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DocumentFinal report - The sense of self in the brain: Neural correlates of self-recognition2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-165
Location: Arquivo PCA - Pasta 12/2006
Title:
165 - The sense of self in the brain: Neural correlates of self-recognition
Duration: 2007-09 - 2010-01
Researcher(s):
Emmanouil (Manos) Tsakiris, Angela Sirigu, Patrick Haggard, Matteus Joffily
Institution(s): Department of Psychology, Royal Holloway, University of London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
1 Poster
2 Articles
1 Book chapter
Language: eng
Author:
Tsakiris, M.
Secondary author(s):
Sirigu, A., Haggard, P., Joffily, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Self / Body awareness

Reference code: PT/FB/BL-2006-165.01
Location: Arquivo PCA - Pasta 12/2006
Title:
Final report - The sense of self in the brain: Neural correlates of self-recognition
Publication year: 2009
URL:
http://www.bial.com/imagem/165-06-20131212.pdf
Abstract/Results: RESULTS:
The exact relation between the sense that one’s body is one’s own (body-ownership) and the sense that one controls one’s own bodily actions (agency) has been the focus of much speculation, but remains unclear. On an ‘additive’ model, agency and body-ownership are strongly related; the ability to control actions is a powerful cue to body-ownership. This view implies a component common to the senses of body-ownership and agency, plus possible additional components unique to agency. An alternative ‘independence’ model holds that agency and body-ownership are qualitatively different experiences, triggered by different inputs, and recruiting distinct brain networks. We tested these two specific models by investigating the sensory and motor aspects of body-representation in the brain using fMRI. Activations in midline cortical structures were associated with a sensory-driven sense of body-ownership, and were absent in agency conditions. Activity in the pre-SMA was linked to the sense of agency, but distinct from the sense of body-ownership. No shared activations that would support the additive model were found. The results support the independence model. Body-ownership involves a psychophysiological baseline, linked to activation of the brain’s default mode network. Agency is linked to premotor and parietal areas involved in generating motor intentions and subsequent action monitoring. The apparently inconsistent results between psychophysical and neuroimaging experiments are interpreted in the context of our recent understanding of neuropsychological syndromes that affect action- and/or body-awareness.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Tsakiris, M.
Secondary author(s):
Sirigu, A., Haggard, P., Joffily, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Agency / Body ownership / Supplementary motor area / Angular gyrus / Cortical midline structures / Self-recognition

Final report - The sense of self in the brain: Neural correlates of self-recognition

Final report - The sense of self in the brain: Neural correlates of self-recognition
DocumentThe sense of self in the brain: neural correlates of self-recognition2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-165
Location: Arquivo PCA - Pasta 12/2006
Title:
165 - The sense of self in the brain: Neural correlates of self-recognition
Duration: 2007-09 - 2010-01
Researcher(s):
Emmanouil (Manos) Tsakiris, Angela Sirigu, Patrick Haggard, Matteus Joffily
Institution(s): Department of Psychology, Royal Holloway, University of London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
1 Poster
2 Articles
1 Book chapter
Language: eng
Author:
Tsakiris, M.
Secondary author(s):
Sirigu, A., Haggard, P., Joffily, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Self / Body awareness

Reference code: PT/FB/BL-2006-165.08
Location: Arquivo PCA - Pasta 12/2006
Title:
The sense of self in the brain: neural correlates of self-recognition
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Two important aspects of self-consciousness are the sense of one’s own body (socalled ‘body-ownership’) and the sense that one controls one’s own bodily actions (agency). The exact relation between these has been the focus of much speculation, but remains unclear. We distinguish two models of their relation. On an ‘additive’ model, agency and body-ownership are strongly related, because the ability to control actions is a powerful cue to body-ownership. This view implies a component common to the senses of body-ownership and agency, plus possible additional components unique to agency. An alternative ‘independence’ model holds that agency and body-ownership are qualitatively different experiences, triggered by different inputs, and recruiting distinct brain networks.
METHODOLOGY:
We developed a paradigm to investigate sensory and motor aspects of body representation in the brain using fMRI. Participant’s either made self-generated finger-movements, or remained passive while similar movements were applied to their fingers by an external force, while seeing a video image of their hand either in real-time or with a systematic delay that generated a conflict.
RESULTS:
Activations in midline cortical structures were associated with a purely sensory-driven sense of body-ownership, and were absent in agency conditions. In contrast, activity in the pre-SMA was linked to the sense of agency, but distinct from the sense of body-ownership. Importantly, no shared activations that would support the additive model were found.
CONCLUSIONS:
The results support an independence model of agency and body-ownership, and do not support the additive model. Agency and body-ownership appear to be qualitatively different experiences, representing two distinct components of self-recognition. The feeling of ownership over one’s body involves a psychophysiological baseline, linked to activation of the brain’s default mode network. Agency over one’s body is linked to premotor and parietal areas involved in the generation of motor intentions and subsequent action monitoring.
Accessibility: Document does not exist in file
Language:
eng
Author:
Tsakiris, M.
Secondary author(s):
Sirigu, A., Haggard, P., Joffily, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Tsakiris, M., Sirigu, A., Haggard, P., & Joffily, M. (2010). The sense of self in the brain: neural correlates of self-recognition. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 243). Porto: Fundação Bial.
Indexed document: No
Keywords: Agency / Body ownership / Supplementary motor area / Angular gyrus / Cortical midline structures / Self-recognition

The sense of self in the brain: neural correlates of self-recognition

The sense of self in the brain: neural correlates of self-recognition
DocumentBrain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-190
Location: BF-GMS
Title:
190 - Sleeping body, sentient mind? Searching for the neural bases of conscious experiences during sleep
Duration: 2017-10 - 2019-06
Researcher(s):
Eus Van Someren, Yishul Wei
Institution(s): Department of Sleep and Cognition, Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Author: Van Someren, E.
Secondary author(s):
Wei, Y.
Number of reproductions:
1
Keywords:
Interoception / Insomnia / Neural correlates of consciousness / Salience / Psychophysiology

Reference code: PT/FB/BL-2016-190.07
Location: BF-GMS
Title:
Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S2213158219303699
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probabilistic diffusion tractography to compare the whole-brain structural connectivity networks of people with ID and those of matched controls without sleep complaints.
Diffusion-weighted images and T1-weighed images were acquired in 51 people diagnosed with ID (21–69 years of age, 37 female) and 48 matched controls without sleep complaints (22–70 years of age, 31 female). Probabilistic tractography was performed to construct the whole-brain structural connectivity network of each participant. Case–control differences in connectivity strength and network efficiency were evaluated with permutation tests.
People with ID showed structural hyperconnectivity within a subnetwork that spread over frontal, parietal, temporal, and subcortical regions and was anchored at the right angular gyrus. The result was robust across different edge-weighting strategies. Moreover, converging support was given by the finding of heightened right angular gyrus nodal efficiency (harmonic centrality) across varying graph density in people with ID. Follow-up correlation analyses revealed that subnetwork connectivity was associated with self-reported reactive hyperarousal.
The findings demonstrate that the right angular gyrus is a hub of enhanced structural connectivity in ID. Hyperconnectivity within the identified subnetwork may contribute to increased reactivity to stimuli and may signify vulnerability to ID.
Accessibility: Document exist in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., Foster-Dingleya, J. C.
Document type:
Article
Number of reproductions:
1
Reference:
Wei, Y., Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., & Foster-Dingleya, J. C. (2019). Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus. NeuroImage: Clinical, 24: 102019. https://doi.org/10.1016/j.nicl.2019.102019
2-year Impact Factor: 4.350|2019
Times cited: 21|2025-09-17
Indexed document: Yes
Quartile: Q2
Keywords: Tractography / Diffusion-weighted MRI / Connectome / Angular gyrus / Insomnia disorder / Reactivity

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
DocumentBrain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.08
Location: Arquivo PCA - Pasta 25/2012
Title:
Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S2213158219303699
Abstract/Results: ABSTRACT:
Insomnia Disorder (ID) is a prevalent and persistent condition, yet its neural substrate is not well understood. The cognitive, emotional, and behavioral characteristics of ID suggest that vulnerability involves distributed brain networks rather than a single brain area or connection. The present study utilized probabilistic diffusion tractography to compare the whole-brain structural connectivity networks of people with ID and those of matched controls without sleep complaints.
Diffusion-weighted images and T1-weighed images were acquired in 51 people diagnosed with ID (21–69 years of age, 37 female) and 48 matched controls without sleep complaints (22–70 years of age, 31 female). Probabilistic tractography was performed to construct the whole-brain structural connectivity network of each participant. Case–control differences in connectivity strength and network efficiency were evaluated with permutation tests.
People with ID showed structural hyperconnectivity within a subnetwork that spread over frontal, parietal, temporal, and subcortical regions and was anchored at the right angular gyrus. The result was robust across different edge-weighting strategies. Moreover, converging support was given by the finding of heightened right angular gyrus nodal efficiency (harmonic centrality) across varying graph density in people with ID. Follow-up correlation analyses revealed that subnetwork connectivity was associated with self-reported reactive hyperarousal.
The findings demonstrate that the right angular gyrus is a hub of enhanced structural connectivity in ID. Hyperconnectivity within the identified subnetwork may contribute to increased reactivity to stimuli and may signify vulnerability to ID.
Accessibility: Document exists in file
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., Foster-Dingleya, J. C.
Document type:
Article-d
Number of reproductions:
1
Reference:
Wei, Y., Bresser, T., Wassing, R., Stoffers, D., Van Someren, E. J. W., & Foster-Dingleya, J. C. (2019). Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus. NeuroImage: Clinical, 24: 102019. https://doi.org/10.1016/j.nicl.2019.102019
2-year Impact Factor: 4.350|2019
Times cited: 21|2025-09-17
Indexed document: Yes
Quartile: Q2
Keywords: Tractography / Diffusion-weighted MRI / Connectome / Angular gyrus / Insomnia disorder / Reactivity

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus

Brain structural connectivity network alterations in insomnia disorder reveal a central role of the right angular gyrus
DocumentA protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-119
Location: BF-GMS
Title:
A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness
Publication year: 2023
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2023.1216468/full
Abstract/Results: ABSTRACT:
Background: Improving the functional recovery of patients with DoC remains one of the greatest challenges of the field. Different theories exist about the role of the anterior (prefrontal areas) versus posterior (parietal areas) parts of the brain as hotspots for the recovery of consciousness. Repetitive transcranial magnetic stimulation (rTMS) is a powerful non-invasive brain stimulation technique for the treatment of DoC. However, a direct comparison of the effect of TMS treatment on the front versus the back of the brain has yet to be performed. In this study, we aim to assess the short- and long-term effects of frontal and parietal rTMS on DoC recovery and characterize responders phenotypically.
Methods/design: Ninety patients with subacute and prolonged DoC will be included in a two-part multicenter prospective study. In the first phase (randomized controlled trial, RCT), patients will undergo four rTMS sessions in a crossover design over 10 days, targeting (i) the left dorsolateral prefrontal cortex (DLPFC) and (ii) the left angular gyrus (AG), as well as (iii & iv) their sham alternatives. In the second phase (longitudinal personalized trial), patients will receive personalized stimulations for 20 working days targeting the brain area that showed the best results in the RCT and will be randomly assigned to either active or sham intervention. The effects of rTMS on neurobehavioral and neurophysiological functioning in patients with DoC will be evaluated using clinical biomarkers of responsiveness (i.e., the Coma Recovery Scale-Revised; CRS-R), and electrophysiological biomarkers (e.g., power spectra, functional and effective connectivity, perturbational complexity index before and after intervention). Functional long-term outcomes will be assessed at 3 and 6 months post-intervention. Adverse events will be recorded during the treatment phase.
Discussion: This study seeks to identify which brain region (front or back) is best to stimulate for the treatment of patients with DoC using rTMS, and to characterize the neural correlates of its action regarding recovery of consciousness and functional outcome. In addition, we will define the responders' profile based on patients' characteristics and functional impairments; and develop biomarkers of responsiveness using EEG analysis according to the clinical responsiveness to the treatment.
Accessibility: Document exists in file
Language:
eng
Document type:
Article
Number of reproductions:
3
Reference:
Vitello, M. M., Rosenfelder, M. J., Cardone, P., Niimi, M., Willacker, L., Thibaut, A., Lejeune, N., Laureys, S., Bender, A., & Gosseries, O. (2023). A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness. Frontiers in Neurology, 14, 1216468. https://doi.org/10.3389/fneur.2023.1216468
2-year Impact Factor: 2.7|2023
Times cited: 5|2025-09-26
Indexed document: Yes
Quartile: Q2
Keywords: Angular gyrus / Coma / Dorsolateral prefrontal cortex / Minimally conscious state / Non-invasive brain stimulation / Treatment / Unresponsive wakefulness syndrome / Vegetative state

A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness

A protocol for a multicenter randomized and personalized controlled trial using rTMS in patients with disorders of consciousness
DocumentFinal report - Schema-based temporal memory in parietal cortex (SCHETEMP)2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-384
Location: BF-GMS
Title:
384 - Schema-based temporal memory in parietal cortex (SCHETEMP)
Duration: 2021-10 - 2023-11
Researcher(s):
Matteo Frisoni, Paolo Capotosto
Institution(s): Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi "G. d'Annunzio" Chieti - Pescara (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Frisoni, M.
Secondary author(s):
Capotosto, P.
Number of reproductions:
1
Keywords:
TMS/EEG / Memory for time / Episodic memory / Schematic knowledge / Psychophysiology

Reference code: PT/FB/BL-2020-384.01
Location: BF-GMS
Title:
Final report - Schema-based temporal memory in parietal cortex (SCHETEMP)
Publication year: 2023
Abstract/Results:
ABSTRACT:
Background
The ability to organize events in time is a hallmark of episodic memory. However, relatively little is known about the cognitive and neural mechanisms underlying temporal memory for complex events.
Aims
We investigated behaviorally the role of schematic prior knowledge on temporal memory. An EEG study aimed to identify an oscillatory signature of temporal memory precision. A TMS study tested the hypothesis of a causal role of the angular gyrus (AG) in temporal memory.
Method
Participants performed a timeline task. Behaviorally, a mismatch between prior knowledge and encoding material was created. For the EEG study, a multivariate pattern analysis (MVPA) of the time-frequency data was used to classify trials associated with low, medium and high precision. A representational similarity analysis (RSA) was used to examine the similarity between the behavioral and neural distance associated with pairs of movie parts. We applied rTMS over AG during the timeline task.
Results
Participants tended to automatically adjust the temporal representation according to their schematic knowledge. We found that widespread oscillatory activity in the high beta/low gamma frequency (28-40Hz) codes for both temporal memory precision and the representation of event structure. We found a facilitatory effect on temporal memory after the beta stimulation of the right AG (but not of the left AG).
Conclusions
We found an automatic effect of prior knowledge on temporal memory. Crucially, we found an oscillatory signature of temporal memory in high beta/low gamma band. This activity seems to be subserved by a distributed cortical network which involves the right angular gyrus.
Accessibility: Document exists in file
Language:
eng
Author:
Frisoni, M.
Secondary author(s):
Capotosto, P.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Temporal episodic memory / Temporal representation / Beta/gamma band / Parietal cortex / Angular gyrus

Final report - Schema-based temporal memory in parietal cortex (SCHETEMP)

Final report - Schema-based temporal memory in parietal cortex (SCHETEMP)