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DocumentFinal report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.01
Location: Arquivo PCA - Pasta 22/2006
Title:
Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Publication year: 2011
URL:
http://www.bial.com/imagem/Bolsa7306_21022014.pdf
Abstract/Results: RESULTS:
During this research project (73/06) we investigated the mechanism underlying implicit contextual learning as well as its neural correlates. Implicit contextual cueing is a learning mechanism in which visual information from our environment is memorized in order to facilitate visual search.
In the first part of our research project we studied the mechanism underlying implicit contextual cueing using eye movement recording. First, we showed that peripheral vision can be used to memorize the context of a target (Van Asselen et al. 2009), whereas in our following study we demonstrated that object-based contextual cueing is associated with shorter fixation durations (Van Asselen et al., 2010). Finally, we showed that when two contextual cues are presented simultaneously, the contextual cueing effect is much larger than when one cue is presented. This effect is associated with fewer fixations and shorter saccade amplitudes, suggesting that a different search strategy is used.
In the second part of this research project we aimed to look at the neural basis of implicit contextual cueing. Therefore, we tested patients with Huntington’s and Parkinson’s disease with a contextual cueing task and found that these patients are not able to benefit from the repeated contextual information (Van Asselen et al., 2009). Since both of these neurodegenerative diseases affect the basal ganglia, our findings suggest an important role for this brain area. Finally, by using fMRI we demonstrated that the exact neural network that is involved in implicit contextual cueing depends on the type of cues (object or spatial) that are used to guide attention.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Implicit contextual learning / Neural correlates / Eye movements / Huntington's disease / Parkinson's disease / Basal ganglia / Perception

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
DocumentThe role of the basal ganglia in implicit contextual learning: A study of Parkinson’s disease2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.02
Location: Arquivo PCA - Pasta 22/2006
Title:
The role of the basal ganglia in implicit contextual learning: A study of Parkinson’s disease
Publication year: 2009
URL:
http://www.sciencedirect.com/science/article/pii/S0028393209000165
Abstract/Results: ABSTRACT:
Implicit contextual learning refers to the ability to memorize contextual information from our environment. This contextual information can then be used to guide our attention to a specific location. Although the medial temporal lobe is important for this type of learning, the basal ganglia might also be involved considering its role in many implicit learning processes. In order to understand the role of the basal ganglia in this top-down process, a group of non-demented early-stage Parkinson's patients were tested with a contextual cueing task. In this visual search task, subjects have to quickly locate a target among a number of distractors. To test implicit contextual learning, some of the configurations are repeated during the experiment, resulting in faster responses. A significant interaction effect was found between Group and Configuration, indicating that the control subjects responded faster when the spatial context was repeated, whereas Parkinson's patients failed to do so. These results, showing that the contextual cueing effect was significantly different for the patients than for the controls, suggest an important role for the basal ganglia in implicit contextual learning, thus extending previous findings of medial temporal lobe involvement. The basal ganglia are therefore not only involved in implicit motor learning, but may also have a role in purely visual implicit learning.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Almeida, I., André, R., Januário, C., Gonçalves, A., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Van Asselen, M., Almeida, I., André, R., Januário, C., Gonçalves, A., & Castelo-Branco, M. (2009). The role of the basal ganglia in implicit contextual learning: A study of Parkinson’s disease. Neuropsychologia, 47(5), 1269-1273. https://doi.org/10.1016/j.neuropsychologia.2009.01.008
2-year Impact Factor: 4.345|2009
Times cited: 37|2024-02-05
Indexed document: Yes
Quartile: Q1
Keywords: Implicit contextual cueing / Spatial / Memory / Parkinson's disease / Basal ganglia

The role of the basal ganglia in implicit contextual learning: A study of Parkinson’s disease

The role of the basal ganglia in implicit contextual learning: A study of Parkinson’s disease
DocumentImplicit contextual learning in prodromal and early stage Huntington's disease patients2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.05
Location: Arquivo PCA - Pasta 22/2006
Title:
Implicit contextual learning in prodromal and early stage Huntington's disease patients
Publication year: 2012
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8631149
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.
Accessibility: Document exists in file (previous version submitted for publication)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simões, M. R., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Van Asselen, M., Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simões, M. R., Castelo-Branco, M. (2012). Implicit contextual learning in prodromal and early stage Huntington's disease patients. Journal of the International Neuropsychological Society, 18(4), 689-696. https://doi.org/10.1017/S1355617712000288
2-year Impact Factor: 2.697|2012
Times cited: 11|2024-02-01
Indexed document: Yes
Quartile: Q2
Keywords: Huntington's disease / Neurodegenerative disorder / Implicit contextual learning / Basal ganglia / Visual search

Implicit contextual learning in prodromal and early stage Huntington's disease patients

Implicit contextual learning in prodromal and early stage Huntington's disease patients
DocumentThe role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-170
Location: Arquivo PCA - Pasta 10/2010
Title:
170 - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Duration: 2011-04 - 2013-11
Researcher(s):
Gina Maria Costa Caetano, Miguel Castelo-Branco, Beatrice de Gelder, Gregor Philipak
Institution(s): Instituto Biomédico de Investigação de Luz e Imagem - IBILI-, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
1 Master's thesis
Language: eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2010-170.03
Location: Arquivo PCA - Pasta 9/2010
Title:
The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0028393213002352
Abstract/Results: ABSTRACT:
In human cognition, most relevant stimuli, such as faces, are processed in central vision. However, it is widely believed that recognition of relevant stimuli (e.g. threatening animal faces) at peripheral locations is also important due to their survival value. Moreover, task instructions have been shown to modulate brain regions involved in threat recognition (e.g. the amygdala). In this respect it is also controversial whether tasks requiring explicit focus on stimulus threat content vs. implicit processing differently engage primitive subcortical structures involved in emotional appraisal.
Here we have addressed the role of central vs. peripheral processing in the human amygdala using animal threatening vs. non-threatening face stimuli. First, a simple animal face recognition task with threatening and non-threatening animal faces, as well as non-face control stimuli, was employed in naïve subjects (implicit task). A subsequent task was then performed with the same stimulus categories (but different stimuli) in which subjects were told to explicitly detect threat signals.
We found lateralized amygdala responses both to the spatial location of stimuli and to the threatening content of faces depending on the task performed: the right amygdala showed increased responses to central compared to left presented stimuli specifically during the threat detection task, while the left amygdala was better prone to discriminate threatening faces from non-facial displays during the animal face recognition task. Additionally, the right amygdala responded to faces during the threat detection task but only when centrally presented. Moreover, we have found no evidence for superior responses of the amygdala to peripheral stimuli. Importantly, we have found that striatal regions activate differentially depending on peripheral vs. central processing of threatening faces. Accordingly, peripheral processing of these stimuli activated more strongly the putaminal region, while central processing engaged mainly the caudate nucleus.
We conclude that the human amygdala has a central bias for face stimuli, and that visual processing recruits different striatal regions, putaminal or caudate based, depending on the task and on whether peripheral or central visual processing is involved.
Accessibility: Document exist in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Almeida, I.
Secondary author(s):
Van Asselen, M., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Almeida, I., Van Asselen, M., & Castelo-Branco, M. (2013). The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content. Neuropsychologia, 51(11), 2120-2129. https://doi.org/10.1016/j.neuropsychologia.2013.07.007
2-year Impact Factor: 3.451|2013
Times cited: 16|2024-02-02
Indexed document: Yes
Quartile: Q2
Keywords: Amygdala / Basal ganglia / Implicit/explicit / Central/peripheral / Threat / Faces

The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content

The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content
DocumentFinal report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-170
Location: Arquivo PCA - Pasta 10/2010
Title:
170 - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Duration: 2011-04 - 2013-11
Researcher(s):
Gina Maria Costa Caetano, Miguel Castelo-Branco, Beatrice de Gelder, Gregor Philipak
Institution(s): Instituto Biomédico de Investigação de Luz e Imagem - IBILI-, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
1 Master's thesis
Language: eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2010-170.01
Location: Arquivo PCA - Pasta 9/2010
Title:
Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Publication year: 2013
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Emotions / Basal ganglia / Amygdala / Colliculus / Categorization

Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study

Final report - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
DocumentThe role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.34
Location: Arquivo PCA - Pasta 21/2006
Title:
The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0028393213002352
Abstract/Results: ABSTRACT:
In human cognition, most relevant stimuli, such as faces, are processed in central vision. However, it is widely believed that recognition of relevant stimuli (e.g. threatening animal faces) at peripheral locations is also important due to their survival value. Moreover, task instructions have been shown to modulate brain regions involved in threat recognition (e.g. the amygdala). In this respect it is also controversial whether tasks requiring explicit focus on stimulus threat content vs. implicit processing differently engage primitive subcortical structures involved in emotional appraisal. Here we have addressed the role of central vs. peripheral processing in the human amygdala using animal threatening vs. non-threatening face stimuli. First, a simple animal face recognition task with threatening and non-threatening animal faces, as well as non-face control stimuli, was employed in naïve subjects (implicit task). A subsequent task was then performed with the same stimulus categories (but different stimuli) in which subjects were told to explicitly detect threat signals. We found lateralized amygdala responses both to the spatial location of stimuli and to the threatening content of faces depending on the task performed: the right amygdala showed increased responses to central compared to left presented stimuli specifically during the threat detection task, while the left amygdala was better prone to discriminate threatening faces from non-facial displays during the animal face recognition task. Additionally, the right amygdala responded to faces during the threat detection task but only when centrally presented. Moreover, we have found no evidence for superior responses of the amygdala to peripheral stimuli. Importantly, we have found that striatal regions activate differentially depending on peripheral vs. central processing of threatening faces. Accordingly, peripheral processing of these stimuli activated more strongly the putaminal region, while central processing engaged mainly the caudate nucleus. We conclude that the human amygdala has a central bias for face stimuli, and that visual processing recruits different striatal regions, putaminal or caudate based, depending on the task and on whether peripheral or central visual processing is involved.
Accessibility: Document does not exist in file
Language:
eng
Author:
Almeida, I.
Secondary author(s):
Van Asselen, M., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
6
Reference:
Almeida, I., Van Asselen, M., & Van Asselen, M. (2013). The role of the amygdala and the basal ganglia in visual processing of central vs. peripheral emotional content. Neuropsychologia, 51(11), 2120-2129. https://doi.org/10.1016/j.neuropsychologia.2013.07.007
2-year Impact Factor: 3.451|2013
Times cited: 16|2024-02-06
Indexed document: Yes
Quartile: Q2
Keywords: Amygdala / Basal ganglia / Central/peripheral / Faces / Implicit/explicit / Threat
File413 - The role of dopamine in behavioral exploration and action selection2015-032018-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology
DocumentNucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.03
Location: BF-GMS
Title:
Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5957524/
Abstract/Results: ABSTRACT:
The nucleus accumbens (NAc) plays a central role in reinforcement and motivation. Around 95% of the NAc neurons are medium spiny neurons (MSNs), divided into those expressing dopamine receptor D1 (D1R) or dopamine receptor D2 (D2R). Optogenetic activation of D2-MSNs increased motivation, whereas inhibition of these neurons produced the opposite effect. Yet, it is still unclear how activation of D2-MSNs affects other local neurons/interneurons or input terminals and how this contributes for motivation enhancement. To answer this question, in this work we combined optogenetic modulation of D2-MSNs with in loco pharmacological delivery of specific neurotransmitter antagonists in rats. First, we showed that optogenetic activation of D2-MSNs increases motivation in a progressive ratio (PR) task. We demonstrated that this behavioral effect relies on cholinergic-dependent modulation of dopaminergic signalling of ventral tegmental area (VTA) terminals, which requires D1R and D2R signalling in the NAc. D2-MSN optogenetic activation decreased ventral pallidum (VP) activity, reducing the inhibitory tone to VTA, leading to increased dopaminergic activity. Importantly, optogenetic activation of D2-MSN terminals in the VP was sufficient to recapitulate the motivation enhancement. In summary, our data suggests that optogenetic stimulation of NAc D2-MSNs indirectly modulates VTA dopaminergic activity, contributing for increased motivation. Moreover, both types of dopamine receptors signalling in the NAc are required in order to produce the positive behavioral effects.
Accessibility: Document exists in file
Language:
eng
Author:
Soares-Cunha, C.
Secondary author(s):
Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., Rodrigues, A. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Soares-Cunha, C., Coimbra, B., Domingues, A. V., Vasconcelos, N., Sousa, N., & Rodrigues, A. J. (2018). Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation. eNeuro, 5(2), e0386-18. https://doi.org/10.1523/ENEURO.0386-18.2018
2-year Impact Factor: 3.544|2019
Impact factor notes: Impact factor computed since 2019
Times cited: 47|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Basal ganglia / Medium spiny neurons / Motivation / Nucleus accumbens / Optogenetics / Reward

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation

Nucleus accumbens microcircuit underlying D2-MSN-driven increase in motivation
DocumentFinal report - The role of dopamine in behavioral exploration and action selection2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.01
Location: BF-GMS
Title:
Final report - The role of dopamine in behavioral exploration and action selection
Publication year: 2018
URL:
https://www.bial.com/imagem/Grant_41314.pdf
Abstract/Results: ABSTRACT:
We are constantly faced with the trade-off between exploiting past actions with known outcomes and exploring novel actions whose outcomes may be better. This exploration-exploitation balance is thought to be influenced by dopaminergic neurons of the substantia nigra pars compacta (SNc) and noradrenergic neurons of the locus coeruleus (LC). However, little is known about SNc and LC network dynamics during exploration. We aimed to characterize dopaminergic and noradrenergic signaling during these distinct behavioral states. We developed a novel behavioral paradigm in mice to investigate exploratory and exploitative behavioural states. Mice were presented with three equidistant nose poke ports and had to explore the environment to discover a sequence of three nose pokes that was rewarded. We then performed calcium imaging in either the SNc or LC of freely behaving mice during performance of this task. Actions were variable as mice explored to find the rewarded sequence, but became stable as they learned to exploit the rewarded sequence. When the rewarded sequence was changed, mice returned to a more variable state. Dopaminergic networks expressed higher levels of sustained activity when mice were exploiting relative to exploring, and these differences could not be accounted for by low-level differences in reward occurrence. Conversely, noradrenergic networks exhibited higher levels of sustained activity when mice were exploring relative to exploiting. These experiments suggest that exploitation is associated with higher sustained levels of dopaminergic activity and lower sustained levels or noradrenergic activity, with potentially important consequences for downstream circuits.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Dopamine / Exploration / Action selection / Basal ganglia

Final report - The role of dopamine in behavioral exploration and action selection

Final report - The role of dopamine in behavioral exploration and action selection
DocumentWhich neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.28
Location: Arquivo PCA - Pasta 18/2006
Title:
Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?
Publication year: 2011
URL:
https://link.springer.com/content/pdf/10.1007/s11434-011-4737-z.pdf
Abstract/Results: ABSTRACT:
Approximately 60% of subjects with schizophrenia present minor neurological signs (neurological soft signs, NSS), which include abnormalities in sensory and motor performance indicative of a non-specific cerebral dysfunction. These are also present in healthy individuals and relatives of patients with psychosis, at significantly lower rates. The excess of NSS in psychosis may be a potential endophenotype for this disorder, and reflect the same neurodevelopmental brain dysfunction that also underlies the cognitive deficits consistently reported in psychosis. To establish whether neurological and cognitive dysfunction meet the essential criterion required for a refined endophenotype for psychosis, the association with the illness, we explored evidence that certain neurological and cognitive deficits co-occur in affected individuals. This evidence suggests that signs of motor dysfunctions may be specific to patients with psychosis, in whom they are associated with dysfunction in cognitive tasks requiring motor skills. Thus, they may form a promising candidate endophenotype for psychosis.
Accessibility: Document exists in file
Language:
eng
Author:
Dazzan, P.
Secondary author(s):
Chan, R. C. K.
Document type:
Article
Number of reproductions:
1
Reference:
Dazzan, P., & Chan, R. C. K. (2011). Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis? Chinese Science Bulletin, 56(32), 3372-3375. https://doi.org/10.1007/s11434-011-4737-z
2-year Impact Factor: 1.321|2011
Times cited: 2|2024-02-01
Indexed document: Yes
Quartile: Q1
Keywords: Schizophrenia / Neurological soft signs / Motor dysfunction / Basal ganglia / Cognition

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?

Which neurological abnormalities and neuropsychological impairments share the same substrate in psychosis?
DocumentDichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states 2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.05
Location: BF-GMS
Title:
Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states
Publication year: 2021
URL:
https://advances.sciencemag.org/content/7/30/eabh2059
Abstract/Results: ABSTRACT:
The balance between exploiting known actions and exploring alternatives is critical for survival and hypothesized to rely on shifts in neuromodulation. We developed a behavioral paradigm to capture exploitative and exploratory states and imaged calcium dynamics in genetically identified dopaminergic and noradrenergic neurons. During exploitative states, characterized by motivated repetition of the same action choice, dopamine neurons in SNc encoding movement vigor showed sustained elevation of basal activity that lasted many seconds. This sustained activity emerged from longer positive responses, which accumulated during exploitative action-reward bouts, and hysteretic dynamics. Conversely, noradrenergic neurons in LC showed sustained inhibition of basal activity due to the accumulation of longer negative responses in LC. Chemogenetic manipulation of these sustained dynamics revealed that dopaminergic activity mediates action drive, whereas noradrenergic activity modulates choice diversity. These data uncover the emergence of sustained neural states in dopaminergic and noradrenergic networks that mediate dissociable aspects of exploitative bouts.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Koralek, A. C., & Costa, R. M. (2021). Dichotomous dopaminergic and noradrenergic neural states mediate distinct aspects of exploitative behavioral states. Science Advances, 7(30): eabh2059. https://doi.org/10.1126/sciadv.abh2059
2-year Impact Factor: 14.980|2021
Times cited: 3|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Dopamine / Exploration / Action selection / Basal ganglia
DocumentFinal report - How do dopamine neurons and striatal populations interact during decision-making?2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-193
Location: BF-GMS
Title:
193 - How do dopamine neurons and striatal populations interact during decision-making?
Duration: 2017-07 - 2022-10
Researcher(s):
Joseph Paton, Sofia Soares, Asma Motiwala, Bruno Cruz
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Author: Paton, J. J.
Secondary author(s):
Soares, S., Motiwala, A.
Number of reproductions:
1
Keywords:
Animal behavior / Cognitive processes / Decision-making / Movement / Perception / Psychophysiology

Reference code: PT/FB/BL-2016-193.01
Location: BF-GMS
Title:
Final report - How do dopamine neurons and striatal populations interact during decision-making?
Publication year: 2022
Abstract/Results:
ABSTRACT:
BACKGROUND
Striatal dynamics and dopamine (DA) neuron activity have been shown to correlate with animals’ judgments of duration.
AIMS
To determine whether DA projecting to different regions of the striatum carry similar signals, To test hypothesis that DA neurons and striatal population functionally interact during timing judgments, to causally test hypotheses emerging from aim 2 by ontogenetically activating DA neuron terminals while recording from local striatal populations.
METHOD
A combination of behavior, fiber photometry, optogenetics, computational modeling, and electrophysiological recordings.
RESULTS
We found that while DA neurons in the SNc that project to dorsal striatum correlate with and can cause changes in animals’ timing judgments, DA neurons in the VTA that project to ventral striatum do not correlate with or cause changes in judgments. Furthermore, computational reinforcement learning modeling (RL) demonstrates that DA responses in SNc are explained if mice used efficient and compressed representations of task variables. Furthermore, subsets of striatal neurons belonging to the direct and indirect pathways subserve broadly opponent aspects of action suppression and production during the task, with the indirect pathway being necessary for accurate decisions. These data suggest that the influence of DA neurons on striatal populations may act through D2 type dopamine receptors on indirect pathway striatal neurons. Lastly, we have found that optogenetically activating dopamine neurons can cause a slowing of striatal response dynamics, consistent with DA’s effect on decision-making being mediated by a direct effect of DA on striatal populations.
CONCLUSIONS
In sum, in line with the broad aims of the grant, we have collected multiple types of data that have helped refine our understanding of how dopamine neurons act on striatal populations of neurons during decision-making, and in doing so have revealed fundamental new principles of both cognition (efficient coding) and motor control (action suppression and production).
Accessibility: Document exists in file
Language:
eng
Author:
Paton, J. J.
Document type:
Final report
Number of reproductions:
1
Reference:
Paton, J. (2022). Final report - How do dopamine neurons and striatal populations interact during decision-making?
Indexed document: No
Keywords: Neuroscience / Basal ganglia / Decision-making / Timing / Reinforcement learning

Final report - How do dopamine neurons and striatal populations interact during decision-making?

Final report - How do dopamine neurons and striatal populations interact during decision-making?