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Type Title Begin End
DocumentVolumetric analysis of cortical and subcortical regions in congenital deafness2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-112
Location: Arquivo PCA - Pasta 10/2012
Title:
112 - Retinotopic reorganization of the auditory cortex of congenitally deaf individuals due to neuroplascticity
Duration: 2013-05
Researcher(s):
Jorge Manuel Castelo Branco de Albuquerque Almeida, Bradford Zack Mahon, Dr. Yanchao Bi, Óscar Filipe Coelho Neves Gonçalves
Institution(s): Faculdade de Psicologia e Ciências da Educação, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Language: eng
Author:
Almeida, J.
Secondary author(s):
Mahon, B., Bi, Y., Gonçalves, O.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Body structure and function / Audition / Brain structure and function

Reference code: PT/FB/BL-2012-112.04
Location: Arquivo PCA - Pasta 10/2012
Title:
Volumetric analysis of cortical and subcortical regions in congenital deafness
Publication year: 2015
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&cad=rja&uact=8&ved=0CB4QFjAAahUKEwibwp3S3pzJAhVIhhoKHfAICCk&url=http%3A%2F%2Fwww.appe.pt%2Fpast%2F2015%2Ffiles%2FProgramaAPPE-2015.pdf&usg=AFQjCNFHnNl7YMzGZPCTy-JSTKIjM2ezFw&sig2=4CO4gAWnotjhJu5-46f7Og&bvm=bv.107763241,d.bGQ
Accessibility: Document exists in file
Language:
eng
Author:
Amaral, L.
Secondary author(s):
Ganho, A., Gonçalves, O., Almeida, J.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Amaral , L. Ganho, A., Gonçalves, O. F., & Almeida, J. (2015, April). Volumetric analysis of cortical and subcortical regions in congenital deafness. Paper presented at the 10º Encontro Nacional da Associação Portuguesa de Psicologia Experimental, Faro, Portugal.
Indexed document: No
Keywords: Neuroplasticity / Congenitally deafness / Sensory reorganization / Auditory cortex / Brain imaging

Volumetric analysis of cortical and subcortical regions in congenital deafness

Volumetric analysis of cortical and subcortical regions in congenital deafness

DocumentNeuroplasticity in congenital deaf humans2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-112
Location: Arquivo PCA - Pasta 10/2012
Title:
112 - Retinotopic reorganization of the auditory cortex of congenitally deaf individuals due to neuroplascticity
Duration: 2013-05
Researcher(s):
Jorge Manuel Castelo Branco de Albuquerque Almeida, Bradford Zack Mahon, Dr. Yanchao Bi, Óscar Filipe Coelho Neves Gonçalves
Institution(s): Faculdade de Psicologia e Ciências da Educação, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Language: eng
Author:
Almeida, J.
Secondary author(s):
Mahon, B., Bi, Y., Gonçalves, O.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Body structure and function / Audition / Brain structure and function

Reference code: PT/FB/BL-2012-112.06
Location: Arquivo PCA - Pasta 10/2012
Title:
Neuroplasticity in congenital deaf humans
Publication year: 2015
URL:
https://sites.google.com/site/revistaportuguesadepsicologia/numeros-publicados/vol-44/v44-39
Abstract/Results: ABSTRACT:
Neuroplasticity reflects the brain’s capacity to reorganize itself due to endogenous or exogenous events, including sensory deprivation. The debate on how neuroplasticity emerges and which structures can suffer and regulate neuroplastic
changes is still fierce. It has been shown that in congenitally deaf humans the auditory cortex (AC) can be co-opted to process visual input. But how is this visual information rerouted to AC? Here, we will present a review of the main studies concerning this issue and emphasize the extant hypotheses that focus on the neuroplastic changes observed in congenital deaf individuals at the neural and behavioral level. Finally, we will focus on the role of the sign language in the neuroplasticity presented by congenitally deaf humans and present some of the important implications that these studies may have on the quality of deaf individual.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Amaral, L.
Secondary author(s):
Almeida, J.
Document type:
Article
Number of reproductions:
1
Reference:
Amaral, L. & Almeida, J. (2015). Neuroplasticity in congenital deaf humans. Revista Portuguesa de Psicologia, 44, 39-45.
Indexed document: No
Keywords: Neuroplasticity / Congenitally deafness / Sensory reorganization / Auditory cortex

Neuroplasticity in congenital deaf humans

Neuroplasticity in congenital deaf humans

DocumentHemispheric asymmetries in subcortical visual and auditory relay structures in congenital deafness2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-112
Location: Arquivo PCA - Pasta 10/2012
Title:
112 - Retinotopic reorganization of the auditory cortex of congenitally deaf individuals due to neuroplascticity
Duration: 2013-05
Researcher(s):
Jorge Manuel Castelo Branco de Albuquerque Almeida, Bradford Zack Mahon, Dr. Yanchao Bi, Óscar Filipe Coelho Neves Gonçalves
Institution(s): Faculdade de Psicologia e Ciências da Educação, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Language: eng
Author:
Almeida, J.
Secondary author(s):
Mahon, B., Bi, Y., Gonçalves, O.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Body structure and function / Audition / Brain structure and function

Reference code: PT/FB/BL-2012-112.08
Location: Arquivo PCA - Pasta 10/2012
Title:
Hemispheric asymmetries in subcortical visual and auditory relay structures in congenital deafness
Publication year: 2016
URL:
http://onlinelibrary.wiley.com/doi/10.1111/ejn.13340/abstract
Abstract/Results: ABSTRACT:
Neuroplasticity – the capacity of the brain to change as a response to internal and external pressures – has been studied from a number of different perspectives. Perhaps one of the most powerful models is the study of populations that have been congenitally deprived of a sense. It has been shown that the right Auditory Cortex (AC) of congenitally deaf humans is neuroplastically modified in order to represent visual properties of a stimulus. One unresolved question is how this visual information is routed to the AC of congenitally deaf individuals. Here, we performed volumetric analysis of subcortical auditory and visual brains regions – namely the thalamus (along with three thalamic nuclei: the pulvinar, the lateral geniculate nucleus and the medial geniculate nucleus), and the inferior and superior colliculi – in deaf and hearing participants in order to identify which structures may be responsible for relaying visual information toward the altered AC. Because there is a hemispheric asymmetry in the neuroplastic changes observed in the AC of the congenitally deaf, we reasoned that subcortical structures that also showed a similar asymmetry in their total volume could have been enlisted in the effort of relaying visual information to the neuroplastically altered right AC. We show that for deaf, but not for hearing individuals, the right thalamus, right lateral geniculate nucleus and right inferior colliculus are larger than their left counterparts. These results suggest that these subcortical structures may be responsible for rerouting visual information to the AC in congenital deafness.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Amaral, L.
Secondary author(s):
Ganho, A., Osório, A., He, D., Chen, Q., Mahon, B., Gonçalves, O., Sampaio, A., Fang, F., Bi, Y., Almeida, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Amaral, L., Ganho, A., Osório, A., He, D., Chen, Q., Mahon, B.Z., Gonçalves, O.F., Sampaio, A., Fang, F., Bi, Y. & Almeida, J. (2016). Hemispheric asymmetries in subcortical visual and auditory relay structures in congenital deafness. European Journal of Neuroscience, 44(6), 2334-2339. doi: 10.1111/ejn.13340
2-year Impact Factor: 2.941|2016
Times cited: 11|2022-10-28
Indexed document: Yes
Quartile: Q2
Keywords: Auditory cortex / Neuroimaging / Neuronal plasticity / Ocular vision / Thalamus

DocumentFinal report - Demixing and visualizing neural population activity in higher cortical areas2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.01
Location: BF-GMS
Title:
Final report - Demixing and visualizing neural population activity in higher cortical areas
Publication year: 2017
URL:
https://www.bial.com/imagem/Bolsa%2038914.pdf
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. In this project we developed and demonstrated advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyzed population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a
single figure.
This project also involved some additional work on dimensionality reduction of electrophysiological datasets, including data from auditory cortex and from input areas to dopaminergic system in rats.
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Auditory cortex

Final report - Demixing and visualizing neural population activity in higher cortical areas

Final report - Demixing and visualizing neural population activity in higher cortical areas

DocumentDemixed principal component analysis of neural population data2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.02
Location: BF-GMS
Title:
Demixed principal component analysis of neural population data
Publication year: 2016
URL:
https://elifesciences.org/content/5/e10989
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we demonstrate the advantages of a new dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the dependence of the neural representation on task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes the task-dependent features of the population response in a single figure.
Accessibility: Document exists in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z. F., Qi, X.-L., Romo, R., Uchida, N., Machens, C. K.
Document type:
Article
Number of reproductions:
1
Percentiles:
3|2022-03-19
Reference:
Kobak, D., Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z. F., Qi, X.-L., Romo, R., Uchida, N., & Machens, C. K. (2016). Demixed principal component analysis of neural population data. eLife 5, e10989. doi: 10.7554/eLife.10989.001
2-year Impact Factor: 7.725|2016
Times cited: 187|2022-10-29
Indexed document: Yes
Quartile: Q1
Keywords: Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Auditory cortex

Demixed principal component analysis of neural population data

Demixed principal component analysis of neural population data

DocumentDemixed principal component analysis of neural population data2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-389
Location: BF-GMS
Title:
389 - Demixing and visualizing neural population activity in higher cortical areas
Duration: 2015-01 - 2017-02
Researcher(s):
Dmitry Kobak, Christian Machens
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
Articles
Language: eng
Author:
Kobak, D.
Secondary author(s):
Machens, C.
Number of reproductions:
1
Keywords:
Population activity / Dimensionality reduction / Prefrontal cortex / Principal component analysis / Psychophysiology

Reference code: PT/FB/BL-2014-389.06
Location: BF-GMS
Title:
Demixed principal component analysis of neural population data
Publication year: 2015
URL:
http://www.gatsby.ucl.ac.uk/nccd/nccd15/abstracts/kobak.html
Abstract/Results: ABSTRACT:
Neurons in higher cortical areas, such as the prefrontal cortex, are often tuned to a variety of sensory and motor variables, and are therefore said to display mixed selectivity. This complexity of single neuron responses can obscure what information these areas represent and how it is represented. Here we present a dimensionality reduction technique, demixed principal component analysis (dPCA), that decomposes population activity into a few components. In addition to systematically capturing the majority of the variance of the data, dPCA also exposes the neural representation in terms of task parameters such as stimuli, decisions, or rewards. To illustrate our method we reanalyze population data from four datasets comprising different species, different cortical areas and different experimental tasks. In each case, dPCA provides a concise way of visualizing the data that summarizes all the relevant features of the population response in a single figure. In addition, dPCA highlights several important and seemingly universal features of the population activity in prefrontal cortex; e.g. that most of the neural activity is not related to any of the controlled task parameters, such as stimuli or decision; or that there are no well-separated functional clusters of cells.
Accessibility: Document does not exist in file
Language:
eng
Author:
Kobak, D.
Secondary author(s):
Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., Mainen, Z., Romo, R., Qi, X.-L., Uchida, N., Machens, C.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Kobak, D., Brendel, W., Constantinidis, C., Feierstein, C. E., Kepecs, A., ..., Machens, C. (2015, August-September). Demixed principal component analysis of neural population data. Poster presented at Neural Coding, Computation and Dynamics (NCCD), Bilbao, Spain.
Indexed document: No
Keywords: Principal Component Analysis / Population activity / Prefrontal cortex / Dimensionality reduction / Auditory cortex