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BIAL Foundation
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DocumentFinal report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.01
Location: BF-GMS
Title:
Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_28314.pdf
Abstract/Results: ABSTRACT:
Nutrition is a key determinant of health, wellbeing and aging. Recent evidences strongly suggest that nutritional amino acids (AAs) are important mediators of this fitness effect in multiple species, including humans. Accordingly, animals have developed behavioral strategies to ensure a proper balance of AA intake. We have for example shown that upon yeast (main dietary protein source of fruit flies) or AA deprivation Drosophila melanogaster increases the intake of yeast leading to a switch in feeding preference from sucrose to yeast. This change in feeding choice underlies the dietary basis for nutritional AA homeostasis and serves as a powerful paradigm to study nutrient choice and homeostasis.
We have identified a distinct class of Drosophila melanogaster gustatory receptor neurons (GRNs) required for intake of yeast. We show that gustatory receptor neurons of the proboscis act in parallel to mediate yeast feeding. While nutritional and reproductive states act in concert to drive yeast appetite, we find a separation of these state signals at the level of yeast GRNs, with amino acid but not mating state enhancing yeast GRN gain. Importantly, the sensitivity of sweet GRNs to sugar is not increased by protein deprivation, providing a potential basis for this nutrient-specific appetite. The emerging picture is that different internal states act at distinct levels of a specific gustatory processing circuit to elicit nutrient-specific appetites towards a complex, ecologically relevant protein source.
Furthermore, we have made important additional discoveries at the level of the impact of gut bacteria on the selection of nutrients and have developed a new approach using genome information for designing diets optimizing both aging and reproductive output.
We have therefore achieved the main goals of the project which aimed at identifying and characterizing circuits regulating nutrient homeostasis and exploring the impact of nutrients on lifespan with a special focus on amino acids.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Nutrition / Diet / Circuits / Drosophila / Brain

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
DocumentMatching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.03
Location: BF-GMS
Title:
Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan
Publication year: 2017
URL:
http://www.cell.com/cell-metabolism/fulltext/S1550-4131(17)30095-5?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413117300955%3Fshowall%3Dtrue
Abstract/Results: ABSTRACT:
Balancing the quantity and quality of dietary protein relative to other nutrients is a key determinant of evolutionary fitness. A theoretical framework for defining a balanced diet would both reduce the enormous workload to optimize diets empirically and represent a breakthrough toward tailoring diets to the needs of consumers. Here, we report a simple and powerful in silico technique that uses the genome information of an organism to define its dietary amino acid requirements. We show for the fruit fly Drosophila melanogaster that such “exome-matched” diets are more satiating, enhance growth, and increase reproduction relative to non-matched diets. Thus, early life fitness traits can be enhanced at low levels of dietary amino acids that do not impose a cost to lifespan. Exome matching also enhanced mouse growth, indicating that it can be applied to other organisms whose genome sequence is known.
Accessibility: Document exists in file
Language:
eng
Author:
Piper, M. D.
Secondary author(s):
Soultoukis, G., Blanc, E., Mesaros, A., Herbert, S., He, X., Juricic, P., Salmonowicz, H., Yang, M., Simpson, S. J., Ribeiro, C., Partridge, L.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Piper, M. D. W., Soultoukis, G. A., Blanc, E., Mesaros, A., Herbert, S. L., He, X., Juricic, P., Salmonowicz, H., Yang, M., Simpson, S. J., Ribeiro, C., & Partridge, L. (2017). Exome matching: a novel in silico approach to optimise dietary amino acid balance for growth and reproduction. Cell Metabolism, 25(3), 610-621. https://doi.org/10.1016/j.cmet.2017.02.005
2-year Impact Factor: 20.565|2017
Times cited: 87|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Nutrition / Diet

Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan

Matching dietary amino acid balance to the in silico-translated exome optimizes growth and reproduction without cost to lifespan