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DocumentMore severe insomnia complaints in people with stronger long-range temporal correlations in wake resting-state EEG2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-252
Location: SEC PCA 252/12
Title:
252 - Sleep state misperception mispercieved
Duration: 2014-06 - 2017-01
Researcher(s):
Eus J. W. Van Someren, J. Ramautar
Institution(s): Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress reports
Final reports
2 Articles
Language: eng
Author:
Van Someren, E.
Secondary author(s):
Ramautar, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Cognitive processes / Memory / Consciousness

Reference code: PT/FB/BL-2012-252.04
Title: More severe insomnia complaints in people with stronger long-range temporal correlations in wake resting-state EEG
Publication year: 2016
URL:
Visitante: / http://journal.frontiersin.org/article/10.3389/fphys.2016.00576/full
Abstract/Results: ABSTRACT:
The complaints of people suffering from Insomnia Disorder (ID) concern both sleep and daytime functioning. However, little is known about wake brain temporal dynamics in people with ID. We therefore assessed possible alterations in Long-Range Temporal Correlations (LRTC) in the amplitude fluctuations of band-filtered oscillations in electroencephalography (EEG) recordings. We investigated whether LRTC differ between cases with ID and matched controls. Within both groups, we moreover investigated whether individual differences in subjective insomnia complaints are associated with LRTC. Resting-state high-density EEG (256-channel) was recorded in 52 participants with ID and 43 age- and sex-matched controls, during Eyes Open (EO) and Eyes Closed (EC). Detrended fluctuation analysis was applied to the amplitude envelope of band-filtered EEG oscillations (theta, alpha, sigma, beta-1, beta-2) to obtain the Hurst exponents (H), as measures of LRTC. Participants rated their subjective insomnia complaints using the Insomnia Severity Index (ISI). Through general linear models, we evaluated whether H, aggregated across electrodes and frequencies, differed between cases and controls, or showed within-group associations with individual differences in ISI. Additionally, we characterized the spatio-spectral profiles of group differences and associations using non-parametric statistics. H did not differ between cases with ID and controls in any of the frequency bands, neither during EO nor EC. During EO, however, within-group associations between H and ISI indicated that individuals who experienced worse sleep quality had stronger LRTC. Spatio-spectral profiles indicated that the associations held most prominently for the amplitude fluctuations of parietal theta oscillations within the ID group, and of centro-frontal beta-1 oscillations in controls. While people suffering from insomnia experience substantially worse sleep quality than controls, their brain dynamics express similar strength of LRTC. In each group, however, individuals experiencing worse sleep quality tend to have stronger LRTC during eyes open wakefulness, in a spatio-spectral range specific for each group. Taken together, the findings indicate that subjective insomnia complaints involve distinct dynamical processes in people with ID and controls. The findings are in agreement with recent reports on decreasing LRTC with sleep depth, and with the hypothesis that sleep balances brain excitability.
Accessibility: Document exists in file
Language:
eng
Author:
Colombo, M.
Secondary author(s):
Wei, Y., Ramautar, J., Linkenkaer-Hansen, K., Tagliazucchi, E., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Percentiles:
74.57|1.21
Reference:
Colombo, M., Wei, Y., Ramautar, J., Linkenkaer-Hansen, K., Tagliazucchi, E., & Van Someren, E. (2016). More severe insomnia complaints in people with stronger long-range temporal correlations in wake resting-state EEG. Frontiers in Physiology, 7:576. https://doi.org/10.3389/fphys.2016.00576
Impact Factor: 4.134|2016
Times cited: 31|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Resting-state / Insomnia / Sleep / HD-EEG / Long-range temporal correlations / Criticality / Detrended fluctuation analysis / Excitation-inhibition balance

More severe insomnia complaints in people with stronger long-range temporal correlations in wake resting-state EEG

More severe insomnia complaints in people with stronger long-range temporal correlations in wake resting-state EEG
DocumentPsychedelics and disorders of consciousness: The current landscape and the path forward2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-141
Location: BF-GMS
Title:
Psychedelics and disorders of consciousness: The current landscape and the path forward
Publication year: 2024
URL:
Visitante: / https://doi.org/10.1093/nc/niae025
Abstract/Results: ABSTRACT:
Modern medicine has been shaken by the surge of psychedelic science that proposes a new approach to mitigate mental disorders, such as depression and post-traumatic stress disorder. Clinical trials to investigate whether psychedelic substances can treat psychiatric conditions are now underway, yet less discussion gravitates around their use in neurological disorders due to brain injury. One suggested implementation of brain-complexity enhancing psychedelics is to treat people with post-comatose disorders of consciousness (DoC). In this article, we discuss the rationale of this endeavour, examining possible outcomes of such experiments by postulating the existence of an optimal level of complexity. We consider the possible counterintuitive effects of both psychedelics and DoC on the functional connectivity of the default mode network and its possible impact on selfhood. We also elaborate on the role of computational modelling in providing complementary information to experimental studies, both contributing to our understanding of the treatment mechanisms and providing a path towards personalized medicine. Finally, we update the discourse surrounding the ethical considerations, encompassing clinical and scientific values.
Accessibility: Document exists in file
Language:
eng
Author:
Cardone, P.
Secondary author(s):
Alnagger, N., Annen, J., Bicego, A., Gosseries, O., Martial, C.
Document type:
Article
Number of reproductions:
3
Percentiles:
89.88|2.36
Reference:
Cardone, P., Alnagger, N., Annen, J., Bicego, A., Gosseries, O., & Martial, C. (2024). Psychedelics and disorders of consciousness: The current landscape and the path forward. Neuroscience of Consciousness, 2024(1), niae025. https://doi.org/10.1093/nc/niae025
Impact Factor: 4.3|2024
Times cited: 10|2026-02-16
Indexed document: Yes
Quartile: Q1
Keywords: Brain complexity / Whole-brain model (WBM) / Disorders of consciousness / Treatment / Psychedelics / Criticality

Psychedelics and disorders of consciousness: The current landscape and the path forward

Psychedelics and disorders of consciousness: The current landscape and the path forward
DocumentPharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-261
Location: BF-GMS
Title:
261 - Phenomenological experience and neurophysiological correlates of shamanic trance in healthy individuals
Duration: 2019-07 - 2021-11
Researcher(s):
Olivia Gosseries
Institution(s): GIGA research center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Gosseries, O.
Number of reproductions:
3
Keywords:
Trance / Phenomenology / Electrophysiology / Consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-261.15
Location: BF-GMS
Title:
Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
Publication year: 2025
URL:
Visitante: / https://doi.org/10.1080/14737175.2025.2500757
Abstract/Results: ABSTRACT:
Introduction: Disorders of consciousness (DoC) are characterized by impaired arousal and/or awareness, ranging from coma to unresponsive wakefulness syndrome, minimally conscious state, and cognitive motor dissociation. Pharmacological treatment options remain limited, complicated by the heterogeneity of etiologies, such as traumatic brain injury, stroke, and infections. The lack of rigorous clinical trials has led to off-label use of treatments, often without clear mechanistic understanding, posing challenges for effective patient care.
Areas covered: In this perspective, the authors report on key studies concerning the effectiveness of pharmacological interventions, including dopaminergic and GABAergic agents, antidepressants, statins, and anticonvulsants, in promoting recovery of consciousness in DoC.
Expert opinion: Robust longitudinal clinical trials are needed, with priority given to early subacute phase intervention. Outcomes should be better defined, considering immediate responses to medication while also increasing the emphasis on long-term quality of life. Unified functional and mechanistic frameworks are needed to guide research and foster collaboration. Furthermore, a shift toward personalized medicine would benefit this heterogeneous population. Moving forward, assessing the efficacy of more unconventional or 'paradoxical' pharmacological options in treatment plans will be essential. The authors also expect an increased use of AI tools to identify factors that best predict treatment responses.
Accessibility: Document exists in file
Language:
eng
Author:
Girard Pepin, R.
Secondary author(s):
Seyfzadeh, F., Williamson, D., Gosseries, O., Duclos, C.
Document type:
Article
Number of reproductions:
3
Percentiles:
77.29|1.45
Reference:
Girard Pepin, R., Seyfzadeh, F., Williamson, D., Gosseries, O., & Duclos, C. (2025). Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues. Expert Review of Neurotherapeutics, 25(6), 613–633. https://doi.org/10.1080/14737175.2025.2500757
Impact Factor: 4.3|2025
Times cited: 7|2026-07-22
Indexed document: Yes
Quartile: Q1
Keywords: Pharmacotherapy / Coma / Criticality / Disorders of consciousness / Mesocircuit / Minimally conscious state / Personalized medicine / Unresponsive wakefulness syndrome

Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues

Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
DoccumentPharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-344
Location: BF-GMS
Title:
344 - Evaluation of psychological traits, pain perception and muscular strength in trance experts
Duration: 2022-01
Researcher(s):
Olivia Gosseries, Paul Hollanders, Yannick Lafon
Institution(s): GIGA Research Center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Language: eng
Notes:
Ongoing project
Author: Gosseries, O.
Secondary author(s):
Hollanders, P., Lafon, Y.
Number of reproductions:
3
Keywords:
Trance / Personality traits / Pain perception / Muscular strenght / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-344.06
Location: BF-GMS
Title:
Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
Publication year: 2025
URL:
Visitante: / https://doi.org/10.1080/14737175.2025.2500757
Abstract/Results: ABSTRACT:
Introduction: Disorders of consciousness (DoC) are characterized by impaired arousal and/or awareness, ranging from coma to unresponsive wakefulness syndrome, minimally conscious state, and cognitive motor dissociation. Pharmacological treatment options remain limited, complicated by the heterogeneity of etiologies, such as traumatic brain injury, stroke, and infections. The lack of rigorous clinical trials has led to off-label use of treatments, often without clear mechanistic understanding, posing challenges for effective patient care.
Areas covered: In this perspective, the authors report on key studies concerning the effectiveness of pharmacological interventions, including dopaminergic and GABAergic agents, antidepressants, statins, and anticonvulsants, in promoting recovery of consciousness in DoC.
Expert opinion: Robust longitudinal clinical trials are needed, with priority given to early subacute phase intervention. Outcomes should be better defined, considering immediate responses to medication while also increasing the emphasis on long-term quality of life. Unified functional and mechanistic frameworks are needed to guide research and foster collaboration. Furthermore, a shift toward personalized medicine would benefit this heterogeneous population. Moving forward, assessing the efficacy of more unconventional or 'paradoxical' pharmacological options in treatment plans will be essential. The authors also expect an increased use of AI tools to identify factors that best predict treatment responses.
Accessibility: Document does not exist in file
Language:
eng
Author:
Girard Pepin, R.
Secondary author(s):
Seyfzadeh, F., Williamson, D., Gosseries, O., Duclos, C.
Document type:
Article
Number of reproductions:
3
Percentiles:
77.29|1.45
Reference:
Girard Pepin, R., Seyfzadeh, F., Williamson, D., Gosseries, O., & Duclos, C. (2025). Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues. Expert Review of Neurotherapeutics, 25(6), 613–633. https://doi.org/10.1080/14737175.2025.2500757
Impact Factor: 4.3|2025
Times cited: 7|2026-07-22
Indexed document: Yes
Quartile: Q1
Keywords: Pharmacotherapy / Coma / Criticality / Disorders of consciousness / Mesocircuit / Minimally conscious state / Personalized medicine / Unresponsive wakefulness syndrome
DocumentA mean-field approach to criticality in spiking neural networks for reservoir computing2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-080
Location: BF-GMS
Title:
080 - Mindfulness meditation state and trait through the eyes of brain computational modelling
Duration: 2021-10 - 2025-10
Researcher(s):
Laura Marzetti
Institution(s): Department of Neurosciences, Imaging and Clinical Sciences, Università degli Studi "G. d'Annunzio" Chieti - Pescara (Italy)
Abstract/Results: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Marzetti, L.
Number of reproductions:
3
Keywords:
Meditation / Brain states / Computational modelling / Neuroimaging / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-080.06
Location: BF-GMS
Title:
A mean-field approach to criticality in spiking neural networks for reservoir computing
Publication year: 2025
URL:
Visitante: / https://doi.org/10.1038/s41598-025-18004-y
Abstract/Results: ABSTRACT:
Spiking Neural Networks (SNNs) exhibit their optimal information-processing capability at the edge of chaos, but tuning them to this critical regime in reservoir-computing architectures usually relies on costly trial-and-error or plasticity-driven adaptation. This work presents an analytical framework for configuring in the critical regime a SNN-based reservoir with a highly general topology. Specifically, we derive and solve a mean-field equation that governs the evolution of the average membrane potential in leaky integrate-and-fire neurons, and provide an approximation for the critical point. This framework reduces the need for an extensive online fine-tuning, offering a streamlined path to near-optimal network performance from the outset. Through extensive numerical experiments, we validate the theoretical predictions by analyzing the network’s spiking dynamics and quantifying its computational capacity using the information-based Lempel-Ziv-Welch complexity near criticality. Finally, we explore self-organized quasi-criticality by implementing a local homeostatic learning rule for synaptic weights, demonstrating that the network’s dynamics remain close to the theoretical critical point. Beyond AI, our approach and findings also have significant implications for computational neuroscience, providing a principled framework for quantitatively understanding how (neuro)biological networks exploit criticality for efficient information processing. The paper is accompanied by Python code, enabling the reproducibility of the findings.
Accessibility: Document exists in file
Language:
eng
Author:
Freddi, R.
Secondary author(s):
Cicala, F., Marzetti, L., Basti, A.
Document type:
Article
Number of reproductions:
3
Percentiles:
0.00|0.00
Reference:
Freddi, R., Cicala, F., Marzetti, L., & Basti, A. (2025). A mean-field approach to criticality in spiking neural networks for reservoir computing. Scientific Reports, 15(1), 34709. https://doi.org/10.1038/s41598-025-18004-y
Impact Factor: 4.9|2025
Times cited: 2|2026-07-22
Indexed document: Yes
Quartile: Q1
Keywords: Spiking neural network / Reservoir computing / Criticality / Complexity

A mean-field approach to criticality in spiking neural networks for reservoir computing

A mean-field approach to criticality in spiking neural networks for reservoir computing
DocumentA virtual clinical trial of psychedelics to treat patients with disorders of consciousness2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-131
Location: BF-GMS
Title:
A virtual clinical trial of psychedelics to treat patients with disorders of consciousness
Publication year: 2025
URL:
Visitante: / https://doi.org/10.1002/advs.202511780
Abstract/Results: ABSTRACT:
Disorders of consciousness (DoC), including unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS), have limited treatment options and are characterized by low complexity of brain activity. Recent research suggests that psychedelic drugs, which enhance the complexity of brain activity, could offer promising therapies. Here, individualized whole-brain computational models are developed for patients with DoC, optimized with empirical functional magnetic resonance imaging data and diffusion-weighted imaging data, upon which the administration of lysergic acid diethylamide (LSD) and psilocybin is simulated. An in silico perturbation protocol is applied to assess brain dynamics, first distinguishing between different states of consciousness, including DoC, anesthesia, and the psychedelic state. Then, brain dynamics are assessed before and after a simulation of psychedelic drugs on patients with DoC. Findings indicated that the simulation of LSD and psilocybin shifted the brain activity of patients with DoC closer to criticality (the point at a phase transition between order and chaos), with a greater effect in patients in the MCS. In patients with UWS, the treatment response correlated with structural connectivity, while in patients in the MCS, it aligned with baseline functional connectivity. These results offer a computational foundation for using psychedelics in DoC treatment and highlight the potential future role of computational modeling in drug discovery and personalized medicine.
Accessibility: Document exists in file
Language:
eng
Author:
Alnagger, N. L. N.
Secondary author(s):
Cardone, P., Martial, C., Perl, Y. S., Mindlin, I., Sitt, J. D., Roseman, L., Carhart-Harris, R., Nutt, D., Mallaroni, P., Mason, N., Ramaekers, J. G., Bonhomme, V., Laureys, S., Deco, G., Gosseries, O., Núñez, P., Annen, J.
Document type:
Article
Number of reproductions:
3
Percentiles:
0.00|0.00
Reference:
Alnagger, N. L. N., Cardone, P., Martial, C., Perl, Y. S., Mindlin, I., Sitt, J. D., Roseman, L., Carhart-Harris, R., Nutt, D., Mallaroni, P., Mason, N., Ramaekers, J. G., Bonhomme, V., Laureys, S., Deco, G., Gosseries, O., Núñez, P., & Annen, J. (2026). A virtual clinical trial of psychedelics to treat patients with disorders of consciousness. Advanced Science, 13(11), e11780. https://doi.org/10.1002/advs.202511780
Impact Factor: 14.1|2025
Impact factor notes: Impact factor not available yet for 2026
Times cited: 1|2026-07-23
Indexed document: Yes
Quartile: Q1
Keywords: Criticality / Diffusion-weighted imaging (DWI) / Disorders of consciousness / Functional magnetic resonance imaging (fMRI) / Psychedelics / Whole-brain modeling

A virtual clinical trial of psychedelics to treat patients with disorders of consciousness

A virtual clinical trial of psychedelics to treat patients with disorders of consciousness