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File134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning2007-012010-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

DocumentFinal report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.01
Location: Arquivo PCA - Pasta 11/2006
Title:
Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa13406.pdf
Abstract/Results: RESULTS:
The data obtained in this project originates the following conclusions:
Chronic exposure to stress results in impaired goal-directed behavior and increased predisposition for habitual strategies.
Chronic stress triggers a divergent structural reorganization of corticostriatal circuits, suggesting that the induced damage to the associative network drives behavioral control to the more wired sensorimotor circuit. Our electrophysiological data in vivo indicates that the structural reorganization of corticostriatal circuits following chronic stress causes changes in neuronal activity in these networks.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Sousa, N.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Chronic stress / Corticosteroids

Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

Final report - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning

DocumentChronic stress causes frontostriatal reorganization and affects decision-making2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.02
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress causes frontostriatal reorganization and affects decision-making
Publication year: 2009
URL:
http://www.sciencemag.org/content/325/5940/621.abstract
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here, we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions on the basis of their consequences. Using two different operant tasks, we revealed that, in making choices, rats subjected to chronic stress became insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying these different behavioral strategies, with atrophy of medial prefrontal cortex and the associative striatum and hypertrophy of the sensorimotor striatum. These data suggest that the relative advantage of circuits coursing through sensorimotor striatum observed after chronic stress leads to a bias in behavioral strategies toward habit.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:
Article
Number of reproductions:
1
Reference:
Dias-Ferreira, E., Sousa, J., Melo, I., Morgado, P., Mesquita, A. R., Cerqueira, J., ... Sousa, N. (2009). Chronic stress causes frontostriatal reorganization and affects decision-making. Science, 325(5940), 621-625. doi: 10.1126/science.1171203
2-year Impact Factor: 29.747|2009
Times cited: 549|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Psychophysiology / Stress / Chronic stress / Decision-making / Striatum

DocumentChronic stress causes corticostriatal reorganization and affects decision-making2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.03
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress causes corticostriatal reorganization and affects decision-making
Publication year: 2008
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=f8fdb142-74dd-4797-95a8-b588d7016d51&cKey=78c9c63c-a5d0-4448-adcc-3a016fdd759d&mKey=%7bAFEA068D-D012-4520-8E42-10E4D1AF7944%7d
Abstract/Results: ABSTRACT:
Maladaptive responses to stress depend on the intensity and duration of stressors; chronic exposure to stressful events has been shown to predispose to several conditions raging from neuropsychiatric disorders to everyday lapses of attention. Several reports implicate chronic stress in executive function impairment. In this study, we investigated the impact that chronic stress (21 days of chronic unpredictable stress (CUS)) would have on corticostriatal circuits, which are critical for decision making. By 3-D analysis of Golgi stained neurons, we confirmed our previous results indicating that exposure to chronic stress results in dramatic reductions in the total length of apical dendrites in the pyramidal neurons in layer II/III of the prelimbic (PL) and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC). Interestingly, the impact of chronic stress on the striatum was not uniform: while we found a significant increase in the total length of dendrites in the medium spiny neurons (MSNs) of the dorsolateral striatum (DLS, or sensorimotor striatum), there was a trend to a decrease in the total length of dendrites in MSNs of the dorsomedial striatum (DMS). Taken together these data suggest that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal networks. These different circuits have been implicated in different types of actions: the PL cortex and the DMS have been implicated in goal-directed actions, which depend on the relation between the execution of the action and potential outcomes, and on the expected value of those outcomes. In contrast, the DLS has been implicated in the formation of habits, which are insensitive to changes in outcome value and changes in the contingency between action and outcome. Therefore, it is conceivable that chronic stress could play a role in decision-making driving the behavior control from actions to habits. In order to test this hypothesis, rats submitted to chronic stress were trained to press a lever for specific outcomes and subsequently tested for their action-outcome behavior. Using two different behavioral assays, we found that responses from animals submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Taken together, our data suggests that chronic stress causes a dramatic structural reorganization of corticostriatal circuits, which results in impaired goal-directed behavior and increased predisposition for habit formation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., Sousa, N.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Dias-Ferreira, E., Sousa, J., Melo, I., Mesquita, A. R., Cerqueira, J., Costa, R. M., & Sousa, N. (2008). Chronic stress causes corticostriatal reorganization and affects decision-making. Program No. 195.5/UU54. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
Indexed document: No
Keywords: Chronic stress / Decision-making / Striatum / Corticosteroids

DocumentChronic stress affects decision-making strategies: Structural and physiological correlates2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.04
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year: 2009
URL:
http://www.frontiersin.org/10.3389/conf.neuro.01.2009.11.008/event_abstract
Abstract/Results: ABSTRACT:
The ability to shift between different behavioral strategies is necessary for appropriate decision-making. Here we show that chronic stress biases decision-making strategies, affecting the ability of stressed animals to perform actions based on their consequences. Using two different operant tasks, we uncovered that choices made by rats and mice submitted to chronic stress become insensitive to changes in outcome value and resistant to changes in action-outcome contingency. Furthermore, we found that chronic stress caused opposing structural changes in the associative and sensorimotor corticostriatal circuits underlying different behavioral strategies, with atrophy of medial prefrontal cortex (mPFC) and the associative striatum (dorsomedial striatum, DMS), and hypertrophy of the sensorimotor striatum (dorsolateral striatum, DLS). In addition, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits after chronic stress cause changes in neural activity in these circuits that could explain the bias in behavioral strategies towards habit.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Neurosci. Conference Abstract: 11th Meeting of the Portuguese Society for Neuroscience. doi: 10.3389/conf.neuro.01.2009.11.008
Indexed document: No
Keywords: Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

DocumentChronic stress affects decision-making strategies: Structural and physiological correlates2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-134
Location: Arquivo PCA - Pasta 11/2006
Title:
134 - The role of stress in cortico-basal ganglia loop processing and instrumental conditioning
Duration: 2007-01 - 2010-02
Researcher(s):
Nuno Jorge Carvalho de Sousa, Rui Manuel Fernandes da Costa, Eduardo Miguel Gonçalves Dias Ferreira, João José Cerqueira, Pedro Alexandre Teixeira
Institution(s): Life and Health Sciences Research Unit, School of Health Sciences, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Sousa, N.
Secondary author(s):
Costa, R. M., Dias-Ferreira, E., Cerqueira, J., Teixeira, P.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Brain structure and function / Cognitive processes / Decision-making

Reference code: PT/FB/BL-2006-134.06
Location: Arquivo PCA - Pasta 11/2006
Title:
Chronic stress affects decision-making strategies: Structural and physiological correlates
Publication year: 2009
URL:
http://www.frontiersin.org/10.3389/conf.neuro.06.2009.03.348/39/Computational_and_systemsneu/all_events/event_abstract
Abstract/Results: ABSTRACT:
The stress response is vital to maintain homeostasis. However, chronic exposure to stress can trigger maladaptive response and predispose to conditions ranging from neuropsychiatric disorders to everyday lapses of attention. Even though previous reports have implicated chronic stress in executive function impairment, a conceivable role in decision-making processes remains to be clarified. Competing corticostriatal circuits are thought to control heterogeneous decision strategies: while the prelimbic (PL) cortex and the dorsomedial striatum (DMS, or associative striatum) have been implicated in goal-directed actions, the dorsolateral striatum (DLS, or sensorimotor striatum) has been implicated in automatic or habitual choices. Here we show that chronic stress impairs the decision-making process, predisposing to habitual behavior in detriment of goal-directed strategies. Using two different criteria to test for action-outcome behavior in a lever pressing task, we found that responses from rats and mice submitted to chronic stress became insensitive to both outcome devaluation and contingency degradation. Furthermore, we found that chronic stress causes opposing structural changes in associative and sensorimotor corticostriatal circuits. Whereas chronic exposure to stress resulted in selective atrophy of pyramidal neurons in layer II/III of the PL and infralimbic (IL) sub-regions of medial prefrontal cortex (mPFC) and in medium spiny neurons (MSNs) of the DMS, it triggered an opposite effect in MSNs of the DLS. To determine if this structural reorganization of frontostriatal circuits has functional consequences, we recorded the simultaneous activity of neuronal ensembles in mPFC, DMS and DLS of control and stressed mice during behavioral training and testing. This approach will allow us to investigate if the changes in wiring observed in the associative and sensorimotor circuits underlie changes in neural activity in these circuits that could explain the bias from goal-directed towards habitual behavior observed in stressed subjects.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dias-Ferreira, E.
Secondary author(s):
Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Dias-Ferreira, E., Melo, I., Jin, X., Sousa, J., Cerqueira, J., Sousa, N., & Costa, R. M. (2009). Chronic stress affects decision-making strategies: Structural and physiological correlates. Front. Syst. Neurosci. Conference Abstract: Computational and systems neuroscience 2009. doi: 10.3389/conf.neuro.01.2009.11.008
Indexed document: No
Keywords: Psychophysiology / Chronic stress / Decision-making / Striatum / Corticosteroids

File090 - Advancing methodology in the psychophysiology of stress: capturing the complexity of immunity2007-072011-03

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-090
Location: Arquivo PCA - Pasta 20/2006
Title:
090 - Advancing methodology in the psychophysiology of stress: capturing the complexity of immunity
Duration: 2007-07 - 2011-03
Researcher(s):
Matt Bristow, Rachel Cook
Institution(s): Department of Psychology, Anglia Ruskian University, Cambridge (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Bristow, M.
Secondary author(s):
Cook, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Psychoneuroimmunology / Immunology

File134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?2010-052014-11

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

DocumentFinal report - Structural and molecular basis of cognitive improvements induced by behavioral training (cognitive enrichment)2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.01
Location: Arquivo PCA - Pasta 22/2008
Title:
Final report - Structural and molecular basis of cognitive improvements induced by behavioral training (cognitive enrichment)
Publication year: 2012
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Learning / Cognitive enrichment / Chronic stress / Neuropsychiatric disorders / Prefrontal cortex / Hippocampus

DocumentChronic stress disrupts neural coherence between cortico-limbic structures2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.02
Location: Arquivo PCA - Pasta 22/2008
Title:
Chronic stress disrupts neural coherence between cortico-limbic structures
Publication year: 2013
URL:
http://www.ncbi.nlm.nih.gov/pubmed/23390414
Abstract/Results: ABSTRACT:
Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
PT/FB/BL-2010-61.02
Author: Oliveira, J. F.
Secondary author(s):
Dias, N., Correia, M., Gama-Pereira, F., Sardinha, V. M., Lima, A., Oliveira, A. F., Jacinto, L. R., Ferreira, D. S., Silva, A. M., Reis, J. S., Cerqueira, J., Sousa, N.
Document type:
Article-d
Number of reproductions:
1
Reference:
Oliveira, J. F., Dias, N., Correia, M., Gama-Pereira, F., Sardinha, V. M. ,Lima, A., . . . & Sousa, N. (2013). Chronic stress disrupts neural coherence between cortico-limbic structures. Frontiers in Neural Circuits, 7, 10, 1-12. doi: 10.3389/fncir.2013.00010
2-year Impact Factor: 2.950|2013
Times cited: 30|2022-05-20
Indexed document: Yes
Quartile: Q2
Keywords: Chronic stress / Coherence / Hippocampus / Power spectrum / Prefrontal cortex

Novo ficheiro

Novo ficheiro

DocumentHow does cognitive enrichment impact on neuronal networks and behavioral performance?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.03
Location: Arquivo PCA - Pasta 22/2008
Title:
How does cognitive enrichment impact on neuronal networks and behavioral performance?
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
Introduction: Several studies in animal models have demonstrated that chronic stress exposure
induces alterations in the structure and function of the hippocampal formation and medial
prefrontal (mPFC). Also relevant, was the finding that such functional and structural changes
partially reverted following cessation of stress exposure; importantly, functional recovery was
correlated with synaptogenesis and dendritic plasticity, at least in the hippocampus.
Objective: The present study aimed to assess the ability of cognitive stimulation to abrogate the
negative effects of chronic stress exposure on learning and memory performances.
Methods: As it is conceivable that specific cognitive stimulation differently enhance brain circuits,
rats free of stress-exposure (CON) and animals previously submitted to chronic unpredictable
stress (CUS) were submitted to spatial reference memory stimulus using the hole board (RM)
paradigm (CON+RM and CUS+RM) while others were trained in a T-maze (WM), a working memory
tasks (CON+WM and CUS+WM).
Results: Behavioral data confirms that stress impairs both reference and working memory.
Importantly, these behavioural underperformances were reverted with cognitive tasks.
Interestingly, however, each individual task ameliorates predominantly that specific cognitive
behaviour, which reinforces the view that neuronal plasticity is circuit-dependent. Structural
analysis of animals submitted chronic stress reveals a trend to recovery of neuropil changes in the
hippocampal formation, but not in the mPFC, after reference memory stimulation (CUS+RM).
Conversely, after working memory stimulation there’s a trend towards recovery of neuropil
changes in the mPFC but not in the hippocampus.
Conclusion and discussion: In conclusion, these preliminary results suggest that reinforcement of
specific cognitive circuits (“cognitive-enrichment”) triggers synaptic plasticity mainly within the
brain circuits implicated in that particular task. These basic experimental procedures provide an
insight on the ability to recover from stress-induced impairments in animal models, which might
prove relevant in the pathogenesis and recovery of several neurological and psychiatric disorders.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Cerqueira, J., Spínola, I., Carvalho, I., Morgado, P. & Taipa, R. (2012). How does cognitive enrichment impact on neuronal networks and behavioral performance? In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 43/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Chronic stress / Plasticity / Long-term potentiation

Novo ficheiro

Novo ficheiro

DocumentChronic stress disrupts neural coherence between cortico-limbic structures2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-061
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
061 - Translation of neuron-glia interactions in complex cognitive functions
Duration: 2011-05 - 2015-07
Researcher(s):
João Filipe Pedreira de Oliveira, Nuno Sérgio Mendes Dias, Luis Ricardo Monteiro Jacinto
Institution(s): Instituto de Investigação em Ciências da Vida e da Saúde (ICVS), Escola de Ciências da Saúde, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
3 Articles
1 Poster
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Dias, N., Jacinto, L. R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2010-061.02
Location: Arquivo PCA - Pastas 17/2010 e 18/2010
Title:
Chronic stress disrupts neural coherence between cortico-limbic structures
Publication year: 2013
URL:
http://www.frontiersin.org/Neural_Circuits/10.3389/fncir.2013.00010/abstract
Abstract/Results: ABSTRACT:
Chronic stress impairs cognitive function, namely on tasks that rely on the integrity of cortico-limbic networks. To unravel the functional impact of progressive stress in cortico-limbic networks we measured neural activity and spectral coherences between the ventral hippocampus (vHIP) and the medial prefrontal cortex (mPFC) in rats subjected to short term stress (STS) and chronic unpredictable stress (CUS). CUS exposure consistently disrupted the spectral coherence between both areas for a wide range of frequencies, whereas STS exposure failed to trigger such effect. The chronic stress-induced coherence decrease correlated inversely with the vHIP power spectrum, but not with the mPFC power spectrum, which supports the view that hippocampal dysfunction is the primary event after stress exposure. Importantly, we additionally show that the variations in vHIP-to-mPFC coherence and power spectrum in the vHIP correlated with stress-induced behavioral deficits in a spatial reference memory task. Altogether, these findings result in an innovative readout to measure, and follow, the functional events that underlie the stress-induced reference memory impairments.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
PT/FB/BL-2008-134.02
Author: Oliveira, J. F.
Secondary author(s):
Dias, N., Correia, M., Gama-Pereira, F., Sardinha, V. M., Lima, A., Oliveira, A. F., Jacinto, L. R., Ferreira, D. S., Silva, A. M., Reis, J. S., Cerqueira, J., Sousa, N.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Oliveira, J. F., Dias, N., Correia, M., Gama-Pereira, F., Sardinha, V. M., ... Sousa, N. (2013). Chronic stress disrupts neural coherence between cortico-limbic structures. Frontiers in Neural Circuits, 7:10, 1-12. doi: 10.3389/fncir.2013.00010
2-year Impact Factor: 2.950|2013
Times cited: 30|2022-05-21
Indexed document: Yes
Quartile: Q2
Keywords: Chronic stress / Coherence / Power spectrum / Hippocampus / Prefrontal cortex

Chronic stress disrupts neural coherence between cortico-limbic structures

Chronic stress disrupts neural coherence between cortico-limbic structures

File130 - Neural mechanisms of cognitive bias2013-092020-11

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-130
Location: Arquivo PCA - Pasta 29/2012
Title:
130 - Neural mechanisms of cognitive bias
Duration: 2013-09 - 2020-11
Researcher(s):
Rui Filipe Nunes Pais de Oliveira, Ana Félix, Sara Cardoso
Institution(s): ISPA, CRL, Lisbon and Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Oliveira, R.
Secondary author(s):
Felix, A., Cardoso, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Chronic stress / Cognitive processes / Brain structure and function

File073 - Cerebrovascular hypothesis of stress-induced behavioral alterations2021-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-073
Location: BF-GMS
Title:
073 - Cerebrovascular hypothesis of stress-induced behavioral alterations
Duration: 2021-09
Researcher(s):
Ana Paula Silva, Filipa Baptista, Ana Rita Gaspar, Ricardo Leitão, Catarina Gomes
Institution(s): Centre for Innovative Biomedicine and Biotechnology - CIBB, Faculty of Medicine, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
This project hasn't started yet
Author: Silva, A. P.
Secondary author(s):
Baptist, F., Gaspar, A. R., Leitão, R., Gomes, C.
Number of reproductions:
1
Keywords:
Chronic stress / Blood-brain barrier / Sex differences / Complement component 3 / Psychophysiology

DocumentResilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-030
Location: BF-GMS
Title:
030 - Exploring the neural basis of motivation
Duration: 2017-01 - 2020-03
Researcher(s):
Ana João Rodrigues, Nivaldo Vasconcelos, Carina Cunha, Bárbara Coimbra, Laura Silva, Patrícia Monteiro, Sónia Borges, Pedro Morgado
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Rodrigues, A. J.
Secondary author(s):
Vasconcelos, N., Cunha, C., Coimbra, B., Silva, L., Monteiro, P., Borges, S., Morgado, P.
Number of reproductions:
1
Keywords:
Reward / Reinforcement / Mesolimbic system / Behavior / Psychophysiology

Reference code: PT/FB/BL-2016-030.07
Location: BF-GMS
Title:
Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S2352289521000102
Abstract/Results: ABSTRACT:
Prenatal exposure to stress or glucocorticoids (GC) is associated with the appearance of psychiatric diseases later in life. Microglia, the immune cells of the brain, are altered in stress-related disorders.
Synthetic GC such as dexamethasone (DEX) are commonly prescribed in case of preterm risk labour in order to promote fetal lung maturation. Recently, we reported long-lasting differences in microglia morphology in a model of in utero exposure to DEX (iuDEX), that presents an anxious phenotype. However, it is still unclear if stress differentially affects iuDEX males and females.
In this work, we evaluated how iuDEX animals of both sexes cope with chronic mild stress for 2 weeks. We evaluated emotional behavior and microglia and neuronal morphology in the dorsal hippocampus (dHIP) and nucleus accumbens (NAc), two brain regions involved in emotion-related disorders. We report that males and females prenatally exposed to DEX have better performance in anxiety- and depression-related behavioral tests after chronic stress exposure in adulthood than non-exposed animals. Interestingly, iuDEX animals present sex-dependent changes in microglia morphology in the dHIP (hypertrophy in females) and in the NAc (atrophy in females and hypertrophy in males). After chronic stress, these cells undergo sex-specific morphological remodeling. Paralleled to these alterations in cytoarchitecture of microglia, we report inter-regional differences in dendritic morphology in a sex-specific manner. iuDEX females present fewer complex neurons in the NAc, whereas iuDEX males presented less complex neuronal morphology in the dHIP. Interestingly, these alterations were modified by stress exposure.
Our work shows that stressful events during pregnancy can exert a preserved sex-specific effect in adulthood. Although the role of the observed cellular remodeling is still unknown, sex-specific differences in microglia plasticity induced by long-term stress exposure may anticipate differences in drug efficacy in the context of stress-induced anxiety- or depression-related behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Gaspar, R.
Secondary author(s):
Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., Gomes, C. A.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Gaspar, R., Soares-Cunha, C., Domingues, A. V., Coimbra, B., Baptista, F. I., Pinto. L., Ambrósio, A. F., Rodrigues, A. J., & Gomes, C. A. (2021). Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia. Neurobiology of Stress, 14, 100302. doi: 10.1016/j.ynstr.2021.100302
2-year Impact Factor: 5.441|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 5|2022-05-25
Indexed document: Yes
Quartile: Q1
Keywords: Prenatal stress / Chronic stress / Microglia morphology / Sex / Nucleus accumbens / Dorsal hippocampus

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

Resilience to stress and sex-specific remodeling of microglia and neuronal morphology in a rat model of anxiety and anhedonia

DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Researcher(s): João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.08
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article-d
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390-. doi: 10.3390/cells11030390
2-year Impact Factor: 6.6|2020
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-05-26
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.18
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390/htm
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390-. doi: 10.3390/cells11030390
2-year Impact Factor: 6.6|2020
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-05-25
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

DocumentThe underestimated sex: A review on female animal models of depression 2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.19
Location: BF-GMS
Title:
The underestimated sex: A review on female animal models of depression
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S0149763421005698?via%3Dihub
Abstract/Results: Major depression (MD) is the most common psychiatric disorder, predicted to affect around 264 million people
worldwide. Although the etiology of depression remains elusive, the interplay between genetics and environmental factors, such as early life events, stress, exposure to drugs and health problems appears to underlie its
development. Whereas depression is twice more prevalent in women than in men, most preclinical studies are
performed in male rodents. In fact, females’ physiology and reproductive experience are associated with changes
to brain, behavior and endocrine profiles that may influence both stress, an important precipitating factor for
depression, and response to treatment. These specificities emphasize the need to choose the most suitable models
and readouts in order to better understand the pathophysiological mechanisms of depression in females.
With this review, we aim to provide an overview of female animal models of depression highlighting the major
differences between models, regarding behavioral, physiological, and molecular readouts, but also the major
gaps in research, attending to the role of etiological factors, protocol variability and sex.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
Lima, S.
Secondary author(s):
Sousa, N., Patrício, P., Pinto, L.
Document type:
Article
Number of reproductions:
1
Reference:
Lima, S., Sousa, N., Patrício, P. & Pinto, L. (2022). The underestimated sex: A review on female animal models of depression. Neuroscience and Biobehavioral Reviers, 133. doi: 10.1016/j.neubiorev.2021.12.021
2-year Impact Factor: 8.989|2020
Impact factor notes: Impact factor not available yet for 2022
Times cited: 0|2022-06-06
Quartile: Q1
Keywords: Depression / Females / Animal models / Chronic stress / Social stress / Genetic models / Sex differences

The underestimated sex: A review on female animal models of depression

The underestimated sex: A review on female animal models of depression