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DocumentFinal report - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-176
Location: Arquivo PCA - Pasta 7/2008
Title:
176 - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection
Duration: 2009-02 - 2011-03
Researcher(s):
Susana Quelhas Lima, Léa Zinck
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Lima, S.
Secondary author(s):
Zinck, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Assessment tools / Affective and social behavior / Animal behavior / Sexual behavior

Reference code: PT/FB/BL-2008-176.01
Location: Arquivo PCA - Pasta 7/2008
Title:
Final report - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection
Publication year: 2011
URL:
http://www.bial.com/imagem/Bolsa176-08_03012014.pdf
Abstract/Results: ABSTRACT:
In this project we focused on assortative mate choice, that may contribute to the reproductive isolation of the two European subspecies of the house mouse, Mus musculus musculus and Mus musculus domesticus. We developed full mating and limited-contact paradigms. We found that receptive musculus females exhibit a robust preference to mate with males of the same subspecies. However, they mate readily with each male in no choice condition, and non-receptive females exhibit no preference. Moreover, when no physical contact is allowed, the female’s preference is maintained regardless of their estrous state. These experiments establish an assortative mate preference assay appropriate for the investigation of its underlying substrates. Our results highlight the interplay between the chooser´s internal state and the nature of the interaction with prospective mates and suggests that the decision is based on a comparison of the options available, rather than on an absolute preference.
We then interrogated the ontogeny of this preference, by performing adoption experiments where musculus females were raised in a domesticus environment. Our results show that female mouse mate preference has a hierarchical dependence on early postnatal life experience and the order of males encountered as an adult. Whereas females raised in their normal musculus environment display a robust homosubspecific preference, females fostered in a domesticus family prefer the first male encountered, regardless of subspecies. Thus, early life experience of musculus females, when and only when concordant with genetic self-identify, overrides sampling order effects, ensuring robust assortative choice. In the absence of this phylogenetic-ontogenetic match, simple primacy effects dominate mate preference.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Lima, S.
Secondary author(s):
Zinck, L.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Neural circuits / Mouse / Mate choice / Behavior / Sexual behavior / Mouse

Final report - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection

Final report - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection
DocumentPrefrontal control of impulsive action2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-127
Location: Arquivo PCA - Pasta 6/2008
Title:
127 - Prefrontal control of impulsive action
Duration: 2009-02 - 2011-03
Researcher(s):
Masayoshi Murakami, Zachary F. Mainen
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Final report
Poster
Language: eng
Author:
Murakami, M.
Secondary author(s):
Mainen, Z.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes

Reference code: PT/FB/BL-2008-127.03
Location: Arquivo PCA - Pasta 6/2008
Title:
Prefrontal control of impulsive action
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
Objectives: Impulse control - withholding short term benefits to achieve longer term goals - is an
important facet of goal-directed behavior. Frontal cortex has been hypothesized to exert top-down
control of impulsive actions. Some of the neural substrates of decisions between immediate and
delayed rewards are identified, including the brain systems involved and properties of the neural
representations. Comparatively little is known about decisions to terminate waiting during a delay.
In particular, in a decision to give up, the time is determined by an internal battle between the
“will” to wait and the “temptation” to give up. What neural processes underlie the timing of such
acts?
Methods: We devised an impulse control task in which rats interacted with a waiting port and a
reward port. While waiting in the waiting port, size of the reward available at the reward port
switched from small to big following a signaled but unpredictable interval. In order to record
spiking activity from multiple neurons, we implanted movable tetrode arrays into the frontal
cortex of rats trained for the impulse control task.
Results: The waiting time of the rats in our impulse control task varied randomly across trials. This
enabled us to search for single-neuron correlate for impulse control. Through multiple single-unit
recordings from the frontal cortical areas, we found neurons whose activity showed transient
correlation with the waiting time. There were 20% of such waiting time predictive neurons in
secondary motor area (M2) of frontal cortex, but close to chance level (7%) in the medial
prefrontal cortex. The predictive neurons might contribute to bias the waiting time toward longer
waiting or shorter waiting. A different analysis revealed that a subpopulation of neurons in the
area M2 showed ramping activity during the waiting, which reached the same firing rate just
before the leaving. The rate of ramping activity was negatively correlated with the waiting time in
a majority of ramping neurons. This type of activity is proposed to serve as an internal trigger for
actions. When we tested the neural activity in 2 different impulse control tasks requiring different
actions, most of neurons showed the predictive activity in only one type of actions, suggesting that
the waiting time predictive activity does not represent action-non-specific signal such as an
impulse control signal, but represents action-specific signal, such as the timing of a particular
action.
Conclusions: These results suggest an involvement of M2 neurons in deciding the timing of action
in the context of impulse control task.
Discussions: Our finding suggests that the waiting time predictive neurons represent action timing
signal rather than abstract signal, such as a value of options or internal state of the animal. But
such abstract signals might be encoded in prefrontal cortical areas, such as the orbitofrontal
cortex, which sends signal to the secondary motor cortex.
Accessibility: Document does not exist in file
Language:
eng
Author:
Murakami, M.
Secondary author(s):
Mainen, Z.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Murakami, M., & Mainen, Z. (2012). Prefrontal control of impulsive action. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (pp. 40-41/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Medial-prefrontal cortex (mPFC) / Secondary motor cortex / Single-unit recordings / Behavior / Impulse control

Novo ficheiro

Novo ficheiro
DocumentHow do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-176
Location: Arquivo PCA - Pasta 7/2008
Title:
176 - How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection
Duration: 2009-02 - 2011-03
Researcher(s):
Susana Quelhas Lima, Léa Zinck
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Lima, S.
Secondary author(s):
Zinck, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Assessment tools / Affective and social behavior / Animal behavior / Sexual behavior

Reference code: PT/FB/BL-2008-176.03
Location: SEC PCA - 176/08
Title:
How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
Objectives: Mate choice is a key driving force of evolution but the proximate mechanisms allowing
mate assessment by the nervous system are still unknown. Our main goal is to understand how
mate value is represented in the female brain.
Methods: In order to understand how mate value and preferences are represented in the brain,
we have established a behavioral paradigm where the subjective value of prospective mates can
be manipulated. Our behavioral paradigm takes advantage of a natural situation occurring in
Europe where two subspecies of mouse, Mus musculus musculus and M. m. domesticus, form a
narrow hybrid zone, and show asymmetric mate choice. By using inbred strains of wild-derived
and laboratory mice we were able to translate this situation into laboratory conditions and to
control female preference in a reproducible way. We investigated mate preference behavior of
musculus females for musculus versus domesticus males in two different paradigms, which either
allowed females to actually mate or only to smell the males through perforated partitions (limited
contact paradigm) preventing the male's behavior to have an influence on female's choice.
Results: In both cases, musculus females exhibited a strong homosubspecific preference, as the
one found in nature, which was revealed by the number of mounts and ejaculations they received
from musculus / domesticus males (in the full contact paradigm) and by the relative time spent by
females near the males (in both paradigms). However if musculus females are fostered in a
domesticus environment at birth, this homosubspecific preference is disrupted in the adulthood,
suggesting that early experience plays a critical role in setting individual mate preference in mice.
Discussion: This result suggests that imprinting may be one of the mechanisms by which
assortative mating is generated, and reproductive isolation maintained, at the musculus /
domesticus hybrid zone. While similar phenomena have been documented in fish and birds this is
the first time, to our knowledge, that imprinting is shown to be involved in setting conspecific
mate preferences in a mammalian species. As females reared in a musculus or a domesticus
environment show different mate preferences, we can now compare the neuronal representation
of the same stimulus male which has a different value in these two types of females. We are
currently taking the first steps to explore which brain regions might underlie this behavioral
preference.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lima, S.
Secondary author(s):
Zinck, L.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Lima, S., & Zinck, L. (2012). How do we choose a partner? Neural circuits involved in inbreeding avoidance and mate selection. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 52/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Mate choice / Behavior / Imprinting / Mouse

Novo ficheiro

Novo ficheiro
DocumentThe dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.02
Location: SEC PCA - 167/10
Title:
The dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila
Publication year: 2013
URL:
http://journal.frontiersin.org/Journal/10.3389/fnins.2013.00012/full
Abstract/Results: ABSTRACT:
To survive and successfully reproduce animals need to maintain a balanced intake of nutrients and energy. The nervous system of insects has evolved multiple mechanisms to regulate feeding behavior. When animals are faced with the choice to feed, several decisions must be made: whether or not to eat, how much to eat, what to eat, and when to eat. Using Drosophila melanogaster substantial progress has been achieved in understanding the neuronal and molecular mechanisms controlling feeding decisions. These feeding decisions are implemented in the nervous system on multiple levels, from alterations in the sensitivity of peripheral sensory organs to the modulation of memory systems. This review discusses methodologies developed in order to study insect feeding, the effects of neuropeptides and neuromodulators on feeding behavior, behavioral evidence supporting the existence of internal energy sensors, neuronal and molecular mechanisms controlling protein intake, and finally the regulation of feeding by circadian rhythms and sleep. From the discussed data a conceptual framework starts to emerge which aims to explain the molecular and neuronal processes maintaining the stability of the internal milieu.
Accessibility: Document does not exist in file
Language:
eng
Author:
Itskov, P. M.
Secondary author(s):
Ribeiro, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Itskov, P. M., & Ribeiro, C. (2013). The dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila. Frontiers in Neuroscience, 7, 12. https://doi.org/10.3389/fnins.2013.00012
2-year Impact Factor: 3.656|2014
Impact factor notes: Impact factor computed since 2014
Times cited: 96|2024-02-02
Indexed document: Yes
Quartile: Q2
Keywords: Behavior / Feeding / Internal state / Neuromodulators / Neuropeptides / Olfaction / Sensory systems / Taste

The dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila

The dilemmas of the gourmet fly: the molecular and neuronal mechanisms of feeding and nutrient decision making in Drosophila
DocumentFinal report - Elucidating the molecular mechanisms mediating feeding behavior2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.01
Location: SEC PCA - 167/10
Title:
Final report - Elucidating the molecular mechanisms mediating feeding behavior
Publication year: 2014
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Ribeiro, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Behavior / Feeding / Sensory systems / Taste
DocumentFinal report - Translation of neuron-glia interactions in complex cognitive functions2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-061
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
061 - Translation of neuron-glia interactions in complex cognitive functions
Duration: 2011-05 - 2015-07
Researcher(s):
João Filipe Pedreira de Oliveira, Nuno Sérgio Mendes Dias, Luis Ricardo Monteiro Jacinto
Institution(s): Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Ciências da Saúde, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 Articles
1 Poster
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Dias, N., Jacinto, L. R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2010-061.01
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
Final report - Translation of neuron-glia interactions in complex cognitive functions
Publication year: 2015
URL:
https://www.bial.com/imagem/Bolsa6110_22092015.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
The classical paradigm that cognitive processing is exclusively neuronal has been challenged in the past ten years by an exciting body of evidence. Indeed, the importance of glial cells is rising due to emerging data supporting dynamic neuron-glia interactions, in which a cross-talk between astrocytes and neurons complements and modulates the communication between pre- and post-synaptic structures.
AIM
The main research objective of this project is to assess the interplay between astrocytes and neurons underlying cognitive function in the brain.
METHODS
We have used complementary state-of-the-art techniques such as in vivo electrophysiology, innovative behavior, anatomical and molecular analysis, to seek a role of astrocytes in the computation of cognitive functions.
RESULTS/CONCLUSIONS
Astrocytes appear as critical elements of the neuroglial network, whose function is required for the normal hippocampal function. This information accounts for new knowledge on the cognitive computation and this new player may account also for the cognitive decline observed for instance in ageing or pathological processes, arising as a possible therapeutic target for the treatment of prevention of cognitive deficits.
Accessibility: Document exists in file
Language:
eng
Author:
Oliveira, J. F.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Astrocyte / Cognition / Neural circuits / Behavior / Electrophysiology

Final report - Translation of neuron-glia interactions in complex cognitive functions

Final report - Translation of neuron-glia interactions in complex cognitive functions
DocumentDo stars govern our actions? Astrocyte involvement in rodent behavior2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-061
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
061 - Translation of neuron-glia interactions in complex cognitive functions
Duration: 2011-05 - 2015-07
Researcher(s):
João Filipe Pedreira de Oliveira, Nuno Sérgio Mendes Dias, Luis Ricardo Monteiro Jacinto
Institution(s): Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Ciências da Saúde, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 Articles
1 Poster
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Dias, N., Jacinto, L. R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2010-061.05
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
Do stars govern our actions? Astrocyte involvement in rodent behavior
Publication year: 2015
URL:
http://www.sciencedirect.com/science/article/pii/S0166223615001733
Abstract/Results: ABSTRACT:
Astrocytes have emerged as important partners of neurons in information processing. Important progress has been made in the past two decades in understanding the role of astrocytes in the generation of neuron–astrocyte network outputs resulting in behavior. We review evidence for astrocyte involvement across four different behavioral domains: cognition, emotion, motor, and sensory processing. Accumulating evidence from animal models has provided a wealth of data that largely supports a direct involvement of astrocytes on diverse aspects of behavior. The development of tools for selectively controlling the temporal and spatial properties of astrocyte activity will help to consolidate our knowledge of the mechanisms underlying this involvement.
Accessibility: Document does not exist in file
Language:
eng
Author:
Oliveira, J. F.
Secondary author(s):
Sardinha, V. M., Guerra-Gomes, S., Araque, A., Sousa, N.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Oliveira, J. F., Sardinha, V. M., Guerra-Gomes, S., Araque, A., & Sousa, N. (2015). Do stars govern our actions? Astrocyte involvement in rodent behavior. Trends in Neurosciences, 38(9), 535-549. https://doi.org/10.1016/j.tins.2015.07.006
2-year Impact Factor: 12.504|2015
Times cited: 123|2024-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Astrocyte / Behavior / Cognition / Emotion / Motor / Sensorial
DocumentA role for lipocalin-2 in hippocampal neurogenesis modulation2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-217
Location: Arquivo PCA - Pasta 27/2012
Title:
217 - Temporal modulation of the subventricular zone neural stem cell niche by choroid plexus-cerebrospinal fluid derived factors
Duration: 2013-08 - 2019-01
Researcher(s):
João Carlos Cruz de Sousa, Fernanda Marques, Joana Palha, Ana Luísa Falcão, Ashley Novais
Institution(s): ICVS/3B's - Laboratório Associado (ICVS/3B's), Universidade do Minho (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
6 Articles
1 Master thesis
Language: eng
Author:
Sousa, J.
Secondary author(s):
Marques, F., Palha, P., Falcão, A., Novais, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function

Reference code: PT/FB/BL-2012-217.06
Location: Arquivo PCA - Pasta 27/2012
Title:
A role for lipocalin-2 in hippocampal neurogenesis modulation
Publication year: 2015
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=3a2ee3c5-1f04-47c0-9dc1-97d906996574&cKey=1d74de64-a47b-4a3c-8492-3bc2fc7dfe18&mKey=d0ff4555-8574-4fbb-b9d4-04eec8ba0c84
Abstract/Results: ABSTRACT:
Stress is defined as a challenge to the homeostatic equilibrium of the organism and when long lasting it severely affects quality of life. In fact, stress maladaptation is considered to be an etiological factor in the emergence of mood disorders like 5depression and anxiety. Stress response elicits a cascade of hormonal and behavioral changes as an attempt to maintain homeostasis and at the level of the central nervous system (CNS), the hippocampus is considered to be a central target and executor of adaptative responses. Of interest, the hippocampus is unique in its structural and cellular plasticity, in the sense that, even in adulthood, stem cells reside and continuously give rise to new neurons. This adult neurogenesis is extremely dynamic and modulated by pharmacological, environmental and physiological stimuli and the newborn neurons are considered to highly contribute to the local network. Of interest, adult neurogenesis is well known to be regulated by stress and, conversely, to regulate stress responses. Of course there is no simple, linear relationship between stress hormones and adult neurogenesis. As an attempt to disclose putative factors in this crosstalk of stress modulation, in the present work we have assessed the modulation of hippocampal neurogenesis in an animal model with a targeted deletion of lipocalin-2 (LCN2). As part of the lipocalin protein family, LCN2 plays a critical role in the regulation of various phyisiological processess, such as inflammation and innate immune response. Several roles for cell proliferation and death have also been attributed to this protein, including during development, in hematopoiesis and even cancer, mainly recognized due to the capacity of LCN2 to traffic iron within cells. In addition, LCN2-null mice were described, at a physiological level, to present a sustained activation of the HPA axis translated into increased levels of corticosterone, accompanied by an anxious and depressive-like phenotypes. Also it was described to control anxiety and neuronal excitability upon stress. But specifically how is hippocampal neurogenesis being modulated upon LCN2 deletion and to which extent it contributes to animal's behavior and stress response is not quite known. Here we show that LCN2-null mice exhibit cell proliferation deficits, accompanied by impairments in adult neurogenesis progress and in contextual fear conditioning paradigms. The current observations will certainly contribute to the current interests on the role of hippocampal neurogenesis in the etiology of mood, identifying LCN2 as a possible key regulator of executor of adaptative responses at the hippocampus.
Accessibility: Document doesn't exist in file
Language:
eng
Collection: (NEUROGENESIS )
Author: Morgado, P.
Secondary author(s):
Ferreira, A. C., Mesquita, S. D., Novais, A., Neves, S. , Sousa, N., Palha, J., Sousa, J. C., Marques, F.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Morgado, P., Ferreira, A. C., Mesquita, S. D., Novais, A., Neves, S., Sousa, N., Palha, J., Sousa, J. C., & Marques, F. (2015, November). A role for lipocalin-2 in hippocampal neurogenesis modulation. Paper presented at the Society for Neuroscience (SFN), Chicago, USA. Abstract available at http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=3a2ee3c5-1f04-47c0-9dc1-97d906996574&cKey=1d74de64-a47b-4a3c-8492-3bc2fc7dfe18&mKey=d0ff4555-8574-4fbb-b9d4-04eec8ba0c84
Indexed document: No
Keywords: Neurogenesis / Behavior / Neurosphere
File030 - Exploring the neural basis of motivation2017-012020-03

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology
File188 - Accuracy and neural correlates of blinded mediumship compared to controls2017-102020-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-188
Location: BF-GMS
Title:
188 - Accuracy and neural correlates of blinded mediumship compared to controls
Duration: 2017-10 - 2020-10
Researcher(s):
Arnaud Delorme, Dean Radin, Helane Wahbeh
Institution(s): Institute of Noetic Sciences, Petaluma, California (USA)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Author: Delorme, A.
Secondary author(s):
Radin, D., Wahbeh, H.
Number of reproductions:
3
Keywords:
Intuition / Electroencephalography / Mediumship / Behavior / Parapsychology and Psychophysiology
DocumentAstrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.02
Location: BF-GMS
Title:
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function
Publication year: 2017
URL:
http://onlinelibrary.wiley.com/doi/10.1002/glia.23205/abstract
Abstract/Results: ABSTRACT:
Astrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with d-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2014-427.02
Author: Sardinha, V. M.
Secondary author(s):
Guerra-Gomes, S., Caetano, I., Tavares, G., Martins, M., Reis, J. S., Correia, J. S., Teixeira-Castro, A., Pinto, L., Sousa, N., Oliveira, J. F.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Sardinha, V. M., Martins, M., Reis, J. S., Correia, J. S., Teixeira-Castro, A., ..., Oliveira, J. F. (2017). Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function. Glia, 65(12), 1-17. https://doi.org/10.1002/glia.23205
2-year Impact Factor: 5.846|2017
Times cited: 60|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Astrocyte / Behavior / Local field potential / Neuronal morphology / Oscillations
DocumentAstrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.02
Location: BF-GMS
Title:
Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function
Publication year: 2017
URL:
http://onlinelibrary.wiley.com/doi/10.1002/glia.23205/abstract
Abstract/Results: ABSTRACT:
Astrocytes interact with neurons at the cellular level through modulation of synaptic formation, maturation, and function, but the impact of such interaction into behavior remains unclear. Here, we studied the dominant negative SNARE (dnSNARE) mouse model to dissect the role of astrocyte-derived signaling in corticolimbic circuits, with implications for cognitive processing. We found that the blockade of gliotransmitter release in astrocytes triggers a critical desynchronization of neural theta oscillations between dorsal hippocampus and prefrontal cortex. Moreover, we found a strong cognitive impairment in tasks depending on this network. Importantly, the supplementation with d-serine completely restores hippocampal-prefrontal theta synchronization and rescues the spatial memory and long-term memory of dnSNARE mice. We provide here novel evidence of long distance network modulation by astrocytes, with direct implications to cognitive function.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2014-207.02
Author: Sardinha, V. M.
Secondary author(s):
Martins, M., Reis, J. S., Correia, J. S., Teixeira-Castro, A., Pinto, L., Sousa, N., Oliveira, J. F.
Document type:
Article-d
Number of reproductions:
1
Reference:
Sardinha, V. M., Martins, M., Reis, J. S., Correia, J. S., Teixeira-Castro, A., ..., Oliveira, J. F. (2017). Astrocytic signaling supports hippocampal-prefrontal theta synchronization and cognitive function. Glia, 65(12), 1-17. https://doi.org/10.1002/glia.23205
2-year Impact Factor: 5.846|2017
Times cited: 60|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Astrocyte / Behavior / Local field potential / Neuronal morphology / Oscillations
DocumentStructure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-185
Location: Arquivo PCA - Pasta 24/2012
Title:
185 - Circuit mechanisms of spatial attention in the zebrafish midbrain
Duration: 2013-06 - 2017-07
Researcher(s):
Michael Brian Orger, Sabine L. Renninger
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
3 Articles
Language: eng
Author:
Orger, M.
Secondary author(s):
Renninger, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Attention / Brain structure and function

Reference code: PT/FB/BL-2012-185.05
Location: Arquivo PCA - Pasta 24/2012
Title:
Structure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering
Publication year: 2018
URL:
https://www.sciencedirect.com/science/article/pii/S0960982217316044
Abstract/Results: ABSTRACT:
An important concept in ethology is that complex behaviors can be constructed from a set of basic motor patterns. Identifying the set of patterns available to an animal is key to making quantitative descriptions of behavior that reflect the underlying motor system organization. We addressed these questions in zebrafish larvae, which swim in bouts that are naturally segmented in time. We developed a robust and general purpose clustering method (clusterdv) to ensure accurate identification of movement clusters and applied it to a dataset consisting of millions of swim bouts, captured at high temporal resolution from a comprehensive set of behavioral contexts. We identified a set of thirteen basic swimming patterns that are used flexibly in various combinations across different behavioral contexts and show that this classification can be used to dissect the sensorimotor transformations underlying larval social behavior and hunting. Furthermore, using the same approach at different levels in the behavioral hierarchy, we show that the set of swim bouts are themselves constructed from a basic set of tail movements and that bouts are executed in sequences specific to different behaviors.
Accessibility: Document does not exist in file
Language:
eng
Author:
Marques, J. C.
Secondary author(s):
Lackner, S., Félix, R., Orger, M. B.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Marques, J. C., Lackner, S., Félix, R., & Orger, M. B. (2018). Structure of the zebrafish locomotor repertoire revealed with unsupervised behavioral clustering. Current Biology, 28(2), 181-195. https://doi.org/10.1016/j.cub.2017.12.002
2-year Impact Factor: 9.193|2018
Times cited: 106|2024-02-09
Indexed document: Yes
Quartile: Q1
Keywords: Zebrafish / Behavior / Locomotion / Cluster analysis / Unsupervised machine / Learning / Visual behavior / Motor control / Sequences / Behavioral motifs / Clusterdv
DocumentFunctional roles of astrocyte calcium elevations: From synapses to behavior2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.03
Location: BF-GMS
Title:
Functional roles of astrocyte calcium elevations: From synapses to behavior
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fncel.2017.00427/full
Abstract/Results: ABSTRACT:
Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially and to temporally quantify and qualify these elevations. However, the impact on brain function remains poorly understood. In this review, we discuss evidences of the functional impact of heterogeneous astrocytic calcium events in several brain regions, and their consequences in synapses, circuits, and behavior.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2014-427.04
Author: Guerra-Gomes, S.
Secondary author(s):
Sousa, N., Pinto, L., Oliveira, J. F.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Guerra-Gomes, S., Sousa, N., Pinto, L., & Oliveira, J. F. (2018). Functional roles of astrocyte calcium elevations: From synapses to behavior. Frontiers in Cellular Neuroscience, 11: 427. https://doi.org/10.3389/fncel.2017.00427
2-year Impact Factor: 3.900|2018
Times cited: 123|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Astrocyte / Calcium / Synapse / Neural circuit / Behavior

Functional roles of astrocyte calcium elevations: From synapses to behavior

Functional roles of astrocyte calcium elevations: From synapses to behavior
DocumentFunctional roles of astrocyte calcium elevations: From synapses to behavior2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.04
Location: BF-GMS
Title:
Functional roles of astrocyte calcium elevations: From synapses to behavior
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fncel.2017.00427/full
Abstract/Results: ABSTRACT:
Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially and to temporally quantify and qualify these elevations. However, the impact on brain function remains poorly understood. In this review, we discuss evidences of the functional impact of heterogeneous astrocytic calcium events in several brain regions, and their consequences in synapses, circuits, and behavior.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2014-207.03
Author: Guerra-Gomes, S.
Secondary author(s):
Sousa, N., Pinto, L., Oliveira, J. F.
Document type:
Article-d
Number of reproductions:
1
Reference:
Guerra-Gomes, S., Sousa, N., Pinto, L., & Oliveira, J. F. (2018). Functional roles of astrocyte calcium elevations: From synapses to behavior. Frontiers in Cellular Neuroscience, 11: 427. https://doi.org/10.3389/fncel.2017.00427
2-year Impact Factor: 3.900|2018
Times cited: 123|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Astrocyte / Calcium / Synapse / Neural circuit / Behavior

Functional roles of astrocyte calcium elevations: From synapses to behavior

Functional roles of astrocyte calcium elevations: From synapses to behavior
DocumentBrain, behavior and cognitive interplay in disorders of consciousness: A multiple case study2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-16
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Brain, behavior and cognitive interplay in disorders of consciousness: A multiple case study
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2018.00665/full
Abstract/Results: ABSTRACT:
Patients with prolonged disorders of consciousness (DoC) after severe brain injury may present residual behavioral and cognitive functions. Yet the bedside assessment of these functions is compromised by patients' multiple impairments. Standardized behavioral scales such as the Coma Recovery Scale-Revised (CRS-R) have been developed to diagnose DoC, but there is also a need for neuropsychological measurement in these patients. The Cognitive Assessment by Visual Election (CAVE) was therefore recently created. In this study, we describe five patients in minimally conscious state (MCS) or emerging from the MCS (EMCS). Their cognitive profiles, derived from the CRS-R and CAVE, are presented alongside their neuroimaging results using structural magnetic resonance imaging (MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET). Scores on the CAVE decreased along with the CRS-R total score, establishing a consistent behavioral/cognitive profile for each patient. Out of these five cases, the one with highest CRS-R and CAVE performance had the least extended cerebral hypometabolism. All patients showed structural and functional brain impairments that were consistent with their behavioral/cognitive profile as based on previous literature. For instance, the presence of visual and motor residual functions was respectively associated with a relative preservation of occipital and motor cortex/cerebellum metabolism. Moreover, residual language comprehension skills were found in the presence of preserved temporal and angular cortex metabolism. Some patients also presented structural impairment of hippocampus, suggesting the presence of memory impairments. Our results suggest that brain-behavior relationships might be observed even in severely brain-injured patients and they highlight the importance of developing new tools to assess residual cognition and language in MCS and EMCS patients. Indeed, a better characterization of their cognitive profile will be helpful in preparation of rehabilitation programs and daily routines.
Accessibility: Document exists in file
Language:
eng
Author:
Aubinet, C.
Secondary author(s):
Murphy, L., Ali Bahri, M., Larroque, S. K., Cassol, H., Annen, A., Carrière, M., Wannez, S., Thibaut, A., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Aubinet, C., Murphy, L., Ali Bahri, M., Larroque, S. K., Cassol, H., Annen, A., Carrière, M., Wannez, S., Thibaut, A., Laureys, S., & Gosseries, O. (2018). Brain, behavior and cognitive interplay in disorders of consciousness: A multiple case study. Frontiers in Neurology, 9: 665. https://doi.org/10.3389/fneur.2018.00665
2-year Impact Factor: 2.635|2018
Times cited: 16|2024-02-09
Indexed document: Yes
Quartile: Q3
Keywords: (emergence from) minimally conscious state / Behavior / Cognitive functions / Neural correlates / Neuropsychological assessment / Positron emission tomography / Structural magnetic resonance imaging

Brain, behavior and cognitive interplay in disorders of consciousness: A multiple case study

Brain, behavior and cognitive interplay in disorders of consciousness: A multiple case study
DocumentEditorial: The impact of stress on cognition and motivation2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.03
Location: BF-GMS
Title:
Editorial: The impact of stress on cognition and motivation
Publication year: 2018
URL:
https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00326/full
Accessibility: Document exists in file
Language:
eng
Author:
Morgado, P.
Secondary author(s):
Cerqueira, J. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Morgado, P., & Cerqueira, J. J. (2018). Editorial: The impact of stress on cognition and motivation. Frontiers in Behavioral Neuroscience, 12: 326. https://doi.org/10.3389/fnbeh.2018.00326
2-year Impact Factor: 2.622|2018
Times cited: 12|2024-02-09
Indexed document: Yes
Quartile: Q2
Keywords: Cognition / Stress / Motivation / Behavior / Decision-making

Editorial: The impact of stress on cognition and motivation

Editorial: The impact of stress on cognition and motivation
DocumentTET enzymes in neurophysiology and brain function2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.06
Location: BF-GMS
Title:
TET enzymes in neurophysiology and brain function
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S014976341830856X?via%3Dihub
Abstract/Results: ABSTRACT
The dynamic nature of epigenetic DNA modifications is crucial for regulating gene expression in an experience-dependent manner and, thus, a potential mediator of neuronal plasticity and behavior. The discovery of the involvement of 5-hydroxymethylcytosine (5hmC) and Ten Eleven Translocation (TET) family of enzymes in the demethylation pathway uncovered a potential link between neuronal TET protein function and cognitive processes. In this review, we provide an overview on how profile of 5hmC and TET enzymes are powerful mechanisms to explain neuronal plasticity and long-term behaviors, such as cognition. More specifically, we discuss how the current knowledge integrates the function of each TET enzyme in neurophysiology and brain function.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Antunes, C.
Secondary author(s):
Sousa, N., Pinto, L., Marques, C. J.
Document type:
Article
Number of reproductions:
1
Percentiles:
5
Reference:
Antunes, C., Sousa, N., Pinto, L., & Marques, C. J. (2019). TET enzymes in neurophysiology and brain function. Neuroscience & Biobehavioral Reviews, 102, 337-344. https://doi.org/10.1016/j.neubiorev.2019.05.006
2-year Impact Factor: 8.330|2019
Times cited: 27|2024-02-12
Indexed document: Yes
Quartile: Q1
Keywords: 5hmC / Behavior / Epigenetics / Neuronal plasticity / TET enzymes

TET enzymes in neurophysiology and brain function

TET enzymes in neurophysiology and brain function
DocumentIP3R2 null mice display a normal acquisition of somatic and neurological development milestones2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.03
Location: BF-GMS
Title:
IP3R2 null mice display a normal acquisition of somatic and neurological development milestones
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14724
Abstract/Results: ABSTRACT:
Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels. These astrocytic Ca2+ elevations emerge from different sources and display complex spatio-temporal properties. Ca2+ elevations are spatially distributed in global (soma and main processes) and/or focal regions (microdomains). The inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model lacks global Ca2+ elevations in astrocytes and it has been used by different laboratories. However, the constitutive deletion of IP3R2 during development may trigger compensating phenotypes, which could bias the results of experiments using developing or adult mice. To address this issue, we performed a detailed neurodevelopmental evaluation of male and female IP3R2 KO mice, during the first 21 days of life, as well as an evaluation of motor function, strength and neurological reflexes in adult mice. Our results show that male and female IP3R2 KO mice display a normal acquisition of developmental milestones, as compared with wild-type (WT) mice. We also show that that IP3R2 KO mice display normal motor coordination, strength and neurological reflexes in adulthood. To exclude a potential compensatory overexpression of other IP3Rs, we quantified the relative mRNA levels of all 3 subtypes, in brain tissue. We found that, along with the complete deletion of Itpr2, there is no compensatory expression of Itpr1 or Itrp3. Overall, our results show that the IP3R2 KO mouse is a reliable model to study the functional impact of global IP3R2-dependent astrocytic Ca2+ elevations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2014-207.09; BL-2014-427.10
Author: Guerra-Gomes, S.
Secondary author(s):
Cunha-Garcia, D. , Marques Nascimento, D. S., Duarte-Silva, S. , Loureiro-Campos, E. , Morais Sardinha, V. , Viana, J. F. , Sousa, N. , Maciel, P. , Pinto, L., Oliveira, J. F.
Document type:
Article
Number of reproductions:
1
Percentiles:
6
Reference:
Guerra-Gomes, S., Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., ... Oliveira, J. F. (2020). IP3R2 null mice display a normal acquisition of somatic and neurological development milestones. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14724
2-year Impact Factor: 3.386|2020
Times cited: 10|2024-02-13
Indexed document: Yes
Quartile: Q3
Keywords: Astrocytes / IP3R2 / Behavior / Calcium signaling / Development
DocumentIP3R2 null mice display a normal acquisition of somatic and neurological development milestones2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.09
Location: BF-GMS
Title:
IP3R2 null mice display a normal acquisition of somatic and neurological development milestones
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/abs/10.1111/ejn.14724
Abstract/Results: ABSTRACT:
Astrocytes are key players in the regulation of brain development and function. They sense and respond to the surrounding activity by elevating their intracellular calcium (Ca2+) levels. These astrocytic Ca2+ elevations emerge from different sources and display complex spatio-temporal properties. Ca2+ elevations are spatially distributed in global (soma and main processes) and/or focal regions (microdomains). The inositol 1,4,5-triphosphate receptor type 2 knockout (IP3R2 KO) mouse model lacks global Ca2+ elevations in astrocytes and it has been used by different laboratories. However, the constitutive deletion of IP3R2 during development may trigger compensating phenotypes, which could bias the results of experiments using developing or adult mice. To address this issue, we performed a detailed neurodevelopmental evaluation of male and female IP3R2 KO mice, during the first 21 days of life, as well as an evaluation of motor function, strength and neurological reflexes in adult mice. Our results show that male and female IP3R2 KO mice display a normal acquisition of developmental milestones, as compared with wild-type (WT) mice. We also show that that IP3R2 KO mice display normal motor coordination, strength and neurological reflexes in adulthood. To exclude a potential compensatory overexpression of other IP3Rs, we quantified the relative mRNA levels of all 3 subtypes, in brain tissue. We found that, along with the complete deletion of Itpr2, there is no compensatory expression of Itpr1 or Itrp3. Overall, our results show that the IP3R2 KO mouse is a reliable model to study the functional impact of global IP3R2-dependent astrocytic Ca2+ elevations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2018-037.03; BL-2014-427.10
Author: Guerra-Gomes, S.
Secondary author(s):
Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., Viana, J. F. , Sousa, N., Maciel, P. , Pinto, L., Oliveira, J. F.
Document type:
Article-d
Number of reproductions:
1
Reference:
Guerra-Gomes, S., Cunha-Garcia, D., Marques Nascimento, D. S., Duarte-Silva, S., Loureiro-Campos, E., Morais Sardinha, V., ... Oliveira, J. F. (2020). IP3R2 null mice display a normal acquisition of somatic and neurological development milestones. European Journal of Neuroscience. https://doi.org/10.1111/ejn.14724
2-year Impact Factor: 3.386|2020
Times cited: 10|2024-02-13
Indexed document: Yes
Quartile: Q3
Keywords: Astrocytes / Behavior / Calcium signaling / Development / IP3R2