results show that increasing the interval length between tone and shock leads to the requirement of an increasing number of brain areas for the association between the two stimuli to be acquired.
Accessibility: Document does not exist in file
Language:
eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Moita, M., & Guimarães, M. (2012). How do we learn to associate events separate in time: a study using trace auditory fear conditioning. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 9/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

How do we learn to associate events separate in time: a study using trace auditory fear conditioning

How do we learn to associate events separate in time: a study using trace auditory fear conditioning

DocumentCognitive impairment in pain through amygdala-driven prefrontal cortical deactivation2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.11
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Cognitive impairment in pain through amygdala-driven prefrontal cortical deactivation
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20392966
Abstract/Results: ABSTRACT:
Cognitive deficits such as impaired decision-making can be a consequence of persistent pain. Normal functions of the intact amygdala and prefrontal cortex are required for emotion-based decision-making that relies on the ability to assess risk, attribute value, and identify advantageous strategies. We tested the hypothesis that pain-related cognitive deficits result from amygdala-driven impairment of medial prefrontal cortical (mPFC) function. To do this, we used electrophysiological single-unit recordings in vivo, patch clamp in brain slices, and various behavioral assays to show that increased neuronal activity in the amygdala in an animal model of arthritis pain was accompanied by decreased mPFC activation and impaired decision-making. Furthermore, pharmacologic inhibition (with a corticotropin-releasing factor 1 receptor antagonist) of pain-related hyperactivity in the basolateral amygdala (BLA), but not central amygdala (CeA), reversed deactivation of mPFC pyramidal cells and improved decision-making deficits. Pain-related cortical deactivation resulted from a shift of balance between inhibitory and excitatory synaptic transmission. Direct excitatory transmission to mPFC pyramidal cells did not change in the pain model, whereas polysynaptic inhibitory transmission increased. GABAergic transmission was reduced by non-NMDA receptor antagonists, suggesting that synaptic inhibition was glutamate driven. The results are consistent with a model of BLA-driven feedforward inhibition of mPFC neurons. In contrast to the differential effects of BLA versus CeA hyperactivity on cortical-cognitive functions, both amygdala nuclei modulate emotional-affective pain behavior. Thus, this study shows that the amygdala contributes not only to emotional-affective but also cognitive effects of pain. The novel amygdalo-cortical pain mechanism has important implications for our understanding of amygdala functions and amygdalo-cortical interactions.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2004-84.10
Author: Ji, G.
Secondary author(s):
Sun, H., Fu, Y., Li, Z., Pais-Vieira, M., Galhardo, V., Neugebauer, V.
Document type:
Article-d
Number of reproductions:
1
Reference:
Ji, G. C., Sun, H., Fu, Y., Li, Z., Pais-Vieira, M., Galhardo, V., & Neugebauer, V. (2010). Cognitive Impairment in Pain through Amygdala-Driven Prefrontal Cortical Deactivation. Journal of Neuroscience, 30(15), 5451-5464. doi: 10.1523/jneurosci.0225-10.2010
2-year Impact Factor: 7.271|2010
Times cited: 259|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Prefrontal cortex / Pain / Anxiety / Decision-making / Central sensitization / Synaptic plasticity

Novo ficheiro

Novo ficheiro

DocumentThe role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-170
Location: Arquivo PCA - Pasta 10/2010
Title:
170 - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Duration: 2011-04 - 2013-11
Researcher(s):
Gina Maria Costa Caetano, Miguel Castelo-Branco, Beatrice de Gelder, Gregor Philipak
Institution(s): Instituto Biomédico de Investigação de Luz e Imagem - IBILI-, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
1 Master's thesis
Language: eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2010-170.03
Location: Arquivo PCA - Pasta 9/2010
Title:
The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0028393213002352
Abstract/Results: ABSTRACT:
In human cognition, most relevant stimuli, such as faces, are processed in central vision. However, it is widely believed that recognition of relevant stimuli (e.g. threatening animal faces) at peripheral locations is also important due to their survival value. Moreover, task instructions have been shown to modulate brain regions involved in threat recognition (e.g. the amygdala). In this respect it is also controversial whether tasks requiring explicit focus on stimulus threat content vs. implicit processing differently engage primitive subcortical structures involved in emotional appraisal.
Here we have addressed the role of central vs. peripheral processing in the human amygdala using animal threatening vs. non-threatening face stimuli. First, a simple animal face recognition task with threatening and non-threatening animal faces, as well as non-face control stimuli, was employed in naïve subjects (implicit task). A subsequent task was then performed with the same stimulus categories (but different stimuli) in which subjects were told to explicitly detect threat signals.
We found lateralized amygdala responses both to the spatial location of stimuli and to the threatening content of faces depending on the task performed: the right amygdala showed increased responses to central compared to left presented stimuli specifically during the threat detection task, while the left amygdala was better prone to discriminate threatening faces from non-facial displays during the animal face recognition task. Additionally, the right amygdala responded to faces during the threat detection task but only when centrally presented. Moreover, we have found no evidence for superior responses of the amygdala to peripheral stimuli. Importantly, we have found that striatal regions activate differentially depending on peripheral vs. central processing of threatening faces. Accordingly, peripheral processing of these stimuli activated more strongly the putaminal region, while central processing engaged mainly the caudate nucleus.
We conclude that the human amygdala has a central bias for face stimuli, and that visual processing recruits different striatal regions, putaminal or caudate based, depending on the task and on whether peripheral or central visual processing is involved.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Almeida, I.
Secondary author(s):
Van Asselen, M., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Almeida, I., Van Asselen, M., & Castelo-Branco, M. (2013). The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content. Neuropsychologia, 51(11), 2120-2129. doi: 10.1016/j.neuropsychologia.2013.07.007
2-year Impact Factor: 3.451|2013
Times cited: 13|2022-05-22
Indexed document: Yes
Quartile: Q2
Keywords: Amygdala / Basal ganglia / Implicit/explicit / Central/peripheral / Threat / Faces

The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content

The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content

DocumentFinal report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-170
Location: Arquivo PCA - Pasta 10/2010
Title:
170 - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Duration: 2011-04 - 2013-11
Researcher(s):
Gina Maria Costa Caetano, Miguel Castelo-Branco, Beatrice de Gelder, Gregor Philipak
Institution(s): Instituto Biomédico de Investigação de Luz e Imagem - IBILI-, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
1 Master's thesis
Language: eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2010-170.01
Location: Arquivo PCA - Pasta 9/2010
Title:
Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Publication year: 2013
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Emotions / Basal ganglia / Amygdala / Colliculus / Categorization

Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study

Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study

DocumentThe role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.34
Location: Arquivo PCA - Pasta 21/2006
Title:
The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0028393213002352
Abstract/Results: ABSTRACT:
In human cognition, most relevant stimuli, such as faces, are processed in central vision. However, it is widely believed that recognition of relevant stimuli (e.g. threatening animal faces) at peripheral locations is also important due to their survival value. Moreover, task instructions have been shown to modulate brain regions involved in threat recognition (e.g. the amygdala). In this respect it is also controversial whether tasks requiring explicit focus on stimulus threat content vs. implicit processing differently engage primitive subcortical structures involved in emotional appraisal. Here we have addressed the role of central vs. peripheral processing in the human amygdala using animal threatening vs. non-threatening face stimuli. First, a simple animal face recognition task with threatening and non-threatening animal faces, as well as non-face control stimuli, was employed in naïve subjects (implicit task). A subsequent task was then performed with the same stimulus categories (but different stimuli) in which subjects were told to explicitly detect threat signals. We found lateralized amygdala responses both to the spatial location of stimuli and to the threatening content of faces depending on the task performed: the right amygdala showed increased responses to central compared to left presented stimuli specifically during the threat detection task, while the left amygdala was better prone to discriminate threatening faces from non-facial displays during the animal face recognition task. Additionally, the right amygdala responded to faces during the threat detection task but only when centrally presented. Moreover, we have found no evidence for superior responses of the amygdala to peripheral stimuli. Importantly, we have found that striatal regions activate differentially depending on peripheral vs. central processing of threatening faces. Accordingly, peripheral processing of these stimuli activated more strongly the putaminal region, while central processing engaged mainly the caudate nucleus. We conclude that the human amygdala has a central bias for face stimuli, and that visual processing recruits different striatal regions, putaminal or caudate based, depending on the task and on whether peripheral or central visual processing is involved.
Accessibility: Document does not exist in file
Language:
eng
Author:
Almeida, I.
Secondary author(s):
Van Asselen, M., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
1
Reference:
Almeida, I., Van Asselen, M., & Van Asselen, M. (2013). The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content. Neuropsychologia, 51(11), 2120-2129. doi: 10.1016/j.neuropsychologia.2013.07.007
2-year Impact Factor: 3.451|2013
Times cited: 13|2022-05-19
Indexed document: Yes
Quartile: Q2
Keywords: Amygdala / Basal ganglia / Central/peripheral / Faces / Implicit/explicit / Threat

DocumentAmygdala Activation in Response to 2D and 3D Emotion-Inducing Stimuli2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-094
Location: Arquivo PCA - Pasta 12/2008
Title:
094 - Manipulação da Emoção em Ambientes de Realidade Virtual Imersiva: Validação Metodológica
Duration: 2009-01 - 2011-10
Researcher(s):
Luís Manuel Coelho Monteiro, João Eduardo Marques Teixeira, Manuel Fernando Santos Barbosa, Jorge Silvério
Institution(s): UnIPSa – Unidade de Investigação em Psicologia e Saúde: Laboratório de Psicofisiologia / Grupo de Psicobiologia / Instituto Superior de Ciências da Saúde – Norte, Paredes (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
DVD (TV news about Virtual reality project, 2 posters)
Newspaper articles
Language: por
Author:
Monteiro, L.
Secondary author(s):
Marques-Teixeira, J., Barbosa, F., Silvério, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2008-094.08
Title: Amygdala Activation in Response to 2D and 3D Emotion-Inducing Stimuli
Publication year: 2014
URL:
http://www.psychnology.org/File/PNJ12(1-2)/PSYCHNOLOGY_JOURNAL_12_1_2_DORES.pdf
Abstract/Results: ABSTRACT:
Studying changes in brain activation according to the valence of emotion-inducing stimuli is essential in the research on emotions. Due to the ecological potential of virtual reality, it is also important to examine whether brain activation in response to emotional stimuli can be modulated by the three-dimensional (3D) properties of the images. This study uses functional Magnetic Resonance Imaging to compare differences between 3D and standard (2D) visual stimuli in the activation of emotion-related brain areas. The stimuli were organized in three virtual-reality scenarios, each with a different emotional valence (pleasant, unpleasant and neutral). The scenarios were presented in a pseudo-randomized order in the two visualization modes to twelve healthy males. Data were analyzed through a GLM-based fixed effects procedure. Unpleasant and neutral stimuli activated the right amygdala more strongly when presented in 3D than in 2D. These results suggest that 3D stimuli, when used as “building blocks” for virtual environments, can induce increased emotional loading, as shown here through neuroimaging.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dores, A.
Secondary author(s):
Barbosa, F., Monteiro, L., Reis, M., Coelho, C., Ribeiro, E., Leitão, M., Carvalho, I., Sousa, L., Castro-Caldas, A.
Document type:
Article
Number of reproductions:
1
Reference:
Dores, A., Barbosa, F., Monteiro, L., Reis, M., Coelho, C., Ribeiro, E., Leitão, M., ... Castro-Caldas, A. (2014). Amygdala Activation in Response to 2D and 3D Emotion-Inducing Stimuli. PsychNology Journal, 12(1-2), 29 - 43.
Indexed document: Yes
Keywords: Virtual reality / 3D/2D visual stimuli / Valence (pleasant, unpleasant, neutral) / Amygdala / Functional magnetic resonance imaging (fMRI)

Amygdala Activation in Response to 2D and 3D Emotion-Inducing Stimuli

Amygdala Activation in Response to 2D and 3D Emotion-Inducing Stimuli

DocumentSleep and Emotional Functions2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-225
Location: Arquivo PCA - Pasta 12/2012
Title:
225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration: 2013-10 - 2016-02
Researcher(s):
Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s): Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Schwartz, S.
Secondary author(s):
Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code: PT/FB/BL-2012-225.02
Location: Arquivo PCA - Pasta 12/2012
Title:
Sleep and Emotional Functions
Publication year: 2014
URL:
http://link.springer.com/chapter/10.1007%2F7854_2013_271
Abstract/Results: ABSTRACT:
In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Perogamvros, L.
Secondary author(s):
Schwartz, S.
Document type:
Article
Number of reproductions:
1
Reference:
Perogamvros, L., & Schwartz, S. (2014). Sleep and Emotional Functions. Current Topics in Behavioral Neurosciences, 25, 411-431. doi: 10.1007/7854_2013_271
Indexed document: Yes
Keywords: Sleep / Sleep deprivation / Dreaming / Emotion / Cognition / Reward / Sexual function / Creativity / Memory consolidation / Brain development / Amygdala / Prefrontal cortex / Hippocampus / Ventral tegmental area / Striatum / Nucleus accumbens / Dopamine / Limbic / Mesolimbic

Sleep and Emotional Functions

Sleep and Emotional Functions

DocumentA fast pathway for fear in human amygdala2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-119
Location: Arquivo PCA - Pastas 20/2012
Title:
119 - Dynamic cortical and nucleus accumbens networks in humans: combining intracranial and MEG recordings
Duration: 2013-06 - 2016-10
Researcher(s):
Bryan Strange, Javier J. Gonzalez-Rosa, Juan A. Barcia, Stephan Moratti, Raffael Kaplan, Marijn Kroe
Institution(s): Laboratory for Clinical Neuroscience, Centre for Biomedical Technology (CTB), Technology University of Madrid (UPM) and Fundación para la Investigación Biomédica del Hospital Clínico San Carlos - Universidad Complutense de Madrid. Instituto de Investigación Sanitario IdISSC (Spain)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 Articles
2 posters
Language: eng
Author:
Strange, B.
Secondary author(s):
Gonzalez-Rosa, J., Barcia, J., Moratti, S., Kaplan, R., Kroe, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Anxiety disorders / Brain structure and function / Cognitive processes / Intervention

Reference code: PT/FB/BL-2012-119.07
Location: Arquivo PCA - Pastas 20/2012
Title:
A fast pathway for fear in human amygdala
Publication year: 2016
URL:
http://www.nature.com/neuro/journal/vaop/ncurrent/full/nn.4324.html
Abstract/Results: ABSTRACT:
A fast, subcortical pathway to the amygdala is thought to have evolved to enable rapid detection of threat. This pathway’s existence is fundamental for understanding nonconscious emotional responses, but has been challenged as a result of a lack of evidence for short-latency fear-related responses in primate amygdala, including humans. We recorded human intracranial electrophysiological data and found fast amygdala responses, beginning 74-ms post-stimulus onset, to fearful, but not neutral or happy, facial expressions. These responses had considerably shorter latency than fear responses that we observed in visual cortex. Notably, fast amygdala responses were limited to low spatial frequency components of fearful faces, as predicted by magnocellular inputs to amygdala. Furthermore, fast amygdala responses were not evoked by photographs of arousing scenes, which is indicative of selective early reactivity to socially relevant visual information conveyed by fearful faces. These data therefore support the existence of a phylogenetically old subcortical pathway providing fast, but coarse, threat-related signals
to human amygdala.
Accessibility: Document exist in file
Language:
eng
Author:
Méndez-Bértolo, C.
Secondary author(s):
Moratti, S., Toledano, R., Lopez-Sosa, F., Martínez-Alvarez, R., Mah, Y., Vuilleumier, P., Gil-Nagel, A., Strange, B.
Document type:
Article
Number of reproductions:
1
Percentiles:
3|2022-03-19
Reference:
Méndez-Bértolo, C., Moratti, S., Toledano, R., Lopez-Sosa, F., Martínez-Alvarez, R., … Strange, B. (2016). A fast pathway for fear in human amygdala. Nature Neuroscience, 19(8), 1041-1049. doi: 10.1038/nn.4324
2-year Impact Factor: 17.839|2016
Impact factor notes: Impact factor not available yet for 2018
Times cited: 155|2022-05-23
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Fear / Psychology

A fast pathway for fear in human amygdala

A fast pathway for fear in human amygdala

DocumentTribal love: the neural correlates of passionate engagement in football fans2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-373
Location: BF-GMS
Title:
373 - Multimodal Mapping of Visual Motion Perceptual Decision: Dissecting the Role of Different Motion Integration Areas in Visual Surface Reconstruction
Duration: 2016-02 - 2017-10
Researcher(s):
Miguel de Sá e Sousa de Castelo Branco, Gabriel Nascimento Ferreira da Costa, Gilberto Silva, João Valente Duarte, Ricardo Martins
Institution(s): ICNAS - Institute for Nuclear Sciences Applied to Health, Coimbra, Portugal; IBILI - Institute for Biomedical Imaging and Life Sciences, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Castelo-Branco, M.
Secondary author(s):
Costa, G., Silva, G., Duarte, J., Martins, R.
Number of reproductions:
1
Keywords:
Motion perception / Decision-making / Perceptual Ambiguity / Decision Models / Psychophysiology

Reference code: PT/FB/BL-2014-373.08
Location: BF-GMS
Title:
Tribal love: the neural correlates of passionate engagement in football fans
Publication year: 2017
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5460049/
Abstract/Results: ABSTRACT:
The tribal character of the affective link between football fans and their teams is a well-recognized phenomenon. Other forms of love such as romantic or maternal attachment have previously been studied from a neuroimaging point of view. Here we aimed to investigate the neural basis of this tribal form of love, which implies both the feeling of belongingness and rivalry against opposing teams. A pool of 56 participants was submitted to an fMRI experimental design involving the presentation of winning and losing football moments of their loved, rival or neutral teams. We found recruitment of amygdala and reward regions, including the ventral tegmental area (VTA) and substantia nigra (SN), as well as other limbic regions involved in emotional cognition, for 'positive vs neutral' and 'positive vs negative' conditions. The latter contrast was correlated with neuropsychological scores of fanaticism in the amygdala and regions within the reward system, as the VTA and SN. The observation of increased response patterns in critical components of the reward system, in particular for positive content related to the loved team, suggests that this kind of non-romantic love reflects a specific arousal and motivational state, which is biased for emotional learning of positive outcomes.
Accessibility: Document exists in file
Language:
eng
Author:
Duarte, I. C.
Secondary author(s):
Afonso, S., Jorge, H., Cayolla, R., Ferreira, C., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Duarte, I. C., Afonso, S., Jorge, H., Cayolla, R., Ferreira, C., & Castelo-Branco, M. (2017). Tribal love: the neural correlates of passionate engagement in football fans. Social Cognitive and Affective Neuroscience, 12(5), 718-728. doi: 10.1093/scan/nsx003
2-year Impact Factor: 3.500|2017
Times cited: 9|2022-05-25
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Football fan / Non-romantic love / Reward system / Substantia nigra / Ventral tegmental area

Tribal love: the neural correlates of passionate engagement in football fans

Tribal love: the neural correlates of passionate engagement in football fans

DocumentRestless REM sleep impedes overnight amygdala adaptation2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.07
Location: Arquivo PCA - Pasta 25/2012
Title:
Restless REM sleep impedes overnight amygdala adaptation
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S0960982219307614
Abstract/Results: ABSTRACT:
Animal studies show that insufficient silencing of the locus coeruleus (LC) during REM sleep impairs sleep-related brain plasticity. Restless REM sleep, a characteristic of several psychiatric disorders, likely reflects insufficient LC silencing. We investigated whether endogenous REM sleep interruptions interfere with overnight reorganization of limbic circuits in human volunteers with a wide range of insomnia severity, from no insomnia complaints to fulfilling community-sample criteria for insomnia disorder. We induced a self-conscious emotion during two functional MRI sessions and recorded sleep EEG in between. Amygdala reactivity decreased overnight in proportion to the total duration of consolidated REM sleep. Restless REM sleep, in contrast, impeded overnight amygdala adaptation. Using targeted memory reactivation with odors tagged to the self-conscious emotional stimulus, we could experimentally enhance both the favorable effect of consolidated REM sleep and the unfavorable effect of restless REM sleep. The findings reveal a maladaptive type of sleep, providing a target for interventions in mental disorders characterized by restless REM sleep.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Schalkwijk, F., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Wassing, R., Lakbila-Kamal, O., Ramautar, J. R., Stoffers, D., Schalkwijk, F., & Van Someren, E. (2019). Restless REM sleep impedes overnight amygdala adaptation. Current Biology, 29(14), 2351-2358.e4. doi: 10.1016/j.cub.2019.06.034
2-year Impact Factor: 9.601|2019
Times cited: 43|2022-05-30
Indexed document: Yes
Quartile: Q1
Keywords: REM sleep fragmentation / Amygdala / Memory reactivation / Self-conscious emotions / Spindles / Transition to REM sleep

File381 - Pathways from prenatal and postnatal stress to sleep quality across childhood: The role of the amygdala and cortisol

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-381
Location: BF-GMS
Title:
381 - Pathways from prenatal and postnatal stress to sleep quality across childhood: The role of the amygdala and cortisol
Researcher(s): Desana Kocevska, Annemarie Luik
Institution(s): Department of Epidemiology, Erasmus Medical Center, Rotterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project hasn't started yet
Author: Kocevska, D.
Secondary author(s):
Luik, A.
Number of reproductions:
1
Keywords:
Sleep / Stress / Amygdala / Cortisol / Psychophysiology

DocumentIs there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.24
Location: Arquivo PCA - Pasta 18/2006
Title:
Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
Publication year: 2012
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0920996412000606?via%3Dihub
Abstract/Results: ABSTRACT:
Patients with psychosis have higher rates of childhood trauma, which is also associated with adverse effects on cognitive functions such as attention, concentration and mental speed, language, and verbal intelligence. Although the pathophysiological substrate for this association remains unclear, these cognitive deficits may represent the functional correlate of changes observed in relation to trauma exposure in structures such as the amygdala and the hippocampus. Interestingly, these structures are often reported as altered in psychosis. This study investigated the association between childhood trauma, cognitive function and amygdala and hippocampus volume, in first-episode psychosis. We investigated 83 patients with first-episode psychosis and 63 healthy controls. All participants underwent an MRI scan acquired with a GE Sigma 1.5-T system, and a standardized neuropsychological assessment of general cognition, memory, processing speed, executive function, visuo-spatial abilities, verbal intelligence, and language. In a subsample of the patients (N=45) information on childhood trauma was collected with the Childhood Experience of Care and Abuse Questionnaire (CECA. Q). We found that amygdala, but not hippocampus, volume was significantly smaller (p=0.001) in patients compared to healthy controls. There was a trend level interaction for hippocampus volume between group and sex (p=0.056). A history of childhood trauma was associated with both worse cognitive performance and smaller amygdala volume. This smaller amygdala appeared to mediate the relationship between childhood trauma and performance on executive function, language and verbal intelligence in patients with psychosis. This points to a complex relationship between childhood trauma exposure, cognitive function and amygdala volume in first-episode psychosis.
Accessibility: Documento does not exist in file
Language:
eng
Author:
Aas, M.
Secondary author(s):
Navari, S., Gibbs, A., Mondelli, V., Fisher, H. L., Morgan, C., Morgan, K., MacCabe, J., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P. B., Murray, R. M., Pariante, C. M., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Aas, M., Navari, S., Gibbs, A., Mondelli, V., Fisher, H. L., Morgan, C., Morgan, K., MacCabe, J., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P. B., Murray, R. M., Pariante, C. M., & Dazzan, P. (2012). Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis? Schizophrenia Research, 137(1-3), 73-79. doi: 10.1016/j.schres.2012.01.035
2-year Impact Factor: 4.590|2012
Times cited: 79|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Hippocampus / Cognitive function / First-episode psychosis / Childhood trauma

DocumentStress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.05
Location: Arquivo PCA - Pasta 22/2008
Title:
Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization
Publication year: 2013
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2013.00127/full
Abstract/Results: ABSTRACT:
Exposure to a novel environment triggers the response of several brain areas that regulate emotional behaviors. Here, we studied theta oscillations within the hippocampus (HPC)-amygdala (AMY)-medial prefrontal cortex (mPFC) network in exploration of a novel environment and subsequent familiarization through repeated exposures to that same environment; in addition, we assessed how concomitant stress exposure could disrupt this activity and impair both behavioral processes. Local field potentials (LFP) were simultaneously recorded from dorsal and ventral hippocampus (dHPC and vHPC, respectively), basolateral amygdala (BLA) and mPFC in freely behaving rats while they were exposed to a novel environment, then repeatedly re-exposed over the course of 3 weeks to that same environment and, finally, on re-exposure to a novel unfamiliar environment. A longitudinal analysis of theta activity within this circuit revealed a reduction of vHPC and BLA theta power and vHPC-BLA theta coherence through familiarization which was correlated with a return to normal exploratory behavior in control rats. In contrast, a persistent over-activation of the same brain regions was observed in stressed rats that displayed impairments in novel exploration and familiarization processes. Importantly, we show that stress also affected intra-hippocampal synchrony and heightened the coherence between vHPC and BLA. In summary, we demonstrate that modulatory theta activity in the aforementioned circuit, namely in the vHPC and BLA, is correlated with the expression of anxiety in novelty-induced exploration and familiarization in both normal and pathological conditions.
Accessibility: Document exists in file
Language:
eng
Author:
Jacinto, L. R.
Secondary author(s):
Reis, J. S., Dias, N. S., Cerqueira, J. J., Correia, J. H., Sousa, N.
Document type:
Article
Number of reproductions:
1
Percentiles:
5|2022-03-19
Reference:
Jacinto, L. R., Reis, J. S., Dias, N. S., Cerqueira, J. J., Correia, J. H., & Sousa, N. (2013). Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization. Frontiers in Behavioral Neuroscience, 7, 127. doi: 10.3389/fnbeh.2013.00127
2-year Impact Factor: 4.160|2013
Times cited: 43|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Stress / Anxiety / Local field potentials / Ventral hippocampus / Amygdala / Pre-frontal cortex

Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

Stress affects theta activity in limbic networks and impairs novelty-induced exploration and familiarization

DocumentThe neurobiological correlates of gaze perception in healthy individuals and neurologic patients2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-203
Location: BF-GMS
Title:
203 - Dynamic eye-movement encoding in human cortex using ultra-high field fMRI (7Tesla)
Duration: 2021-10
Researcher(s):
Alessio Fracasso
Institution(s): Institute of Neuroscience and Psychology, University of Glasgow, Scotland (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Fracasso, A.
Number of reproductions:
1
Keywords:
Gain-field / Modelling / Saccades / Ultra high-field MRI / Psychophysiology

Reference code: PT/FB/BL-2020-203.04
Location: BF-GMS
Title:
The neurobiological correlates of gaze perception in healthy individuals and neurologic patients
Publication year: 2022
URL:
https://pubmed.ncbi.nlm.nih.gov/35327431/
Abstract/Results: The ability to adaptively follow conspecific eye movements is crucial for establishing shared attention and survival. Indeed, in humans, interacting with the gaze direction of others causes the reflexive orienting of attention and the faster object detection of the signaled spatial location. The behavioral evidence of this phenomenon is called gaze-cueing. Although this effect can be conceived as automatic and reflexive, gaze-cueing is often susceptible to context. In fact, gaze-cueing was shown to interact with other factors that characterize facial stimulus, such as the kind of cue that induces attention orienting (i.e., gaze or non-symbolic cues) or the emotional expression conveyed by the gaze cues. Here, we address neuroimaging evidence, investigating the neural bases of gaze-cueing and the perception of gaze direction and how contextual factors interact with the gaze shift of attention. Evidence from neuroimaging, as well as the fields of non-invasive brain stimulation and neurologic patients, highlights the involvement of the amygdala and the superior temporal lobe (especially the superior temporal sulcus (STS)) in gaze perception. However, in this review, we also emphasized the discrepancies of the attempts to characterize the distinct functional roles of the regions in the processing of gaze. Finally, we conclude by presenting the notion of invariant representation and underline its value as a conceptual framework for the future characterization of the perceptual processing of gaze within the STS.
Accessibility: Document exists in file
Language:
eng
Author:
Battaglia, S.
Secondary author(s):
Fabius, J. H., Moravkova, K., Fracasso, A., Borgomaneri, S.
Document type:
Article
Number of reproductions:
1
Reference:
Battaglia, S., Fabius, J. H., Moravkova, K., Fracasso, A., & Borgomaneri, S. (2022). The neurobiological correlates of gaze perception in healthy individuals and neurologic patients. Biomedicines, 10, 3, 627. doi: 10.3390/biomedicines10030627
2-year Impact Factor: 6.081|2020
Impact factor notes: Impact factor not available yet for 2022
Times cited: 2|2022-06-06
Indexed document: Yes
Quartile: Q1
Keywords: Gaze perception / Gaze-cueing / Neuroimaging / Superior temporal sulcus / Amygdala / Neurologic patients / Neurocognitive mechanisms / Non-invasive brain stimulation

The neurobiological correlates of gaze perception in healthy individuals and neurologic patients

The neurobiological correlates of gaze perception in healthy individuals and neurologic patients