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BIAL Foundation
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DE:"Cortical response"
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Type Title Begin End
DocumentEvent-related potentials to painful stimuli are reduced during placebo analgesia2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.19
Location: Arquivo PCA - Pasta 12/2006
Title:
Event-related potentials to painful stimuli are reduced during placebo analgesia
Publication year: 2009
URL:
http://www.psychosomatic.org/AnMeeting/PastEvents/meeting2009/meetingAbstract2009.pdf
Abstract/Results: ABSTRACT:
PURPOSE:
Placebo analgesia refers to a reduction in recorded pain after administration of a capsule containing an inactive ingredient, with the information that it is a powerful painkiller. The present study investigated if placebo analgesia could be observed as reduced cortical response to heat stimuli. If placebo analgesia was associated with a reduced cortical response, this would indicate that the pain signal was reduced prior to cortical processing. A capsule containing an inactive ingredient was administrated with information that it was a powerful painkiller in the Placebo condition. Contact heat stimulation was administrated to the arm before and after the administration of the capsule. In the Natural History condition, heat stimuli were administrated without the capsule and the information.
SUBJECTS:
Forty (20 females) healthy volunteers aged 19 to 40 years.
METHODS:
Painful heat stimuli at 51 C with abrupt rise time and duration of less than 0.1sec were administrated by a thermode applied to the lower arm. Pain was recorded by a visual analogue scale, and by 32 channel electroencephalography. Event-related potentials (ERPs) to painful stimulation were computed by the Vision Analyzer software. A withinsubject design was used. All subjects were run in a Placebo condition where pain was applied before and after administration of a capsule with information that it was a painkiller, and a Natural History condition where pain was applied, but no capsule was administrated. The order of the conditions was counterbalanced.
RESULTS:
Pain unpleasantness was reduced in the Placebo condition compared to the Natural History condition (F = 7.95, p = .01). The P2 component in the ERP data was reduced in the Placebo condition compared to the Natural History condition (F = 3.39, p = .045).
CONCLUSIONS:
Placebo analgesic responding was observed as reduced pain report and as reduced cortical response to painful stimuli. This indicates that the pain signal to the brain is reduced by information that a powerful painkiller has been administrated, and that the placebo response is not due to response bias.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aslaksen, P.
Secondary author(s):
Flaten, M.
Document type:
Abstract
Number of reproductions:
1
Reference:
Aslaksen, P., & Flaten, M. (2009). Event-related potentials to painful stimuli are reduced during placebo analgesia. Psychosomatic Medicine, 71(3), A - 103.
Indexed document: Yes
Keywords: Placebo analgesia / Heat pain / Cortical response / Event-related potential (ERP)

Event-related potentials to painful stimuli are reduced during placebo analgesia

Event-related potentials to painful stimuli are reduced during placebo analgesia
DocumentPlacebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-161
Location: Arquivo PCA - Pasta 12/2006
Title:
161 - The relation of mind to body. Psychophysiological studies of the placebo effect
Duration: 2007-01 - 2010-05
Researcher(s):
Magne Arve Flaten, Oddmund Johansen, Terje Simonsen, Per M. Aslaksen, Peter Lyby, Espen Bjorkedal
Institution(s): Department of Psychology, University of Tromso (Norway)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
2 Articles
Language: eng
Author:
Flaten, M.
Secondary author(s):
Johansen, O., Simonsen, T., Aslaksen, P., Lyby, P., Bjørkedal, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Emotion

Reference code: PT/FB/BL-2006-161.21
Location: Arquivo PCA - Pasta 12/2006
Title:
Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress
Publication year: 2009
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=c1d0bb63-590d-4b97-b41b-1109ba7db4d1&cKey=89a4f0b3-17b0-4dea-8b65-4043ea5c50be&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
Abstract/Results: ABSTRACT:
Placebo analgesia refers to reduced pain report after administration of a placebo with information that it is a painkiller. This study investigated whether placebo analgesia could be observed as a reduced cortical response to pain, and whether placebo analgesia could be related to reduction in stress. Thirty-three participants (17 females) were exposed to phasic contact heat pain at 510C before and 10-30 minutes after administration of capsules containing lactose with information that the capsules contained a powerful painkiller. In a control condition the participants were exposed to the same painful stimuli, but the capsules were not administrated. The placebo and control conditions were separated by a minimum of 24 hours, and the order of the conditions was balanced. Pain report was recorded on a visual analogue scale, and cortical activity to painful stimulation was recorded by electroencephalography from 32 electrodes with linked ears reference. Only data from the Cz electrode are reported here. Phasic painful stimulation reliably generates cortical activity that can be observed as a positive component at about 200-300 ms after stimulus onset in the event related potential. The results showed significantly lower pain unpleasantness, and a significantly reduced P2 component in the placebo condition. Placebo analgesia was also related to a decrease in stress levels. The findings indicate that placebo analgesia is due to a reduced nociceptive signal to the cortex, or to reduced processing of the nociceptive signal in the cortex.
Accessibility: Document does not exist in file
Language:
eng
Author:
Lyby, P.
Secondary author(s):
Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., Aslaksen, P.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Lyby, P., Vambheim, S., Bystad, M., Solbakken, L., Sjølie, E., Thorvaldsen, J., Flaten, M., & Aslaksen, P. (2009). Placebo analgesia: Reduced event related potentials to painful stimulation related to decreased stress. Program No. 654.20/Z31. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
Indexed document: No
Keywords: Pain / Placebo analgesia / Electroencephalogram (EEG) / Cortical response