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DocumentAdult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-217
Location: Arquivo PCA - Pasta 27/2012
Title:
217 - Temporal modulation of the subventricular zone neural stem cell niche by choroid plexus-cerebrospinal fluid derived factors
Duration: 2013-08 - 2019-01
Researcher(s):
João Carlos Cruz de Sousa, Fernanda Marques, Joana Palha, Ana Luísa Falcão, Ashley Novais
Institution(s): ICVS/3B's - Laboratório Associado (ICVS/3B's), Universidade do Minho (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
6 Articles
1 Master thesis
Language: eng
Author:
Sousa, J.
Secondary author(s):
Marques, F., Palha, P., Falcão, A., Novais, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function

Reference code: PT/FB/BL-2012-217.11
Location: Arquivo PCA - Pasta 27/2012
Title:
Adult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin
Publication year: 2018
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6275434/
Abstract/Results: ABSTRACT:
Neudesin (Neuron-derived neurotrophic factor, NENF), a membrane-associated progesterone receptor family (MAPR) member, is a neuron secreted protein with neurotrophic properties during embryonic stages. However, its role in the adult brain is still poorly addressed. In this study we have used neudesin-null (Nenf-/-) mice and performed a characterization of the proliferation state of the adult neurogenic niches, the adult subventricular zone (SVZ) and the hippocampus subgranular zone (SGZ). Nenf-/- males did not presented any deficits in proliferation in the SVZ neither in vivo nor in vitro. On the other hand a decrease in cell proliferation in the SGZ was observed, as well as a decrease in the number of newborn neurons in the dentate gyrus (DG) that was accompanied by impaired context discrimination in a contextual fear conditioning (CFC) task. Since NENF neurotrophic action is suggested to occur via the formation of a progesterone stability complex for the activation of non-genomic cascade, we further evaluated progesterone metabolism in the absence of NENF. Interestingly, expression of progesterone catabolic rate-determining enzyme, 5-a-reductase was upregulated in the DG of Nenf-/-, together with a significant increase in the expression of the dGABAA receptor gene, involved in DG tonic inhibition. Taken together, these findings add in vivo evidence on the neurotrophic properties of NENF in the adult brain. Furthermore, the mechanism of action of NENF in this process might implicate neurosteroids modulation, at least in the DG.
Accessibility: Document exists in file
Language:
eng
Author:
Novais, A.
Secondary author(s):
Silva, A., Ferreira, A. C., Falcão, A., Sousa, N., Palha, J. A., Marques, F., Sousa, J. C.
Document type:
Article
Number of reproductions:
1
Reference:
Novais, A., Silva, A., Ferreira, A. C., Falcão, A., Sousa, N., Palha, J. A., Marques, F., & Sousa, J. C. (2018). Adult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin. Frontiers in Cellular Neuroscience, 12, 463. https://doi.org/10.3389/fncel.2018.00463
2-year Impact Factor: 3.900|2018
Times cited: 9|2025-02-11
Indexed document: Yes
Quartile: Q2
Keywords: Newborn neurons / NENF / Dentate gyrus / Delta GABA A receptor / Progesterone

Adult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin

Adult hippocampal neurogenesis modulation by the membrane-associated progesterone receptor family member neudesin
DocumentAstrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10 - 2019-11
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.08
Location: BF-GMS
Title:
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S0006899320300561#s0105
Abstract/Results: ABSTRACT:
The central nervous system (CNS) has a limited auto-regeneration capacity, which makes it challenging for the development of new therapies. Previous studies from our lab have demonstrated the applicability of human bone marrow mesenchymal stem cells (hBM-MSCs) secretome as a possible therapeutic tool for CNS. Astrocytes, glial cells present in all brain regions, are important players in brain function through their vast influence in extracellular homeostasis, neuro-vascular regulation, synaptic modulation and neurogenesis. Thus, in the present work, we aimed to evaluate the specific impact of MSCs secretome on hippocampal proliferation and astrocyte morphology, in both WT and dnSNARE mice, a transgenic model that presents impaired astrocytic exocytosis and consequently impaired astrocytic function. Results demonstrated increased levels of proliferation for WT when treated with secretome. Additionally, it was possible to observe that dnSNARE animals injected with hBM-MSCs secretome disclosed increased levels of proliferating GFAP stained cells at the SGZ. Morphometrical evaluation found increased process hypertrophy and branching of dnSNARE astrocytes when treated with secretome. These results are closely related with the trophic factors present in the secretome, namely FGF-2, BDNF, GDNF, IGF-1, VEGF, CADH2, PEDF and miR-16. Moreover, the impaired exocytosis of astrocytes may also have implications for the response to the proliferative stimulus, given the established autocrine signaling through this mechanism.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2018-037.02
Author: Campos, J.
Secondary author(s):
Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., Salgado, A. J.
Document type:
Article
Number of reproductions:
1
Reference:
Campos, J., Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., & Salgado, A. J. (2020). Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Research, 1732: 146700. https://doi.org/10.1016/j.brainres.2020.146700
2-year Impact Factor: 3.252|2020
Times cited: 6|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Mesenchymal stem cells / Secretome / Astrocytes / dnSNARE / Proliferation / Radial glia / Dentate gyrus
DocumentAstrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.02
Location: BF-GMS
Title:
Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/pii/S0006899320300561#s0105
Abstract/Results: ABSTRACT:
The central nervous system (CNS) has a limited auto-regeneration capacity, which makes it challenging for the development of new therapies. Previous studies from our lab have demonstrated the applicability of human bone marrow mesenchymal stem cells (hBM-MSCs) secretome as a possible therapeutic tool for CNS. Astrocytes, glial cells present in all brain regions, are important players in brain function through their vast influence in extracellular homeostasis, neuro-vascular regulation, synaptic modulation and neurogenesis. Thus, in the present work, we aimed to evaluate the specific impact of MSCs secretome on hippocampal proliferation and astrocyte morphology, in both WT and dnSNARE mice, a transgenic model that presents impaired astrocytic exocytosis and consequently impaired astrocytic function. Results demonstrated increased levels of proliferation for WT when treated with secretome. Additionally, it was possible to observe that dnSNARE animals injected with hBM-MSCs secretome disclosed increased levels of proliferating GFAP stained cells at the SGZ. Morphometrical evaluation found increased process hypertrophy and branching of dnSNARE astrocytes when treated with secretome. These results are closely related with the trophic factors present in the secretome, namely FGF-2, BDNF, GDNF, IGF-1, VEGF, CADH2, PEDF and miR-16. Moreover, the impaired exocytosis of astrocytes may also have implications for the response to the proliferative stimulus, given the established autocrine signaling through this mechanism.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
BL-2014-207.08
Author: Campos, J.
Secondary author(s):
Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., Salgado, A. J.
Document type:
Article-d
Number of reproductions:
1
Reference:
Campos, J., Guerra-Gomes, S., Serra, S. C., Baltazar, G., Oliveira, J. F., Teixeira, F. G., & Salgado, A. J. (2020). Astrocyte signaling impacts the effects of human bone marrow mesenchymal stem cells secretome application into the hippocampus: A proliferation and morphometrical analysis on astrocytic cell populations. Brain Research, 1732: 146700. https://doi.org/10.1016/j.brainres.2020.146700
2-year Impact Factor: 3.252|2020
Times cited: 6|2025-02-14
Indexed document: Yes
Quartile: Q3
Keywords: Mesenchymal stem cells / Secretome / Astrocytes / dnSNARE / Proliferation / Radial glia / Dentate gyrus
DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-037
Location: BF-GMS
Title:
037 - Decoding the neuron-astrocyte dialogue that supports cognitive processing
Duration: 2020-02 - 2024-04
Researcher(s):
João Filipe Oliveira, Luísa Pinto, Diana Nascimento, Sónia Gomes, Inês Caetano, João Viana
Institution(s): Life and Health Sciences Research Institute - ICVS, Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Oliveira, J. F.
Secondary author(s):
Pinto, L., Nascimento, D., Gomes, S., Caetano, I., Viana, J.
Number of reproductions:
1
Keywords:
Astrocyte / Neural oscillations / Learning and memory / Hippocampus / Psychophysiology

Reference code: PT/FB/BL-2018-037.08
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article-d
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390-. https://doi.org/10.3390/cells11030390
2-year Impact Factor: 6.000|2022
Times cited: 12|2025-02-17
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
DocumentBeyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-427
Location: BF-GMS
Title:
427 - Gliogenesis control of brain neuroplasticity, neurophysiology and cognitive function
Duration: 2015-09 - 2019-10
Researcher(s):
Luísa Alexandra Meireles Pinto, Ana Rita Machado dos Santos, António Maria Restolho Mateus Pinheiro, Cristina Joana Moreira Marques, Joana Sofia da Silva Correia, João Filipe Pedreira de Oliveira, João Miguel Bessa Peixoto, Nuno Dinis Alves, Patrícia Carvalho Patrício, Vítor Manuel da Silva Pinto
Institution(s): Life and Health Sciences Research Institute - ICVS, University of Minho and ICVS/3B's- Government Associate Laboratory, Braga (Portugal); Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Pinto, L.
Secondary author(s):
Santos, A., Pinho, A., Marques, A., Correia, J., Oliveira, J. F., Peixoto, J., Alves, N., Patrício, P., Pinto, V.
Number of reproductions:
1
Keywords:
Astrogliogenesis / Neuroplasticity / Cognition / Electrophysiology / Psychophysiology

Reference code: PT/FB/BL-2014-427.18
Location: BF-GMS
Title:
Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure
Publication year: 2022
URL:
https://www.mdpi.com/2073-4409/11/3/390/htm
Abstract/Results: Abstract
Depression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, little is known about the importance of de novo generated astrocytes in the mammalian brain and in particular its possible involvement in the precipitation of depression and in the therapeutic actions of current antidepressants (ADs). Therefore, we studied the modulation of astrocytes and adult astrogliogenesis in the hippocampal dentate gyrus (DG) of rats exposed to an unpredictable chronic mild stress (uCMS) protocol, untreated and treated for two weeks with antidepressants—fluoxetine and imipramine. Our results show that adult astrogliogenesis in the DG is modulated by stress and imipramine. This study reveals that distinct classes of ADs impact differently in the astrogliogenic process, showing different cellular mechanisms relevant to the recovery from behavioral deficits induced by chronic stress exposure. As such, in addition to those resident, the newborn astrocytes in the hippocampal DG might also be promising therapeutic targets for future therapies in the neuropsychiatric field.
Accessibility: Document exists in file
Language:
eng
Author:
Machado-Santos, A. R.
Secondary author(s):
Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., Pinto, L.
Document type:
Article
Number of reproductions:
1
Reference:
Machado-Santos, A. R., Loureiro-Campos, E., Patrício, P., Araújo, B., Alves, N., Mateus-Pinheiro, A., Correia, J., Morais, M., Bessa, J., Sousa, N., Rodrigues, A., Oliveira, J., & Pinto, L. (2022). Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure. Cells, 11(3), 390. https://doi.org/10.3390/cells11030390
2-year Impact Factor: 6.000|2022
Times cited: 12|2025-02-17
Indexed document: Yes
Quartile: Q2
Keywords: Astrocytes / Hippocampus / Dentate gyrus / Astrogliogenesis / Chronic stress / Antidepressants

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure

Beyond new neurons in the adult hippocampus: Imipramine acts as a pro-astrogliogenic factor and rescues cognitive impairments induced by stress exposure