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DocumentFinal report - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-057
Location: Arquivo PCA - Pasta 6/2006
Title:
057 - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Duration: 2007-02 - 2009-05
Researcher(s):
Angela Clow, Phil Evans, Frank Hucklebridge, Lisa Thorn
Institution(s): Psychophysiology and Stress Research Group, Dep. of Psychology and Human and Health Sciences, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health / Mood disorders

Reference code: PT/FB/BL-2006-057.01
Location: Arquivo PCA - Pasta 6/2006
Title:
Final report - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Publication year: 2009
URL:
http://www.bial.com/imagem/Bolsa5706_21022014.pdf
Abstract/Results: RESULTS:
This study compared the daily pattern of cortisol secretion in winter and in summer between two groups; participants with seasonal affective disorder (SAD) and age and sex-matched healthy controls. The diurnal pattern of cortisol secretion was assessed across two consecutive days in summer, and two in winter. 52 participants completed the study with an equal number in each group. In both winter and summer, participants collected multiple saliva samples across the day to capture the cortisol awakening response (CAR) and declining levels across the day. In addition, state stress and arousal, perceived stress, anxiety and depression were assessed using validated questionnaires. The results indicated that SAD and control participants had similar psychological and cortisol profiles in summer. However, in winter, SAD participants reported greater depression, stress and anxiety compared with controls. In addition, they showed lower levels of arousal (i.e. more drowsy, tired and sluggish, less alert, active, energetic and stimulated) following awakening in the morning. The control group did not show seasonal changes in the pattern of cortisol secretion. By contrast, the CAR was significantly attenuated in SAD participants during winter months but not during the summer. There was no difference in cortisol levels during the rest of the day for SAD participants in winter. This study contributes to the understanding of the physiology of SAD and provides evidence for potential underlying pathophysiological mechanisms in SAD. It further substantiates the evidence that light therapy following awakening in the morning may be beneficial for SAD sufferers by increasing cortisol to normal levels, which in turn may alleviate symptoms.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Seasonal affective disorder / Endocrinology / Cortisol / Cortisol awakening response / Seasonal differences

Final report - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)

Final report - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
DocumentSeasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-057
Location: Arquivo PCA - Pasta 6/2006
Title:
057 - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Duration: 2007-02 - 2009-05
Researcher(s):
Angela Clow, Phil Evans, Frank Hucklebridge, Lisa Thorn
Institution(s): Psychophysiology and Stress Research Group, Dep. of Psychology and Human and Health Sciences, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health / Mood disorders

Reference code: PT/FB/BL-2006-057.02
Location: Arquivo PCA - Pasta 6/2006
Title:
Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
Publication year: 2011
URL:
http://www.sciencedirect.com/science/article/pii/S0306453010002817
Abstract/Results: ABSTRACT:
This study compared the daily pattern of free salivary cortisol secretion in winter and in summer between two groups; participants with self-assessed seasonal affective disorder (SAD) and age- and sex-matched healthy controls. Fifty-two participants completed the study with an equal number in each group. The diurnal pattern of cortisol secretion was assessed across two consecutive weekdays in summer, and two in winter, with conditions being counterbalanced. On each study day participants collected multiple saliva samples in the domestic setting to capture the cortisol awakening response (CAR) and declining levels across the day. In addition, perceived stress, anxiety, depression, state stress and state arousal were assessed using validated questionnaires. There was no evidence for any seasonal changes in psychological data or cortisol pattern for the healthy control population. In summer, self-assessed SAD and control participants had similar psychological and cortisol profiles. In winter however, SAD participants reported greater depression, stress and anxiety, and lower levels of arousal. Furthermore, the CAR was significantly attenuated in SAD participants during winter months. There was no difference in cortisol levels during the rest of the day between controls and SAD participants in winter. In line with the above findings and previous research, there was an inverse relationship between the increase in cortisol following awakening and a measure of seasonality in winter. Furthermore in winter, a general dysphoria construct correlated inversely with the CAR, indicating that participants reporting greater depression, stress and anxiety and lower arousal, exhibited lower CARs. In conclusion, during the shortened photoperiod in winter, the cortisol response to awakening is attenuated in participants with self-assessed SAD in comparison to controls. These findings contribute to the understanding of the physiology of SAD.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Thorn, L.
Secondary author(s):
Evans, P., Cannon, A., Hucklebridge, F., Clow, A.
Document type:
Article
Number of reproductions:
1
Reference:
Thorn, L., Evans, P., Cannon, A., Hucklebridge, F., & Clow, A. (2011). Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder. Psychoneuroendocrinology, 36(6), 816–823. https://doi.org/10.1016/j.psyneuen.2010.11.003
2-year Impact Factor: 5.809|2011
Times cited: 39|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Saliva / Cortisol awakening response / Diurnal cortisol / Seasonal differences / Seasonality / Seasonal affective disorder

Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder

Seasonal differences in the diurnal pattern of cortisol secretion in healthy participants and those with self-assessed seasonal affective disorder
DocumentCortisol awakening response and the autotelic personality: an exploratory study2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-130
Location: Arquivo PCA - Pasta 12/2008
Title:
130 - As Experiências Óptimas na vida diária e Padrões Fisiológicos associados: para um conhecimento da Personalidade Autotélica
Duration: 2009-01 - 2011-09
Researcher(s):
Teresa Freire, Mário João Pereira Sequeira Santos, Marta Bassi, Gabriela Matias
Institution(s): Centro de Investigação em Psicologia (CIPsi), Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Articles
Posters
Language: por, eng
Author:
Freire, T.
Secondary author(s):
Santos, M. J., Bassi, M., Matias, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Personality / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2008-130.04
Location: Arquivo PCA - Pasta 12/2008
Title:
Cortisol awakening response and the autotelic personality: an exploratory study
Publication year: 2009
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Matias, G.
Secondary author(s):
Freire, T.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Matias, G., & Freire, T. (2009, September). Cortisol awakening response and the autotelic personality: an exploratory study. Poster presented at the 23rd Conference of the European Health Psychology Society, Pisa, Italy.
Indexed document: No
Keywords: Autotelic personality / Cortisol awakening response / Experience sampling method (ESM)

Novo ficheiro

Novo ficheiro

Novo ficheiro

Novo ficheiro
DocumentHypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.07
Location: Arquivo PCA - Pasta 18/2006
Title:
Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
Publication year: 2011
URL:
http://www.psyneuen-journal.com/article/PIIS030645301100268X/abstract?rss=yes
Abstract/Results: ABSTRACT:
BACKGROUND:
Abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported in patients with psychosis, but it is still unclear how these are related to the clinical symptomatology. Inconsistent findings have emerged from previous studies on the association between cortisol levels and clinical symptoms. Methodological and/or clinical factors, such as patients' diagnosis or illness phase, might partially account for these inconsistencies. The aim of this study was to investigate the association between HPA axis activity and clinical symptoms in first-episode psychosis, taking into account diagnosis and illness phase.
METHOD:
Saliva samples were collected in 55 subjects with first-episode psychosis to assess the Cortisol Awakening Response (CAR) and diurnal cortisol levels (AUC-DAY). Severity of symptoms was assessed with the Positive and Negative Syndrome Scale (PANSS). Scores for subscales and symptom dimensions were used as predictors in multivariate analyses in different diagnostic subgroups and in clinically remitted patients. In addition, a systematic review of the literature on this topic was conducted.
RESULTS:
In subjects with schizophrenia (n=36), the CAR was predicted by the severity of positive symptoms (beta=0.47, p=0.04); in subjects with depressive psychoses (n=8) the CAR was predicted by excitement (beta=0.58, p=0.005), disorganization (beta=0.39, p=0.007) and depressive symptoms (beta=0.32, p=0.005). In patients with bipolar psychoses (n=11) AUC-DAY was predicted negatively by disorganization (beta=-2.82, p=0.009) and positively by excitement (beta=2.06, p=0.009) and positive symptoms (beta=1.28, p=0.02). In the sample in clinical remission (n=9), the CAR was associated with the severity of positive symptoms (beta=1.34, p=0.009) and, negatively, with excitement (beta=-1.05, p=0.04). The systematic review (on a total of 28 papers, including n=1022 patients), found that in patients with psychosis cortisol levels have been associated with the severity of multiple symptom dimensions.
CONCLUSIONS:
HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis. Patients' diagnosis and clinical phase partially influence these associations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Belvederi Murri, M.
Secondary author(s):
Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., Mondelli, V.
Document type:
Article
Number of reproductions:
1
Reference:
Belvederi Murri, M., Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., & Mondelli, V. (2011). Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis. Psychoneuroendocrinology, 37(5), 629-644. https://doi.org/10.1016/j.psyneuen.2011.08.013
2-year Impact Factor: 5.809|2011
Times cited: 69|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis / Symptoms / Psychosis / Schizophrenia / Bipolar / Depression / Diagnosis / Remission / Neuroendocrinology
DocumentThe diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-057
Location: Arquivo PCA - Pasta 6/2006
Title:
057 - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Duration: 2007-02 - 2009-05
Researcher(s):
Angela Clow, Phil Evans, Frank Hucklebridge, Lisa Thorn
Institution(s): Psychophysiology and Stress Research Group, Dep. of Psychology and Human and Health Sciences, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health / Mood disorders

Reference code: PT/FB/BL-2006-057.03
Location: Arquivo PCA - Pasta 6/2006
Title:
The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
This study compared the daily pattern of free salivary cortisol secretion in winter and in summer between two groups; participants with seasonal affective disorder (SAD) and age- and sex-matched healthy controls. The aim was to enhance theoretical understanding of the regulation of cortisol secretion over the day and contribute to the understanding of the pathophysiology and treatment of SAD.
METHODS:
Fifty-two participants completed the study with an equal number in each group. The diurnal pattern of cortisol secretion was assessed across two consecutive days in summer, and two in winter, with conditions being counterbalanced. On each study day participants collected multiple saliva samples in the domestic setting to capture the cortisol awakening response (CAR) and declining levels across the day. In addition,
perceived stress, anxiety, depression, state stress and state arousal were assessed using validated questionnaires.
RESULTS:
In summer, SAD and control participants had similar psychological and cortisol profiles. In winter however, SAD participants reported greater depression, stress and anxiety, and lower levels of arousal (i.e. more drowsy, tired and sluggish, less alert, active, energetic and stimulated) following awakening in the morning. Furthermore, the CAR was significantly attenuated in SAD participants during winter months. There was no
difference in cortisol levels during the rest of the day between controls and SAD participants in winter. In line with the above findings and previous research there was a negative relationship between the increase in cortisol following awakening and a measure of seasonality in winter. Participants who reported greater propensity for seasonal changes in mood exhibited an attenuated CAR in winter.
CONCLUSIONS:
In winter, when light levels are low the cortisol response to awakening is attenuated in participants with seasonal affective disorder in comparison to controls. This study provides a new understanding of the physiology of clinical condition and will inform treatment.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Clow, A., Evans, P., Hucklebridge, F., & Thorn, L. (2010). The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD). In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 211). Porto: Fundação Bial.
Indexed document: No
Keywords: Seasonal affective disorder / Cortisol / Cortisol awakening response / Seasonal differences

The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)

The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
DocumentFinal report - The psychophysiology of positive psychology2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.01
Location: Arquivo PCA - Pasta 8/2010
Title:
Final report - The psychophysiology of positive psychology
Publication year: 2013
URL:
http://www.bial.com/imagem/96-10-20131212.pdf
Abstract/Results: RESULTS:
Well-being was associated with attachment style: securely attached people exhibited better well-being. However neither well-being nor attachment style were associated with the cortisol awakening response (CAR), the cortisol diurnal decline or mean levels of cortisol across the day in a population of healthy young females. These findings led us to explore age-related effects using hair measures of cortisol.
Hair cortisol (HC) provides a retrospective trait measure of cortisol secretion. Again there was no association between HC and well-being in young healthy females. The older females had higher HC than the healthy young, which is interpreted as a consequence of aging. Surprisingly we found that older females with higher HC had higher levels of well-being. This finding suggests that cortisol acts as an ‘energiser’ in healthy older females. Together these results question the validity of cortisol as a useful biomarker in the healthy young. It also provides evidence for the neurotoxicity hypothesis of cortisol secretion: well-being did not relate to cortisol secretion in early adulthood with effects emerging in late adulthood.
A subsidiary methodological finding from the study was that previously considered ‘safe’ saliva sampling delays of around 8 min between awakening and the start of sampling resulted in erroneous over-estimated CAR magnitude and earlier CAR peak timing. Five min saliva sampling in the post-awakening period suggested this was a consequence of a 10 min time lag between awakening and the start of the cortisol rise (previously considered to be linear). In contrast, non-adherence 3-12 hours post-awakening did not impact on diurnal cortisol measures. This can usefully inform future CAR studies.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Clow, A.
Secondary author(s):
Hucklebridge, F., Thorn, L., Smyth, N.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Attachment style / Well-being / Salivary cortisol secretion / Cortisol awakening response / Aging / Endocrinology

Final report - The psychophysiology of positive psychology

Final report - The psychophysiology of positive psychology
DocumentDelays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.02
Location: Arquivo PCA - Pasta 8/2010
Title:
Delays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S030645301200426X
Abstract/Results: ABSTRACT:
Linking psychosocial measures to the cortisol awakening response (CAR) demands accurate saliva sampling times. Monitoring adherence to the saliva sampling protocol requires electronic monitoring of both awakening and sampling times since self-reported times are inaccurate. Delays greater than 15min between awakening and commencement of saliva sampling reduce CAR magnitude. Less delay has been judged tolerable but remains unexplored for different magnitude measures, and for timing of the CAR peak.
Study 1: Fifty healthy females (21±4 years) were instructed to collect saliva on four days at 0, 15, 30 and 45min post-awakening (samples 1-4). Both self-reported awakening and sampling times were electronically monitored using actigraphy and track caps. Self-reported awakening was later than actigraph estimated awakening (median difference of 4min). Estimates of CAR magnitude were significantly greater on non-adherent days (delay of 5-15min) compared to adherent days (delay<5min). On non-adherent compared to adherent days cortisol on average peaked earlier, at sample 3 rather than at sample 4.
Study 2: Accurately timed cortisol values were obtained in an intensive investigation of 10 participants who collected saliva on 2 days every 5min for 30min post-awakening. Cortisol did not significantly increase until 10min post-awakening, suggesting a time lag may be typical between awakening and observation of a cortisol increase. We conclude that moderate delays between awakening and collection of saliva samples previously considered tolerable result in erroneous estimation of CAR magnitude and timing of the peak. These results are attributed to an approximate 10min time lag between awakening and the start of the cortisol rise. The absence of this latent period in calculations leads to overestimation of the CAR magnitude on moderately non-adherent sampling days. These findings, if more universally generalizable, will further theoretical understanding of the physiology of the CAR, but are methodologically challenging for researchers since self-reported awakening times are not accurate enough to override the concerns raised. However accurate electronic measurement of adherence to protocol would enable sampling delays to be taken into account in computing CAR estimates.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Clow, A., Thorn, L., Hucklebridge, F., Evans, P.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Clow, A., Thorn, L., Hucklebridge, F., & Evans, P. (2013). Delays of 5-15min between awakening and the start of saliva sampling matter in assessment of the cortisol awakening response. Psychoneuroendocrinology, 38(9), 1476-1483. https://doi.org/10.1016/j.psyneuen.2012.12.013
2-year Impact Factor: 5.591|2013
Times cited: 64|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Saliva / Cortisol awakening response / Non-adherence / Awakening / Actigraphy / Track caps / Time lag / Sampling delay
DocumentDiscrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.05
Location: Arquivo PCA - Pasta 8/2010
Title:
Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)
Publication year: 2012
URL:
http://www.psychosomatic.org/anmeeting/PastEvents/meeting2012/abstractbooklet.pdf
Abstract/Results: ABSTRACT:
The CAR is frequently studied in participants’ natural environment using self-collection of saliva samples. For measurement of the CAR accurate timing of saliva sampling is crucial; poor adherence to sampling protocol leads to misleading assessments of the CAR. Studies often rely on self-report and exclude samples rated as 10-15 minutes late. This study compared actimeter-determined awakening and electronic monitoring of sampling times with self-reported awakening and sampling times. It also explored demographic, situational or psychosocial correlates of delayed self-report of both awakening and sampling times. Fifty students (mean 21±4.4 y) collected saliva samples on 4 days at 0, 15, 30 and 45 minutes post awakening. Awakening times were determined by wrist-worn actimeters and sampling was monitored by electronic devices (Medication Event Monitoring: MEM). Participants were informed that these devices monitored their adherence to the protocol. Participants also reported their awakening and sample collection times using the usual diary report method. Actimeter-determined awakening was significantly earlier than self-reported awakening - average difference was 8.0±1.5 minutes, (F(1,25)=37.666, p<0.001, K² =.601). Sampling delay was calculated as the average delay for all 4 samples, objective sampling delay was derived from actimeter-determined awakening and MEM. Self-reported delay was derived from self-reported awakening and sampling. Figure 1 shows that objective sampling delay was significantly longer than self-reported delay, (F(1,25)=22.838,p<0.001,K²=.477). Across the 4 days the average objective delay was 10.0±3.6 minutes. Age, social-economic status, trait and state well-being and ill-being, busyness, sleep quality, waking time, and ease were not significantly correlated with either objective or self-reported delay for awakening and sampling. Results suggest that
self-reported awakening and sampling delay differs to that determined by electronic monitoring, this was largely attributable to inaccuracy in determining awakening. Also, no measured variable was related to awakening and sampling delay, suggesting that it may be related to other factors such as sleep inertia following awakening.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Thorn, L., Evans, P., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Evans, P., Hucklebridge, F., & Clow, A. (2012). Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR). Abstracts of the American Psychosomatic Society 70th Annual Meeting: “Symptoms and patient reported outcomes” (A - 58). Athens, Greece.
Indexed document: No
Keywords: Cortisol awakening response / Saliva / Actimeter-determined awakening / Self-reported awakening

Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)

Discrepancies between self-reported and objective sampling delay for the cortisol awakening response (CAR)
DocumentTrait hedonic and eudemonic Well-being and diurnal cortisol patterns2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.06
Location: Arquivo PCA - Pasta 8/2010
Title:
Trait hedonic and eudemonic Well-being and diurnal cortisol patterns
Publication year: 2013
URL:
http://www.psychosomatic.org/anmeeting/PDF/2013abstractBooklet.pdf
Abstract/Results: ABSTRACT:
The field of Positive Psychology has generated interest into the beneficial health outcomes of trait well-being. Two strands of wellbeing are documented: hedonia, which refers to pleasure and satisfaction in life and eudaimonia which refers more to meaning and fulfilment in life. Debate exists within the literature over the relative independence and importance of these two strands of well-being for health. Although well-being has been related to cortisol secretion studies have mostly been in middle-aged and older populations and have focused on hedonic, largely ignoring eudemonic, aspects of wellbeing. This study aimed to explore the independence of hedonic and eudemonic well-being and examine relationships with cortisol secretion in a young healthy female sample. Participants (n=50; mean age 21 years) completed measures of trait hedonic well-being (e.g. subjective happiness and life satisfaction), trait eudemonic well-being (e.g. psychological well-being) and ill-being (e.g. perceived stress and depression). Over four study days’ participants collected saliva samples at 0, 15, 30 and 45 min postawakening to measure the cortisol awakening response, and again at 3 and 12 hr post-awakening to measure the diurnal decline. Objective measures of awakening and adherence to the saliva sampling protocol were taken to encourage and monitor adherence to the protocol. Factor analyses of a larger population from which this sample was taken (n=240; mean age 21 years) showed that there were two components of well-being which were interpreted as hedonic well-being and eudemonic ill-being. Non-adherent saliva samples were excluded; well-being or ill-being was not related to the cortisol awakening response or the diurnal decline. We conclude that in a study carefully controlled for adherence to protocol in healthy young females neither hedonic well-being nor eudemonic ill-being was related to patterns of cortisol secretion. Relationships between trait well-being and cortisol secretion may emerge in later life as a consequence of neurotoxicity across the lifespan.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Evans, P., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Smyth, N., Evans, P., Thorn, L., Hucklebridge, F., & Clow, A. (2013). Trait hedonic and eudemonic Well-being and diurnal cortisol patterns. Abstracts of the American Psychosomatic Society 71st Annual Meeting: “Impact and Innovation” (A - 88). Miami, FL.
Indexed document: No
Keywords: Well-being / Hedonia / Eudaimonia / Cortisol awakening response / Cortisol

Trait hedonic and eudemonic Well-being and diurnal cortisol patterns

Trait hedonic and eudemonic Well-being and diurnal cortisol patterns
DocumentState Well-being or Ill-being does not predict cortisol patterns in a young healthy sample2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.07
Location: Arquivo PCA - Pasta 8/2010
Title:
State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample
Publication year: 2013
URL:
http://www.psychosomatic.org/anmeeting/PDF/2013abstractBooklet.pdf
Abstract/Results: ABSTRACT:
Many studies have explored the relationship between cortisol secretion and state well-being or ill-being; however, results are inconsistent. This may be explained to some extent by participant non-adherence to the saliva sampling protocol particularly for studies investigating the cortisol awakening response (CAR) as delays (> 5 min) in collecting the first saliva sample lead to misleading measurements of the CAR. Another factor may be the age group of the participants. Consistent associations are found in middle-aged and older populations, whereas relatively weak relationships tend to be found in younger individuals. This study aimed to objectively monitor adherence to the saliva sampling protocol and investigate the relationship between well-being and the CAR and cortisol over the day in a young healthy female sample.
50 healthy female students collected saliva samples on four days at 0, 15, 30, and 45 minutes, 3 and 12 hours post-awakening. State wellbeing and ill-being was assessed by mood ratings throughout each sampling day. Participants rated the extent to which they felt pleased, happy, goal-directed, stressed, out of control, frustrated, and down using electronic devices. Participants were made aware that awakening and sampling times were objectively monitored.
Participants were relatively adherent to the saliva sampling protocol, delays of < 5 min (mean: 1±1 min) was achieved on the majority of sampling days (N=80). Days with delays of over 5 minutes (mean: 13±12 min) were excluded (N=73) from analyses involving the CAR. Mixed modelling showed there was no relationship between well-being or ill-being and the CAR, the diurnal decline and cortisol over the day.
The lack of an association between well-being or ill-being and cortisol on days where saliva samples were collected accurately supports the neurotoxicity hypothesis of HPA axis dysregulation. In young healthy individuals the HPA-axis is resilient and thus associations between well-being or ill-being and cortisol will be absent or weak. We would hypothesise that these associations would be stronger in participants with vulnerability as a result of early life stress (not measured in this study) and in older adults.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Evans, P., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Smyth, N., Evans, P., Thorn, L., Hucklebridge, F., & Clow, A. (2013). State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample. Abstracts of the American Psychosomatic Society 71st Annual Meeting: “Impact and Innovation” (A - 122). Miami, FL.
Indexed document: No
Keywords: Cortisol / Well-being / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis

State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample

State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample
DocumentThe cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.08
Location: Arquivo PCA - Pasta 8/2010
Title:
The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed
Publication year: 2013
URL:
http://www.psychosomatic.org/anmeeting/PDF/2013abstractBooklet.pdf
Abstract/Results: ABSTRACT:
Research linking the Cortisol Awakening Response (CAR) to psychosocial and health domains needs CAR measures to be based on
accurately timed saliva samples. How accurate? Typically a CAR is big and brief, and even quite modest delays between awakening and initial saliva sample might theoretically be expected to compromise accuracy; but delays up to 15 min reportedly do not do so. This paradox is explored and predictions examined in new data for effects of moderate delays (5-15 min) on several different CAR magnitude measures, and on timing of the CAR peak. Both self-reported awakening and sampling times were objectively checked by actigraphy and track caps. 50 healthy females (21±4 years) were told to collect saliva on 4 days at 0, 15, 30 and 45 min post-awakening. Self-reports were significantly later by 8 (±11) min than objective estimates of awakening. Selfreported sampling time intervals were accurate (< 2 min mean error). Minimally delayed data (< 5 min) were compared with moderately delayed (5-15 min). CAR magnitude was significantly greater for delayed data and peaked earlier. Plots of cortisol values in real time suggested effects were due to a time lag between awakening and start of cortisol rise; cortisol rise was not linear. Further evidence for this was sought and found in an intensive investigation of 10 participants who collected saliva every 5 min from 0-30 min post-awakening. We conclude that moderate delays in saliva sampling previously thought tolerable lead to errors in estimating CAR magnitude and peak-timing, due to an approximate 10 min lag between awakening and cortisol rise. Ignoring this lag in calculations leads to overestimation of CAR magnitude, even if sampling is only moderately delayed. These findings, if generalizable, clarify how the physiology of the CAR unfolds, but are methodologically challenging for researchers since self-reported awakening times are not accurate enough to override concerns raised. Objective measurement of sampling time would, however, permit known delays to be taken into account when computing CAR estimates.
Accessibility: Document does not exist in file
Language:
eng
Author:
Evans, P.
Secondary author(s):
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Evans, P., Smyth, N., Thorn, L., Hucklebridge, F., & Clow, A. (2013). The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed. Abstracts of the American Psychosomatic Society 71st Annual Meeting: “Impact and Innovation” (A - 48). Miami, FL.
Indexed document: No
Keywords: Cortisol awakening response / Saliva / Sampling delay / Actigraphy / Track caps / Time lag / Sampling delay

The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed

The cortisol awakening response: why tolerable errors in timing may not be so tolerable and why linearity of cortisol rise should not be assumed
DocumentThe cortisol awakening response in context2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-057
Location: Arquivo PCA - Pasta 6/2006
Title:
057 - The diurnal pattern of cortisol secretion in relation to season in healthy participants and those with seasonal affective disorder (SAD)
Duration: 2007-02 - 2009-05
Researcher(s):
Angela Clow, Phil Evans, Frank Hucklebridge, Lisa Thorn
Institution(s): Psychophysiology and Stress Research Group, Dep. of Psychology and Human and Health Sciences, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Clow, A.
Secondary author(s):
Evans, P., Hucklebridge, F., Thorn, L.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychoneuroimmunology / Endocrinology / Biopsychological problems / Mental health / Mood disorders

Reference code: PT/FB/BL-2006-057.04
Location: Arquivo PCA - Pasta 6/2006
Title:
The cortisol awakening response in context
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20970005
Abstract/Results: ABSTRACT:
The cortisol awakening response (CAR) is a crucial point of reference within the healthy cortisol circadian rhythm, with cortisol secretion typically peaking between 30 and 45 min post awakening. This chapter reviews the history of investigation into the CAR and highlights evidence that its regulation is relatively distinct from cortisol secretion across the rest of the day. It is initiated by awakening, under the influence of the hypothalamic suprachiasmatic nucleus, and "fine tuned" by a direct neural input to the adrenal cortex by the sympathetic nervous system. This chapter also examples the CAR in relation to other awakening-induced processes, such as restoration of consciousness, attainment of full alertness, changes in other hormones, changes in the balance of the immune system, and mobilization of the motor system, and speculates that there is a role for the CAR in these processes.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clow, A.
Secondary author(s):
Hucklebridge, F., Thorn, L.
Document type:
Article
Number of reproductions:
1
Reference:
Clow, A., Hucklebridge, F., Thorn, L. (2010). The cortisol awakening response in context. International Review of Neurobiology, 93, 153-175. https://doi.org/10.1016/S0074-7742(10)93007-9
2-year Impact Factor: 2.183|2010
Times cited: 122|2025-02-07
Indexed document: Yes
Quartile: Q3
Keywords: Cortisol awakening response / Immune system
DocumentCortisol awakening response and the autotelic personality: an exploratory study2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-130
Location: Arquivo PCA - Pasta 12/2008
Title:
130 - As Experiências Óptimas na vida diária e Padrões Fisiológicos associados: para um conhecimento da Personalidade Autotélica
Duration: 2009-01 - 2011-09
Researcher(s):
Teresa Freire, Mário João Pereira Sequeira Santos, Marta Bassi, Gabriela Matias
Institution(s): Centro de Investigação em Psicologia (CIPsi), Universidade do Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Articles
Posters
Language: por, eng
Author:
Freire, T.
Secondary author(s):
Santos, M. J., Bassi, M., Matias, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Personality / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2008-130.11
Location: Arquivo PCA - Pasta 12/2008
Title:
Cortisol awakening response and the autotelic personality: an exploratory study
Publication year: 2009
URL:
http://www.tandfonline.com/doi/abs/10.1080/08870440903126421#.UuZPMdGp0q4
Accessibility: Document does not exist in file
Language:
eng
Author:
Matias, G.
Secondary author(s):
Freire, T.
Document type:
Abstract
Number of reproductions:
1
Reference:
Matias, G., & Freire, T. (2009). Cortisol awakening response and the autotelic personality: an exploratory study. Psychology & Health, 24(Suppl. 1), 264.
Indexed document: Yes
Keywords: Autotelic personality / Cortisol awakening response

Cortisol awakening response and the autotelic personality: an exploratory study

Cortisol awakening response and the autotelic personality: an exploratory study
DocumentAssessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-072
Location: Arquivo PCA - Pasta 8/2012
Title:
072 - The psychophysiology of human attachment and stress
Duration: 2013-10 - 2015-09
Researcher(s):
Angela Clow, Lisa Thorn, Andrea Oskis, Nina Smyth
Institution(s): Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
2 Articles
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Oskis, A., Smyth, N.
Number of reproductions:
1
Keywords:
Psychophysiology / Affective and social behavior / Attachment / Psychoneuroimmunology / Endocrinology / Stress and health

Reference code: PT/FB/BL-2012-072.06
Location: Arquivo PCA - Pasta 8/2012
Title:
Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy
Publication year: 2016
URL:
http://www.psyneuen-journal.com/article/S0306-4530(16)30489-9/fulltext
Abstract/Results: ABSTRACT:
The cortisol awakening response (CAR) is typically measured in the domestic setting. Moderate sample timing inaccuracy has been shown to result in erroneous CAR estimates and such inaccuracy has been shown partially to explain inconsistency in the CAR literature. The need for more reliable measurement of the CAR has recently been highlighted in expert consensus guidelines where it was pointed out that less than 6% of published studies provided electronic-monitoring of saliva sampling time in the post-awakening period. Analyses of a merged data-set of published studies from our laboratory are presented. To qualify for selection, both time of awakening and collection of the first sample must have been verified by electronic-monitoring and sampling commenced within 15min of awakening. Participants (n=128) were young (median age of 20 years) and healthy. Cortisol values were determined in the 45min post-awakening period on 215 sampling days. On 127days, delay between verified awakening and collection of the first sample was less than 3min ('no delay' group); on 45days there was a delay of 4-6min ('short delay' group); on 43days the delay was 7-15min ('moderate delay' group). Cortisol values for verified sampling times accurately mapped on to the typical post-awakening cortisol growth curve, regardless of whether sampling deviated from desired protocol timings. This provides support for incorporating rather than excluding delayed data (up to 15min) in CAR analyses. For this population the fitted cortisol growth curve equation predicted a mean cortisol awakening level of 6nmols/l (±1 for 95% CI) and a mean CAR rise of 6nmols/l (±2 for 95% CI). We also modelled the relationship between real delay and CAR magnitude, when the CAR is calculated erroneously by incorrectly assuming adherence to protocol time. Findings supported a curvilinear hypothesis in relation to effects of sample delay on the CAR. Short delays of 4-6min between awakening and commencement of saliva sampling resulted in an overestimated CAR. Moderate delays of 7-15min were associated with an underestimated CAR. Findings emphasize the need to employ electronic-monitoring of sampling accuracy when measuring the CAR in the domestic setting.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2010-096.11
Author: Smyth, N.
Secondary author(s):
Thorn, L., Hucklebridge, F., Clow, A., Evans, P.
Document type:
Article-d
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A., & Evans, P. (2016). Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy. Psychoneuroendocrinology, 74, 380-386. https://doi.org/10.1016/j.psyneuen.2016.09.026
2-year Impact Factor: 4.788|2016
Times cited: 23|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: CAR / Cortisol / Cortisol awakening response / Growth cortisol curve / Saliva / Sample timing inaccuracy
DocumentAssessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.11
Location: Arquivo PCA - Pasta 8/2010
Title:
Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy
Publication year: 2016
URL:
http://www.psyneuen-journal.com/article/S0306-4530(16)30489-9/fulltext
Abstract/Results: ABSTRACT:
The cortisol awakening response (CAR) is typically measured in the domestic setting. Moderate sample timing inaccuracy has been shown to result in erroneous CAR estimates and such inaccuracy has been shown partially to explain inconsistency in the CAR literature. The need for more reliable measurement of the CAR has recently been highlighted in expert consensus guidelines where it was pointed out that less than 6% of published studies provided electronic-monitoring of saliva sampling time in the post-awakening period. Analyses of a merged data-set of published studies from our laboratory are presented. To qualify for selection, both time of awakening and collection of the first sample must have been verified by electronic-monitoring and sampling commenced within 15min of awakening. Participants (n=128) were young (median age of 20 years) and healthy. Cortisol values were determined in the 45min post-awakening period on 215 sampling days. On 127days, delay between verified awakening and collection of the first sample was less than 3min ('no delay' group); on 45days there was a delay of 4-6min ('short delay' group); on 43days the delay was 7-15min ('moderate delay' group). Cortisol values for verified sampling times accurately mapped on to the typical post-awakening cortisol growth curve, regardless of whether sampling deviated from desired protocol timings. This provides support for incorporating rather than excluding delayed data (up to 15min) in CAR analyses. For this population the fitted cortisol growth curve equation predicted a mean cortisol awakening level of 6nmols/l (±1 for 95% CI) and a mean CAR rise of 6nmols/l (±2 for 95% CI). We also modelled the relationship between real delay and CAR magnitude, when the CAR is calculated erroneously by incorrectly assuming adherence to protocol time. Findings supported a curvilinear hypothesis in relation to effects of sample delay on the CAR. Short delays of 4-6min between awakening and commencement of saliva sampling resulted in an overestimated CAR. Moderate delays of 7-15min were associated with an underestimated CAR. Findings emphasize the need to employ electronic-monitoring of sampling accuracy when measuring the CAR in the domestic setting.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2012-072.06
Author: Smyth, N.
Secondary author(s):
Thorn, L., Hucklebridge, F., Clow, A., Evans, P.
Document type:
Article
Number of reproductions:
1
Reference:
Smyth, N., Thorn, L., Hucklebridge, F., Clow, A., & Evans, P. (2016). Assessment of the cortisol awakening response: Real-time analysis and curvilinear effects of sample timing inaccuracy. Psychoneuroendocrinology, 74, 380-386. https://doi.org/10.1016/j.psyneuen.2016.09.026
2-year Impact Factor: 4.788|2016
Times cited: 23|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: CAR / Cortisol / Cortisol awakening response / Growth cortisol curve / Saliva / Sample timing inaccuracy