History
Processing, please wait...
Database
search
in
Filter year from
to
Language
Country
  • Enter your search phrase in the search box.
  • General search:
    • The Boolean operator AND between the terms is assumed by default. If you enter the words European Union in the search box, the system returns all records in which both words occur, regardless of their order.
    • When entering a set of words in quotes, e.g "european union", all records containing the literal term "European Union" will be retrieved.
  • Search by access fields (e.g. author, title, etc.):
    • To direct your search, choose the field in which you want to search the word or expression.
    • Search in the field assumes by default the expression in quotes, e.g. European union will retrieve all records containing the literal term "European Union"
  • To perform more complex searches, additional words or expressions may be added.
  • If you want to refine the search results, you can always access the link "search" in the upper left corner of the page of search results.
  • The search engine is not case sensitive. For example, the word congress has the same meaning that Congress or CONGRESS.
  • To truncate your search expression, use the $ character
  • You can filter the results of your search by a date or date range, filling the appropriate boxes.
Base:
BIAL Foundation
Search:
DE:"Developmental psychopathology"
Results
1
to
12
from
12
found.
View
Selection Description
Type Title Begin End
DocumentPsychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.06
Location: Arquivo PCA - Pasta 17/2006
Title:
Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom
Publication year: 2008
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=1927620
Abstract/Results: ABSTRACT:
BACKGROUND:
The incidence of schizophrenia and the prevalence of psychotic symptoms in the general adult population are elevated in migrant and ethnic minority groups relative to host populations. These increases are particularly prominent among African-Caribbean migrants to the UK. This study examined the associations of ethnicity and migrant status with a triad of putative antecedents of schizophrenia in a UK community sample of children aged 9–12 years. The antecedent triad comprised: (i) psychotic-like experiences; (ii) a speech and/or motor developmental delay or abnormality; and (iii) a social, emotional or behavioural problem.
METHOD:
Children (n=595) and their primary caregivers, recruited via schools and general practitioners in southeast London, completed questionnaires. Four indices of risk were examined for associations with ethnicity and migrant status: (i) certain experience of at least one psychotic-like experience; (ii) severity of psychotic-like experiences (total psychotic-like experience score); (iii) experience of the antecedent triad; and (iv) severity of antecedent triad experiences (triad score).
RESULTS:
African-Caribbean children, as compared to white British children, experienced greater risk on all four indices. There were trends for South Asian and Oriental children to present lowered risk on several indices, relative to white British children. Migration status was unrelated to any risk index.
CONCLUSION:
Prevalence of the putative antecedents of schizophrenia is greater among children of African-Caribbean origin living in the UK than among white British children. This parallels the increased incidence of schizophrenia and elevated prevalence of psychotic symptoms among adults of African-Caribbean origin.
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
West, S. A., Murray, R., Hodgins, S.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., West, S. A., Murray, R., & Hodgins, S. (2008). Psychotic-like experiences and other developmental antecedents of schizophrenia in children aged 9-12 years: A comparison of ethnic and migrant groups in the United Kingdom. Psychological Medicine, 38(8), 1103-1112. https://doi.org/10.1017/S0033291707001845
2-year Impact Factor: 4.718|2008
Times cited: 56|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Developmental psychopathology / Psychosis / Risk factors
DocumentPersisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.18
Location: Arquivo PCA - Pasta 17/2006
Title:
Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
Publication year: 2013
URL:
http://www.schres-journal.com/article/S0920-9964(12)00701-3/abstract
Abstract/Results: ABSTRACT:
BACKGROUND:
Persisting psychotic-like experiences (PLEs) are associated with an increased risk of internalising symptoms in adolescence. Whether this association holds similarly for externalising symptoms, and from mid-childhood, is unclear. This prospective study investigated the extent to which PLE persistence was associated with internalising and externalising psychopathology in a community sample of children aged 9–11years at study commencement.
METHODS:
8099 children (mean age 10.4years) completed questionnaires assessing PLEs, externalising and internalising symptoms. A subsample of 547 children completed reassessment, on average, two years later.
RESULTS:
Two-thirds (66%) of children reported PLEs at baseline. Approximately two years later, PLEs persisted in 39% of those children. After adjustment for previous psychopathology and other potential confounds, children with persisting PLEs were at higher risk for internalising (odds ratio [OR]=1.94; 95% confidence interval [CI] 1.13–3.34) and externalising (OR=1.97; 95% CI 1.19–3.26) psychopathology than children whose PLEs remitted; and, than children who never presented PLEs.
CONCLUSIONS:
Persistent PLEs from mid-childhood are associated with later internalising and externalising psychopathology in the general population, whereas transitory PLEs may be part of a spectrum of normative childhood development. Interventions that target persistent PLEs may contribute to a reduction in common childhood psychopathology.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Downs, J. M.
Secondary author(s):
Cullen, A. E., Barragan, M., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Downs, J. M., Cullen, A. E., Barragan, M., & Laurens, K. R. (2013). Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort. Schizophrenia Research, 144(1), 99-104. https://doi.org/10.1016/j.schres.2012.12.009
2-year Impact Factor: 4.426|2013
Times cited: 68|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Childhood / Adolescence / Developmental psychopathology / Community sample / Risk factors / Psychosis

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort

Persisting psychotic-like experiences are associated with both externalising and internalising psychopathology in a longitudinal general population child cohort
DocumentSystematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.19
Location: Arquivo PCA - Pasta 17/2006
Title:
Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years
Publication year: 2013
URL:
http://www.sciencedirect.com/science/article/pii/S0022395613000964
Abstract/Results: ABSTRACT:
Social withdrawal is a robust childhood risk factor for later schizophrenia. The aims of this paper were to assess the evidence for childhood social withdrawal among adults with schizophrenia and, comparatively, in children aged 9–14 years who are putatively at-risk of developing schizophrenia. We conducted a meta-analysis, including cohort and case-control studies reporting social withdrawal measured by the Child Behavior Checklist (CBCL) in adults with schizophrenia vs. controls. Further, an experimental study compared CBCL withdrawal scores from typically-developing children with scores from two groups of putatively at-risk children: (i) children displaying a triad of replicated antecedents for schizophrenia, and (ii) children with at least one first- or second-degree relative with schizophrenia or schizoaffective disorder. Six studies met inclusion criteria for the meta-analysis (N = 3828), which demonstrated a large effect of increased childhood social withdrawal in adults with schizophrenia (standardized mean difference [SMD] score = 1.035, 95% CI = 0.304–1.766, p = 0.006), with no indication of publication bias, but considerable heterogeneity (I2 = 91%). Results from the experimental study also indicated a large effect of increased social withdrawal in children displaying the antecedent triad (SMD = 0.743, p = 0.001), and a weaker effect in children with a family history of schizophrenia (SMD = 0.442, p = 0.051). Childhood social withdrawal may constitute a vulnerability marker for schizophrenia in the presence of other antecedents and/or genetic risk factors for schizophrenia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Matheson, S. L.
Secondary author(s):
Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Matheson, S. L., Vijayan, H., Dickson, H., Shepherd, A. M., Carr, V. J., & Laurens, K. R. (2013). Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years. Journal of Psychiatric Research, 47(8), 1061-1068. https://doi.org/10.1016/j.jpsychires.2013.03.013
2-year Impact Factor: 4.092|2013
Times cited: 48|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Child Behavior Checklist (CBCL) / Antecedents / Risk factors / Psychosis / Developmental psychopathology

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years

Systematic meta-analysis of childhood social withdrawal in schizophrenia, and comparison with data from at-risk children aged 9–14 years
DocumentCognitive impairment among children at-risk for schizophrenia2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.23
Location: Arquivo PCA - Pasta 17/2006
Title:
Cognitive impairment among children at-risk for schizophrenia
Publication year: 2014
URL:
http://www.sciencedirect.com/science/article/pii/S0022395613003695
Abstract/Results: ABSTRACT:
Adults with schizophrenia present cognitive impairments, as do individuals at ultra-high risk for the disorder, youth with relatives with schizophrenia spectrum disorders, and children with antecedents of schizophrenia. The present study aimed to determine if impairments in childhood differed depending on the definition of risk and/or on the degree of relatedness to an affected individual, and if impairments were explained by IQ. Four groups of children aged 9–12 years were studied: (1) 13 children with =1 first-degree or =2 second-degree affected relatives (high familial loading: FHxH); (2) 14 with =1 affected second-degree relative (lower familial loading: FHxL); (3) 32 with well-replicated antecedents of schizophrenia (ASz); and (4) 45 typically-developing (TD) children with neither a positive family history nor antecedents. Compared to TD children, both FHxH and ASz children exhibited significantly poorer verbal comprehension, scholastic achievement, and verbal working memory, while FHxH children additionally displayed significantly lower full-scale IQ, and verbal memory and executive function impairments. After adjusting statistical analyses for IQ, group differences were attenuated. Relative to TD children, FHxL children showed no significant differences in performance. The results imply that impairments in verbal comprehension, scholastic achievement, and verbal working memory may index vulnerability for schizophrenia among children with affected relatives with the disorder and among those with multiple antecedents of the disorder who have no affected relatives. More accurate identification of children at-risk for schizophrenia and the specific deficits that they present provides opportunities for interventions such as cognitive remediation that may impact the development of the illness.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dickson, H.
Secondary author(s):
Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D., Morris, R., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Dickson, H., Cullen, A. E., Reichenberg, A., Hodgins, S., Campbell, D. D., Morris, R. G., & Laurens, K. R. (2014). Cognitive impairment among children at-risk for schizophrenia. Journal of Psychiatric Research, 50, 92-99. https://doi.org/10.1016/j.jpsychires.2013.12.003
2-year Impact Factor: 3.957|2014
Times cited: 34|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Intelligence / Psychosis / Risk factors / Genetic liability / Developmental psychopathology / Psychotic-like experiences
DocumentToward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.03
Location: Arquivo PCA - Pasta 25/2012
Title:
Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study
Publication year: 2016
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4823320/
Abstract/Results: ABSTRACT:
PURPOSE:
The London Child Health and Development Study (CHADS) is a prospective, longitudinal investigation of children, sampled from the general community aged 9-11 years and assessed biennially, who present premorbid risk markers for schizophrenia. The study aims to characterise developmental trajectories of psychological, cognitive, and biological functioning in at-risk children and identify potential targets for early preventative intervention. This review summarises CHADS findings, discusses these in the context of recent theory regarding aetiology and prevention of schizophrenia, and highlights challenges to be addressed with future research.
METHODS:
We review (1) epidemiological information on the prevalence and correlates of developmental antecedents of schizophrenia in the general child population, (2) evidence of psychosocial, cognitive, and biological dysfunctions in at-risk children presenting multiple antecedents of schizophrenia and at-risk children with a family history of schizophrenia, and (3) related findings from an associated sample of help-seeking children receiving intervention.
RESULTS:
Community-based screening of 9-11-year olds identified ~9 % with a triad of antecedents of schizophrenia [including psychotic-like experiences (PLEs)] who are putatively at-risk of psychosis; these children reported greater exposure and responsivity to stressors, impairments in general intelligence and specific cognitive functions, brain structure and function abnormalities, and neuromotor dysfunction. Preliminary evidence suggests distressing PLEs are a viable target for cognitive-behavioural intervention in at-risk children.
CONCLUSIONS:
Intervention in early, premorbid phases of illness might alleviate current difficulties and avert future schizophrenia using benign treatments. The CHADS programme has identified several markers that may index early pathophysiology and constitute potential targets for preventative intervention.
Accessibility: Document exists in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Cullen, A. E.
Document type:
Article
Number of reproductions:
1
Reference:
Laurens, K. R., & Cullen, A. E. (2016). Toward earlier identification and preventative intervention in schizophrenia: Evidence from the London Child Health and Development Study. Social Psychiatry and Psychiatric Epidemiology, 51(4), 475-491. https://doi.org/10.1007/s00127-015-1151-x
2-year Impact Factor: 2.922|2016
Times cited: 53|2025-02-11
Indexed document: Yes
Quartile: Q2
Keywords: Adolescence / Developmental psychopathology / High-risk / Psychosis / Psychotic-like experiences

Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study

Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study
DocumentTrajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.04
Location: Arquivo PCA - Pasta 25/2012
Title:
Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study
Publication year: 2016
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4855987/
Abstract/Results: ABSTRACT:
Adolescent internalizing and externalizing psychopathology is strongly associated with adult psychiatric morbidity, including psychotic disorders. This study examined whether internalizing or externalizing trajectories (continuity/discontinuity of symptoms) from middle childhood were associated with adolescent psychotic-like experiences (PLEs). Prospective data were collected from a community sample of 553 children (mean age = 10.4 years; 50% male) and their primary caregivers. Participants completed questionnaire reports of internalizing and externalizing psychopathology and PLEs at baseline, and again approximately 2 years later. Logistic regression was used to examine the association of adolescent PLEs with four trajectories of internalizing and externalizing psychopathology (persistent, incident, remitting, and none), controlling for a range of potential confounders and sampling bias. Significant associations were identified between adolescent PLEs and the incident internalizing (adjusted odds ratio [adj. OR] = 2.96; 95% confidence interval [CI] = 1.60–5.49) and externalizing psychopathology (adj. OR = 2.14; 95% CI = 1.11–4.14) trajectories, as well as the persistent internalizing (adj. OR = 1.90; 95% CI = 1.13–3.18) and externalizing (adj. OR = 1.81, 95% CI = 1.02–3.19) trajectories. Children with remitting psychopathology trajectories were no more likely to present later PLEs than those who never experienced psychopathology. While for many individuals symptoms and illness remit during development without intervention, this study provides important insights regarding potential targets and timing for delivery of early intervention and prevention programs.
Accessibility: Document exists in file
Language:
eng
Author:
Lancefield, K. S.
Secondary author(s):
Raudino, A., Downs, J. M., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Lancefield, K. S., Raudino, A., Downs, J. M., & Laurens, K. R. (2016). Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study. Development and Psychopathology, 28(2), 527-536. https://doi.org/10.1017/S0954579415001108
2-year Impact Factor: 3.244|2016
Times cited: 49|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: Adolescence / Developmental psychopathology / High-risk / Psychosis / Psychotic-like experiences

Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study

Trajectories of childhood internalizing and externalizing psychopathology and psychotic-like experiences in adolescence: A prospective population-based cohort study
DocumentAdolescent trajectories of cognition and risk for psychosis2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.05
Location: Arquivo PCA - Pasta 25/2012
Title:
Adolescent trajectories of cognition and risk for psychosis
Publication year: 2016
URL:
http://www.nature.com/public/article-assets/npg/npjschz/abstracts/npjschz201610.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Impairments in multiple cognitive domains are apparent among youth who later develop schizophrenia, but it has been hypothesized that different impairments might follow distinct developmental courses from childhood into adolescence. The aim of the study was to examine developmental trajectories of cognitive growth during adolescence in youth at-risk for psychosis.
METHODS
104 participants were assessed at approximately 24-month intervals (time 1, aged 9-12 years; time 2, 11-14 years; and time 3,
13-17 years) on measures of scholastic achievement, memory, and executive function. Cognitive development between ages 9-17 years was compared between youth characterized by a triad of wellreplicated developmental antecedents of schizophrenia (ASz, N = 32); youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 29); and typically developing youth (TD, N = 45).
RESULTS
longitudinal mixed models for repeated measures data indicated that, between the ages of 9-17 years, ASz and FHx groups (relative to TD youth) displayed static impairments on word reading, numerical operations, verbal working memory, visual memory and some aspects of executive functioning, but dynamically changing patterns of cognitive growth on spelling, verbal memory and verbal fluency subtests.
DISCUSSION
The present study identified two important patterns of cognitive growth among youth at-risk for psychosis that have also been observed premorbidly among individuals with schizophrenia. The stable cognitive deficits observed in this study may represent
more suitable targets for cognitive training interventions than dynamically changing patterns of cognitive growth that appear to reflect developmental plasticity and recuperation.
Accessibility: Document exists in file
Language:
eng
Author:
Dickson, H.
Secondary author(s):
Cullen, A. E., Jones, R., Reichenberg, A., Roberts, R. E., Hodgins, S., Morris, R. M., Laurens, K. R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dickson, H., Cullen, A. E., Jones, R., Reichenberg, A., Roberts, R. E., Hodgins, S., Morris, R. M., & Laurens, K. R. (2016). Adolescent trajectories of cognition and risk for psychosis. Poster presentation at the 5th Biennial Schizophrenia International Research Society Conference, Florence, Italy. npj Schizophrenia 2, Article number: 16007, 15. https://doi.org/10.1038/npjschz.2016.7
Indexed document: No
Keywords: Developmental psychopathology / Adolescence / High-risk / Psychosis / Cognitive impairments

Adolescent trajectories of cognition and risk for psychosis

Adolescent trajectories of cognition and risk for psychosis
DocumentAdolescent trajectories of motor function and risk for psychosis2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.06
Location: Arquivo PCA - Pasta 25/2012
Title:
Adolescent trajectories of motor function and risk for psychosis
Publication year: 2016
URL:
http://www.nature.com/public/article-assets/npg/npjschz/abstracts/npjschz20168.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Evidence indicates that individuals who subsequently develop schizophrenia/ schizophrenia spectrum disorders (SDD) in adulthood display poorer motor function during early and middle childhood than individuals who do not develop these disorders.
However, among individuals who develop schizophrenia/SSD in adulthood, motor dysfunction is not apparent at all stages of childhood development and may reduce with increasing age. Currently, little is known about the developmental trajectories of motor function in adolescence among youth at-risk for the disorder.
METHODS
94 participants were assessed at approximately 24-month intervals (time 1, aged 9-12 years; time 2, 11-14 years; and time 3, 13-17 years) on the Purdue Pegboard assessment, comprising four subtests: dominant hand, non-dominant hand, both hands, assembly subtest. Motor function between ages 9-16 years was compared between youth characterized by a triad of well-replicated developmental antecedents of schizophrenia (ASz, N = 29); youth with a least one affected relative with schizophrenia or schizoaffective disorder (FHx; N = 26); and typically developing youth (TD, N = 42).
RESULTS
Longitudinal mixed models for repeated measures data indicated significant improvements with age in TD youth on the assembly subtest only. Relative to TD youth, FHx children exhibited an early deficit on the dominant hand and both hand subtests which was followed by faster rates of improvement with age, but a stable impairment on the assembly subtest across adolescence. In contrast, compared to the TD group, ASz youth showed an early deficit followed by significant improvements for the assembly subtest, but a stable impairment on the dominant hand and both hand subtests across adolescence.
DISCUSSION
Findings are consistent with existing literature indicating that risk for schizophrenia/SSD is associated with delayed motor development. The motor dysfunction observed in both at-risk groups may reflect cerebellar dysfunction, and provides additional support for a cognitive dysmetria model of schizophrenia.
Accessibility: Document exists in file
Language:
eng
Author:
Dickson, H.
Secondary author(s):
Roberts, R. E., To, M., Loh, M., Hodgins, S., Laurens, K. R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Dickson, H., Roberts, R. E., To, M., Loh, M., Hodgins, S., & Laurens, K. R. (2016). Adolescent trajectories of motor function and risk for psychosis. Poster presentation at the 5th Biennial Schizophrenia International Research Society Conference, Florence, Italy. npj Schizophrenia 2, Article number: 16008, 15. https://doi.org/10.1038/npjschz.2016.8
Indexed document: No
Keywords: Motor function / Developmental psychopathology / High-risk / Psychosis / Adolescence

Adolescent trajectories of motor function and risk for psychosis

Adolescent trajectories of motor function and risk for psychosis
DocumentMapping development of the MMN and P3a potentials during adolescence: A longitudinal investigation of healthy individuals and individuals at-risk for psychosis2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.07
Location: Arquivo PCA - Pasta 25/2012
Title:
Mapping development of the MMN and P3a potentials during adolescence: A longitudinal investigation of healthy individuals and individuals at-risk for psychosis
Publication year: 2015
URL:
http://www.frontiersin.org/10.3389/conf.fnhum.2015.217.00267/1692/XII_International_Conference_on_Cognitive_Neuroscience_(ICON-XII)/all_events/event_abstract
Abstract/Results: ABSTRACT:
Adolescence marks a period of transition from childhood to adulthood that is characterised by major changes in brain structure and function, and increased vulnerability to psychiatric disorder, including psychosis. Characterising normative developmental trajectories of brain function establishes an important baseline against which to map mechanisms contributing to pathological development. Cross-sectional investigations measuring the mismatch negativity (MMN) and P3a event-related potential components in healthy children and young adults have typically inferred increasing amplitudes and decreasing latencies during adolescence, interpreted as improved efficiency of sensory and cognitive processing. We sought to characterise within-individual trajectories of brain function in adolescence using a longitudinal design incorporating up to three assessments from late childhood though adolescence. Using a duration deviant passive auditory oddball paradigm, MMN and P3a components were recorded from 49 healthy children at approximately 24-month intervals (spanning ages 9-17 years). Linear mixed models, accounting for repeated measures, examined MMN and P3a amplitude and latency data from electrode FCz. Children at early pubertal stages had smaller MMN amplitude than adolescents in later pubertal stages, whereas MMN latency did not change with age or pubertal status. Random intercept models revealed a significant linear increase in P3a amplitude with age, while P3a latency increased initially from 11 years and stabilised by around 15 years. Longitudinal data analysis in children at-risk for psychosis is being finalised, with the aim of identifying the age(s) at which developmental trajectories of these components begin to diverge from the norm, and the nature of these deviations (e.g., delay vs. arrest of development).
Accessibility: Document does not exist in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Murphy, J., Dickson, H., Roberts, R.
Document type:
Abstract
Number of reproductions:
1
Reference:
Laurens, K., Murphy, J., Dickson, H., & Roberts, R. (2015). Mapping development of the MMN and P3a potentials during adolescence: A longitudinal investigation of healthy individuals and individuals at-risk for psychosis. Frontiers Human Neuroscience. Conference Abstract: XII International Conference on Cognitive Neuroscience (ICON-XII). https://doi.org/10.3389/conf.fnhum.2015.217.00267
Indexed document: Yes
Keywords: Attention / Psychosis / ERP / Developmental psychopathology / Child and adolescent developmen
DocumentFinal report - Characterising developmental trajectories of brain function from childhood into adolescence2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.01
Location: Arquivo PCA - Pasta 25/2012
Title:
Final report - Characterising developmental trajectories of brain function from childhood into adolescence
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_19412.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Little longitudinal data is available tracking cognitive development using event-related potentials (ERP) during adolescence, either in typically developing (TD) youth or in high-risk youth.
AIMS
1. To delineate a normative pattern of development on multiple indices of cognitive function;
2. To determine anomalies of development on these brain function indices among high-risk youth.
METHOD
The project used longitudinal data from the London Child Health and Development Study to examine the development of brain function among TD youth and among youth at high-risk for the development of schizophrenia, including a high-risk group with family history of schizophrenia (FHx), and another high-risk group presenting a triad of developmental antecedents of schizophrenia (ASz; i.e., motor/speech delays, social/emotional/behavioral problems, and psychotic-like experiences). Data from three assessments in the cohort were used, spanning middle childhood (9-11 years), early adolescence (11-13 years), and mid-adolescence (13-16 years).
RESULTS
We characterised the trajectories of normative development among TD youth, and demonstrated that high-risk ASz and FHx youth display some early cognitive deficits that remain stable during adolescence. On other cognitive measures, ASz and FHx children showed faster rates of development during adolescence than their TD peers, so that early delays observed in brain function normalised later in adolescence.
CONCLUSION
These differential patterns of deviation from normative adolescent cognitive development among high-risk youth imply scope for targeting interventions to specific cognitive deficits at different developmental phases.
Accessibility: Document exists in file
Language:
eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Child and adolescent development / Developmental psychopathology / Cognition / Event-related potentials

Final report - Characterising developmental trajectories of brain function from childhood into adolescence

Final report - Characterising developmental trajectories of brain function from childhood into adolescence
DocumentIncreased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code: PT/FB/BL-2012-194.17
Location: BF-GMS
Title:
Increased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0920996423000294?via%3Dihub
Abstract/Results: ABSTRACT:
Among children with psychotic-like experiences (PLEs), the presence of co-occurring psychopathology may distinguish children's self-report of clinically significant experiences (i.e., PLEs that are distressing and/or impairing of daily functioning) from reports of more benign experiences. The aim of this study was to examine whether the likelihood of distressing or impairing PLEs differed according to type of co-occurring psychopathology symptoms. A community sample of 5268 children aged 9-12 years were recruited from Greater London, UK. Participants completed the Psychotic-Like Experiences Questionnaire for Children, and the Strengths and Difficulties Questionnaire to measure internalising and externalising problems. Multinomial logistic regressions were used to determine the likelihood of PLEs being distressing and/or impairing (vs. not) among children with different co-occurring symptom profiles (PLEs only; PLEs with internalising problems only - PLE-I; PLEs with externalising problems only - PLE-E; and PLEs with both internalising and externalising problems - PLE-IE). Children with co-occurring internalising and/or externalising problems had greater odds of distressing and/or impairing PLEs compared to children without co-occurring psychopathology (PLEs only). These associations were moderate for PLE-E and strong for PLE-I and PLE-IE, with the greatest odds of distressing and impairing PLEs evident in the presence of internalising plus externalising comorbidities (odds ratios [with 99 % confidence intervals] for PLE-IE relative to PLE-I = 2.00 [1.34-2.99]; PLE-IE relative to PLE-E = 5.46 [3.78-7.90]). These results affirm the importance of screening for the presence and type of co-occurring psychopathology among children with PLEs to demarcate potentially different treatment needs.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2006.035.31
Author: Gutteridge, T. P.
Secondary author(s):
Kelly, A. B., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Gutteridge, T. P., Kelly, A. B., & Laurens, K. R. (2023). Increased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems. Schizophrenia Research, 252, 225-230. https://doi.org/10.1016/j.schres.2023.01.017
2-year Impact Factor: 3.6|2023
Times cited: 2|2025-02-18
Indexed document: Yes
Quartile: Q2
Keywords: Community screening / Developmental psychopathology / Early intervention / Middle childhood / Psychosis symptoms
DocumentIncreased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006.035.31
Location: Arquivo PCA - Pasta 17/2006
Title:
Increased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S0920996423000294?via%3Dihub
Abstract/Results: ABSTRACT:
Among children with psychotic-like experiences (PLEs), the presence of co-occurring psychopathology may distinguish children's self-report of clinically significant experiences (i.e., PLEs that are distressing and/or impairing of daily functioning) from reports of more benign experiences. The aim of this study was to examine whether the likelihood of distressing or impairing PLEs differed according to type of co-occurring psychopathology symptoms. A community sample of 5268 children aged 9–12 years were recruited from Greater London, UK. Participants completed the Psychotic-Like Experiences Questionnaire for Children, and the Strengths and Difficulties Questionnaire to measure internalising and externalising problems. Multinomial logistic regressions were used to determine the likelihood of PLEs being distressing and/or impairing (vs. not) among children with different co-occurring symptom profiles (PLEs only; PLEs with internalising problems only – PLE-I; PLEs with externalising problems only – PLE-E; and PLEs with both internalising and externalising problems – PLE-IE). Children with co-occurring internalising and/or externalising problems had greater odds of distressing and/or impairing PLEs compared to children without co-occurring psychopathology (PLEs only). These associations were moderate for PLE-E and strong for PLE-I and PLE-IE, with the greatest odds of distressing and impairing PLEs evident in the presence of internalising plus externalising comorbidities (odds ratios [with 99 % confidence intervals] for PLE-IE relative to PLE-I = 2.00 [1.34–2.99]; PLE-IE relative to PLE-E = 5.46 [3.78–7.90]). These results affirm the importance of screening for the presence and type of co-occurring psychopathology among children with PLEs to demarcate potentially different treatment needs.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Related objects:
BL-2012-194.17
Author: Gutteridge, T. P.
Secondary author(s):
Kelly, A. B., Laurens, K. R
Document type:
Article-d
Number of reproductions:
1
Reference:
Gutteridge, T. P., Kelly, A. B., & Laurens, K. R. (2023). Increased likelihood of distressing and functionally impairing psychotic-like experiences among children with co-occurring internalising and externalising problems. Schizophrenia Research, 252, 225-230. https://doi.org/10.1016/j.schres.2023.01.017
2-year Impact Factor: 3.6|2023
Times cited: 2|2025-02-18
Indexed document: Yes
Quartile: Q2
Keywords: Psychosis symptoms / Developmental psychopathology / Community screening / Middle childhood / Early intervention