History
Processing, please wait...
Database
search
in
Filter year from
to
Language
Country
  • Enter your search phrase in the search box.
  • General search:
    • The Boolean operator AND between the terms is assumed by default. If you enter the words European Union in the search box, the system returns all records in which both words occur, regardless of their order.
    • When entering a set of words in quotes, e.g "european union", all records containing the literal term "European Union" will be retrieved.
  • Search by access fields (e.g. author, title, etc.):
    • To direct your search, choose the field in which you want to search the word or expression.
    • Search in the field assumes by default the expression in quotes, e.g. European union will retrieve all records containing the literal term "European Union"
  • To perform more complex searches, additional words or expressions may be added.
  • If you want to refine the search results, you can always access the link "search" in the upper left corner of the page of search results.
  • The search engine is not case sensitive. For example, the word congress has the same meaning that Congress or CONGRESS.
  • To truncate your search expression, use the $ character
  • You can filter the results of your search by a date or date range, filling the appropriate boxes.
Base:
BIAL Foundation
Search:
DE:"Astrocytes"
Results
1
to
12
from
12
found.
View
Selection Description
Type Title Begin End
DocumentThe choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-217
Location: Arquivo PCA - Pasta 27/2012
Title:
217 - Temporal modulation of the subventricular zone neural stem cell niche by choroid plexus-cerebrospinal fluid derived factors
Duration: 2013-08 - 2019-01
Researcher(s):
João Carlos Cruz de Sousa, Fernanda Marques, Joana Palha, Ana Luísa Falcão, Ashley Novais
Institution(s): ICVS/3B's - Laboratório Associado (ICVS/3B's), Universidade do Minho (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
6 Articles
1 Master thesis
Language: eng
Author:
Sousa, J.
Secondary author(s):
Marques, F., Palha, P., Falcão, A., Novais, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function

Reference code: PT/FB/BL-2012-217.02
Location: Arquivo PCA - Pasta 27/2012
Title:
The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system
Publication year: 2015
URL:
http://journal.frontiersin.org/article/10.3389/fncel.2015.00136/abstract
Abstract/Results: ABSTRACT:
The blood brain barrier (BBB) and the blood cerebrospinal fluid barrier (BCSFB) form the barriers of the brain. These barriers are essential not only for the protection of the brain, but also in regulating the exchange of cells and molecules in and out of the brain. The choroid plexus (CP) epithelial cells and the arachnoid membrane form the BCSFB. The CP is structurally divided into two independent compartments: one formed by a unique and continuous line of epithelial cells that rest upon a basal lamina; and, a second consisting of a central core formed by connective and highly vascularized tissue populated by diverse cell types (fibroblasts, macrophages and dendritic cells). Here, we review how the CP transcriptome and secretome vary depending on the nature and duration of the stimuli to which the CP is exposed. Specifically, when the peripheral stimulation is acute the CP response is rapid, strong and transient, whereas if the stimulation is sustained in time the CP response persists but it is weaker. Furthermore, not all of the epithelium responds at the same time to peripheral stimulation, suggesting the existence of a synchrony system between individual CP epithelial cells.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Marques, F.
Secondary author(s):
Sousa, J.
Document type:
Article
Number of reproductions:
1
Reference:
Marques, F., & Sousa, J. C. (2015). The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system. Frontiers in Cellular Neuroscience, 9:136. https://doi.org/10.3389/fncel.2015.00136
2-year Impact Factor: 4.609|2015
Times cited: 33|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Choroid plexus / Epithelial cell / Lipocalin 2 / Inflammation / Multiple sclerosis / Experimental autoimmune encephalomyelitis / Astrocytes / Cerebrospinal fluid

The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system

The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system
DocumentAstrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10 - 2019-11
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.08
Location: BF-GMS
Title:
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S0006899320300561#s0105
Abstract/Results: ABSTRACT:
The central nervous system (CNS) has a limited auto-regeneration capacity, which makes it challenging for the development of new therapies. Previous studies from our lab have demonstrated the applicability of human bone marrow mesenchymal stem cells (hBM-MSCs) secretome as a possible therapeutic tool for CNS. Astrocytes, glial cells present in all brain regions, are important players in brain function through their vast influence in extracellular homeostasis, neuro-vascular regulation, synaptic modulation and neurogenesis. Thus, in the present work, we aimed to evaluate the specific impact of MSCs secretome on hippocampal proliferation and astrocyte morphology, in both WT and dnSNARE mice, a transgenic model that presents impaired astrocytic exocytosis and consequently impaired astrocytic function. Results demonstrated increased levels of proliferation for WT when treated with secretome. Additionally, it was possible to observe that dnSNARE animals injected with hBM-MSCs secretome disclosed increased levels of proliferating GFAP stained cells at the SGZ. Morphometrical evaluation found increased process hypertrophy and branching of dnSNARE astrocytes when treated with secretome. These results are closely related with the trophic factors present in the secretome, namely FGF-2, BDNF, GDNF, IGF-1, VEGF, CADH2, PEDF and miR-16. Moreover, the impaired exocytosis of astrocytes may also have implications for the response to the proliferative stimulus, given the established autocrine signaling through this mechanism.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2018-037.02
Author: Campos, J.
Secondary author(s):
Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., Salgado, A. J.
Document type:
Article
Number of reproductions:
1
Reference:
Campos, J., Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., & Salgado, A. J. (2020). Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Research, 1732: 146700. https://doi.org/10.1016/j.brainres.2020.146700
2-year Impact Factor: 3.252|2020
Times cited: 6|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Mesenchymal stem cells / Secretome / Astrocytes / dnSNARE / Proliferation / Radial glia / Dentate gyrus
DocumentAstrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.02
Location: BF-GMS
Title:
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S0006899320300561#s0105
Abstract/Results: ABSTRACT:
The central nervous system (CNS) has a limited auto-regeneration capacity, which makes it challenging for the development of new therapies. Previous studies from our lab have demonstrated the applicability of human bone marrow mesenchymal stem cells (hBM-MSCs) secretome as a possible therapeutic tool for CNS. Astrocytes, glial cells present in all brain regions, are important players in brain function through their vast influence in extracellular homeostasis, neuro-vascular regulation, synaptic modulation and neurogenesis. Thus, in the present work, we aimed to evaluate the specific impact of MSCs secretome on hippocampal proliferation and astrocyte morphology, in both WT and dnSNARE mice, a transgenic model that presents impaired astrocytic exocytosis and consequently impaired astrocytic function. Results demonstrated increased levels of proliferation for WT when treated with secretome. Additionally, it was possible to observe that dnSNARE animals injected with hBM-MSCs secretome disclosed increased levels of proliferating GFAP stained cells at the SGZ. Morphometrical evaluation found increased process hypertrophy and branching of dnSNARE astrocytes when treated with secretome. These results are closely related with the trophic factors present in the secretome, namely FGF-2, BDNF, GDNF, IGF-1, VEGF, CADH2, PEDF and miR-16. Moreover, the impaired exocytosis of astrocytes may also have implications for the response to the proliferative stimulus, given the established autocrine signaling through this mechanism.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2014-207.08
Author: Campos, J.
Secondary author(s):
Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., Salgado, A. J.
Document type:
Article-d
Number of reproductions:
1
Reference:
Campos, J., Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., & Salgado, A. J. (2020). Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Research, 1732: 146700. https://doi.org/10.1016/j.brainres.2020.146700
2-year Impact Factor: 3.252|2020
Times cited: 6|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Mesenchymal stem cells / Secretome / Astrocytes / dnSNARE / Proliferation / Radial glia / Dentate gyrus
DocumentTet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09 - 2019-10
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.09
Location: BF-GMS
Title:
Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice
Publication year: 2020
URL:
https://www.ncbi.nlm.nih.gov/pubmed/32103150
Abstract/Results: ABSTRACT:
TET3 is a member of the ten-eleven translocation (TET) family of enzymes which oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC). Tet3 is highly expressed in the brain, where 5hmC levels are most abundant. In adult mice, we observed that TET3 is present in mature neurons and oligodendrocytes but is absent in astrocytes. To investigate the function of TET3 in adult postmitotic neurons, we crossed Tet3 floxed mice with a neuronal Cre-expressing mouse line, Camk2a-CreERT2, obtaining a Tet3 conditional KO (cKO) mouse line. Ablation of Tet3 in adult mature neurons resulted in increased anxiety-like behavior with concomitant hypercorticalism, and impaired hippocampal-dependent spatial orientation. Transcriptome and gene-specific expression analysis of the hippocampus showed dysregulation of genes involved in glucocorticoid signaling pathway (HPA axis) in the ventral hippocampus, whereas upregulation of immediate early genes was observed in both dorsal and ventral hippocampal areas. In addition, Tet3 cKO mice exhibit increased dendritic spine maturation in the ventral CA1 hippocampal subregion. Based on these observations, we suggest that TET3 is involved in molecular alterations that govern hippocampal-dependent functions. These results reveal a critical role for epigenetic modifications in modulating brain functions, opening new insights into the molecular basis of neurological disorders.
Accessibility: Document does not exist in file
Language:
eng
Author:
Antunes, C.
Secondary author(s):
Da Silva, J. D., Guerra-Gomes, S., Alves, N. D., Ferreira, F., Loureiro-Campos, E., Branco, M. R., Sousa, N., Reik, W., Pinto, L., Marques, C. J.
Document type:
Article
Number of reproductions:
1
Reference:
Antunes, C., Da Silva, J. D., Guerra-Gomes, S., Alves, N. D., Ferreira, F., Loureiro-Campos, E., ..., Marques, C. J. (2020). Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice. Molecular Psychiatry, 26(5), 1445–1457. https://doi.org/10.1038/s41380-020-0695-7
2-year Impact Factor: 15.992|2020
Times cited: 41|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Astrocytes / Anxiety-like behavior
DocumentIP3R2 null mice display a normal acquisition of somatic and neurological development milestones2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.03
Location: BF-GMS
Title:
IP3R2 null mice display a normal acquisition of somatic and neurological development milestones
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14724
Abstract/Results: ABSTRACT:
Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels. These astrocytic Ca2+ elevations emerge from different sources and display complex spatio-temporal properties. Ca2+ elevations are spatially distributed in global (soma and main processes) and/or focal regions (microdomains). The inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model lacks global Ca2+ elevations in astrocytes and it has been used by different laboratories. However, the constitutive deletion of IP3R2 during development may trigger compensating phenotypes, which could bias the results of experiments using developing or adult mice. To address this issue, we performed a detailed neurodevelopmental evaluation of male and female IP3R2 KO mice, during the first 21 days of life, as well as an evaluation of motor function, strength and neurological reflexes in adult mice. Our results show that male and female IP3R2 KO mice display a normal acquisition of developmental milestones, as compared with wild-type (WT) mice. We also show that that IP3R2 KO mice display normal motor coordination, strength and neurological reflexes in adulthood. To exclude a potential compensatory overexpression of other IP3Rs, we quantified the relative mRNA levels of all 3 subtypes, in brain tissue. We found that, along with the complete deletion of Itpr2, there is no compensatory expression of Itpr1 or Itrp3. Overall, our results show that the IP3R2 KO mouse is a reliable model to study the functional impact of global IP3R2-dependent astrocytic Ca2+ elevations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2014-207.09; BL-2014-427.10
Author: Guerra-Gomes, S.
Secondary author(s):
Cunha-Garcia, D. , Marques Nascimento, D. S., Duarte-Silva, S. , Loureiro-Campos, E. , Morais Sardinha, V. , Viana, J. F. , Sousa, N. , Maciel, P. , Pinto, L., Oliveira, J. F.
Document type:
Article
Number of reproductions:
1
Reference:
Guerra-Gomes, S., Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., ... Oliveira, J. F. (2020). IP3R2 null mice display a normal acquisition of somatic and neurological development milestones. European Journal of Neuroscience, 54(5), 5673–5686. https://doi.org/10.1111/ejn.14724
2-year Impact Factor: 3.386|2020
Times cited: 11|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Astrocytes / IP3R2 / Behavior / Calcium signaling / Development
DocumentIP3R2 null mice display a normal acquisition of somatic and neurological development milestones2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10 - 2019-11
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.09
Location: BF-GMS
Title:
IP3R2 null mice display a normal acquisition of somatic and neurological development milestones
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14724
Abstract/Results: ABSTRACT:
Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels. These astrocytic Ca2+ elevations emerge from different sources and display complex spatio-temporal properties. Ca2+ elevations are spatially distributed in global (soma and main processes) and/or focal regions (microdomains). The inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model lacks global Ca2+ elevations in astrocytes and it has been used by different laboratories. However, the constitutive deletion of IP3R2 during development may trigger compensating phenotypes, which could bias the results of experiments using developing or adult mice. To address this issue, we performed a detailed neurodevelopmental evaluation of male and female IP3R2 KO mice, during the first 21 days of life, as well as an evaluation of motor function, strength and neurological reflexes in adult mice. Our results show that male and female IP3R2 KO mice display a normal acquisition of developmental milestones, as compared with wild-type (WT) mice. We also show that that IP3R2 KO mice display normal motor coordination, strength and neurological reflexes in adulthood. To exclude a potential compensatory overexpression of other IP3Rs, we quantified the relative mRNA levels of all 3 subtypes, in brain tissue. We found that, along with the complete deletion of Itpr2, there is no compensatory expression of Itpr1 or Itrp3. Overall, our results show that the IP3R2 KO mouse is a reliable model to study the functional impact of global IP3R2-dependent astrocytic Ca2+ elevations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2018-037.03; BL-2014-427.10
Author: Guerra-Gomes, S.
Secondary author(s):
Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., Viana, J. F. , Sousa, N., Maciel, P. , Pinto, L., Oliveira, J. F.
Document type:
Article-d
Number of reproductions:
1
Reference:
Guerra-Gomes, S., Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., ... Oliveira, J. F. (2020). IP3R2 null mice display a normal acquisition of somatic and neurological development milestones. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14724
2-year Impact Factor: 3.386|2020
Times cited: 11|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Astrocytes / Behavior / Calcium signaling / Development / IP3R2
DocumentIP3R2 null mice display a normal acquisition of somatic and neurological development milestones2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09 - 2019-10
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.10
Location: BF-GMS
Title:
IP3R2 null mice display a normal acquisition of somatic and neurological development milestones
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14724
Abstract/Results: ABSTRACT:
Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels. These astrocytic Ca2+ elevations emerge from different sources and display complex spatio-temporal properties. Ca2+ elevations are spatially distributed in global (soma and main processes) and/or focal regions (microdomains). The inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model lacks global Ca2+ elevations in astrocytes and it has been used by different laboratories. However, the constitutive deletion of IP3R2 during development may trigger compensating phenotypes, which could bias the results of experiments using developing or adult mice. To address this issue, we performed a detailed neurodevelopmental evaluation of male and female IP3R2 KO mice, during the first 21 days of life, as well as an evaluation of motor function, strength and neurological reflexes in adult mice. Our results show that male and female IP3R2 KO mice display a normal acquisition of developmental milestones, as compared with wild-type (WT) mice. We also show that that IP3R2 KO mice display normal motor coordination, strength and neurological reflexes in adulthood. To exclude a potential compensatory overexpression of other IP3Rs, we quantified the relative mRNA levels of all 3 subtypes, in brain tissue. We found that, along with the complete deletion of Itpr2, there is no compensatory expression of Itpr1 or Itrp3. Overall, our results show that the IP3R2 KO mouse is a reliable model to study the functional impact of global IP3R2-dependent astrocytic Ca2+ elevations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2018-037.03; BL-2014-207.09
Author: Guerra-Gomes, S.
Secondary author(s):
Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., Viana, J. F. , Sousa, N., Maciel, P. , Pinto, L., Oliveira, J. F.
Document type:
Article-d
Number of reproductions:
1
Reference:
Guerra-Gomes, S., Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., ... Oliveira, J. F. (2020). IP3R2 null mice display a normal acquisition of somatic and neurological development milestones. European Journal of Neuroscience, 54(5), 5673–5686. https://doi.org/10.1111/ejn.14724
2-year Impact Factor: 3.386|2020
Times cited: 11|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Astrocytes / Behavior / Calcium signaling / Development / IP3R2
DocumentAstrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.05
Location: BF-GMS
Title:
Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
Publication year: 2020
URL:
https://www.nature.com/articles/s41467-020-18024-4
Abstract/Results: ABSTRACT:
Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2014-207.11
Author: Falcón-Moya, R.
Secondary author(s):
Pérez-Rodríguez, M., Prius-Mengual, J., Andrade-Talavera, Y., Arroyo-García, L. E., Pérez-Artés, R., Mateos-Aparicio, P., Guerra-Gomes, S., Oliveira, J. F., Flores, G., Rodríguez-Moreno, A.
Document type:
Article
Number of reproductions:
1
Reference:
Falcón-Moya, R., Pérez-Rodríguez, M., Prius-Mengual, J., Andrade-Talavera, Y., Arroyo-García, L. E., Pérez-Artés, R., ..., Rodríguez-Moreno, A. (2020). Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development. Nature Communications, 11, Article number: 4388. https://doi.org/10.1038/s41467-020-18024-4
2-year Impact Factor: 14.919|2020
Times cited: 68|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Astrocytes

Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development

Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
DocumentAstrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10 - 2019-11
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.11
Location: BF-GMS
Title:
Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
Publication year: 2020
URL:
https://www.nature.com/articles/s41467-020-18024-4
Abstract/Results: ABSTRACT:
Presynaptic spike timing-dependent long-term depression (t-LTD) at hippocampal CA3-CA1 synapses is evident until the 3rd postnatal week in mice, disappearing during the 4th week. At more mature stages, we found that the protocol that induced t-LTD induced t-LTP. We characterized this form of t-LTP and the mechanisms involved in its induction, as well as that driving this switch from t-LTD to t-LTP. We found that this t-LTP is expressed presynaptically at CA3-CA1 synapses, as witnessed by coefficient of variation, number of failures, paired-pulse ratio and miniature responses analysis. Additionally, this form of presynaptic t-LTP does not require NMDARs but the activation of mGluRs and the entry of Ca2+ into the postsynaptic neuron through L-type voltage-dependent Ca2+ channels and the release of Ca2+ from intracellular stores. Nitric oxide is also required as a messenger from the postsynaptic neuron. Crucially, the release of adenosine and glutamate by astrocytes is required for t-LTP induction and for the switch from t-LTD to t-LTP. Thus, we have discovered a developmental switch of synaptic transmission from t-LTD to t-LTP at hippocampal CA3-CA1 synapses in which astrocytes play a central role and revealed a form of presynaptic LTP and the rules for its induction.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2018-037.05
Author: Falcón-Moya, R.
Secondary author(s):
Pérez-Rodríguez, M., Prius-Mengual, J., Andrade-Talavera, Y., Arroyo-García, L. E., Pérez-Artés, R., Mateos-Aparicio, P., Guerra-Gomes, S., Oliveira, J. F., Flores, G., Rodríguez-Moreno, A.
Document type:
Article-d
Number of reproductions:
1
Reference:
Falcón-Moya, R., Pérez-Rodríguez, M., Prius-Mengual, J., Andrade-Talavera, Y., Arroyo-García, L. E., Pérez-Artés, R., ..., Rodríguez-Moreno, A. (2020). Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development. Nature Communications, 11, Article number: 4388. https://doi.org/10.1038/s41467-020-18024-4
2-year Impact Factor: 14.919|2020
Times cited: 68|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Astrocytes

Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development

Astrocyte-mediated switch in spike timing-dependent plasticity during hippocampal development
DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.08
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article-d
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390-. https://doi.org/10.3390/cells11030390
2-year Impact Factor: 6.000|2022
Times cited: 12|2025-02-17
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09 - 2019-10
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.18
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390/htm
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390. https://doi.org/10.3390/cells11030390
2-year Impact Factor: 6.000|2022
Times cited: 12|2025-02-17
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
DocumentAstrocyte regulation of neural circuit activity and network states2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.09
Location: BF-GMS
Title:
Astrocyte regulation of neural circuit activity and network states
Publication year: 2022
URL:
https://onlinelibrary.wiley.com/doi/10.1002/glia.24178
Abstract/Results: Astrocytes are known to influence neuronal activity through different mechanisms, including the homeostatic control of extracellular levels of ions and neurotransmitters and the exchange of signaling molecules that regulate synaptic formation, structure, and function. While a great effort done in the past has defined many molecular mechanisms and cellular processes involved in astrocyte-neuron interactions at the cellular level, the consequences of these interactions at the network level in vivo have only relatively recently been identified. This review describes and discusses recent findings on the regulatory effects of astrocytes on the activity of neuronal networks in vivo. Accumulating but still limited, evidence indicates that astrocytes regulate neuronal network rhythmic activity and synchronization as well as brain states. These studies demonstrate a critical contribution of astrocytes to brain activity and are paving the way for a more thorough understanding of the cellular bases of brain function.
Accessibility: Document does not exist in file
Language:
eng
Author:
Oliveira, J. F.
Secondary author(s):
Araque, A.
Document type:
Article
Number of reproductions:
1
Reference:
Oliveira, J. F. & Araque, A. (2022). Astrocyte regulation of neural circuit activity and network states. Glia, 70(8), 1455-1466. https://doi.org/10.1002/glia.24178
2-year Impact Factor: 6.200|2022
Times cited: 48|2025-02-17
Indexed document: Yes
Quartile: Q1
Keywords: Astrocyte-neuron signaling / Astrocytes / Brain states / Neural network activity / Neuronal synchronization / Tripartite synapses