Reference code: | NDE-83 |
Location: | BF-GMS
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Title:
| Altered intrinsic functonal brain connectivity after first-time exposure to short-term gravitational alterations induced by parabolic flight
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Publication year: | 2018
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URL:
| https://orbi.uliege.be/handle/2268/248308
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Abstract/Results: | ABSTRACT:
Spaceflight severely impacts the human body. Moreover, little is known about how gravity and gravitational alterations affect the human brain. Here, we aimed at measuring the effects of acute exposure to gravity transitions. We exposed 28 naïve participants to repetitive alterations between normal, hyper- and microgravity induced by a parabolic flight (PF) and measured functional MRI connectivity changes. Scans were acquired before and after the PF. To mitigate motion sickness, PF participants received scopolamine prior to PF. To account for the scopolamine, 12 non-PF controls were scanned prior to and after scopolamine injection. Changes in functional connectivity were explored with the Intrinsic Connectivity Contrast (ICC). Seed-based analysis on the regions exhibiting localized changes was subsequently performed to understand the networks associated with the identified nodes. We found that the PF group was characterized by lower ICC scores in the right temporo-parietal junction (rTPJ), an area involved in multisensory integration and spatial tasks. The encompassed network revealed PF-related decreases in within- and inter-hemispheric anticorrelations between the rTPJ and the supramarginal gyri, indicating both altered vestibular and self-related functions. Our findings shed light how the brain copes with gravity transitions, on gravity internalization and are relevant for the understanding of bodily self-consciousness.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Van Ombergen, A.
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Secondary author(s):
| Wuyts, F. L., Jeurissen, B., Sijbers, J., Vanhevel, F., Jillings, S., Parizel, P. M., Sunaert, S., Van De Heyning, P. H., Dousset, V., Laureys, S., Demertzi, A.
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Document type:
| Conference paper
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Number of reproductions:
| 3
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Reference:
| Van Ombergen, A., Wuyts, F. L., Jeurissen, B., Sijbers, J., Vanhevel, F., Jillings, S., Parizel, P. M., Sunaert, S., Van De Heyning, P. H., Dousset, V., Laureys, S., & Demertzi, A. (2018). Altered intrinsic functonal brain connectivity after first-time exposure to short-term gravitational alterations induced by parabolic flight. Proceedings of the 69th International Astronautical Congress. Code 147415.
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2-year Impact Factor: | N/A
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Times cited: | N/A
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Indexed document: | Yes
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Quartile: | N/A
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Keywords: | Aerospace / Brain / Brain connectivity / Microgravity / Parabolic flight / Resting-state functional MRI
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