Processing, please wait...
Database
search
in
Filter year from
to
Language
Country
  • Enter your search phrase in the search box.
  • General search:
    • The Boolean operator AND between the terms is assumed by default. If you enter the words European Union in the search box, the system returns all records in which both words occur, regardless of their order.
    • When entering a set of words in quotes, e.g "european union", all records containing the literal term "European Union" will be retrieved.
  • Search by access fields (e.g. author, title, etc.):
    • To direct your search, choose the field in which you want to search the word or expression.
    • Search in the field assumes by default the expression in quotes, e.g. European union will retrieve all records containing the literal term "European Union"
  • To perform more complex searches, additional words or expressions may be added.
  • If you want to refine the search results, you can always access the link "search" in the upper left corner of the page of search results.
  • The search engine is not case sensitive. For example, the word congress has the same meaning that Congress or CONGRESS.
  • To truncate your search expression, use the $ character
  • You can filter the results of your search by a date or date range, filling the appropriate boxes.
Base:
BIAL Foundation
Search:
DE:"Dopamine"
Results
1
to
20
from
23
found.
12
View
Selection Description
Type Title Begin End
DocumentEstudo da relação entre memória de curto prazo e percepção subjectiva de tempo, usando como modelo a doença de Parkinson [Time perception: efect of aging and Parkinsonism]2004

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-1998
Location: Arquivo PCA - Pastas 1 a 11/1998
Title:
1998 Grants
Start date: 1999-01 - 2005-12
Dimension/support:
11 caixas de arquivo

Reference code: PT/FB/BL-1998-059
Location: Arquivo PCA - Pasta 7/1998
Title:
059 - Estudo da relação entre memória de curto prazo e percepção subjectiva de tempo, usando como modelo a doença de Parkinson
Duration: 1999-01 - 2002-06
Researcher(s):
Isabel Pavão Martins, Joaquim José Ferreira, Miguel Vilhena Soares Coelho
Institution(s): Centro Estudos Egas Moniz / H. Sta. Maria, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Unpublished document (oral communication)
Language: por
Author:
Martins, I. P.
Secondary author(s):
Ferreira, J., Coelho, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Memory / Perception / Neurodegenerative disorders / Parkinson's disease / Developmental psychology

Reference code: PT/FB/BL-1998-059.09
Location: Arquivo PCA - Pasta 7/1998
Title:
Estudo da relação entre memória de curto prazo e percepção subjectiva de tempo, usando como modelo a doença de Parkinson [Time perception: efect of aging and Parkinsonism]
Publication year: 2004
URL:
http://www.bial.com/pt/fundacao_bial.11/simposios.19/edicoes_anteriores.75/5%C2%BA_simposio.a111.html
Abstract/Results: ABSTRACT:
Studies concerning time perception lack a validated assessment tool and a consensual “gold-standard” measure. Moreover, the present evidence suggests modification of timing with aging. This study aimed to develop and validate a neuropsychological tool to measure time perception and to study temporal perception with aging. Eighty-six healthy subjects, aged 15-90 years-old, were asked to verbally estimate and produce empty intervals signaled by auditory beeps, of 7, 32 and 58 seconds duration. Two tests were used as “gold-standards”: estimating the duration of time necessary to draw a clock (“clock time”) and estimation of the duration of neuropsychological evaluation (“global time”). Results showed a correlation between estimation and production (p<0.01) and a correlation between estimation or production and “global time” (p<0.01). The
correlation between either estimation or production and age (p<0.01), indicated a faster “internal-clock” with aging. A comparison between three age groups (15-40 yrs-old; 41-64 yrs-old; 65-90 yrs-old) showed a trend toward time overestimation and underproduction with older age, reaching significance between the extreme age groups (p< 0.05). The results suggest that these tests are potentially a useful tool to measure the subjective perception of time and corroborate the hypothesis of an acceleration of “internal-clock” with aging. In other study, ten patients with Parkinson`s disease and “wearing-off” and no dementia performed
the above tasks for time estimation and production; patients were evaluated in the “ON” and “OFF” stage. We found no difference between patients and controls. In a sub-group analysis, two different behaviors emerged: a subgroup of patients had a faster “internal-clock” during “ON” stage while other had a faster “internal-clock” off levodopa, but this difference did not reach statistical significance. Further studies are needed to investigate the role of dopamine in time perception.
Accessibility: Document does not exist in file
Language:
eng
Author:
Martins, I. P.
Secondary author(s):
Ferreira, J., Coelho, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Martins, I. P., Ferreira, J., & Coelho, M. (2004). Time perception: effect of aging and Parkinsonism. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 5th Symposium of Fundação Bial (pp. 284-285). Porto: Fundação Bial.
Indexed document: No
Keywords: Psychophysiology / Time perception / Aging / Parkinson's disease / Dopamine

Time perception: effect of aging and Parkinsonism

Time perception: effect of aging and Parkinsonism

DocumentLearning impairments and dopaminergic changes in monoarthritic rats2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.11
Location: Arquivo PCA - Pasta 19/2004
Title:
Learning impairments and dopaminergic changes in monoarthritic rats
Publication year: 2008
Accessibility:
Document exists in file (in attachment to the final report)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pais-Vieira, M.
Secondary author(s):
Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Pais-Vieira, M., Mendes-Pinto, M., Lima, D., & Galhardo, V. (2008). Learning impairments and dopaminergic changes in monoarthritic rats [Unpublished document].
Indexed document: No
Keywords: Monoarthritis / Complete Freund's adjuvant / Dopamine / Hippocampus / Orbitofrontal cortex / Learning / Working memory / Reference memory

Learning impairments and dopaminergic changes in monoarthritic rats

Learning impairments and dopaminergic changes in monoarthritic rats

DocumentFinal report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-031
Location: Arquivo PCA - Pasta 17/2006
Title:
031 - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Duration: 2007-04 - 2010-09
Researcher(s):
Caroline Dalton, Jeff Breckon, Robert Copeland, Brian Hall, Gavin Reynolds
Institution(s): Biomedical Research Centre and Centre for Sport and Exercise Science, Faculty of Health and Wellbeing, Sheffield (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Poster
Language: eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Obesity / Intervention / Motivation

Reference code: PT/FB/BL-2006-031.01
Location: Arquivo PCA - Pasta 17/2006
Title:
Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme
Publication year: 2010
URL:
http://www.bial.com/imagem/Bolsa3106.pdf
Abstract/Results: RESULTS:
The overall aim of this study was to investigate the influence of serotonin and dopamine receptor gene polymorphisms on various parameters relevant to the successful participation of obese people taking part in a diet and exercise obesity intervention. We demonstrated that serotonin receptor gene genotype has a significant influence on perception of hunger. We also showed that dopamine receptor gene polymorphisms significantly influence the drop out rate from an obesity intervention study, and suggest that this is due to the influence of these polymorphisms both on motivation to exercise and on restrained eating behaviours. Finally we demonstrated the efficacy of motivational interviewing in an obesity intervention programme and have shown that motivational interviews influence the relationship between measures of motivation or eating behaviours and weight loss measured by BMI change These novel findings indicate that serotonin plays a key role in determining appetite. They also indicate that extent of dopamine signalling may influence an individual's motivation to engage in weight-loss programmes. Further studies are required to confirm these findings and investigate the underlying mechanisms involved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Dalton, C.
Secondary author(s):
Breckon, J., Copeland, R., Hall, B., Reynolds, G.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Genotype / Obesity / Motivation / Intervention program / Serotonin / Dopamine / Weight loss

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

Final report - The use of a biological marker, 5-HT2C genotype, as a predictor of motivation, adherence and weight loss in participants of an obesity intervention programme

DocumentMovement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.03
Location: Arquivo PCA - Pasta 17/2006
Title:
Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?
Publication year: 2012
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8443224
Abstract/Results: ABSTRACT:
BACKGROUND:
Both involuntary dyskinetic movements and psychotic-like experiences (PLEs) are reported to be antecedents of schizophrenia that may reflect dysfunctional dopaminergic activity in the striatum. The present study compared dyskinetic movement abnormalities displayed by children with multiple antecedents of schizophrenia (ASz), including speech and/or motor developmental lags or problems, internalising/externalising problems in the clinical range, and PLEs, with those displayed by children with no antecedents (noASz).
METHOD:
The sample included 21 ASz and 31 noASz children, aged 9-12 years old. None had taken psychotropic medication or had relatives with psychosis. The antecedents of schizophrenia were assessed using questionnaires completed by children and caregivers. A trained rater, blind to group status, coded dyskinetic movement abnormalities using a validated tool from videotapes of interviews with the children.
RESULTS:
ASz children reported, on average, 'certain experience' of 2.5 PLEs, while noASz children, by definition, reported none. The ASz children, as compared with noASz children, displayed significantly more dyskinetic movement abnormalities in total, and in the facial and the upper-body regions, after controlling for sex and age. Receiver operator characteristics analyses yielded high area under the curve values for the total score (0.94), facial score (0.91) and upper-body score (0.86), indicating that these scores distinguished between the ASz and noASz children with great accuracy.
CONCLUSIONS:
Brief questionnaires identified children with multiple antecedents of schizophrenia who displayed significantly more involuntary dyskinetic movement abnormalities than children without antecedents. The presence of PLEs and dyskinesias could reflect early disruption of striatal dopamine circuits.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
MacManus, D.
Secondary author(s):
Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., Hodgins, S.
Document type:
Article
Number of reproductions:
1
Reference:
MacManus, D., Laurens, K. R., Walker, E. F., Brasfield, J., Riaz, M., & Hodgins, S. (2012). Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia? Psychological Medicine, 42(1), 99-109. doi: 10.1017/S0033291711001085
2-year Impact Factor: 5.587|2012
Times cited: 21|2021-05-14
Indexed document: Yes
Quartile: Q1
Keywords: Antecedents / Dopamine / Dyskinesia / Psychosis / Risk factors

Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

Movement abnormalities and psychotic-like experiences in childhood: Markers of developing schizophrenia?

DocumentRodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.03
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3189637/
Abstract/Results: ABSTRACT:
Impaired decision-making is a core problem in several psychiatric disorders including attention-deficit/hyperactivity disorder, schizophrenia, obsessive–compulsive disorder, mania, drug addiction, eating disorders, and substance abuse as well as in chronic pain. To ensure progress in the understanding of the neuropathophysiology of these disorders, animal models with good construct and predictive validity are indispensable. Many human studies aimed at measuring decision-making capacities use the Iowa gambling task (IGT), a task designed to model everyday life choices through a conflict between immediate gratification and long-term outcomes. Recently, new rodent models based on the same principle have been developed to investigate the neurobiological mechanisms underlying IGT-like decision-making on behavioral, neural, and pharmacological levels. The comparative strengths, as well as the similarities and differences between these paradigms are discussed. The contribution of these models to elucidate the neurobehavioral factors that lead to poor decision-making and to the development of better treatments for psychiatric illness is considered, along with important future directions and potential limitations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
De Visser, L.
Secondary author(s):
Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., Fitoussi, A., Galhardo, V., Van den Boos, R., Winstanley, C., Dellu-Hagedorn, F.
Document type:
Article
Number of reproductions:
1
Reference:
De Visser, L., Homberg, J., Mitsogiannis, M., Zeeb, F., Rivalan, M., ..., Dellu-Hagedorn, F. (2011). Rodent Versions of the Iowa Gambling Task: Opportunities and Challenges for the Understanding of Decision-Making. Frontiers in Neuroscience, 5, 109. doi: 10.3389/fnins.2011.00109
Impact factor notes: Impact factor computed since 2014
Times cited: 102|2021-05-18
Indexed document: Yes
Keywords: Iowa gambling task (IGT) / Animal models / Validity / Dopamine / Serotonin / Neurobiology

Novo ficheiro

Novo ficheiro

DocumentO-41 - Intravascular food reward2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.02
Location: Arquivo PCA - Pasta 14/2010
Title:
O-41 - Intravascular food reward
Publication year: 2012
URL:
http://www.sciencedirect.com/science/article/pii/S092493381274141X
Abstract/Results: ABSTRACT:
INTRODUCTION:
We recently found that, in mice, independently of orosensory input, sucrose consumption is sufficient to condition the development of spout preferences and dopamine release in the ventral striatum.
OBJECTIVES:
To clarify if the appetitive behavioral and dopaminergic responses to the postingestive effects of calorie-containing sugars reflect preabsorptive or postabsorptive events.
AIMS:
To understand if endovenous injection of glucose is sufficient to condition spout preferences and dopamine release.
METHODS:
Measurements of the behavioural, metabolic and neurochemical effects of the administration of glucose solutions, enterically, and in the jugular (JV) or hepatic-portal (HPV) veins of rats.
RESULTS:
High concentration glucose solutions administered in the JV were sufficient to condition spout preferences in a two-bottle behavioral task. Additionally, a low concentration glucose solution conditioned robust behavioral responses when administered in the HPV, but not the JV. Finally, using fast-scan cyclic voltammetry we found that, in accordance to behavioral findings, a low concentration glucose solution caused an increase of spontaneous dopamine release events in the nucleus accumbens shell when administered in the HPV, but not the JV.
CONCLUSIONS:
The postabsorptive effects of glucose are sufficient to mimic the behavioral and dopaminergic responses that result from sugar consumption. Furthermore, glycemia levels in the HPV contribute more significantly for this effect than systemic glycemia, arguing for the participation of an intra-abdominal visceral sensor for glucose.
Accessibility: Document does not exist in file
Language:
eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Roberts, C. D., Walker, Q. D., Luo, B., Kuhn, C., Simon, A., Nicolelis, M.
Document type:
Abstract
Number of reproductions:
1
Reference:
Oliveira-Maia, A. J., Roberts, C. D., Walker, Q. D., Luo, B., Kuhn, C., Simon, A., & Nicolelis, M. (2012). O-41 - Intravascular food reward. European Psychiatry, 27(Suppl. 1), 1. doi: 10.1016/S0924-9338(12)74141-X
Indexed document: Yes
Keywords: Dopamine / Glucose

DocumentImpulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.04
Location: Arquivo PCA - Pasta 14/2010
Title:
Impulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience
Publication year: 2013
URL:
http://iospress.metapress.com/content/e1642885x17hu14n/?genre=article&issn=0953-4180&volume=27&issue=4&spage=547
Abstract/Results: ABSTRACT:
Non-motor symptoms contribute significantly to Parkinson's disease (PD) related disability. Impulse control disorders (ICDs) have been recently added to the behavioural spectrum of PD-related non-motor symptoms. Such behaviours are characterized by an inappropriate drive to conduct repetitive behaviours that are usually socially inadequate or result in harmful consequences. Parkinson disease impulse control disorders (PD-ICDs) have raised significant interest in the scientific and medical community, not only because of their incapacitating nature, but also because they may represent a valid model of ICDs beyond PD and a means to study the physiology of drive, impulse control and compulsive actions in the normal brain. In this review, we discuss some unresolved issues regarding PD-ICDs, including the association with psychiatric co-morbidities such as obsessive-compulsive disorder and with dopamine related side effects, such as hallucinations and dyskinesias; the relationship with executive cognitive dysfunction; and the neural underpinnings of ICDs in PD. We also discuss the contribution of neuroscience studies based on animal-models towards a mechanistic explanation of the development of PD-ICDs, specifically regarding corticostriatal control of goal directed and habitual actions.
Accessibility: Document does not exist in file
Language:
eng
Author:
Bugalho, P.
Secondary author(s):
Oliveira-Maia, A. J.
Document type:
Article
Number of reproductions:
1
Reference:
Bugalho, P., & Oliveira-Maia, A. J. (2013). Impulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience. Behavioural Neurology, 27(4), 547-557. doi: 10.3233/BEN-129019
2-year Impact Factor: 1.642|2013
Times cited: 11|2021-05-18
Indexed document: Yes
Quartile: Q3
Keywords: Parkinson's disease / Impulse control disorders / Non-motor symptoms / Frontostriatal circuits / Dopamine

Impulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience

Impulse control disorders in Parkinson's disease: crossroads between neurology, psychiatry and neuroscience

DocumentActivation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.20
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Activation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury
Publication year: 2014
URL:
http://www.jneurosci.org/content/34/17/5861.abstract
Abstract/Results: ABSTRACT:
Dopamine plays an important role in several forms of synaptic plasticity in the hippocampus, a crucial brain structure for working memory (WM) functioning. In this study, we evaluated whether the working-memory impairment characteristic of animal models of chronic pain is dependent on hippocampal dopaminergic signaling. To address this issue, we implanted multichannel arrays of electrodes in the dorsal and ventral hippocampal CA1 region of rats and recorded the neuronal activity during a food-reinforced spatial WM task of trajectory alternation. Within-subject behavioral performance and patterns of dorsoventral neuronal activity were assessed before and after the onset of persistent neuropathic pain using the Spared Nerve Injury (SNI) model of neuropathic pain. Our results show that the peripheral nerve lesion caused a disruption in WM and in hippocampus spike activity and that this disruption was reversed by the systemic administration of the dopamine D2/D3 receptor agonist quinpirole (0.05 mg/kg). In SNI animals, the administration of quinpirole restored both the performance-related and the task-related spike activity to the normal range characteristic of naive animals, whereas quinpirole in sham animals caused the opposite effect. Quinpirole also reversed the abnormally low levels of hippocampus dorsoventral connectivity and phase coherence. Together with our finding of changes in gene expression of dopamine receptors and modulators after the onset of the nerve injury model, these results suggest that disruption of the dopaminergic balance in the hippocampus may be crucial for the clinical neurological and cognitive deficits observed in patients with painful syndromes.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cardoso-Cruz, H.
Secondary author(s):
Dourado, M., Monteiro, M., Matos, M., Galhardo, V.
Document type:
Article
Number of reproductions:
1
Reference:
Cardoso-Cruz, H., Dourado, M., Monteiro, M., Matos, M., & Galhardo, V. (2014). Activation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury. Journal of Neuroscience, 34(17), 5861-5873. doi: 10.1523/JNEUROSCI.0021-14.2014
2-year Impact Factor: 6.344|2014
Times cited: 22|2021-05-18
Indexed document: Yes
Quartile: Q1
Keywords: Awake animal physiology / Dopamine / Hippocampus / Neuropathy / Pain / Working memory

Activation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury

Activation of dopaminergic d2/d3 receptors modulates dorsoventral connectivity in the hippocampus and reverses the impairment of working memory after nerve injury

DocumentFinal report - Dopaminergic regulation of dietary learning in humans and rodents2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.01
Location: Arquivo PCA - Pasta 14/2010
Title:
Final report - Dopaminergic regulation of dietary learning in humans and rodents
Publication year: 2014
URL:
https://www.bial.com/imagem/Bolsa17610_18112014.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
The postingestive effects of food stimulate food intake. Dopamine is critically involved in encoding food reward, including postingestive reward.
AIMS:
We proposed to explore the possibility of conditioning flavor-nutrient associations in humans and, in parallel, use invasive tools in mice to explore the relevance of dopaminergic neuron activity in the VTA for nutrient conditioning.
METHODS:
To test flavour-nutrient conditioning in human subjects, consumption levels and pleasantness ratings of flavoured yoghurts were recorded prior to and after a conditioning protocol where one flavour was paired to delivery of a tasteless carbohydrate. In mice, we established instrumental learning paradigms where postingestive feedback was isolated using intragastric infusion of sugars, contingent upon lever pressing, or using trpm5 KO mice, a transgenic model with deficits in orosensory processing of sweet taste. Finally, cell-type specific deletion of NMDAR1 was performed in VTA dopamine neurons to abolish phasic bursting of these neurons.
RESULTS:
In healthy human volunteers the conditioning process did not change flavour pleasantness ratings. However, after conditioning there was increased preference for carbohydrate-paired flavours when preference was calculated according to consumption levels, rather than pleasantness. In mice, caloric postingestive feedback was sufficient to sustain instrumental responses, and bursting activity of VTA dopamine neurons is necessary for such to occur.
CONCLUSIONS:
Nutrient value modulates instrumental responses and food choice independently of orosensory and olfactory cues, in a process that depends on activity patterns of VTA dopamine neurons.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Instrumental conditioning / Flavor-nutrient conditioning / Postingestive reward / Dopamine / Ventral tegmental area

File413 - The role of dopamine in behavioral exploration and action selection2015-032018-06

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

File442 - Neurochemical Substrates of Neurofeedback2016-042020-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-442
Location: BF-GMS
Title:
442 - Neurochemical Substrates of Neurofeedback
Duration: 2016-04 - 2020-09
Researcher(s):
Tomas Ros, Nathalie Ginovart
Institution(s): Interfacultary Center for Neuroscience, University of Geneva (Switzerland); Division of Nuclear Medicine, University Hospitals Geneva (Switzerland)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Ros, T.
Secondary author(s):
Ginovart, N
Number of reproductions:
1
Keywords:
Neurofeedback / Electroencephalogram / Positron emission tomography / Dopamine / Psychophysiology

DocumentSleep and Emotional Functions2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-225
Location: Arquivo PCA - Pasta 12/2012
Title:
225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration: 2013-10 - 2016-02
Researcher(s):
Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s): Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Schwartz, S.
Secondary author(s):
Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code: PT/FB/BL-2012-225.02
Location: Arquivo PCA - Pasta 12/2012
Title:
Sleep and Emotional Functions
Publication year: 2014
URL:
http://link.springer.com/chapter/10.1007%2F7854_2013_271
Abstract/Results: ABSTRACT:
In this chapter, we review studies investigating the role of sleep in emotional functions. In particular, evidence has recently accumulated to show that brain regions involved in the processing of emotional and reward-related information are activated during sleep. We suggest that such activation of emotional and reward systems during sleep underlies the reprocessing and consolidation of memories with a high affective and motivational relevance for the organism. We also propose that these mechanisms occurring during sleep promote adapted cognitive and emotional responses in the waking state, including overnight performance improvement, creativity, and sexual functions. Activation across emotional-limbic circuits during sleep also appears to promote emotional maturation and the emergence of consciousness in the developing brain.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Perogamvros, L.
Secondary author(s):
Schwartz, S.
Document type:
Article
Number of reproductions:
1
Reference:
Perogamvros, L., & Schwartz, S. (2014). Sleep and Emotional Functions. Current Topics in Behavioral Neurosciences, 25, 411-431. doi: 10.1007/7854_2013_271
Indexed document: Yes
Keywords: Sleep / Sleep deprivation / Dreaming / Emotion / Cognition / Reward / Sexual function / Creativity / Memory consolidation / Brain development / Amygdala / Prefrontal cortex / Hippocampus / Ventral tegmental area / Striatum / Nucleus accumbens / Dopamine / Limbic / Mesolimbic

Sleep and Emotional Functions

Sleep and Emotional Functions

DocumentThe power of suggestion: Placebo, hypnosis, imaginative suggestion and attention2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-248
Location: Arquivo PCA - Pasta 6/2012
Title:
248 - Using hypnosis to distinguish between cognitive and metacognitive conscious experience
Duration: 2013-10 - 2015-05
Researcher(s):
Pedro Alexandre Magalhães de Saldanha da Gama, Axel Cleeremans, Zoltan Dienes, Amir Raz
Institution(s): Université Libre de Bruxelles (Belgium)
Contents: Contents:
Application form
Correspondence
Article
Progress report
Final report
PhD thesis
Article
Language: eng
Author:
Gama, P.
Secondary author(s):
Cleeremans, A., Dienes, Z., Raz, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Decision-making / Consciousness / Altered states of consciousness / Hypnosis

Reference code: PT/FB/BL-2012-248.03
Location: Arquivo PCA - Pasta 6/2012
Title:
The power of suggestion: Placebo, hypnosis, imaginative suggestion and attention
Publication year: 2014
URL:
http://theses.ulb.ac.be/ETD-db/collection/available/ULBetd-02152015-111308/
Abstract/Results: ABSTRACT:
People have always been fascinated by the extent to which belief or will may influence behavior. Proverbs, like “we tend to get what we expect,” and concepts, such as optimistic thinking or self-fulfilling prophecy, reflect this intuition of an important link between one’s dispositions and subsequent behavior. In other words, one’s predictions directly or indirectly cause them to become true. In a similar manner, every culture, country or religion has their own words for ‘expectation,’ ‘belief,’ ‘disappointment,’ ‘surprise,’ and generally all have the same meaning: under uncertainty, what one expects or believes is the most likely to happen. This relation between what caused a reaction in the past will probably cause it again in the future might not be realistic. If the expected outcome is not confirmed, it may result in a personal ‘disappointment’, and if the outcome fits no expectations, it will be a ‘surprise’. Our brain is hardwired with this heuristic capacity of learning the cause-effect relationship and to project its probability as the basis for much of our behavior, as well as cognitions. This experience-based expectation is a form of learning that helps the brain to bypass an exhaustive search in finding a satisfactory solution. Expectations may thus be considered an innate theory of causality; that is, a set of factors (causes) generating a given phenomenon (effects) influence the way we treat incoming information but also the way we retrieve the stored information. These expectancy templates may well represent one of the basic rules of how the brain processes information, affecting the way we perceive the world, direct our attention and deal with conflicting information. In fact, expectations have been shown to influence our judgments and social interactions, along with our volition to individually decide and commit to a particular course of action. However, people’s expectations may elicit the anticipation of their own automatic reactions to various situations and behaviors cues, and can explain that expecting to feel an increase in alertness after coffee consumption leads to experiencing the consequent physiologic and behavioral states. We call this behavior-response expectancy. This non-volitional form of expectation has been shown to influence cognitions such as memory, pain, visual awareness, implicit learning and attention, through the mediation of phenomena like placebo effects and hypnotic behaviors. Importantly,when talking about expectations, placebo and hypnosis, it is important to note that we are also talking about suggestion and its modulating capability. In other words, suggestion has the power to create response expectancies that activate automatic responses, which will, in turn, influence cognition and behavior so as to shape them congruently with the expected outcome. Accordingly, hypnotic inductions are a systematic manipulation of expectancy, similar to placebo, and therefore they both work in a similar way. Considering such assumptions, the major question we address in this PhD thesis is to know if these expectancy-based mechanisms are capable of modulating more high-level information processing such as cognitive conflict resolution, as is present in the well-known Stroop task. In fact, in a recent series of studies, reduction or elimination of Stroop congruency effects was obtained through suggestion and hypnotic induction. In this PhD thesis, it is asked whether a suggestion reinforced by placebos, operating through response-expectancy mechanisms, is able to induce a top-down cognitive modulation to overcome cognitive conflict in the Stroop task, similar to those results found using suggestion and hypnosis manipulation.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Gama, P.
Document type:
Doctoral thesis
Number of reproductions:
1
Reference:
Gama, P. (2014). The power of suggestion: Placebo, hypnosis, imaginative suggestion and attention (Unpublished doctoral thesis). Université Libre de Bruxelles, Faculté des Sciences Psychologiques et de l’Education, Bélgium.
Indexed document: No
Keywords: Placebo effect / Hypnosis / Hypnotic Response / Hypnotizability / Placebo / Alertness / Hypnotic Susceptibility / Object-based Attentional Selection / Eye-Blink, Inhibition / Stroop effect / Waterloo-Stanford Group C (WSGC) scale / Stroop task / Attention / Cognitive Control / Attentional Networks / Dopamine / Suggestion / Stroop / Response expectancy / Expectancy / Expectations / Imagination / Suggestability / Suggestion

DocumentFinal report - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-225
Location: Arquivo PCA - Pasta 12/2012
Title:
225 - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Duration: 2013-10 - 2016-02
Researcher(s):
Sophie Schwartz, Lampros Perogamvros, Kristoffer Aberg, Virginie Sterpenich
Institution(s): Geneva Neuroscience Center, University of Geneva (Switzerland)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Article
Language: eng
Author:
Schwartz, S.
Secondary author(s):
Perogamvros, L., Aberg, K., Sterpenich, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Cognitive processes / Memory / Emotion / Brain structure and function

Reference code: PT/FB/BL-2012-225.01
Location: Arquivo PCA - Pasta 12/2012
Title:
Final report - Roles of the reward system in sleep, dreaming, and the consolidation of emotional memories
Publication year: 2016
URL:
https://www.bial.com/imagem/Grant22512.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES
We previously suggested that abnormal sleep behaviors, as found in parasomnias, may relate to an increased activity of the dopaminergic-reward system during sleep. Because nightmares and sleepwalking predominate during REM and NREM sleep respectively, here we tested whether exploratory excitability, a waking personality trait reflecting high activity within the mesolimbic dopaminergic system, is associated with changes in REM and NREM sleep in these two sleep disorders.
METHODS
24 unmedicated patients with parasomnia (12 with idiopathic nightmares, 12 sleepwalkers) were studied. Each patient spent one night of sleep monitored by polysomnography. The Temperament and Character Inventory (TCI) was administered to all patients and healthy controls from the Geneva population (n = 293).
RESULTS
Sleepwalkers were more anxious than patients with idiopathic nightmares (Spielberger Trait anxiety/STAI-T), but the patient groups did not differ on any personality dimension as estimated by the TCI. Compared to controls, all parasomnia patients scored higher on the Novelty Seeking (NS) TCI scale and in particular on the exploratory excitability/curiosity (NS1) subscale, and lower on the Self-directedness (SD) TCI scale, suggesting a general increase in reward sensitivity and impulsivity. Moreover, exploratory excitability (NS1) correlated with the severity of parasomnia, and time spent in REM sleep in patients with nightmares.
CONCLUSIONS
These results support the hypothesis that reward networks are activated during human sleep. By showing that patients with parasomnia share common waking personality traits associated to reward-related brain functions, these findings may inspire targeted therapeutic strategies.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Schwartz, S.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Sleep / Dreaming / Reward / Dopamine / Parasomnia

File292 - Oxytocin: On the psychophysiology of trust and cooperation2017-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Notes: This project hasn't started yet
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

DocumentFinal report - The role of dopamine in behavioral exploration and action selection2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.01
Location: BF-GMS
Title:
Final report - The role of dopamine in behavioral exploration and action selection
Publication year: 2018
URL:
https://www.bial.com/imagem/Grant_41314.pdf
Abstract/Results: ABSTRACT:
We are constantly faced with the trade-off between exploiting past actions with known outcomes and exploring novel actions whose outcomes may be better. This exploration-exploitation balance is thought to be influenced by dopaminergic neurons of the substantia nigra pars compacta (SNc) and noradrenergic neurons of the locus coeruleus (LC). However, little is known about SNc and LC network dynamics during exploration. We aimed to characterize dopaminergic and noradrenergic signaling during these distinct behavioral states. We developed a novel behavioral paradigm in mice to investigate exploratory and exploitative behavioural states. Mice were presented with three equidistant nose poke ports and had to explore the environment to discover a sequence of three nose pokes that was rewarded. We then performed calcium imaging in either the SNc or LC of freely behaving mice during performance of this task. Actions were variable as mice explored to find the rewarded sequence, but became stable as they learned to exploit the rewarded sequence. When the rewarded sequence was changed, mice returned to a more variable state. Dopaminergic networks expressed higher levels of sustained activity when mice were exploiting relative to exploring, and these differences could not be accounted for by low-level differences in reward occurrence. Conversely, noradrenergic networks exhibited higher levels of sustained activity when mice were exploring relative to exploiting. These experiments suggest that exploitation is associated with higher sustained levels of dopaminergic activity and lower sustained levels or noradrenergic activity, with potentially important consequences for downstream circuits.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Dopamine / Exploration / Action selection / Basal ganglia

Final report - The role of dopamine in behavioral exploration and action selection

Final report - The role of dopamine in behavioral exploration and action selection

DocumentDopaminergic network dynamics during behavioral exploration 2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.03
Location: BF-GMS
Title:
Dopaminergic network dynamics during behavioral exploration
Publication year: 2016
Abstract/Results:
ABSTRACT:
We are constantly faced with the trade-off between exploiting past actions with known outcomes and exploring novel actions whose outcomes may be better. When environmental rewards are stable, it is preferable to perform actions known to be rewarding. However, when environmental rewards are changeable, it is adaptive to explore alternative actions and revisit previous actions whose value may have changed. This exploration-exploitation balance is thought to be coded by dopaminergic neurons of the substantia nigra pars compacta (SNc). However, little is known about the ways in which environmental changes impact action selection, and even less is known about SNc network dynamics during exploration. We developed a novel behavioral paradigm in mice to investigate how changes in environmental stability affect behavioral variability. Mice were placed in environments with three equidistant nose poke ports and had to explore the environment to discover which sequence of three nose pokes was rewarded. Actions were variable as mice explored to find the rewarded sequence, but became stable as they learned to exploit the rewarded sequence. We then performed calcium imaging in freely behaving mice during task performance, which allowed us to simultaneously record activity in large populations of genetically-identified neurons and track the same populations throughout training. We saw an evolution of single-cell responses associated with task-relevant events over the course of learning. In addition, we observed changes in SNc network dynamics during periods of exploration versus periods of exploitation. These experiments support a role for dopaminergic networks in behavioral exploration.
Accessibility: Document exists in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Koralek, A. C., & Costa, R. M. (2016). Dopaminergic network dynamics during behavioral exploration. Poster presented at the Annual meeting of the Society for Neuroscience 2016, San Diego, CA. Abstract retrieved at http://www.abstractsonline.com/pp8/index.html#!/4071/presentation/29642
Indexed document: No
Keywords: Dopamine / Exploration / Exploitation

DocumentDopaminergic network dynamics during behavioral exploration2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-413
Location: BF-GMS
Title:
413 - The role of dopamine in behavioral exploration and action selection
Duration: 2015-03 - 2018-06
Researcher(s):
Aaron Christopher Koralek
Institution(s): Champalimaud Neuroscience Programme, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Article
Language: eng
Author:
Koralek, A. C.
Number of reproductions:
1
Keywords:
Dopamine / Action selection / Basal ganglia / In vivo imaging / Psychophysiology

Reference code: PT/FB/BL-2014-413.04
Location: BF-GMS
Title:
Dopaminergic network dynamics during behavioral exploration
Publication year: 2016
URL:
http://www.google.pt/url?sa=t&rct=j&q=&esrc=s&source=web&cd=4&cad=rja&uact=8&ved=0ahUKEwiVpfvo8dXbAhXJPBQKHXqjBm8QFgg9MAM&url=http%3A%2F%2Fareadne.org%2F2016%2Fpezaris-hatsopoulos-2016-areadne.pdf&usg=AOvVaw0R4Q3L9_gZpmO16OyVV1HH
Accessibility: Document exist in file
Language:
eng
Author:
Koralek, A. C.
Secondary author(s):
Costa, R. M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Koralek, A. C., & Costa, R. M. (2016). Dopaminergic network dynamics during behavioral exploration. in Pezaris , J. S. & Hatsopoulos, N. G. (Eds.), AREADNE Research in Encoding and Decoding of Neural Ensembles, Nomikos Conference Centre Santorini, Greece, 22-26 June 2016 (p. 85). Cambridge, Massachusetts, USA: The AREADNE Foundation, Inc.
Indexed document: No
Keywords: Dopamine / Exploration

Dopaminergic network dynamics during behavioral exploration

Dopaminergic network dynamics during behavioral exploration

DocumentTreating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-39
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2019.00248/full
Abstract/Results: ABSTRACT
BACKGROUND
There are few available therapeutic options to promote recovery among patients with chronic disorders of consciousness (DOC). Among pharmacological treatments, apomorphine, a dopamine agonist, has exhibited promising behavioral effects and safety of use in small-sample pilot studies. The true efficacy of the drug and its neural mechanism are still unclear. Apomorphine may act through a modulation of the anterior forebrain mesocircuit, but neuroimaging and neurophysiological investigations to test this hypothesis are scarce. This clinical trial aims to (1) assess the treatment effect of subcutaneous apomorphine infusions in patients with DOC, (2) better identify the phenotype of responders to treatment, (3) evaluate tolerance and side effects in this population, and (4) examine the neural networks underlying its modulating action on consciousness.
METHODS/DESIGN
This study is a prospective double-blind randomized parallel placebo-controlled trial. Forty-eight patients diagnosed with DOC will be randomized to receive a 30-day regimen of either apomorphine hydrochloride or placebo subcutaneous infusions. Patients will be monitored at baseline 30 days before initiation of therapy, during treatment and for 30 days after treatment washout, using standardized behavioral scales (Coma Recovery Scale-Revised, Nociception Coma Scale-Revised), neurophysiological measures (electroencephalography, body temperature, actigraphy) and brain imaging (magnetic resonance imaging, positron emission tomography). Behavioral follow-up will be performed up to 2 years using structured phone interviews. Analyses will look for changes in behavioral status, circadian rhythmicity, brain metabolism, and functional connectivity at the individual level (comparing before and after treatment) and at the group level (comparing apomorphine and placebo arms, and comparing responder and non-responder groups).
DISCUSSION
This study investigates the use of apomorphine for the recovery of consciousness in the first randomized placebo-controlled double-blind trial using multimodal assessments. The results will contribute to define the role of dopamine agonists for the treatment of these challenging conditions and identify the neural correlates to their action. Results will bring objective evidence to further assess the modulation of the anterior forebrain mesocircuit by pharmacological agents, which may open new therapeutic perspectives.
Accessibility: Document exists in file
Language:
eng
Author:
Sanz, L. R.
Secondary author(s):
Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., Farber, N. M., Zafonte, R. D., Schiff, N. D., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Reference:
Sanz, L. R., Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., ... Gosseries, O. (2019). Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments. Frontiers in Neurology, 10:248. doi: 10.3389/fneur.2019.00248
2-year Impact Factor: 2.889|2019
Times cited: 1|2021-05-20
Indexed document: Yes
Quartile: Q2
Keywords: Disorders of consciousness / Unresponsive wakefulness syndrome / Minimally conscious state / Apomorphine / Dopamine / Mesocircuit / Clinical trial / Protocol

Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments

Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments

DocumentPostingestive modulation of food seeking depends on vagus-mediated dopamine neuron activity2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-176
Location: Arquivo PCA - Pasta 14/2010
Title:
176 - Dopaminergic regulation of dietary learning in humans and rodents
Duration: 2011-07 - 2014-07
Researcher(s):
Albino Jorge Carvalho de Sousa Oliveira Maia, Rui M. Costa
Institution(s): Champalimaud Foundation, Lisbon (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Oliveira-Maia, A. J.
Secondary author(s):
Costa, R. M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Biopsychological problems / Diseases/Injuries / Obesity / Brain structure and function

Reference code: PT/FB/BL-2010-176.08
Location: Arquivo PCA - Pasta 14/2010
Title:
Postingestive modulation of food seeking depends on vagus-mediated dopamine neuron activity
Publication year: 2020
URL:
https://www.cell.com/neuron/pdf/S0896-6273(20)30216-6.pdf?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627320302166%3Fshowall%3Dtrue
Abstract/Results: ABSTRACT:
Postingestive nutrient sensing can induce food preferences. However, much less is known about the ability of postingestive signals to modulate food-seeking behaviors. Here we report a causal connection between postingestive sucrose sensing and vagus-mediated dopamine neuron activity in the ventral tegmental area (VTA), supporting food seeking. The activity of VTA dopamine neurons increases significantly after administration of intragastric sucrose, and deletion of the NMDA receptor in these neurons, which affects bursting and plasticity, abolishes lever pressing for postingestive sucrose delivery. Furthermore, lesions of the hepatic branch of the vagus nerve significantly impair postingestive-dependent VTA dopamine neuron activity and food seeking, whereas optogenetic stimulation of left vagus nerve neurons significantly increases VTA dopamine neuron activity. These data establish a necessary role of vagus-mediated dopamine neuron activity in postingestive-dependent food seeking, which is independent of taste signaling.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Fernandes, A. B.
Secondary author(s):
Alves da Silva, J., Almeida, J., Cui, G., Gerfen, C. R. , Costa, R. M. , Oliveira-Maia, A.
Document type:
Article
Number of reproductions:
1
Reference:
Fernandes, A. B., Alves da Silva, J., Almeida, J., Cui, G., Gerfen, C. R., Costa, R. M., & Oliveira-Maia, A. (2020). Postingestive modulation of food seeking depends on vagus-mediated dopamine neuron activity. Neuron. doi: 10.1016/j.neuron.2020.03.009
2-year Impact Factor: 17.173|2020
Times cited: 16|2021-07-28
Indexed document: Yes
Quartile: Q1
Keywords: Postingestive / Ventral Tegmental Area / Dopamine / Feeding behavior / Food seeking / Nutrient sensing / Vagus nerve