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DocumentRight structural and functional reorganization in four-year-old children with perinatal arterial ischemic stroke predict language production2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-244
Location: BF-GMS
Title:
244 - Induced brain plasticity after perinatal stroke: structural and functional connectivity
Duration: 2015-02 - 2017-09
Researcher(s):
Antoni Rodriguez-Fornells, Alfredo García-Alix, Carme Fons, Clément François, Jordi Muchart, Laura Bosch, Mónica Rebollo, Pablo Ripollés
Institution(s): Department of Basic Psychology, University of Barcelona (Spain); Hospital Sant Joan de Deu, Esplugues de Llobregat (Spain)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Rodriguez-Fornells, A.
Secondary author(s):
García-Alix, A., Fons, C., François, C., Muchart, J., Bosch, L., Rebollo, M., Ripollés, P.
Number of reproductions:
1
Keywords:
Perinatal stroke / Brain plasticity / Language development / NeuroImaging / Psychophysiology

Reference code: PT/FB/BL-2014-244.04
Location: BF-GMS
Title:
Right structural and functional reorganization in four-year-old children with perinatal arterial ischemic stroke predict language production
Publication year: 2019
URL:
https://www.eneuro.org/content/6/4/ENEURO.0447-18.2019.long
Abstract/Results: ABSTRACT:
Brain imaging methods have contributed to shed light on the mechanisms of recovery after early brain insult. The assumption that the unaffected right hemisphere can take over language functions after left perinatal stroke is still under debate. Here, we report how patterns of brain structural and functional reorganization were associated with language outcomes in a group of four-year-old children with left perinatal arterial ischemic stroke (PAIS). Specifically, we gathered specific fine-grained developmental measures of receptive and productive aspects of language as well as standardized measures of cognitive development. We also collected structural neuroimaging data as well as functional activations during a passive listening story-telling fMRI task and a resting state session (rs-fMRI). Children with a left perinatal stroke showed larger lateralization indices of both structural and functional connectivity of the dorsal language pathway towards the right hemisphere that, in turn, were associated with better language outcomes. Importantly, the pattern of structural asymmetry was significantly more right-lateralized in children with a left perinatal brain insult than in a group of matched healthy controls. These results strongly suggest that early lesions of the left dorsal pathway and the associated perisylvian regions can induce the interhemispheric transfer of language functions to right homolog regions. This study provides combined evidence of structural and functional brain reorganization of language networks after early stroke with strong implications for neurobiological models of language development.
Accessibility: Document exists in file
Language:
eng
Author:
François, C.
Secondary author(s):
Ripollés, P. , Ferreri, L. , Muchart, J. , Sierpowska, J. , Fons, C. , Solé, J. , Rebollo, M. , Zatorre, R. J. , Garcia-Alix, A. , Bosch, L. , Rodriguez-Fornells, A.
Document type:
Article
Number of reproductions:
1
Reference:
François, C., Ripollés, P., Ferreri, L., Muchart, J., Sierpowska, J., Fons, C., ... Rodriguez-Fornells, A. (2019). Right structural and functional reorganization in four-year-old children with perinatal arterial ischemic stroke predict language production. eNeuro, 6(4). https://doi.org/10.1523/ENEURO.0447-18.2019
2-year Impact Factor: 3.544|2019
Times cited: 19|2025-02-13
Indexed document: Yes
Quartile: Q2
Keywords: Diffusion tensor imaging / fMRI / Hyperconnectivity / Interhemispheric plasticity / Language production / Perinatal arterial ischemic stroke

Right structural and functional reorganization in four-year-old children with perinatal arterial ischemic stroke predict language production

Right structural and functional reorganization in four-year-old children with perinatal arterial ischemic stroke predict language production
DocumentSignatures of brain plasticity supporting language recovery after perinatal arterial ischemic stroke2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-244
Location: BF-GMS
Title:
244 - Induced brain plasticity after perinatal stroke: structural and functional connectivity
Duration: 2015-02 - 2017-09
Researcher(s):
Antoni Rodriguez-Fornells, Alfredo García-Alix, Carme Fons, Clément François, Jordi Muchart, Laura Bosch, Mónica Rebollo, Pablo Ripollés
Institution(s): Department of Basic Psychology, University of Barcelona (Spain); Hospital Sant Joan de Deu, Esplugues de Llobregat (Spain)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Rodriguez-Fornells, A.
Secondary author(s):
García-Alix, A., Fons, C., François, C., Muchart, J., Bosch, L., Rebollo, M., Ripollés, P.
Number of reproductions:
1
Keywords:
Perinatal stroke / Brain plasticity / Language development / NeuroImaging / Psychophysiology

Reference code: PT/FB/BL-2014-244.05
Location: BF-GMS
Title:
Signatures of brain plasticity supporting language recovery after perinatal arterial ischemic stroke
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S0093934X20301395
Abstract/Results: ABSTRACT:
Brain imaging methods such as functional Magnetic Resonance Imaging (fMRI) and Diffusion Tensor Imaging (DTI) have already been used to decipher the functional and structural brain changes occurring during normal language development. However, little is known about the differentiation of the language network after an early lesion. While in adults, stroke over the left hemisphere generally induces post-stroke aphasia, it is not always the case when a stroke occurs in the perinatal period, thus revealing a remarkable plastic power of the language network during early development. In particular, the role of perilesional tissues, as opposed to undamaged brain areas in the functional recovery of language functions after an early insult, remains unclear. In this review article, we provide an overview of the extant literature using functional and structural neuroimaging data revealing the signatures of brain plasticity underlying near-normal language development.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
François, C.
Secondary author(s):
Garcia-Alix, A., Bosch, L., Rodriguez-Fornells, A.
Document type:
Article
Number of reproductions:
1
Reference:
François, C., Garcia-Alix, A., Bosch, L., & Rodriguez-Fornells, A. (2021). Signatures of brain plasticity supporting language recovery after perinatal arterial ischemic stroke. Brain and Language, 212, 10488. https://doi.org/10.1016/j.bandl.2020.104880
2-year Impact Factor: 2.781|2021
Times cited: 11|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Language recovery / Perinatal arterial ischemic stroke / Functional Magnetic Resonance Imaging / Diffusion tensor imaging / Brain plasticity
DocumentConsistent altered internal capsule white matter microstructure in insomnia disorder2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.11
Title: Consistent altered internal capsule white matter microstructure in insomnia disorder
Publication year: 2020
URL:
https://academic.oup.com/sleep/article/43/8/zsaa031/5775301
Abstract/Results: ABSTRACT:
Study Objectives: Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls.
Methods: 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case-control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity.
Results: FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (beta = -9.76e(-3); SE = 4.17e(-3), p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (beta = -8.05e(- 4) FA/ISI point, SE = 2.60e(- 4), p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons.
Conclusions: The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia.
Accessibility: Document exists in file
Language:
eng
Author:
Bresser, T.
Secondary author(s):
Foster-Dingley, J. C., Wassing, R., Leerssen, J., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., van den Heuvel, M., van Someren, E. J. W,
Document type:
Article
Number of reproductions:
1
Reference:
Bresser, T., Foster-Dingley, J. C., Wassing, R., Leerssen, J., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., van den Heuvel, M.,& van Someren, E. J. W. (2020). Consistent altered internal capsule white matter microstructure in insomnia disorder. Sleep, 43(8): zsaa031. https://doi.org/10.1093/sleep/zsaa031
2-year Impact Factor: 5.849|2020
Times cited: 13|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia disorder / White matter / Internal capsule / Diffusion tensor imaging / Fractional anisotropy

Consistent altered internal capsule white matter microstructure in insomnia disorder

Consistent altered internal capsule white matter microstructure in insomnia disorder
DocumentSchizophrenia polygenic risk score influence on white matter microstructure2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.06
Location: BF-GMS
Title:
Schizophrenia polygenic risk score influence on white matter microstructure
Publication year: 2020
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0022395619307137
Abstract/Results: ABSTRACT:
Schizophrenia (SZ) and bipolar disorder (BD) are highly heritable, share symptomatology, and have a polygenic architecture. The impact of recent polygenic risk scores (PRS) for psychosis, which combine multiple genome-wide associated risk variations, should be assessed on heritable brain phenotypes also previously associated with the illnesses, for a better understanding of the pathways to disease. We have recently reported on the current SZ PRS's ability to predict 1st episode of psychosis case-control status and general cognition. Herein, we test its penetrance on white matter microstructure, which is known to be impaired in SZ, in BD and their relatives, using 141 participants (including SZ, BP, relatives of SZ or BP patients, and healthy volunteers), and two white matter integrity indexes: fractional anisotropy (FA) and mean diffusivity (MD). No significant correlation between the SZ PRS and FA or MD was found, thus it remains unclear whether white matter changes are primarily associated with SZ genetic risk profiles.
Accessibility: Document does not exist in file
Language:
eng
Author:
Simões, B.
Secondary author(s):
Vassos, E., Shergill, S., McDonald, C., Toulopoulou, T., Kalidindi, S., Kane, F., Murray, R, Bramon, E., Ferreira, H., Prata, D.
Document type:
Article
Number of reproductions:
1
Reference:
Simões, B., Vassos, E., Shergill, S., McDonald, C., Toulopoulou, T., Kalidindi, S., Kane, F., Murray, R., Bramon, E., Ferreira, H., & Prata, D. (2020). Schizophrenia polygenic risk score influence on white matter microstructure. Journal of Psychiatric Research, 121, 62-67. https://doi.org/10.1016/j.jpsychires.2019.11.011
2-year Impact Factor: 4.791|2020
Impact factor notes: Impact factor not available yet for 2020
Times cited: 11|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Polygenic risk score / PRS / Schizophrenia / Bipolar disorder / White matter / Diffusion tensor imaging / Psychosi / Fractional anisotropy / Mean diffusivity / GWA / Genome-wide association
DocumentSmall vessel disease and cognitive impairment: The relevance of central network connections2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-220
Location: Arquivo PCA - Pasta 15/2012
Title:
220 - Consciousness disconnects during sleep
Duration: 2013-04 - 2016-05
Researcher(s):
Giovanni Piantoni
Institution(s): Cortical Physiology Lab, Massachusets General Hospital, Harvard Medical School (USA) and Netherlands Institute for Neuroscience, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final reports
1 article
Submitted papers
Language: eng
Author:
Piantoni, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams

Reference code: PT/FB/BL-2012-220.11
Location: Arquivo PCA - Pasta 15/2012
Title:
Small vessel disease and cognitive impairment: The relevance of central network connections
Publication year: 2016
URL:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905790/
Abstract/Results: ABSTRACT:
Central brain network connections greatly contribute to overall network efficiency. Here we examined whether small vessel disease (SVD) related white matter alterations in central brain network connections have a greater impact on executive functioning than alterations in non-central brain network connections. Brain networks were reconstructed from diffusion-weighted MRI scans in 72 individuals (75 ± 8 years) with cognitive impairment and SVD on MRI. The centrality of white matter connections in the network was defined using graph theory. The association between the fractional anisotropy (FA) of central versus non-central connections, executive functioning, and markers of SVD was evaluated with linear regression and mediation analysis. Lower FA in central network connections was more strongly associated with impairment in executive functioning than FA in non-central network connections (r = 0.41 vs. r = 0.27; P < 0.05). Results were consistent across varying thresholds to define the central subnetwork (>50%–10% connections). Higher SVD burden was associated with lower FA in central as well as non-central network connections. However, only central network FA mediated the relationship between white matter hyperintensity volume and executive functioning [change in regression coefficient after mediation (95% CI): -0.15 (-0.35 to -0.02)]. The mediation effect was not observed for FA alterations in non-central network connections [-0.03 (-0.19 to 0.04)]. These findings suggest that the centrality of network connections, and thus their contribution to global network efficiency, appears to be relevant for understanding the relationship between SVD and cognitive impairment.
Accessibility: Document exists in file
Language:
eng
Author:
Reijmer, Y. D.
Secondary author(s):
Fotiadis, P., Piantoni, G., Boulouis, G., Kelly, K. E., Gurol, M. E., Leemans, A., O'Sullivan, M. J., Greenberg, S. M., Viswanathan, A
Document type:
Article
Number of reproductions:
1
Reference:
Reijmer, Y. D., Fotiadis, P., Piantoni, G., Boulouis, G., Kelly, K. E., Gurol, M. E., Leemans, A., O'Sullivan, M. J., Greenberg, S. M., & Viswanathan, A. (2016). Small vessel disease and cognitive impairment: The relevance of central network connections. Human Brain Mapping, 37(7), 2446-2454. https://doi.org/10.1002/hbm.23186
2-year Impact Factor: 4.530|2016
Times cited: 35|2025-02-11
Indexed document: Yes
Quartile: Q1
Keywords: Diffusion tensor imaging / Vascular brain injury / Cognition / White matter / Executive function

Small vessel disease and cognitive impairment: The relevance of central network connections

Small vessel disease and cognitive impairment: The relevance of central network connections
DocumentConsistent altered internal capsule white matter microstructure in insomnia disorder2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-252
Location: SEC PCA 252/12
Title:
252 - Sleep state misperception mispercieved
Duration: 2014-06 - 2017-01
Researcher(s):
Eus J. W. Van Someren, J. Ramautar
Institution(s): Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress reports
Final reports
2 Articles
Language: eng
Author:
Van Someren, E.
Secondary author(s):
Ramautar, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Cognitive processes / Memory / Consciousness

Reference code: PT/FB/BL-2012-252.08
Location: BF-GMS
Title:
Consistent altered internal capsule white matter microstructure in insomnia disorder
Publication year: 2020
URL:
https://pubmed.ncbi.nlm.nih.gov/32123914/
Abstract/Results: Abstract
Study objectives: Suggested neural correlates of insomnia disorder have been hard to replicate. Even the most consistent finding, altered white matter microstructure in the anterior limb of the internal capsule, is based on handful studies. The urge for replicable targets to understand the underlying mechanisms of insomnia made us study white matter fractional anisotropy (FA) across three samples of cases and controls.
Methods: 3-Tesla MRI diffusion tensor imaging data of three independent samples were combined for analysis, resulting in n = 137 participants, of whom 73 were diagnosed with insomnia disorder and 64 were matched controls without sleep complaints. Insomnia severity was measured with the Insomnia Severity Index (ISI). White matter microstructure was assessed with FA. White matter tracts were skeletonized and analyzed using tract-based spatial statistics. We performed a region-of-interest analysis using linear mixed-effect models to evaluate case-control differences in internal capsule FA as well as associations between internal capsule FA and insomnia severity.
Results: FA in the right limb of the anterior internal capsule was lower in insomnia disorder than in controls (ß = -9.76e-3; SE = 4.17e-3, p = .034). In the entire sample, a higher ISI score was associated with a lower FA value of the right internal capsule (ß = -8.05e- 4 FA/ISI point, SE = 2.60e- 4, p = .008). Ancillary whole brain voxel-wise analyses showed no significant group difference or association with insomnia severity after correction for multiple comparisons.
Conclusions: The internal capsule shows small but consistent insomnia-related alterations. The findings support a circuit-based approach to underlying mechanisms since this tract connects many brain areas previously implicated in insomnia.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
Bresser, T.
Secondary author(s):
Foster-Dingley, J. C., Wassing, R., Leerssen, J., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., van den Heuvel, M., van Someren, E. J. W.
Document type:
Article-d
Number of reproductions:
1
Reference:
Bresser, T., Foster-Dingley, J. C., Wassing, R., Leerssen, J., Ramautar, J. R., Stoffers, D., Lakbila-Kamal, O., van den Heuvel, M.,& van Someren, E. J. W. (2020). Consistent altered internal capsule white matter microstructure in insomnia disorder. Sleep, 43(8): zsaa031. https://doi.org/10.1093/sleep/zsaa031
2-year Impact Factor: 5.849|2020
Times cited: 13|2025-02-14
Indexed document: Yes
Quartile: Q1
Keywords: Diffusion tensor imaging / Fractional anisotropy / Insomnia disorder / Internal capsule / White matter
DocumentVariability in white matter structure relates to hallucination proneness2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-146
Location: BF-GMS
Title:
146 - The me and the I: Dissociating ownership and agency in sensorimotor processing
Duration: 2021-09
Researcher(s):
Ana Pinheiro, Sonja Kotz, Michael Schwartze
Institution(s): Centro de Investigação em Ciência Psicológica - CICPSI, Faculdade de Psicologia da Universidade de Lisboa (Portugal); Faculty of Psychology and Neuroscience, University of Maastricht (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Article
Language: eng
Notes:
Ongoing project
Author: Pinheiro, A. P.
Secondary author(s):
Kotz, S., Schwartze, M.
Number of reproductions:
1
Keywords:
Self / Agency / Ownership / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2020-146.04
Location: BF-GMS
Title:
Variability in white matter structure relates to hallucination proneness
Publication year: 2024
URL:
https://doi.org/10.1016/j.nicl.2024.103643
Abstract/Results: ABSTRACT:
Hallucinations are a prominent transdiagnostic psychiatric symptom but are also prevalent in individuals who do not require clinical care. Moreover, persistent psychosis-like experience in otherwise healthy individuals may be related to an increased risk to transition to a psychotic disorder. This suggests a common etiology across clinical and non-clinical individuals along a multidimensional psychosis continuum that may be detectable in structural variations of the brain. The current diffusion tensor imaging study assessed 50 healthy individuals (35 females) to identify possible differences in white matter associated with hallucination proneness (HP). This approach circumvents potential confounds related to medication, hospitalization, and disease progression common in clinical individuals. We determined how HP relates to white matter structure in selected association, commissural, and projection fiber pathways putatively linked to psychosis. Increased HP was associated with enhanced fractional anisotropy (FA) in the right uncinate fasciculus, the right anterior and posterior arcuate fasciculus, and the corpus callosum. These findings support the notion of a psychosis continuum, providing first evidence of structural white matter variability associated with HP in healthy individuals. Furthermore, alterations in the targeted pathways likely indicate an association between HP-related structural variations and the putative salience and attention mechanisms that these pathways subserve.
Accessibility: Document exists in file
Language:
eng
Author:
Johnson, J. F.
Secondary author(s):
Schwartze, M., Belyk, M., Pinheiro, A. P., Kotz, S. A.
Document type:
Article
Number of reproductions:
1
Reference:
Johnson, J. F., Schwartze, M., Belyk, M., Pinheiro, A. P., & Kotz, S. A. (2024). Variability in white matter structure relates to hallucination proneness. NeuroImage Clinical, 43, 103643. https://doi.org/10.1016/j.nicl.2024.103643
2-year Impact Factor: 3.4|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 1|2025-02-19
Indexed document: Yes
Quartile: Q2
Keywords: Diffusion tensor imaging / Hallucination / Psychosis-like experience / White matter / Cerebellum

Variability in white matter structure relates to hallucination proneness

Variability in white matter structure relates to hallucination proneness