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DocumentImbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder 2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-133
Location: Arquivo PCA - Pasta 9/2012
Title:
133 - The role of the core and extended face networks in visual perception and high level social cognition
Duration: 2013-11 - 2016-01
Researcher(s):
Miguel Castelo-Branco, Marco Simões, Carlos Amaral, Gregor Philipiak, José Rebola, João Castelhano
Institution(s): IBILI, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Simões, M., Amaral, C., Philipiak, G., Rebola, J., Castelhano, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Perception / Attention / Affective and social behavior / Social cognition / Brain structure and function

Reference code: PT/FB/BL-2012-133.09
Location: Arquivo PCA - Pasta 9/2012
Title:
Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder
Publication year: 2015
URL:
http://brain.oxfordjournals.org/content/early/2015/01/06/brain.awu379
Abstract/Results: ABSTRACT:
Intrusive thoughts and compulsive urges to perform stereotyped behaviours are typical symptoms of obsessive-compulsive disorder. Emerging evidence suggests a cognitive bias towards habit formation at the expense of goal-directed performance in obsessive-compulsive disorder. In this study, we test this hypothesis using a novel individualized ecologically valid symptom provocation design: a live provocation functional magnetic resonance imaging paradigm with synchronous video-recording of behavioural avoidance responses. By pairing symptom provocation with online avoidance responses on a trial-by-trial basis, we sought to investigate the neural mechanisms leading to the compulsive avoidance response. In keeping with the model of habit formation in obsessive-compulsive disorder, we hypothesized that this disorder would be associated with lower activity in regions implicated in goal-directed behaviours and higher activity in regions implicated in habitual behaviours. Fifteen patients with obsessive-compulsive disorder and 15 healthy control volunteers participated in this functional magnetic resonance imaging study. Online stimuli were individually tailored to achieve effective symptom provocation at neutral, intermediate and strong intensity levels. During the symptom provocation block, the participant could choose to reject or terminate the provoking stimuli resulting in cessation of the symptom provocation. We thus separately analysed the neural correlates of symptom provocation, the urge to avoid, rejection and relief. Strongly symptom-provoking conditions evoked a dichotomous pattern of deactivation/activation in patients, which was not observed either in control conditions or in healthy subjects: a deactivation of caudate-prefrontal circuits accompanied by hyperactivation of subthalamic nucleus/putaminal regions. This finding suggests a dissociation between regions engaged in goal-directed and habitual behaviours. The putaminal hyperactivity during patients’ symptom provocation preceded subsequent deactivation during avoidance and relief events, indicating a pivotal role of putamen in regulation of behaviour and habit formation in obsessive-compulsive disorder. Effective connectivity analysis identified the ventromedial prefrontal cortex/orbitofrontal cortex as the main structure in this circuitry involved in the modulation of compulsivity in obsessive-compulsive disorder. These findings suggest an imbalance in circuitry underlying habitual and goal-directed action control, which may represent a fundamental mechanism underlying compulsivity in obsessive-compulsive disorder. Our results complement current models of symptom generation in obsessive-compulsive disorder and may enable the development of future therapeutic approaches that aim to alleviate this imbalance.
Accessibility: Document does not exist in file
Language:
eng
Author:
Banca, P.
Secondary author(s):
Voon, V., Vestergaard, M., Philipiak, G., Almeida, I., Pocinho, F., Relvas, J., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Banca, P., Voon, V., Vestergaard, M., Philipiak, G., Almeida, I., Pocinho, F., Relvas, J., & Castelo-Branco, M. (2015). Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder. Brain, 138(Pt 3), 798-811. https://doi.org/10.1093/brain/awu379
2-year Impact Factor: 10.103|2015
Times cited: 86|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Live symptom provocation / Obsessive-compulsive disorder / Causality / Imbalanced circuitry / Caudate/putamen
DocumentImbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-132
Location: Arquivo PCA - Pasta 11/2012
Title:
132 - A direct test of the binding by synchrony hypothesis in humans: the neural correlates of coherent object perception
Duration: 2013-11 - 2016-01
Researcher(s):
Miguel Castelo-Branco, Maria Ribeiro, João Duarte, Gabriel Costa
Institution(s): IBILI, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Ribeiro, M., Duarte, J., Costa, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2012-132.09
Location: Arquivo PCA - Pasta 11/2012
Title:
Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder
Publication year: 2015
URL:
http://brain.oxfordjournals.org/content/early/2015/01/06/brain.awu379
Abstract/Results: ABSTRACT:
Intrusive thoughts and compulsive urges to perform stereotyped behaviours are typical symptoms of obsessive-compulsive disorder. Emerging evidence suggests a cognitive bias towards habit formation at the expense of goal-directed performance in obsessive-compulsive disorder. In this study, we test this hypothesis using a novel individualized ecologically valid symptom provocation design: a live provocation functional magnetic resonance imaging paradigm with synchronous video-recording of behavioural avoidance responses. By pairing symptom provocation with online avoidance responses on a trial-by-trial basis, we sought to investigate the neural mechanisms leading to the compulsive avoidance response. In keeping with the model of habit formation in obsessive-compulsive disorder, we hypothesized that this disorder would be associated with lower activity in regions implicated in goal-directed behaviours and higher activity in regions implicated in habitual behaviours. Fifteen patients with obsessive-compulsive disorder and 15 healthy control volunteers participated in this functional magnetic resonance imaging study. Online stimuli were individually tailored to achieve effective symptom provocation at neutral, intermediate and strong intensity levels. During the symptom provocation block, the participant could choose to reject or terminate the provoking stimuli resulting in cessation of the symptom provocation. We thus separately analysed the neural correlates of symptom provocation, the urge to avoid, rejection and relief. Strongly symptom-provoking conditions evoked a dichotomous pattern of deactivation/activation in patients, which was not observed either in control conditions or in healthy subjects: a deactivation of caudate-prefrontal circuits accompanied by hyperactivation of subthalamic nucleus/putaminal regions. This finding suggests a dissociation between regions engaged in goal-directed and habitual behaviours. The putaminal hyperactivity during patients’ symptom provocation preceded subsequent deactivation during avoidance and relief events, indicating a pivotal role of putamen in regulation of behaviour and habit formation in obsessive-compulsive disorder. Effective connectivity analysis identified the ventromedial prefrontal cortex/orbitofrontal cortex as the main structure in this circuitry involved in the modulation of compulsivity in obsessive-compulsive disorder. These findings suggest an imbalance in circuitry underlying habitual and goal-directed action control, which may represent a fundamental mechanism underlying compulsivity in obsessive-compulsive disorder. Our results complement current models of symptom generation in obsessive-compulsive disorder and may enable the development of future therapeutic approaches that aim to alleviate this imbalance.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2012-133.09
Author: Banca, P.
Secondary author(s):
Voon, V., Vestergaard, M., Philipiak, G., Almeida, I., Pocinho, F., Relvas, J., Castelo-Branco, M.
Document type:
Article-d
Number of reproductions:
1
Reference:
Banca, P., Voon, V., Vestergaard, M., Philipiak, G., Almeida, I., Pocinho, F., Relvas, J., & Castelo-Branco, M. (2015). Imbalance in habitual versus goal directed neural systems during symptom provocation in obsessive-compulsive disorder. Brain, 138(Pt 3), 798-811. https://doi.org/10.1093/brain/awu379
2-year Impact Factor: 10.103|2015
Times cited: 86|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Live symptom provocation / Obsessive-compulsive disorder / Causality / Imbalanced circuitry / Caudate/putamen
DocumentPrimary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-298
Location: BF-GMS
Title:
298 - Empowering feedback connections in temporo-occipital network to boost visual perception of emotions
Duration: 2017-09
Researcher(s):
Sara Borgomaneri, Marco Zanon, Alessio Avenanti, Caterina Bertini
Institution(s): Center for studies and research in Cognitive Neuroscience, Department of Psychology, University of Bologna, Cesena (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Author: Borgomaneri, S.
Secondary author(s):
Zanon, M., Avenanti, A., Bertini, C.
Number of reproductions:
1
Keywords:
Emotion perception / Transcranial magnetic stimulation (TMS) / Cortical plasticity / Feedback connections / Psychophysiology

Reference code: PT/FB/BL-2016-298.13
Location: BF-GMS
Title:
Primary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment
Publication year: 2017
URL:
https://www.sciencedirect.com/science/article/pii/S1053811917301866?via%3Dihub
Abstract/Results: ABSTRACT:
The presence of a network of areas in the parietal and premotor cortices, which are active both during action execution and observation, suggests that we might understand the actions of other people by activating those motor programs for making similar actions. Although neurophysiological and imaging studies show an involvement of the somatosensory cortex (SI) during action observation and execution, it is unclear whether SI is essential for understanding the somatosensory aspects of observed actions. To address this issue, we used off-line transcranial magnetic continuous theta-burst stimulation (cTBS) just before a weight judgment task. Participants observed the right hand of an actor lifting a box and estimated its relative weight. In counterbalanced sessions, we delivered sham and active cTBS over the hand region of the left SI and, to test anatomical specificity, over the left motor cortex (Ml) and the left superior parietal lobule (SPL). Active cTBS over SI, but not over Ml or SPL, impaired task performance relative to sham cTBS. Moreover, active cTBS delivered over SI just before participants were asked to evaluate the weight of a bouncing ball did not alter performance compared to sham cTBS. These findings indicate that SI is critical for extracting somatosensory features (heavy/light) from observed action kinematics and suggest a prominent role of SI in action understanding.
Accessibility: Document exists in file
Language:
eng
Author:
Valchev, N.
Secondary author(s):
Tidoni, E., Hamilton, A. F. C., Gazzola, V., Avenanti, A.
Document type:
Article
Number of reproductions:
1
Reference:
Valchev, N., Tidoni, E., Hamilton, A. F. C., Gazzola, V., & Avenanti, A. (2017). Primary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment. NeuroImage, 152, 195-206. https://doi.org/10.1016/j.neuroimage.2017.02.075
2-year Impact Factor: 5.426|2017
Times cited: 45|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: Somatosensory cortex (SI) / Transcranial magnetic stimulation (TMS) / Causality / Action observation / Weight lifting

Primary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment

Primary somatosensory cortex necessary for the perception of weight from other people's action: A continuous theta-burst TMS experiment
DocumentNot in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-333
Location: BF-GMS
Title:
333 - Mindfulness and psychedelics: A neurophenomenological approach to the characterization of acute and sustained response to DMT in experienced meditators
Duration: 2021-10 - 2024-05
Researcher(s):
Milan Scheidegger, Daniel Meling, Michael Kometer, Dario Dornbierer
Institution(s): Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich (Switzerland); University Medical Center Freiburg (Germany)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Final report
Language: eng
Author:
Scheidegger, M.
Secondary author(s):
Meling, D., Kometer, M., Dornbierer, D.
Number of reproductions:
3
Keywords:
Meditation / Psychedelics / Neurophenomenology / Brain imaging / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-333.03
Location: BF-GMS
Title:
Not in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective
Publication year: 2023
Abstract/Results:
ABSTRACT:
Psychedelics are psychoactive substances that receive renewed interest from science and society. Increasing empirical evidence shows that the effects of psychedelics are associated with alterations in biochemical processes, brain activity, and lived experience. Still, how these different levels relate remains subject to debate. The current literature presents two influential views on the relationship between the psychedelic molecule, neural events, and experience: The integration view and the pluralistic view. The main aim of this article is to contribute a promising complementary view by re-evaluating the psychedelic molecule-brain-experience relationship from an enactive perspective. We approach this aim via the following main research questions: (1) What is the causal relationship between the psychedelic drug and brain activity? (2) What is the causal relationship between brain activity and the psychedelic experience? In exploring the first research question, we apply the concept of autonomy to the psychedelic molecule-brain relationship. In exploring the second research question, we apply the concept of dynamic co-emergence to the psychedelic brain-experience relationship. Addressing these two research questions from an enactive position offers a perspective that emphasizes interdependence and circular causality on multiple levels. This enactive perspective not only supports the pluralistic view but enriches it through a principled account of how multi-layered processes come to interact. This renders the enactive view a promising contribution to questions around causality in the therapeutic effects of psychedelics with important implications for psychedelic therapy and psychedelic research.
Accessibility: Document exists in file
Language:
eng
Author:
Meling, D.
Secondary author(s):
Scheidegger, M.
Document type:
Article
Number of reproductions:
3
Reference:
Meling, D., & Scheidegger, M. (2023). Not in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective. Frontiers in Psychology, 14, 1100058. https://doi.org/10.3389/fpsyg.2023.1100058
2-year Impact Factor: 3.800|2022
Impact factor notes: Impact factor not available yet for 2023
Times cited: 7|2025-02-18
Indexed document: Yes
Quartile: Q1
Keywords: Psychedelics / Neuroscience / Phenomenology / Drug / Enaction / Causality / Psychedelic therapy / Biopsychosocial model

Not in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective

Not in the drug, not in the brain: Causality in psychedelic experiences from an enactive perspective
File346 - Charting the moral compass: TMS-EEG Investigation of causal brain dynamics in moral judgment

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2024
Location: BF-GMS
Title:
2024 Grants
Start date: 2025-01

Reference code: PT/FB/BL-2024-346
Location: BF-GMS
Title:
346 - Charting the moral compass: TMS-EEG Investigation of causal brain dynamics in moral judgment
Researcher(s): Alessio Avenanti, Kamela Cenka, Yanyan Gao, Alice Marra
Institution(s): Department of Psychology "Renzo Canestrari", University of Bologna (Italy)
Contents: Contents:
Application form
Correspondence
Language: eng
Notes:
This project has not started yet
Author: Avenanti, A.
Secondary author(s):
Cenka, K., Gao, Y., Marra, A.
Number of reproductions:
1
Keywords:
Empathy / Moral judgment / Connectivity / Causality / Psychophysiology