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BIAL Foundation
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DocumentFinal report - Defining the functional architecture of motion vision sensitive visual-motor circuits2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-191
Location: Arquivo PCA - Pasta 19/2012
Title:
191 - Defining the functional architecture of motion vision sensitive visual-motor circuits
Duration: 2013-08 - 2016-10
Researcher(s):
Eugenia Chiappe, Tomás Cruz
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Submitted paper
Language: eng
Author:
Chiappe, E.
Secondary author(s):
Cruz, T.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Body structure and function / Vision / Movement

Reference code: PT/FB/BL-2012-191.01
Location: Arquivo PCA - Pasta 19/2012
Title:
Final report - Defining the functional architecture of motion vision sensitive visual-motor circuits
Publication year: 2016
URL:
https://www.bial.com/imagem/Bolsa%2019112.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
Under natural conditions, the nervous system and the body of a moving animal interact continuously, and it is from this interaction that neural circuits form internal representations that guide animal behaviour, including our own. We focus on two internal representations: spatial perception and self-movement estimation. These representations depend on multimodal sensory-motor integration. How this integration is implemented across neural circuits is still an open question.
AIMS
To answer this question, we study how movement is incorporated to visual motion processing into: 1) guide oriented behaviors, and 2) to estimate self-movement.
METHOD & RESULTS
We combined anatomical, electropysiological and optical techniques, and identified novel visual neurons sensitive to small-field visual motion stimuli in the fruitfly Drosophila melanogaster. We are currently assessing their role in spatial orientation by reversible manipulations of their activity in behavioral paradigms we developed for oriented locomotion. For the second aim, we performed electrophysiological recordings from optic-flow sensitive neurons during explorative walking and found that these cells represent the fly’s walking movements accurately (even in the absence of vision) by integrating visual and walking-related motor signals.
CONCLUSIONS
The identified novel visual neurons open the opportunity to study their role in orientated behaviors to understand how the brain combines walking with visual processing to create spatial perception. In addition, we demonstrated that optic-flow sensitive neurons receive non-visual detailed information about the walking movements of the fly to create a faithful representation of self-movement.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Chiappe, E.
Secondary author(s):
Cruz, T.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Drosophila melanogaster / Motion vision / Walking / Oriented behaviors / Self-movement estimation / Sensorimotor integration
DocumentA faithful internal representation of walking movements in the Drosophila visual system2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-191
Location: Arquivo PCA - Pasta 19/2012
Title:
191 - Defining the functional architecture of motion vision sensitive visual-motor circuits
Duration: 2013-08 - 2016-10
Researcher(s):
Eugenia Chiappe, Tomás Cruz
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Submitted paper
Language: eng
Author:
Chiappe, E.
Secondary author(s):
Cruz, T.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Body structure and function / Vision / Movement

Reference code: PT/FB/BL-2012-191.02
Location: Arquivo PCA - Pasta 19/2012
Title:
A faithful internal representation of walking movements in the Drosophila visual system
Publication year: 2017
URL:
http://www.nature.com/neuro/journal/v20/n1/pdf/nn.4435.pdf
Abstract/Results: ABSTRACT:
The integration of sensorimotor signals to internally estimate self-movement is critical for spatial perception and motor control. However, which neural circuits accurately track body motion and how these circuits control movement remain unknown. We found that a population of Drosophila neurons that were sensitive to visual flow patterns typically generated during locomotion, the horizontal system (HS) cells, encoded unambiguous quantitative information about the fly's walking behavior independently of vision. Angular and translational velocity signals were integrated with a behavioral-state signal and generated direction-selective and speed-sensitive graded changes in the membrane potential of these non-spiking cells. The nonvisual direction selectivity of HS cells cooperated with their visual selectivity only when the visual input matched that expected from the fly's movements, thereby revealing a circuit for internally monitoring voluntary walking. Furthermore, given that HS cells promoted leg-based turning, the activity of these cells could be used to control forward walking.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Fujiwara, T.
Secondary author(s):
Cruz, T., Bohnslav, J. P., Chiappe, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
93.03|2.59
Reference:
Fujiwara, T., Cruz, T. L., Bohnslav, J. P., & Chiappe, M. E. (2017). A faithful internal representation of walking movements in the Drosophila visual system. Nature Neuroscience, 20, 72-81. https://doi.org/10.1038/nn.4435
2-year Impact Factor: 19.912|2017
Times cited: 84|2026-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Drosophila melanogaster / Motion vision / Walking / Oriented behaviors / Self-movement estimation / Sensorimotor integration
DocumentGonadal ecdysone titers are modulated by protein availability but do not impact protein appetite2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.04
Location: BF-GMS
Title:
Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite
Publication year: 2018
URL:
http://www.sciencedirect.com/science/article/pii/S0022191017301130?via%3Dihub
Abstract/Results: ABSTRACT:
How animals survey internal nutrient availability to modulate specific appetites is currently largely unknown. Dietary proteins have a profound impact on the reproductive capacity and the selection of food sources in insects. When deprived of dietary proteins, insects stop producing eggs and develop strong protein appetites. In many adult insects, the ovaries are the site of synthesis of the ecdysone hormone. Therefore, an attractive hypothesis is that protein availability changes the gonadal production of ecdysone, which instructs the brain to increase its preference for yeast. We combine quantitative feeding assays, dietary manipulations, hormonal measurements, and genetic germline manipulations to test this hypothesis in Drosophila melanogaster. Our results show that upon yeast deprivation mated adult female Drosophila develop a strong yeast appetite and strongly reduce their egg production. This dietary manipulation also leads to a drastic reduction in ecdysone titers. However, the drop in ecdysone is not linked to the increase in yeast appetite as mutants with impaired oogenesis are able to adapt yeast intake to their nutrient state while displaying a constitutive low ecdysone titer. Interestingly, a low ecdysone titer is correlated with a lower level of overall food intake. Our data therefore show that in mated females the level of ecdysone reflects the level of protein in the diet and the physiological state of the ovaries. While the ovaries and ecdysone are unlikely to instruct the brain to develop a yeast appetite upon protein deprivation, they seem to be able to control overall food intake.
Accessibility: Document does not exist in file
Language:
eng
Author:
Carvalho-Santos, Z.
Secondary author(s):
Ribeiro, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
53.99|0.60
Reference:
Carvalho-Santos, Z., & Ribero, C. (2018). Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite. Journal of Insect Physiology, 106, 30-35. https://doi.org/10.1016/j.jinsphys.2017.08.006
2-year Impact Factor: 2.862|2018
Times cited: 9|2026-02-11
Indexed document: Yes
Quartile: Q1
Keywords: Ecdysone / Feeding behavior / Gonads / Drosophila melanogaster / Nutrient homeostasis / Protein appetite