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DocumentPain control from the brain: Gene therapy in the treatment of chronic pain2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-015
Location: Arquivo PCA - Pasta 21/2004
Title:
015 - Pain control from the brain - Gene therapy in the treatment of chronic pain
Duration: 2005-01 - 2009-01
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Marta Pinto, Isabel Martins
Institution(s): Instituto de Histologia e Embriologia, Faculdade de Medicina da Universidade do Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 posters
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2004-015.14
Location: Arquivo PCA - Pasta 21/2004
Title:
Pain control from the brain: Gene therapy in the treatment of chronic pain
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES: Develop new methods of manipulation of the supraspinal pain control system to correct the neurobiological changes induced by chronic pain. The studies were focused on two components of the supraspinal pain control system: the dorsal reticular nucleus (DRt) and the caudal ventrolateral medulla(VLM). These two areas were elected based on the profound knowledge of their participation in pain modulation at the spinal cord level. The DRt is involved in pain facilitation whereas the VLM appears to be involved in mixed effects (facilitatory and inhibitory).
METHODS:
Transduction of neurons by HSV-1 (Herpes-Simplex Virus, type 1) or lentiviral based constructs (replication- defective forms) and evaluation of nociceptive behaviours in sustained and chronic pain models. In the case of the DRt, three studies were performed using the following constructs and pain models: 1) HSV-1 vectors
overexpressing pre-proenkephalin in monoarthritic animals; 2) HSV-1 vectors overexpressing mu-opioid receptors (MOR) in a neuropathic pain model; 3) HSV-1 vectors that reduce the release of noradrenaline in a neuropathic pain model. In the VLM, we studied the effect of overexpressing pre-proenkephalin in an inflammatory pain model.
RESULTS:
In summary, the studies demonstrated that chronic pain affects descending modulation and that gene transfer can correct those effects in a sustained manner. The studies indicate that during chronic pain, a depression in the expression of MOR at the DRt is associated with hyperalgesic effects induced by local injection of opioids. The hyeperalgesia induced by overexpression of enkephalins at the DRt can be switched to analgesia by overexpression of MOR. It is possible that the VLM does not undergo similar changes since local overexpression of enkephalins induces analgesia. A decrease of noradrenaline release at the DRt is analgesic probably because chronic pain increases the tonus of noradrenergic input to the DRt and facilitates pain modulation from this nucleus.
CONCLUSION:
By allowing sustained and directed manipulation, gene transfer is an effective tool to study pain modulation from the brain. Vector constructs produced taking into account the specific changes induced by chronic pain in the brain will continue to be developed.
PUBLICATIONS (full papers):
1. Pinto M, Lima D, Tavares I. (2007). Neuronal activation at the spinal cord and medullary pain control centres after brief stimulation of an inflamed joint: a c-fos study in the monoarthritic rat. Neuroscience, 147:1076-1089.
2. Pinto M, Castro AR, Tushdy F, Wilson SP, Lima D, Tavares I. (2008). Opioids modulate pain facilitation from the dorsal reticular nucleus. Mol. Cell Neurosci, 39: 508-518.
3. Pinto M, Sousa M, Lima D, Tavares I. (2008) Expression of µ-opioid, GABAB and NK1 receptors in spinally-projecting neurons of the caudal medulla oblongata: implications for descending modulation of nociceptive transmission. J. Comp. Neurol., 510: 175-187.
4. Tavares I, Lima D. (2007). From neuroanatomy to gene therapy: searching for new ways to manipulate the supraspinal endogenous pain modulatory system. J. Anatomy, 211: 261-268.
5. Martins I, Pinto M, Lima D, Wilson SP, Tavares I. (2008). Dynamic of migration of HSV-1 from a medullary pronociceptive centre: antinociception by overexpression of the preproenkephalin transgene". Eur. J. Neurosci., 28: 2075-2083.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Pinto, M., Martins, I.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Lima, D., Tavares, I., Pinto, M., & Martins, I. (2010). Pain control from the brain: Gene therapy in the treatment of chronic pain. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (pp. 184-185). Porto: Fundação Bial.
Indexed document: No
Keywords: Receptor expression / Animal models / Gene transfer / Viral vectors

Pain control from the brain: Gene therapy in the treatment of chronic pain

Pain control from the brain: Gene therapy in the treatment of chronic pain
DocumentRodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.03
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189637/
Abstract/Results: ABSTRACT:
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain. To ensure progress in the understanding of the neuropathophysiology of these disorders, animal models with good construct and predictive validity are indispensable. Many human studies aimed at measuring decision-making capacities use the Iowa gambling task (IGT), a task designed to model everyday life choices through a conflict between immediate gratification and long-term outcomes. Recently, new rodent models based on the same principle have been developed to investigate the neurobiological mechanisms underlying IGT-like decision-making on behavioral, neural, and pharmacological levels. The comparative strengths, as well as the similarities and differences between these paradigms are discussed. The contribution of these models to elucidate the neurobehavioral factors that lead to poor decision-making and to the development of better treatments for psychiatric illness is considered, along with important future directions and potential limitations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
De Visser, L.
Secondary author(s):
Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., Fitoussi, A., Galhardo, V., Van den Boos, R., Winstanley, C., Dellu-Hagedorn, F.
Document type:
Article
Number of reproductions:
1
Reference:
De Visser, L., Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., ..., Dellu-Hagedorn, F. (2011). Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making. Frontiers in Neuroscience, 5, 109. https://doi.org/10.3389/fnins.2011.00109
2-year Impact Factor: N/A
Impact factor notes: Impact factor computed since 2014
Times cited: 90|2025-02-24
Indexed document: Yes
Quartile: N/A
Keywords: Iowa gambling task (IGT) / Animal models / Validity / Dopamine / Serotonin / Neurobiology

Novo ficheiro

Novo ficheiro
DocumentThe underestimated sex: A review on female animal models of depression 2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09 - 2019-10
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.19
Location: BF-GMS
Title:
The underestimated sex: A review on female animal models of depression
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0149763421005698?via%3Dihub
Abstract/Results: Major depression (MD) is the most common psychiatric disorder, predicted to affect around 264 million people
worldwide. Although the etiology of depression remains elusive, the interplay between genetics and environmental factors, such as early life events, stress, exposure to drugs and health problems appears to underlie its
development. Whereas depression is twice more prevalent in women than in men, most preclinical studies are
performed in male rodents. In fact, females’ physiology and reproductive experience are associated with changes
to brain, behavior and endocrine profiles that may influence both stress, an important precipitating factor for
depression, and response to treatment. These specificities emphasize the need to choose the most suitable models
and readouts in order to better understand the pathophysiological mechanisms of depression in females.
With this review, we aim to provide an overview of female animal models of depression highlighting the major
differences between models, regarding behavioral, physiological, and molecular readouts, but also the major
gaps in research, attending to the role of etiological factors, protocol variability and sex.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
Lima, S.
Secondary author(s):
Sousa, N., Patrício, P., Pinto, L.
Document type:
Article
Number of reproductions:
1
Reference:
Lima, S., Sousa, N., Patrício, P. & Pinto, L. (2022). The underestimated sex: A review on female animal models of depression. Neuroscience and Biobehavioral Reviews, 133, 104498. https://doi.org/10.1016/j.neubiorev.2021.12.021
2-year Impact Factor: 8.200|2022
Times cited: 15|2025-02-17
Indexed document: Yes
Quartile: Q1
Keywords: Depression / Females / Animal models / Chronic stress / Social stress / Genetic models / Sex differences

The underestimated sex: A review on female animal models of depression

The underestimated sex: A review on female animal models of depression
DocumentInteractions between sleep and emotions in humans and animal models2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-169
Location: BF-GMS
Title:
169 - The potential effect of behavioral stimulation on social competence in dogs (via endogenous oxytocin release)
Duration: 2017-01 - 2021-11
Researcher(s):
Anna Kis, József Topál, Alin Ciobica, Radu Lefter, Katinka Tóth
Institution(s): Institute of Cognitive Neuroscience and Psychology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest (Hungary); Department of Animal Physiology and Behaviour "Alexandru Ioan Cuza" University, Iasi (Romania)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Kis, A.
Secondary author(s):
Topál, J., Ciobica, A., Lefter, R., Tóth, K.
Number of reproductions:
1
Keywords:
Dog (Canis familiaris) / Social stimutation / Oxytocin / Social cognition / Psychophysiology

Reference code: PT/FB/BL-2016-169.30
Location: BF-GMS
Title:
Interactions between sleep and emotions in humans and animal models
Publication year: 2022
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8877042/
Abstract/Results: Recently, increased interest and efforts were observed in describing the possible interaction between sleep and emotions. Human and animal model studies addressed the implication of both sleep patterns and emotional processing in neurophysiology and neuropathology in suggesting a bidirectional interaction intimately modulated by complex mechanisms and factors. In this context, we aimed to discuss recent evidence and possible mechanisms implicated in this interaction, as provided by both human and animal models in studies. In addition, considering the affective component of brain physiological patterns, we aimed to find reasonable evidence in describing the two-way association between comorbid sleep impairments and psychiatric disorders. The main scientific literature databases (PubMed/Medline, Web of Science) were screened with keyword combinations for relevant content taking into consideration only English written papers and the inclusion and exclusion criteria, according to PRISMA guidelines. We found that a strong modulatory interaction between sleep processes and emotional states resides on the activity of several key brain structures, such as the amygdala, prefrontal cortex, hippocampus, and brainstem nuclei. In addition, evidence suggested that physiologically and behaviorally related mechanisms of sleep are intimately interacting with emotional perception and processing which could advise the key role of sleep in the unconscious character of emotional processes. However, further studies are needed to explain and correlate the functional analysis with causative and protective factors of sleep impairments and negative emotional modulation on neurophysiologic processing, mental health, and clinical contexts.
Accessibility: Document exists in file
Language:
eng
Author:
Lefter, R.
Secondary author(s):
Cojocariu, R. O., Ciobica, A., Balmus, I.-M., Kis, A.
Document type:
Article
Number of reproductions:
1
Reference:
Lefter, R., Cojocariu, R.O., Ciobica, A., Balmus, I.-M., Mavroudis, I. & Kis, A. (2022). Interactions between sleep and emotions in humans and animal models. Medicina, 58(2), 274. https://doi.org/10.3390/medicina58020274
2-year Impact Factor: 2.600|2022
Times cited: 7|2025-02-17
Indexed document: Yes
Quartile: Q3
Keywords: Sleep / Emotions / Human / Animal models

Interactions between sleep and emotions in humans and animal models

Interactions between sleep and emotions in humans and animal models
DocumentBrain state identification and neuromodulation to promote recovery of consciousness2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-142
Location: BF-GMS
Title:
Brain state identification and neuromodulation to promote recovery of consciousness
Publication year: 2024
URL:
https://doi.org/10.1093/braincomms/fcae362
Abstract/Results: ABSTRACT:
Experimental and clinical studies of consciousness identify brain states (i.e. quasi-stable functional cerebral organization) in a non-systematic manner and largely independent of the research into brain state modulation. In this narrative review, we synthesize advances in the identification of brain states associated with consciousness in animal models and physiological (sleep), pharmacological (anaesthesia) and pathological (disorders of consciousness) states of altered consciousness in humans. We show that in reduced consciousness the frequencies in which the brain operates are slowed down and that the pattern of functional communication is sparser, less efficient, and less complex. The results also highlight damaged resting-state networks, in particular the default mode network, decreased connectivity in long-range connections and especially in the thalamocortical loops. Next, we show that therapeutic approaches to treat disorders of consciousness, through pharmacology (e.g. amantadine, zolpidem), and (non-) invasive brain stimulation (e.g. transcranial direct current stimulation, deep brain stimulation) have shown partial effectiveness in promoting consciousness recovery. Although some features of conscious brain states may improve in response to neuromodulation, targeting often remains non-specific and does not always lead to (behavioural) improvements. The fields of brain state identification and neuromodulation of brain states in relation to consciousness are showing fascinating developments that, when integrated, might propel the development of new and better-targeted techniques for disorders of consciousness. We here propose a therapeutic framework for the identification and modulation of brain states to facilitate the interaction between the two fields. We propose that brain states should be identified in a predictive setting, followed by theoretical and empirical testing (i.e. in animal models, under anaesthesia and in patients with a disorder of consciousness) of neuromodulation techniques to promote consciousness in line with such predictions. This framework further helps to identify where challenges and opportunities lay for the maturation of brain state research in the context of states of consciousness. It will become apparent that one angle of opportunity is provided through the addition of computational modelling. Finally, it aids in recognizing possibilities and obstacles for the clinical translation of these diagnostic techniques and neuromodulation treatment options across both the multimodal and multi-species approaches outlined throughout the review.
Accessibility: Document exists in file
Language:
eng
Author:
van der Lande, G. J. M.
Secondary author(s):
Casas-Torremocha, D., Manasanch, A., Dalla Porta, L., Gosseries, O., Alnagger, N., Barra, A., Mejías, J. F., Panda, R., Riefolo, F., Thibaut, A., Bonhomme, V., Thirion, B., Clasca, F., Gorostiza, P., Sanchez-Vives, M. V., Deco, G., Laureys, S., Zamora-López, G., Annen, J.
Document type:
Article
Number of reproductions:
3
Reference:
van der Lande, G. J. M., Casas-Torremocha, D., Manasanch, A., Dalla Porta, L., Gosseries, O., Alnagger, N., Barra, A., Mejías, J. F., Panda, R., Riefolo, F., Thibaut, A., Bonhomme, V., Thirion, B., Clasca, F., Gorostiza, P., Sanchez-Vives, M. V., Deco, G., Laureys, S., Zamora-López, G., & Annen, J. (2024). Brain state identification and neuromodulation to promote recovery of consciousness. Brain Communications, 6(5), fcae362. https://doi.org/10.1093/braincomms/fcae362
2-year Impact Factor: 4.1|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2025-02-19
Indexed document: Yes
Quartile: Q1
Keywords: (disorders of) Consciousness / Anaesthesia / Animal models / Brain states / Neuromodulation

Brain state identification and neuromodulation to promote recovery of consciousness

Brain state identification and neuromodulation to promote recovery of consciousness