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DocumentFinal report - É possível a comunicação telepática com os doentes em coma? - um estudo exploratório 2002

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-1996
Location: Arquivo PCA - Pastas 1 a 8/1996
Title:
1996 Grants
Start date: 1997-01 - 2005-05
Dimension/support:
8 caixas de arquivo

Reference code: PT/FB/BL-1996-014
Location: Arquivo PCA - Pasta 8/1996
Title:
014 - É possível a comunicação telepática com os doentes em coma? - Um estudo exploratório
Duration: 1997-01 - 2002-05
Researcher(s):
Irene Ferreira
Institution(s): Universidade de Ciências Médicas de São Paulo (Brazil)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Final report
Language: por
Author:
Ferreira, M. I.
Number of reproductions:
2
Keywords:
Parapsychology / Extrasensory perception (ESP) / Telepathy / Altered states of consciousness / Survival after bodily death / Near-death experience

Reference code: PT/FB/BL-1996-014.01
Location: Arquivo PCA - Pasta 8/1996
Title:
Final report - É possível a comunicação telepática com os doentes em coma? - um estudo exploratório
Publication year: 2002
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
por
Author:
Ferreira, M. I.
Document type:
Final report
Number of reproductions:
2
Indexed document:
No
Keywords: Parapsychology / Telepathy / Coma

Novo ficheiro

Novo ficheiro
DocumentÉ possível a comunicação telepática com doentes em coma? Um estudo exploratório1998

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-1996
Location: Arquivo PCA - Pastas 1 a 8/1996
Title:
1996 Grants
Start date: 1997-01 - 2005-05
Dimension/support:
8 caixas de arquivo

Reference code: PT/FB/BL-1996-014
Location: Arquivo PCA - Pasta 8/1996
Title:
014 - É possível a comunicação telepática com os doentes em coma? - Um estudo exploratório
Duration: 1997-01 - 2002-05
Researcher(s):
Irene Ferreira
Institution(s): Universidade de Ciências Médicas de São Paulo (Brazil)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Final report
Language: por
Author:
Ferreira, M. I.
Number of reproductions:
2
Keywords:
Parapsychology / Extrasensory perception (ESP) / Telepathy / Altered states of consciousness / Survival after bodily death / Near-death experience

Reference code: PT/FB/BL-1996-014.02
Location: Arquivo PCA - Pasta 8/1996
Title:
É possível a comunicação telepática com doentes em coma? Um estudo exploratório
Publication year: 1998
URL:
http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/2%C2%BA_simposio.a108.html
Accessibility: Document does not exist in file
Language:
por
Author:
Ferreira, M. I.
Document type:
Conference paper
Number of reproductions:
2
Reference:
Ferreira, M. I. (1998). É possível a comunicação telepática com doentes em coma? Um estudo exploratório. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 2nd Symposium of Fundação Bial (pp. 223-226). Porto: Fundação Bial.
Indexed document: No
Keywords: Parapsychology / Telepathy / Coma / Near-death experience / Conscience

Novo ficheiro

Novo ficheiro
DocumentComa Science Group

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/E
Entity holding: BIAL Foundation
Title: Documentation and Information Center
History: Books that are part of the documentation center

Reference code: PT/FB/E/107
Title: Coma Science Group
Número de inventário: M-0110
URL: http://www.coma.ulg.ac.be/
Abstract/Results: We aim to improve the medical care and understanding of disorders of consciousness following an acute injury such as coma, "vegetative"/unresponsive wakefulness, minimally conscious or locked-in syndromes
Document type: Website
Keywords:
Coma / Mind-matter interaction / Altered states of consciousness
DocumentNear-death experiences: actual considerations2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-07
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Near-death experiences: actual considerations
Publication year: 2017
URL:
https://link.springer.com/chapter/10.1007/978-3-319-55964-3_14
Abstract/Results: ABSTRACT:
The notion that death represents a passing to an afterlife, where we are reunited with loved ones and live eternally in a utopian paradise, is common in the anecdotal reports of people who have encountered a “near-death experience” (NDE). These experiences are usually portrayed as being extremely pleasant including features such as a feeling of peacefulness, the vision of a dark tunnel leading to a brilliant light, the sensation of leaving the body, or the experience of a life review. NDEs are increasingly being reported as a clearly identifiable physiological and psychological reality of clinical and scientific significance. The definition and causes of the phenomenon as well as the identification of NDE experiencers are still matters of debate. The phenomenon has been thoroughly portrayed by the media, but the science of NDEs is rather recent and still lacking of rigorous experimental data and reproducible controlled experiments. It seems that the most appropriate theories to explain the phenomenon tend to integrate both psychological and neurobiological mechanisms. The paradoxical dissociation between the richness and intensity of the memory, probably occurring during a moment of brain dysfunction, offers a unique opportunity to better understand the neural correlates of consciousness. In this chapter, we will attempt to describe NDEs and the methods to identify them. We will also briefly discuss the NDE experiencers’ characteristics. We will then address the main current explicative models and the science of NDEs.
Accessibility: Document does not exists in file
Language:
eng
Author:
Charland-Verville, V.
Secondary author(s):
Martial, C., Cassol, H., Laureys, S.
Document type:
Book chapter
Number of reproductions:
3
Reference:
Charland-Verville, V., Martial, C., Cassol, H., & Laureys, S. (2017). Near-death experiences: actual considerations. In C. Schnakers & S. Laureys (Eds.), Coma and Disorders of Consciousness (2nd ed.) (pp. 235-263). Cham, Switzerland: Springer International Publishing AG. https://doi.org/10.1007/978-3-319-55964-3
Indexed document: Yes
Keywords: Near-death experience / Consciousness / Coma

DocumentTheta network centrality correlates with tDCS response in disorders of consciousness2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-11
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Theta network centrality correlates with tDCS response in disorders of consciousness
Publication year: 2018
URL:
https://www.brainstimjrnl.com/article/S1935-861X(18)30304-8/fulltext
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Thibaut, A.
Secondary author(s):
Chennu, S., Chatelle, C., Martens, G., Annen, J., Cassol, H., Laureys, S.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Thibaut, A., Chennu, S., Chatelle, C., Martens, G., Annen, J., Cassol, H., & Laureys, S. (2018). Theta network centrality correlates with tDCS response in disorders of consciousness. Brain Stimulation, 11, 1407-1409. https://doi.org/10.1016/j.brs.2018.09.002
2-year Impact Factor: 6.919|2018
Times cited: 17|2024-02-09
Indexed document: Yes
Quartile: Q1
Keywords: Coma / Disorders of consciousness / Electroencephalography (EEG) / Connectivity / Transcranial direct current stimulation (tDCS)
DocumentFinal report - Implications of near-death experiences for the mind-brain relationship2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-101
Location: BF-GMS
Title:
101 - Implications of near-death experiences for the mind-brain relationship
Duration: 2017-04 - 2018-11
Researcher(s):
Bruce Greyson, Surbhi Khanna, Lauren Moore, Lori Derr, Sue Ruddock
Institution(s): Division of Perceptual Studies, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Author: Greyson, B.
Secondary author(s):
Khanna, S., Moore, L., Derr, L., Ruddock, S.
Number of reproductions:
3
Keywords:
Near-death experience / Parapsychology and Psychophysiology

Reference code: PT/FB/BL-2016-101.01
Location: BF-GMS
Title:
Final report - Implications of near-death experiences for the mind-brain relationship
Publication year: 2018
Abstract/Results:
ABSTRACT:
BACKGROUND
Most neuroscientists believe that brain generates consciousness, An alternative view is that mind operates independent of its associated brain but is dependent on the brain for expression. The idea that brain generates consciousness is challenged by near-death experiences (NDEs), complex experiences that can occur when the brain is severely disabled. Exploration of brain activity during NDEs may shed light on the mind-brain relationship.
AIM OF THE STUDY
We reviewed the medical record of a detailed NDE during deep coma, focusing on the severity of condition and neurophysiology, in order to assess the implications of such NDEs for the mind-brain relationship.
METHOD
Three physicians separately reviewed the medical record of an 8-day coma during which the patient experienced a vivid NDE.
RESULTS
The patient had an NDE with vivid perceptions, intense emotions, and clear memory, including of events around his body during the period of deepest coma. Medical records document that he was not expected to survive and that his brain function was severely impaired and unable to generate consciousness at the time of the NDE.
CONCLUSION
The patient was comatose and unresponsive, but nonetheless had a vivid NDE including complex perceptions, cognitions, emotions, and memory. This NDE during documented deep coma is incompatible with consciousness being produced by brain, but is compatible with consciousness being filtered by brain. We encourage other clinical investigators to report examples of NDEs in patients with severely compromised brain function in order to explore further the brain mechanisms associated with complex consciousness and the relationship between consciousness and brain function.
Accessibility: Document exists in file
Language:
eng
Author:
Greyson, B.
Secondary author(s):
Khanna, S., Moore, L., Derr, L., Ruddock, S.
Document type:
Final report
Number of reproductions:
3
Reference:
Greyson, B., Khanna, S., Moore, L., Derr, L., & Ruddock, S. (2018). Final report - Implications of near-death experiences for the mind-brain relationship
Indexed document: No
Keywords: Near-death experience / Mind-body relationship / Meningitis / Encephalitis / Coma

Final report - Implications of near-death experiences for the mind-brain relationship

Final report - Implications of near-death experiences for the mind-brain relationship
DocumentFull neurological recovery from Escherichia coli Meningitis associated with near-death experience2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-101
Location: BF-GMS
Title:
101 - Implications of near-death experiences for the mind-brain relationship
Duration: 2017-04 - 2018-11
Researcher(s):
Bruce Greyson, Surbhi Khanna, Lauren Moore, Lori Derr, Sue Ruddock
Institution(s): Division of Perceptual Studies, Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Author: Greyson, B.
Secondary author(s):
Khanna, S., Moore, L., Derr, L., Ruddock, S.
Number of reproductions:
3
Keywords:
Near-death experience / Parapsychology and Psychophysiology

Reference code: PT/FB/BL-2016-101.02
Location: BF-GMS
Title:
Full neurological recovery from Escherichia coli Meningitis associated with near-death experience
Publication year: 2018
URL:
https://journals.lww.com/jonmd/Abstract/2018/09000/Full_Neurological_Recovery_From_Escherichia_coli.12.aspx
Abstract/Results: ABSTRACT:
A 54-year-old otherwise healthy man presented with altered mental status. On admission, the patient was confused and agitated, with a Glasgow Coma Scale (GCS) score of 11, suggesting moderate brain injury. He was sedated, placed on a ventilator, and started on tobramycin and ceftazidime for presumed bacterial meningitis, but switched to ceftriaxone once cultures returned as Escherichia coli. During his 8-day hospitalization, his mental status fluctuated from confused to nonresponsive, with GCS scores between 6 and 11. Although E. coli meningitis has a high rate of neurological complications and death, this patient recovered completely without any deficits, and recalled an elaborate near-death experience that occurred during his coma. This case highlights the importance of studying near-death experiences occurring during compromised brain function to further our understanding of the brain and consciousness.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Khanna, S.
Secondary author(s):
Moore, L., Greyson, B.
Document type:
Article
Number of reproductions:
3
Percentiles:
7
Reference:
Khanna, S., Moore, L., & Greyson, B. (2018). Full neurological recovery from Escherichia coli Meningitis associated with near-death experience. Journal of Nervous and Mental Disease, 206(9), 744-747. https://doi.org/10.1097/NMD.0000000000000874
2-year Impact Factor: 1.859|2018
Times cited: 4|2024-02-09
Indexed document: Yes
Quartile: Q3
Keywords: Meningitis / Encephalitis / Escherichia coli / Coma / Near-death experience
DocumentDiagnostic, pronostic et traitements des troubles de la conscience2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-18
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Diagnostic, pronostic et traitements des troubles de la conscience
Publication year: 2018
URL:
https://www.sciencedirect.com/science/article/pii/S1627483017300661
Abstract/Results: ABSTRACT:
Advances in medicine and intensive care have led to an increase in the number of patients surviving a severe brain injury. Although some patients recover quickly, others remain in a state of altered consciousness. These patients can progress from a coma to a vegetative state or unresponsive wakefulness syndrome (VS/UWS) and later to a minimally conscious state (MCS). In this review, we first describe the different behavioral and neuroimaging methods used in the diagnosis of patients in an altered state of consciousness. We then describe the factors that can influence the prognosis and recovery of these patients, as well as the treatment and therapeutic management that can be proposed in order to improve their state of consciousness. Finally, we conclude this review by highlighting ethical considerations and end-of-life issues.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
french
Author:
Cassol, H.
Secondary author(s):
Aubinet, C., Thibaut, A., Wannez, S., Martial, C., Martens, G., Laureys, S.
Document type:
Article
Number of reproductions:
3
Reference:
Cassol, H., Aubinet, C., Thibaut, A., Wannez, S., Martial, C., Martens, G., & Laureys, S. (2018). Diagnosis, prognosis and treatment in disorders of consciousness [Diagnostic, pronostic et traitements des troubles de la conscience]. NPG Neurologie - Psychiatrie - Geriatrie, 18(103), 38-46.
2-year Impact Factor: N/A
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Consciousness / Brain injury / Diagnosis / Prognosis / Treatment / Altered states of consciousness / Coma / Vegetative state / Unresponsive wakefulness syndrome / Minimally conscious state / Locked-in syndrome / Neuroimaging / Positron emission tomography / Coma Recovery Scale-Revised / Magnetic resonance / Electroencephalography / Transcranial magnetic stimulation
DocumentClinical and electrophysiological investigation of spastic muscle overactivity in patients with disorders of consciousness following severe brain injury2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-36
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Clinical and electrophysiological investigation of spastic muscle overactivity in patients with disorders of consciousness following severe brain injury
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/pii/S1388245718313816?via%3Dihub
Abstract/Results: ABSTRACT
OBJECTIVE
The clinical and electrophysiological profile of spastic muscle overactivity (SMO) is poorly documented in patients with disorders of consciousness (DOC) following severe cortical and subcortical injury. We aim at investigating the link between the clinical observations of SMO and the electrophysiological spastic over-reactivity in patients with prolonged DOC.
METHODS
We prospectively enrolled adult patients with DOC at least 3?months post traumatic or non-traumatic brain injury. The spastic profile was investigated using the Modified Ashworth Scale and the Hmax/Mmax ratio. T1 MRI data and impact of medication were analyzed as well.
RESULTS
21 patients were included (mean age: 41?±?11?years; time since injury: 4?±?5?years; 9 women; 10 traumatic etiologies). Eighteen patients presented signs of SMO and 11 had an increased ratio. Eight patients presented signs of SMO but no increased ratio. We did not find any significant correlation between the ratio and the MAS score for each limb (all ps?>?0.05). The presence of medication was not significantly associated with a reduction in MAS scores or Hmax/Mmax ratios.
CONCLUSIONS
In this preliminary study, the Hmax/Mmax ratio does not seem to reflect the clinical MAS scores in patients with DOC. This supports the fact they do not only present spasticity but other forms of SMO and contracture.
SIGNIFICANCE
Patients with DOC are still in need of optimized tools to evaluate their spastic profile and therapeutic approaches should be adapted accordingly.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Martens, G.
Secondary author(s):
Deltombe, T., Foidart-Dessalle, M., Laureys, S., Thibaut, A.
Document type:
Article
Number of reproductions:
3
Percentiles:
7
Reference:
Martens, G., Deltombe, T., Foidart-Dessalle, M., Laureys, S., & Thibaut, A. (2019). Clinical and electrophysiological investigation of spastic muscle overactivity in patients with disorders of consciousness following severe brain injury. Clinical Neurophysiology, 130(2), 207-213. https://doi.org/10.1016/j.clinph.2018.10.021
2-year Impact Factor: 3.214|2019
Times cited: 2|2024-02-12
Indexed document: Yes
Quartile: Q2
Keywords: Coma / H/M ratio / Minimally conscious state / Modified Ashworth Scale / Spasticity / Unresponsive wakefulness syndrome
DocumentNear-death experience as a probe to explore (disconnected) consciousness2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-50
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Near-death experience as a probe to explore (disconnected) consciousness
Publication year: 2020
URL:
https://www.cell.com/trends/cognitive-sciences/fulltext/S1364-6613(19)30312-2
Abstract/Results: ABSTRACT:
Forty-five years ago, the first evidence of near-death experience (NDE) during comatose state was provided, setting the stage for a new paradigm for studying the neural basis of consciousness in unresponsive states. At present, the state of consciousness associated with NDEs remains an open question. In the common view, consciousness is said to disappear in a coma with the brain shutting down, but this is an oversimplification. We argue that a novel framework distinguishing awareness, wakefulness, and connectedness is needed to comprehend the phenomenon. Classical NDEs correspond to internal awareness experienced in unresponsive conditions, thereby corresponding to an episode of disconnected consciousness. Our proposal suggests new directions for NDE research, and more broadly, consciousness science.
Accessibility: Document exists in file
Language:
eng
Author:
Martial, C.
Secondary author(s):
Cassol, H., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Martial, C., Cassol, H., Laureys, S., & Gosseries, O. (2020). Near-death experience as a probe to explore (disconnected) consciousness. Trends in Cognitive Sciences, 24(3), 173-183. https://doi.org/10.1016/j.tics.2019.12.010
2-year Impact Factor: 20.229|2020
Times cited: 32|2024-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Consciousness / Connectedness / Near-death experience / Phenomenology / Coma

Near-death experience as a probe to explore (disconnected) consciousness

Near-death experience as a probe to explore (disconnected) consciousness
DocumentThe Brief Evaluation of Receptive Aphasia test for the detection of language impairment in patients with severe brain injury2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-61
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
The Brief Evaluation of Receptive Aphasia test for the detection of language impairment in patients with severe brain injury
Publication year: 2021
URL:
https://www.tandfonline.com/doi/abs/10.1080/02699052.2021.1894482?journalCode=ibij20
Abstract/Results: ABSTRACT:
PRIMARY OBJECTIVE:
The assessment of language in patients post-comatose patients is limited by their reduced behavioral repertoire. We developed the Brief Evaluation of Receptive Aphasia (BERA) tool for assessing phonological, semantic and morphosyntactic abilities in patients with severe brain injury based on visual fixation responses.
RESEARCH DESIGN:
Prospective cross-sectional study and case reports.
METHODS AND PROCEDURE:
The BERA and Language Screening Test were first administered to 52 conscious patients with aphasia on two consecutive days in order to determine the validity and reliability of the BERA. Four post-comatose patients were further examined with the BERA, the Coma Recovery Scale-Revised (CRS-R), positron emission tomography and structural magnetic resonance imaging.
MAIN OUTOCME AND RESULTS:
The BERA showed satisfactory intra- and inter-rater reliability, as well as internal and concurrent validity in patients with aphasia. The BERA scores indicated selective receptive difficulties for phonological, semantic and particularly morphosyntactic abilities in post-comatose patients. These results were in line with the cortical distribution of brain lesions.
CONCLUSIONS:
The BERA may complement the widely used CRS-R for assessing and diagnosing patients with disorders of consciousness by providing a systematic and detailed characterization of residual language abilities.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aubinet, C.
Secondary author(s):
Chatelle, C., Gillet, S., Lejeune, N., Thunus, M., Hennen, N., Cassol, H., Laureys, S., Majerus, S.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Aubinet, C., Chatelle, C., Gillet, S., Lejeune, N., Thunus, M., Hennen, N., Cassol, H., Laureys, S., & Majerus, S. (2021). The Brief Evaluation of Receptive Aphasia test for the detection of language impairment in patients with severe brain injury. Brain Injury. https://doi.org/10.1080/02699052.2021.1894482
2-year Impact Factor: 2.311|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 4|2024-02-14
Indexed document: Yes
Quartile: Q2
Keywords: Coma / Aphasia / Behavioral assessment / Language / Minimally conscious state
DocumentClinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-69
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S1388245720304302
Abstract/Results: ABSTRACT:
The analysis of spontaneous EEG activity and evoked potentials is a cornerstone of the instrumental evaluation of patients with disorders of consciousness (DoC). The past few years have witnessed an unprecedented surge in EEG-related research applied to the prediction and detection of recovery of consciousness after severe brain injury, opening up the prospect that new concepts and tools may be available at the bedside. This paper provides a comprehensive, critical overview of both consolidated and investigational electrophysiological techniques for the prognostic and diagnostic assessment of DoC. We describe conventional clinical EEG approaches, then focus on evoked and event-related potentials, and finally we analyze the potential of novel research findings. In doing so, we (i) draw a distinction between acute, prolonged and chronic phases of DoC, (ii) attempt to relate both clinical and research findings to the underlying neuronal processes and (iii) discuss technical and conceptual caveats. The primary aim of this narrative review is to bridge the gap between standard and emerging electrophysiological measures for the detection and prediction of recovery of consciousness. The ultimate scope is to provide a reference and common ground for academic researchers active in the field of neurophysiology and clinicians engaged in intensive care unit and rehabilitation.
Accessibility: Document exists in file
Language:
eng
Author:
Comanducci, A.
Secondary author(s):
Boly, M., Claassen, J., De Lucia, M., Gibson, R. M., Juan, E., Laureys, S., Naccache, L., Owen, A. M., Rosanova, M., Rossetti, A. O., Schnakers, C., Sitt, J. D., Schiff, N. D., Massimini, M.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Comanducci, A., Boly, M., Claassen, J., De Lucia, M., Gibson, R. M., Juan, E., ... Massimini, M. (2020). Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group. Clinical Neurophysiology, 131(11), 2736-2765. https://doi.org/10.1016/j.clinph.2020.07.015
2-year Impact Factor: 3.708|2020
Times cited: 78|2024-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Disorders of consciousness / EEG / Evoked potentials / Event-related potentials / Vegetative state / Minimally conscious state / Coma

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group

Clinical and advanced neurophysiology in the prognostic and diagnostic evaluation of disorders of consciousness: review of an IFCN-endorsed expert group
DocumentTherapies to restore consciousness in patients with severe brain injuries: A gap analysis and future directions2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-89
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Therapies to restore consciousness in patients with severe brain injuries: A gap analysis and future directions
Publication year: 2021
URL:
https://link.springer.com/article/10.1007%2Fs12028-021-01227-y
Abstract/Results: ABSTRACT:
BACKGROUND/OBJECTIVE:
For patients with disorders of consciousness (DoC) and their families, the search for new therapies has been a source of hope and frustration. Almost all clinical trials in patients with DoC have been limited by small sample sizes, lack of placebo groups, and use of heterogeneous outcome measures. As a result, few therapies have strong evidence to support their use; amantadine is the only therapy recommended by current clinical guidelines, specifcally for patients with DoC caused by severe traumatic brain injury. To foster and advance development of consciousness-promoting therapies for patients with DoC, the Curing Coma Campaign convened a Coma Science Work Group to perform a gap analysis.
METHODS:
We consider fve classes of therapies: (1) pharmacologic; (2) electromagnetic; (3) mechanical; (4) sensory; and (5) regenerative. For each class of therapy, we summarize the state of the science, identify gaps in knowledge, and suggest future directions for therapy development.
RESULTS:
Knowledge gaps in all fve therapeutic classes can be attributed to the lack of: (1) a unifying conceptual framework for evaluating therapeutic mechanisms of action; (2) large-scale randomized controlled trials; and (3) pharmacodynamic biomarkers that measure subclinical therapeutic efects in early-phase trials. To address these gaps, we propose a precision medicine approach in which clinical trials selectively enroll patients based upon their physiological receptivity to targeted therapies, and therapeutic efects are measured by complementary behavioral, neuroimaging, and electrophysiologic endpoints.
CONCLUSIONS:
This personalized approach can be realized through rigorous clinical trial design and international collaboration, both of which will be essential for advancing the development of new therapies and ultimately improving the lives of patients with DoC.
Accessibility: Document exists in file
Language:
eng
Author:
Edlow, B. L.
Secondary author(s):
Sanz, L. R.,, Polizzotto, L., Pouratian, N., Rolston, J. D., Snider, S. B., Thibaut, A., Stevens, R. D., Gosseries, O., Curing Coma Campaign and its contributing members
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Edlow, B. L., Sanz, L. R., Polizzotto, L., Pouratian, N., Rolston, J. D., Snider, S. B., Thibaut, A., Stevens, R. D., Gosseries, O., & Curing Coma Campaign and its contributing members (2021). Therapies to restore consciousness in patients with severe brain injuries: A gap analysis and future directions. Neurocritical Care, 35(Suppl 1), 68-85. https://doi.org/10.1007/s12028-021-01227-y
2-year Impact Factor: 3.210|2020
Impact factor notes: Impac factor not available yet for 2021
Times cited: 41|2024-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Coma / Consciousness / Disorders of consciousness / Gap analysis / Precision medicine

Therapies to restore consciousness in patients with severe brain injuries: A gap analysis and future directions

Therapies to restore consciousness in patients with severe brain injuries: A gap analysis and future directions
DocumentSimplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-94
Location: BF-GMS
Title:
Simplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S1877065720301603?via%3Dihub
Abstract/Results: ABSTRACT:
Background
The Coma Recovery Scale-Revised (CRS-R) is the gold standard to assess severely brain-injured patients with prolonged disorders of consciousness (DoC). However, the amount of time needed to complete this examination may limit its use in clinical settings. Objective. We aimed to validate a new faster tool to assess consciousness in individuals with DoC.
Methods
This prospective validation study introduces the Simplified Evaluation of CONsciousness Disorders (SECONDs), a tool composed of 8 items: arousal, localization to pain, visual fixation, visual pursuit, oriented behaviors, command-following, and communication (both intentional and functional). A total of 57 individuals with DoC were assessed on 2 consecutive days by 3 blinded examiners: one CRS-R and one SECONDs were performed on 1 day, whereas 2 SECONDs were performed on the other day. A Mann-Whitney U test was used to compare the duration of administration of the SECONDs versus the CRS-R, and weighted Fleiss’ kappa coefficients were used to assess inter-/intra-rater reliability as well as concurrent validity.
Results
In the 57 participants, the SECONDs was about 2.5 times faster to administer than the CRS-R. The comparison of the CRS-R versus the SECONDs on the same day or the best of the 3 SECONDs led to “substantial” or “almost perfect” agreement (kappa coefficients ranging from 0.78 to 0.85). Intra-/inter-rater reliability also showed almost perfect agreement (kappa coefficients from 0.85 to 0.91 and 0.82 to 0.85, respectively).
Conclusions
The SECONDs appears to be a fast, reliable and easy-to-use scale to diagnose DoC and may be a good alternative to other scales in clinical settings where time constraints preclude a more thorough assessment.
Accessibility: Document exists in file
Language:
eng
Author:
Aubinet, C.
Secondary author(s):
Cassol, H., Bodart, O., Sanz, L., Wannez, S., Martial, C., Thibaut, A., Martens, G., Carrière, M., Gosseries, O., Laureys, S., Chatelle, C.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Aubinet, C., Cassol, H., Bodart, O., Sanz, L., Wannez, S., Martial, C., Thibaut, A., Martens, G., Carrière, M., Gosseries, O., Laureys, S., & Chatelle, C. (2021). Simplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study. Annals of Physical and Rehabilitation Medicine, 64(5), 101432. https://doi.org/10.1016/j.rehab.2020.09.001
2-year Impact Factor: 4.919|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 21|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Coma / Disorders of consciousness / Trauma / Rehabilitation

Simplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study

Simplified evaluation of CONsciousness disorders (SECONDs) in individuals with severe brain injury: A validation study
DocumentUpdate on neuroimaging in disorders of consciousness2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-98
Location: BF-GMS
Title:
Update on neuroimaging in disorders of consciousness
Publication year: 2021
URL:
https://journals.lww.com/co-neurology/Abstract/2021/08000/Update_on_neuroimaging_in_disorders_of.4.aspx
Abstract/Results: ABSTRACT:
Purpose of review:
Neuroimaging has acquired a prominent place in the assessment of disorders of consciousness (DoC). Rapidly evolving technologies combined with state-of-the-art data analyses open new horizons to probe brain activity, but selecting appropriate imaging modalities from the plethora of available techniques can be challenging for clinicians. This update reviews selected advances in neuroimaging that demonstrate clinical relevance and translational potential in the assessment of severely brain-injured patients with DoC.
Recent findings:
Magnetic resonance imaging and high-density electroencephalography provide measurements of brain connectivity between functional networks, assessments of language function, detection of covert consciousness, and prognostic markers of recovery. Positron emission tomography can identify patients with preserved brain metabolism despite clinical unresponsiveness and can measure glucose consumption rates in targeted brain regions. Transcranial magnetic stimulation and near-infrared spectroscopy are noninvasive and practical tools with promising clinical applications.
Summary:
Each neuroimaging technique conveys advantages and pitfalls to assess consciousness. We recommend a multimodal approach in which complementary techniques provide diagnostic and prognostic information about brain function. Patients demonstrating neuroimaging evidence of covert consciousness may benefit from early adapted rehabilitation. Translating methodological advances to clinical care will require the implementation of recently published international guidelines and the integration of neuroimaging techniques into patient-centered decision-making algorithms.
Accessibility: Document does not exist in file
Language:
eng
Author:
Sanz, L.
Secondary author(s):
Thibaut, A., Edlow, B. L., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Sanz, L., Thibaut, A., Edlow, B. L., Laureys, S., & Gosseries, O. (2021). Update on neuroimaging in disorders of consciousness. Current Opinion in Neurology, 34(4), 488-496. https://doi.org/10.1097/WCO.0000000000000951
2-year Impact Factor: 5.710|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 28|2024-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Coma / Diagnosis / Disorders of consciousness / Neuroimaging / Prognosis
DocumentTranscranial pulsed-current stimulation versus transcranial direct current stimulation in patients with disorders of consciousness: A pilot, sham-controlled cross-over double-blind study2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-102
Location: BF-GMS
Title:
Transcranial pulsed-current stimulation versus transcranial direct current stimulation in patients with disorders of consciousness: A pilot, sham-controlled cross-over double-blind study
Publication year: 2022
URL:
https://www.mdpi.com/2076-3425/12/4/429/htm
Abstract/Results: Transcranial direct-current stimulation (tDCS) over the prefrontal cortex can improve signs of consciousness in patients in a minimally conscious state. Transcranial pulsed-current stimulation (tPCS) over the mastoids can modulate brain activity and connectivity in healthy controls. This study investigated the feasibility of tPCS as a therapeutic tool in patients with disorders of consciousness (DoC) and compared its neurophysiological and behavioral effects with prefrontal tDCS. This pilot study was a randomized, double-blind sham-controlled clinical trial with three sessions: bi-mastoid tPCS, prefrontal tDCS, and sham. Electroencephalography (EEG) and behavioral assessments were collected before and after each stimulation session. Post minus pre differences were compared using Kruskal–Wallis and Wilcoxon signed-rank tests. Twelve patients with DoC were included in the study (eight females, four traumatic brain injury, 50.3 ± 14 y.o., 8.8 ± 10.5 months post-injury). We did not observe any side-effects following tPCS, nor tDCS, and confirmed their feasibility and safety. We did not find a significant effect of the stimulation on EEG nor behavioral outcomes for tPCS. However, consistent with prior findings, our exploratory analyses suggest that tDCS induces behavioral improvements and an increase in theta frontal functional connectivity.
Accessibility: Document exists in file
Language:
eng
Author:
Barra, A.
Secondary author(s):
Rosenfelder, M., Mortaheb, S., Carrière, M., Martens, G., Bodien, Y., Morales-Quezada, L., Bender, A., Laureys, S., Thibaut, A., Fregni, F.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Barra, A., Rosenfelder, M., Mortaheb, S., Carrière, M., Martens, G., Bodien, Y.-G., Morales-Quezada, L., Bender, A., Laureys, S., Thibaut, A. & Fregni, F. (2022) Transcranial pulsed-current stimulation versus transcranial direct current stimulation in patients with disorders of consciousness: A pilot, sham-controlled cross-over double-blind study. Brain Sciences, 12, 4, 429. https://doi.org/10.3390/brainsci12040429
2-year Impact Factor: 3.300|2022
Times cited: 8|2024-02-15
Indexed document: Yes
Quartile: Q3
Keywords: Minimally conscious state / Coma / Non-invasive brain stimulation / Electrophysiology / Neuromodulation / Randomized controlled trial

Transcranial pulsed-current stimulation versus transcranial direct current stimulation in patients with disorders of consciousness: A pilot, sham-controlled cross-over double-blind study

Transcranial pulsed-current stimulation versus transcranial direct current stimulation in patients with disorders of consciousness: A pilot, sham-controlled cross-over double-blind study
DocumentLinks between swallowing and consciousness: A narrative review2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-103
Location: BF-GMS
Title:
Links between swallowing and consciousness: A narrative review
Publication year: 2022
URL:
https://link.springer.com/article/10.1007/s00455-022-10452-2
Abstract/Results: This literature review explores a wide range of themes addressing the links between swallowing and consciousness. Signs of consciousness are historically based on the principle of differentiating reflexive from volitional behaviors. We show that the sequencing of the components of swallowing falls on a continuum of voluntary to reflex behaviors and we describe several types of volitional and non-volitional swallowing tasks. The frequency, speed of initiation of the swallowing reflex, efficacy of the pharyngeal phase of swallowing and coordination between respiration and swallowing are influenced by the level of consciousness during non-pathological modifications of consciousness such as sleep and general anesthesia. In patients with severe brain injury, the level of consciousness is associated with several components related to swallowing, such as the possibility of extubation, risk of pneumonia, type of feeding or components directly related to swallowing such as oral or pharyngeal abnormalities. Based on our theoretical and empirical analysis, the efficacy of the oral phase and the ability to receive exclusive oral feeding seem to be the most robust signs of consciousness related to swallowing in patients with disorders of consciousness. Components of the pharyngeal phase (in terms of abilities of saliva management) and evoked cough may be influenced by consciousness, but further studies are necessary to determine if they constitute signs of consciousness as such or only cortically mediated behaviors. This review also highlights the critical lack of tools and techniques to assess and treat dysphagia in patients with disorders of consciousness.
Accessibility: Document exists in file
Language:
eng
Author:
Mélotte, E.
Secondary author(s):
Maudaux, A., Panda, R., Kaux, J.-F., Lagier, A., Herr, R., Belorgeot, M., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
6
Reference:
Mélotte, E., Maudaux, A., Panda, R., Kaux, J.F., Lagier, A., Herr, R., Belorgeot, M, Laureys, S. & Gosseries, O. (2022). Links beteween swallowing and consciousness: A narrative review. Dysphagia. https://doi.org/10.1007/s00455-022-10452-2
2-year Impact Factor: 2.600|2022
Times cited: 2|2024-02-15
Indexed document: Yes
Quartile: Q2
Keywords: Dysphagia / Swallowing / Severe brain injury / Disorders of consciousness / Consciousness / Coma

Links between swallowing and consciousness: A narrative review

Links between swallowing and consciousness: A narrative review
DocumentTowards modern post-coma care based on neuroscientific evidence2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-109
Location: BF-GMS
Title:
Towards modern post-coma care based on neuroscientific evidence
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1697260023000066?via%3Dihub
Abstract/Results: ABSTRACT:
Background:
Understanding the mechanisms underlying human consciousness is pivotal to improve the prognostication and treatment of severely brain-injured patients. Consciousness remains an elusive concept and the identification of its neural correlates is an active subject of research, however recent neuroscientific advances have allowed scientists to better characterize disorders of consciousness. These breakthroughs question the historical nomenclature and our current management of post-comatose patients.
Method:
This review examines the contribution of consciousness neurosciences to the current clinical management of severe brain injury. It investigates the major impact of consciousness disorders on healthcare systems, the scientific frameworks employed to identify their neural correlates and how evidence-based data from neuroimaging research have reshaped the landscape of post-coma care in recent years.
Results:
Our increased ability to detect behavioral and neurophysiological signatures of consciousness has led to significant changes in taxonomy and clinical practice. We advocate for a multimodal framework for the management of severely brain-injured patients based on precision medicine and evidence-based decisions, integrating epidemiology, health economics and neuroethics.
Conclusions:
Major progress in brain imaging and clinical assessment have opened the door to a new era of post-coma care based on standardized neuroscientific evidence. We highlight its implications in clinical applications and call for improved collaborations between researchers and clinicians to better translate findings to the bedside.
Accessibility: Document exists in file
Language:
eng
Author:
Sanz, L. R. D.
Secondary author(s):
Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Sanz, L. R. D., Laureys, S., & Gosseries, O. (2023). Towards modern post-coma care based on neuroscientific evidence. International Journal of Clinical and Health Psychology, 23(3), 100370. https://doi.org/10.1016/j.ijchp.2023.100370
2-year Impact Factor: 5.3|2023
Times cited: 4|2024-02-16
Indexed document: Yes
Quartile: Q1
Keywords: Disorders of consciousness / Neuroimaging / Coma / Unresponsive wakefulness syndrome / Minimally conscious state

Towards modern post-coma care based on neuroscientific evidence

Towards modern post-coma care based on neuroscientific evidence
DocumentThe current and future contribution of neuroimaging to the understanding of disorders of consciousness2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-111
Location: BF-GMS
Title:
The current and future contribution of neuroimaging to the understanding of disorders of consciousness
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S0755498222000562?via%3Dihub
Abstract/Results: ABSTRACT:
Patients with disorders of consciousness (DoC) represent a group of severely brain-injured patients with varying capacities for consciousness in terms of both wakefulness and awareness. The current state-of-the-art for assessing these patients is through standardised behavioural examinations, but inaccuracies are commonplace. Neuroimaging and electrophysiological techniques have revealed vast insights into the relationships between neural alterations, andcognitive and behavioural features of consciousness in patients with DoC. This has led to the establishment of neuroimaging paradigms for the clinical assessment of DoC patients. Here, we review selected neuroimaging findings on the DoC population, outlining key findings of the dysfunction underlying DoC and presenting the current clinical utility of neuroimaging tools. We discuss that whilst individual brain areas play instrumental roles in generating and supporting consciousness, activation of these areas alone is not sufficient for conscious experience. Instead, for consciousness to arise, we need preserved thalamo-cortical circuits, in addition to sufficient connectivity between distinctly differentiated brain networks, underlined by connectivity both within, and between such brain networks. Finally, we present recent advances and future perspectives in computational methodologies applied to DoC, supporting the notion that progress in the science of DoC will be driven by a symbiosis of these data-driven analyses, and theory-driven research. Both perspectives will work in tandem to provide mechanistic insights contextualised within theoretical frameworks which ultimately inform the practice of clinical neurology.
Accessibility: Document exists in file
Language:
eng
Author:
Alnagger, N.
Secondary author(s):
Cardone, P., Martial, C., Laureys, S., Annen, J., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Alnagger, N., Cardone, P., Martial, C., Laureys, S., Annen, J., & Gosseries, O. (2023). The current and future contribution of neuroimaging to the understanding of disorders of consciousness. Presse Medicale, 52(2), 104163. https://doi.org/10.1016/j.lpm.2022.104163
2-year Impact Factor: 3.2|2023
Times cited: 2|2024-02-16
Indexed document: Yes
Quartile: Q2
Keywords: Disorders of consciousness / Coma / Unresponsive wakefulness syndrome / Vegetative state / Minimally conscious state / Electroencephalogram (EEG) / Neuroimaging / Whole brain models

The current and future contribution of neuroimaging to the understanding of disorders of consciousness

The current and future contribution of neuroimaging to the understanding of disorders of consciousness
DocumentTranscutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-113
Location: BF-GMS
Title:
Transcutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1697260022000680
Abstract/Results: ABSTRACT:
Background:
Patients with disorders of consciousness (DoC) are a challenging population prone to misdiagnosis with limited effective treatment options. Among neuromodulation techniques, transcutaneous auricular vagal nerve stimulation (taVNS) may act through a bottom-up manner to modulate thalamo-cortical connectivity and promote patients' recovery. In this clinical trial, we aim to (1) assess the therapeutic clinical effects of taVNS in patients with DoC; (2) investigate the neural mechanisms underlying the effects of its action; (3) assess the feasibility and safety of the procedure in this challenging population; (4) define the phenotype of clinical responders; and (5) assess the long-term efficacy of taVNS in terms of functional outcomes.
Methods:
We will conduct a prospective parallel randomized controlled double-blind clinical trial investigating the effects of taVNS as a treatment in DoC patients. Forty-four patients in the early period post-injury (7 to 90 days following the injury) will randomly receive 5 days of either active bilateral vagal stimulation (45 min duration with 30s alternative episodes of active/rest periods; 3mA; 200-300µs current width, 25Hz.) or sham stimulation. Behavioural (i.e., Coma Recovery Scale-Revised, CRS-R) and neurophysiological (i.e., high-density electroencephalography, hd-EEG) measures will be collected at baseline and at the end of the 5-day treatment. Analyses will seek for changes in the CRS-R and the EEG metrics (e.g., alpha band power spectrum, functional connectivity) at the group and individual (i.e., responders) levels.
Discussion:
These results will allow us to investigate the vagal afferent network and will contribute towards a definition of the role of taVNS for the treatment of patients with DoC. We aim to identify the neural correlates of its action and pave the way to novel targeted therapeutic strategies.
Accessibility: Document exists in file
Language:
eng
Author:
Vitello, M. M.
Secondary author(s):
Briand, M. M., Ledoux, D., Annen, J., El Tahry, R., Laureys, S., Martin, D., Gosseries, O., Thibaut, A.
Document type:
Article
Number of reproductions:
3
Percentiles:
4
Reference:
Vitello, M. M., Briand, M. M., Ledoux, D., Annen, J., El Tahry, R., Laureys, S., Martin, D., Gosseries, O., & Thibaut, A. (2023). Transcutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial. International Journal of Clinical and Health Psychology, 23(2), 100360. https://doi.org/10.1016/j.ijchp.2022.100360
2-year Impact Factor: 5.3|2023
Times cited: 3|2024-02-16
Indexed document: Yes
Quartile: Q1
Keywords: Behavior / Coma / Disorders of consciousness / Electroencephalography / Minimally conscious state / Randomized clinical trial / Treatment / Unresponsive wakefulness syndrome / Vagal nerve stimulation / Vegetative state

Transcutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial

Transcutaneous vagal nerve stimulation to treat disorders of consciousness: Protocol for a double-blind randomized controlled trial