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DocumentStress and the hypothalamic pituitary adrenal axis activity in first episode psychosis2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.13
Location: Arquivo PCA - Pasta 18/2006
Title:
Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Hypothalamic-pituitary-adrenal (HPA) axis is the main biological system involved in the stress response. The aim of our study was to evaluate objective and subjective stress together with HPA axis activity in first-episode psychosis patients and healthy controls.
METHODS:
We recruited 40 first-episode psychosis patients (mean +/- SEM age: 29.4 +/-1.2 yrs; gender: 35% females) and 30 controls (mean age: 27.4 +/- 1.0 yrs; gender: 23.3% females) as part of the large Genetic And Psychosis (GAP) study, carried out in South London. Information about childhood trauma, recent stressful events and perceived stress were collected using validated schedules. Salivary cortisol was obtained at awakening, at 15, 30, and 60 minutes after awakening, and at 12 pm, and 8 pm. We calculated the Areas Under the Curve to investigate the cortisol levels during the day and the cortisol response to awakening. An independent t-test and was used to analyze differences in the stress variables and cortisol secretion. Correlation analyses were run to investigate the association between stress variables and cortisol secretion.
RESULTS:
First-episode psychosis patients reported more childhood trauma, recent stressful events, and higher perceived stress compared with controls (P < .001). Patients showed no significant difference in cortisol levels during the day compared with controls (P = .2). However, patients showed a significantly lower cortisol awakening response than controls (P = .034). A positive correlation was found between number of recent stressors or perceived stress and cortisol during the day in controls (r = .377, P = .04 and r = .321, P = .08). In contrast, a negative correlation between number of recent stressors or perceived stress and cortisol during the day was found in patients (r = -.413, P = .01 and r = -.356, P = .04).
CONCLUSIONS:
Our data show that first episode psychosis patients have higher number of stressful events but similar cortisol levels during the day when compared with healthy controls. First episode psychosis patients have an impaired HPA axis response to stress as shown by the blunted cortisol response to awakening and by the negative correlation between measures of recent stress and cortisol secretion during the day.
ACKNOWLEDGMENT:
This research is funded by NARSAD Mental Health Research Association, British Academy, and NIHR Biomedical Research Centre Institute of Psychiatry (Kings’ College London).
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Aas, M., D'Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., David, A. S., Dazzan, P., Murray, R., Pariante, C.
Document type:
Abstract
Number of reproductions:
1
Reference:
Mondelli, V., Aas, M., D’Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., . . . Pariante, C. (2009). Stress and the hypothalamic-pituitary-adrenal axis activity in first episode psychosis. Schizophrenia Bulletin, 35(Suppl. 1), 149-149.
Indexed document: Yes
Keywords: Hypothalamic-pituitary-adrenal axis / Stress / First-episode psychosis / Childhood trauma

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis
DocumentIs there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.24
Location: Arquivo PCA - Pasta 18/2006
Title:
Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis?
Publication year: 2012
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0920996412000606?via%3Dihub
Abstract/Results: ABSTRACT:
Patients with psychosis have higher rates of childhood trauma, which is also associated with adverse effects on cognitive functions such as attention, concentration and mental speed, language, and verbal intelligence. Although the pathophysiological substrate for this association remains unclear, these cognitive deficits may represent the functional correlate of changes observed in relation to trauma exposure in structures such as the amygdala and the hippocampus. Interestingly, these structures are often reported as altered in psychosis. This study investigated the association between childhood trauma, cognitive function and amygdala and hippocampus volume, in first-episode psychosis. We investigated 83 patients with first-episode psychosis and 63 healthy controls. All participants underwent an MRI scan acquired with a GE Sigma 1.5-T system, and a standardized neuropsychological assessment of general cognition, memory, processing speed, executive function, visuo-spatial abilities, verbal intelligence, and language. In a subsample of the patients (N=45) information on childhood trauma was collected with the Childhood Experience of Care and Abuse Questionnaire (CECA. Q). We found that amygdala, but not hippocampus, volume was significantly smaller (p=0.001) in patients compared to healthy controls. There was a trend level interaction for hippocampus volume between group and sex (p=0.056). A history of childhood trauma was associated with both worse cognitive performance and smaller amygdala volume. This smaller amygdala appeared to mediate the relationship between childhood trauma and performance on executive function, language and verbal intelligence in patients with psychosis. This points to a complex relationship between childhood trauma exposure, cognitive function and amygdala volume in first-episode psychosis.
Accessibility: Documento does not exist in file
Language:
eng
Author:
Aas, M.
Secondary author(s):
Navari, S., Gibbs, A., Mondelli, V., Fisher, H. L., Morgan, C., Morgan, K., MacCabe, J., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P. B., Murray, R. M., Pariante, C. M., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Percentiles:
92.28|2.62
Reference:
Aas, M., Navari, S., Gibbs, A., Mondelli, V., Fisher, H. L., Morgan, C., Morgan, K., MacCabe, J., Reichenberg, A., Zanelli, J., Fearon, P., Jones, P. B., Murray, R. M., Pariante, C. M., & Dazzan, P. (2012). Is there a link between childhood trauma, cognition, and amygdala and hippocampus volume in first-episode psychosis? Schizophrenia Research, 137(1-3), 73-79. https://doi.org/10.1016/j.schres.2012.01.035
2-year Impact Factor: 4.590|2012
Times cited: 100|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Hippocampus / Cognitive function / First-episode psychosis / Childhood trauma
DocumentPituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.32
Location: BF-GMS
Title:
Pituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia
Publication year: 2015
URL:
https://www.cambridge.org/core/journals/psychological-medicine/article/abs/pituitary-gland-volume-and-psychosocial-stress-among-children-at-elevated-risk-for-schizophrenia/97FDCCD276481C6ED6113D4FE6746FBA
Abstract/Results: Abstract
Background
Pituitary volume enlargements have been observed among individuals with first-episode psychosis. These abnormalities are suggestive of hypothalamic–pituitary–adrenal (HPA) axis hyperactivity, which may contribute to the development of psychosis. However, the extent to which these abnormalities characterize individuals at elevated risk for schizophrenia prior to illness onset is currently unclear, as volume increases, decreases and no volume differences have all been reported relative to controls. The current study aimed to determine whether antipsychotic-naive, putatively at-risk children who present multiple antecedents of schizophrenia (ASz) or a family history of illness (FHx) show pituitary volume abnormalities relative to typically developing (TD) children. An additional aim was to explore the association between pituitary volume and experiences of psychosocial stress.
Method
ASz (n = 30), FHx (n = 22) and TD (n = 32) children were identified at age 9–12 years using a novel community-screening procedure or as relatives of individuals with schizophrenia. Measures of pituitary volume and psychosocial stress were obtained at age 11–14 years.
Results
Neither ASz nor FHx children showed differences in pituitary volume relative to TD children. Among FHx children only, pituitary volume was negatively associated with current distress relating to negative life events and exposure to physical punishment.
Conclusions
The lack of pituitary volume abnormalities among ASz and FHx children is consistent with our previous work demonstrating that these children are not characterized by elevated diurnal cortisol levels. The findings imply that these biological markers of HPA axis hyperactivity, observed in some older samples of high-risk individuals, may emerge later, more proximally to disease onset.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
Day, F. L., Roberts, R. E., Pariante, C. M., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Percentiles:
49.88|0.54
Reference:
Cullen, A., Day, F., Roberts, R., Pariante, C., & Laurens, K. (2015). Pituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia. Psychological Medicine, 45(15), 3281-3292. https://doi.org/10.1017/S0033291715001282
2-year Impact Factor: 5.491|2015
Times cited: 17|2026-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Childhood trauma / Diathesis-stress model / Genetic high risk / Hypothalamic-pituitary-adrenal axis / Psychosis vulnerability
DocumentFrom childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.05
Location: BF-GMS
Title:
From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia
Publication year: 2023
URL:
https://www.frontiersin.org/articles/10.3389/fnhum.2023.990581/full
Abstract/Results: ABSTRACT:
Introduction:
A new line of insomnia research focuses on the developmental trajectories from early live stress to insomnia in adulthood. Adverse childhood experiences (ACE's) might create a vulnerability for later maladaptive coping with distress, as seen in chronic hyperarousal or insomnia. In an functional magnetic resonance imaging (fMRI) study, failure to dissociate the neurobiological components of shame from autobiographical shameful memories in insomnia was reflected by continued activation of the dorsal anterior cingulate cortex (dACC), which may be a result of maladaptive coping in the wake of ACE's. Following up on that study, the current pilot study explores the relation between ACE's, shame coping-styles, adult insomnia, hyperarousal, and neurobiology of autobiographical memory.
Methods:
We used existing data (N = 57) from individuals with insomnia (N = 27) and controls (N = 30), and asked these participants to complete the childhood trauma questionnaire (CTQ). Two structural equation models were used to test the hypotheses that shame-coping styles and insomnia symptom severity mediate the association between ACE's and (1) self-rated hyperarousal symptoms and (2) dACC activation to recall of autobiographical memories.
Results:
For the association between ACE's and hyperarousal, there was a significant mediation of shame-coping style (p < 0.05). This model also indicated worse shame coping with more ACE's (p < 0.05) and worse insomnia symptoms with more ACES's (p < 0.05), but no association between shame coping and insomnia symptoms (p = 0.154). In contrast, dACC activation to recall of autobiographical memories could only be explained by its direct association with ACE's (p < 0.05), albeit that in this model more ACE's were also associated with worse insomnia symptoms.
Discussion:
These findings could have an implication for the approach of treatment for insomnia. It could be focused more on trauma and emotional processing instead of conventional sleep interventions. Future studies are recommended to investigate the relationship mechanism between childhood trauma and insomnia, with additional factors of attachment styles, personality, and temperament.
Accessibility: Document exists in file
Language:
eng
Author:
Schalkwijk, F.
Secondary author(s):
Van Someren, E. J. W., Nicolai, N. J., Uijttewaal, J. L., Wassing, R.
Document type:
Article
Number of reproductions:
1
Percentiles:
53.18|0.66
Reference:
Schalkwijk, F., Van Someren, E. J. W., Nicolai, N. J., Uijttewaal, J. L., & Wassing, R. (2023). From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia. Frontiers in Human Neuroscience, 17, 990581. https://doi.org/10.3389/fnhum.2023.990581
2-year Impact Factor: 2.4|2023
Times cited: 4|2026-02-15
Indexed document: Yes
Quartile: Q2
Keywords: Adverse childhood experiences (ACEs) / Childhood trauma / dorsal anterior cingulate cortex (dACC) / Hyperarousal / Insomnia / Shame

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia
DocumentImpact of childhood trauma on dreams in adulthood: An Argentine survey2025

Reference code: PT/FB/BL-2018-008.04
Location: BF-GMS
Title:
Impact of childhood trauma on dreams in adulthood: An Argentine survey
Publication year: 2025
URL:
https://dx.doi.org/10.1037/drm0000307
Abstract/Results: ABSTRACT:
The aim of this study was to assess whether participants who present more frequently with nightmares or distressing dreams have had traumatic experiences in their childhood and their relationship with current personality traits. Three instruments were administered to a sample of 446 adults from the Argentine population: the Dreams Questionnaire, Negative Childhood Experiences Questionnaire, and an abbreviated version of the Symptoms Assessment. The results showed that participants presented specific dream content, such as hearing voices/music in dreams (88%), lucid dreams (79%), night terrors (64%), evil/demonic presences (61%), and dreams about a traumatic events (40%). The results also showed a correlation between the frequency of dream experiences and parental maltreatment (emotional, sexual, and physical abuse) and a positive and significant correlation between dream recall with propensity for mental health vulnerability symptoms, which confirmed the two main hypotheses. In addition, a gender difference showed that males tended to have greater dream recall compared to females, and females tended to show predominantly more auditory dreams and night terrors compared to males.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Parra, A.
Document type:
Article
Number of reproductions:
2
Percentiles:
0.00|0.00
Reference:
Parra, A. (2025). Impact of childhood trauma on dreams in adulthood: An Argentine survey. Dreaming, 35(3), 243–253. https://doi.org/10.1037/drm0000307
2-year Impact Factor: 1.1|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2026-02-17
Indexed document: Yes
Quartile: Q3
Keywords: Nightmares / Childhood trauma / Mental health / Disturbing dreams