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BIAL Foundation
DE:"Corticostriatal projections"
Selection Description
Type Title Begin End
DocumentThe role of cortico-striatal projections in social hierarchies2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
BIAL Foundation Archive
Start date: 1994
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-266
Location: BF-GMS
266 - Early life stress and social hierarchies: The role of cortico-striatal circuits
Duration: 2017-01 - 2021-01
João Peça, Joana Guedes, Ana Luísa Cardoso, Mohammed Hussien, Lara Franco, Mário Carvalho
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Research Funding Agreement
Progress report
Final report
Author: Peça, J.
Secondary author(s):
Guedes, J., Cardoso, A. L., Hussien, M., Franco, L., Carvalho, M.
Number of reproductions:
Animal behavior / Social hierarchy / Stress / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2016-266.03
Location: BF-GMS
The role of cortico-striatal projections in social hierarchies
Publication year: 2017
In nature, animals in a group will engage in competition for dominance, leading to the formation of a hierarchy. A social hierarchy allows some individuals (of higher rank) to gain priority in accessing food, mate selection and resting places, reducing both the number and intensity of conflicts. Recent neuroimaging studies have begun to elucidate the neurobiological underpinnings of social hierarchy formation, by identifying and characterizing key brain regions involved in behavior repertoire. Furthermore, cortical projections between the mPFC (medial PFC) and Nucleus Accumbens (NAc) have been widely described to guide mice behaviour during non-social and, more recently, during social contexts. However, little is known about their role in social dominance behaviour.
In the course of this work, we found evidence that suggest that these two regions may encode winning information in the tube test setting. Furthermore, we were able to disrupt an already established social hierarchy by optogenetically activating corticostriatal projections, making the subordinate become dominant. Furthermore, we also found evidence that suggest that this change in rank can induce a “winner effect” in the stimulated mouse, winning trials even when not stimulated. However, this change was not long lasting, with the stimulated mouse returning to its initial rank after only a few days. Taken all into account, we provide further insight into the role of these projections and their involvement in social dominance behaviour.
Accessibility: Document exists in file
By permission
Reis, T.
Document type:
Master's thesis
Number of reproductions:
Reis, T. (2017). The role of cortico-striatal projections in social hierarchies (Unpublished master´s thesis). Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
Indexed document: No
Keywords: Social hierarchy / medial prefrontal cortex (mPFC) / nucleus accumbens (NAc) / Corticostriatal projections / Optogenetics / In Vivo Electrophysiology