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Type Title Begin End
DocumentA holidic medium for Drosophila melanogaster2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.03
Location: SEC PCA - 167/10
Title:
A holidic medium for Drosophila melanogaster
Publication year: 2013
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3877687/
Abstract/Results: ABSTRACT:
A critical requirement for research using model organisms is an appropriate, well-defined and consistent diet. There is currently no complete chemically defined (holidic) diet available for Drosophila melanogaster. We describe a holidic medium that is equal in performance to an oligidic diet optimized for adult fecundity and lifespan. It is also sufficient to support development over multiple generations, but at a reduced rate. During seven years of experiments, the holidic diet yielded more consistent experimental outcomes than oligidic food for adult fitness traits. Furthermore, nutrients and drugs are more accessible to flies in holidic medium and, similar to dietary restriction on oligidic food, amino acid dilution increases fly lifespan. We also report amino acid specific effects on food choice behavior and that folic acid from the microbiota is sufficient for development. These insights could not be gained using oligidic or meridic diets.
Accessibility: Document does not exist in file
Language:
eng
Author:
Piper, M. D.
Secondary author(s):
Blanc, E., Leitão-Gonçalves, R., Yang, M., Linford, N. J., Hoddinott, M. P., Hopfen, C., Soultoukis, G., Niemeyer, C., Kerr, F., Pletcher, S., Ribeiro, C., Partridge, L.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Piper, M. D., Yang, M., Linford, N. J., Hoddinott, M. P., Hopfen, C., Soultoukis, G., ... Partridge, L. (2013). A holidic medium for Drosophila melanogaster. Nature Methods, 11(1), 100-105. https://doi.org/10.1038/nmeth.2731
2-year Impact Factor: 25.953|2013
Times cited: 224|2024-02-02
Indexed document: Yes
Quartile: Q1
Keywords: Drosophila / Feeding behaviour / Behavioural genetics / Metabolism

A holidic medium for Drosophila melanogaster

A holidic medium for Drosophila melanogaster

DocumentNutrition: Rejection Is the Fly’s Protection2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.04
Location: SEC PCA - 167/10
Title:
Nutrition: Rejection Is the Fly’s Protection
Publication year: 2014
URL:
http://www.sciencedirect.com/science/article/pii/S0960982214002115
Abstract/Results: ABSTRACT:
Animals need to ingest a full set of essential amino acids through their diet. A new study in Drosophila larvae describes how activation of the kinase GCN2 in three dopaminergic neurons mediates the rejection of amino-acid-imbalanced food.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Herbert, S.
Secondary author(s):
Ribeiro, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Herbert, S., & Ribeiro, C. (2014). Nutrition: Rejection Is the Fly’s Protection. Current Biology, 24(7), R278–R280. https://doi.org/10.1016/j.cub.2014.02.043
2-year Impact Factor: 9.571|2014
Times cited: 1|2024-02-02
Indexed document: Yes
Quartile: Q1
Keywords: Drosophila / Feeding behavior

Nutrition: Rejection Is the Fly’s Protection

Nutrition: Rejection Is the Fly’s Protection

DocumentUsing neuron specific RNAi in Drosophila for understanding the molecular and neuronal basis of behavior2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.05
Location: SEC PCA - 167/10
Title:
Using neuron specific RNAi in Drosophila for understanding the molecular and neuronal basis of behavior
Publication year: 2014
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Leitão-Gonçalves, R.
Secondary author(s):
Ribeiro, C.
Document type:
Book chapter
Number of reproductions:
1
Reference:
Leitão-Gonçalves, R., & Ribeiro, C. (2014). Using neuron specific RNAi in Drosophila for understanding the molecular and neuronal basis of behavior. In J. Dubnau (Ed.), Handbook of behavioral genetics of Drosophila melanogaster (pp. 202-216). United Kingdom, UK: Cambridge University Press.
Indexed document: Yes
Keywords: Drosophila / Feeding behaviour

DocumentAutomated monitoring and quantitative analysis of feeding behaviour in Drosophila2014

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.06
Location: SEC PCA - 167/10
Title:
Automated monitoring and quantitative analysis of feeding behaviour in Drosophila
Publication year: 2014
URL:
http://www.nature.com/ncomms/2014/140804/ncomms5560/full/ncomms5560.html
Abstract/Results: ABSTRACT:
Food ingestion is one of the defining behaviours of all animals, but its quantification and analysis remain challenging. This is especially the case for feeding behaviour in small, genetically tractable animals such as Drosophila melanogaster. Here, we present a method based on capacitive measurements, which allows the detailed, automated and high-throughput quantification of feeding behaviour. Using this method, we were able to measure the volume ingested in single sips of an individual, and monitor the absorption of food with high temporal resolution. We demonstrate that flies ingest food by rhythmically extending their proboscis with a frequency that is not modulated by the internal state of the animal. Instead, hunger and satiety homeostatically modulate the microstructure of feeding. These results highlight similarities of food intake regulation between insects, rodents, and humans, pointing to a common strategy in how the nervous systems of different animals control food intake.
Accessibility: Document exist in file
Language:
eng
Author:
Itskov, P. M.
Secondary author(s):
Moreira, J., Vinnik, E., Lopes, G., Safarik, S., Dickinson, M. , Ribeiro, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Itskov, P. M., Moreira, J., Vinnik, E., Lopes, G., Safarik, S., Dickinson, M., & Ribeiro, C. (2014). Automated monitoring and quantitative analysis of feeding behaviour in Drosophila. Nature Communications, 5: 4560. https://doi.org/10.1038/ncomms5560
2-year Impact Factor: 11.470|2014
Times cited: 113|2024-02-02
Indexed document: Yes
Quartile: Q1
Keywords: Feeding behaviour / Drosophila

Automated monitoring and quantitative analysis of feeding behaviour in Drosophila

Automated monitoring and quantitative analysis of feeding behaviour in Drosophila

DocumentUsing a holidic medium to study nutrient homeostasis in Drosophila melanogaster 2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-167
Location: Arquivo PCA - Pasta 13/2010
Title:
167 - Elucidating the molecular mechanisms mediating feeding behavior
Duration: 2011-05 - 2014-09
Researcher(s):
Carlos Vidal Ribeiro, Maria Teresa Montez, Laura Belmonte, Samantha Herbert
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Montez, M., Belmonte, L., Herbert, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Motivation / Eating behavior

Reference code: PT/FB/BL-2010-167.07
Location: SEC PCA - 167/10
Title:
Using a holidic medium to study nutrient homeostasis in Drosophila melanogaster
Publication year: 2013
URL:
http://edrc2013.org/doc/EDRC2013ProgrammeandBookofAbstracts.pdf
Abstract/Results: ABSTRACT:
Animals choose which macronutrient to eat according to their current internal nutrient and mating status and optimize the
protein to carbohydrate ratio in their diet to maximize their evolutionary fitness in terms of lifetime egg production. In the field it is well accepted that yeast is mainly used by Drosophila melanogaster as a protein and therefore amino acid source but a detailed nutritional analysis of this food source remains hampered by its chemically complexity. To disentangle the different nutritional contributions of yeast on life history traits and feeding behavior we have used a novel holidic medium that is adequate for fly development as well as adult traits, such as behavior, fecundity and lifespan. Using detailed and quantitative behavior analyses of food choice and feeding behavior we show that specifically removing amino acids from the adult diet leads to a foraging phenotype which fully mimics a lack of dietary yeast. Furthermore this effect can be triggered by the lack of single essential amino acids while removing non essential amino acids from the diet has no effect on food choice. Interestingly, flies raised in the absence of yeast preferred yeast when amino acids deprived, suggesting the existence of an innate system for yeast valuation. These data shed light on the exquisite behavioral sensitivity of Drosophila to the lack of single nutritional components and the foraging strategies used to achieve nutrient homeostasis. Our study also exemplifies the power of using a holidic diet for examining nutrient sensitive traits such as nutrient homeostasis.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Leitão-Gonçalves, R.
Secondary author(s):
Fioreze, G., Francisco, A., Piper, M. D., Ribeiro, C.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Leitão-Gonçalves, R., Fioreze, G., Francisco, A., Piper, M. D., & Ribeiro, C. (2013). Using a holidic medium to study nutrient homeostasis in Drosophila melanogaster. In Programme & Book of abstracts: EDRC 23rd European Drosophila research conference (p. 114). Barcelona, Spain.
Indexed document: No
Keywords: Drosophila / Feeding behaviour

Using a holidic medium to study nutrient homeostasis in Drosophila melanogaster

Using a holidic medium to study nutrient homeostasis in Drosophila melanogaster

File283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2015-052017-07

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

File279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-279
Location: BF-GMS
Title:
279 - Harnessing the power of closed-loop neuronal control to identify the circuit basis of decision making
Researcher(s): Carlos Ribeiro, Pavel Itskov, Ana Paula Elias, Samuel Walker, José Moreir
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Notes: Ongoing project
Author: Ribeiro, C.
Secondary author(s):
Itskov, P. M., Elias, A., Walker, S., Moreira, J.
Number of reproductions:
1
Keywords:
Drosophila / Optogenetics / Feeding / Gustation / Psychophysiology

DocumentFinal report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.01
Location: BF-GMS
Title:
Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_28314.pdf
Abstract/Results: ABSTRACT:
Nutrition is a key determinant of health, wellbeing and aging. Recent evidences strongly suggest that nutritional amino acids (AAs) are important mediators of this fitness effect in multiple species, including humans. Accordingly, animals have developed behavioral strategies to ensure a proper balance of AA intake. We have for example shown that upon yeast (main dietary protein source of fruit flies) or AA deprivation Drosophila melanogaster increases the intake of yeast leading to a switch in feeding preference from sucrose to yeast. This change in feeding choice underlies the dietary basis for nutritional AA homeostasis and serves as a powerful paradigm to study nutrient choice and homeostasis.
We have identified a distinct class of Drosophila melanogaster gustatory receptor neurons (GRNs) required for intake of yeast. We show that gustatory receptor neurons of the proboscis act in parallel to mediate yeast feeding. While nutritional and reproductive states act in concert to drive yeast appetite, we find a separation of these state signals at the level of yeast GRNs, with amino acid but not mating state enhancing yeast GRN gain. Importantly, the sensitivity of sweet GRNs to sugar is not increased by protein deprivation, providing a potential basis for this nutrient-specific appetite. The emerging picture is that different internal states act at distinct levels of a specific gustatory processing circuit to elicit nutrient-specific appetites towards a complex, ecologically relevant protein source.
Furthermore, we have made important additional discoveries at the level of the impact of gut bacteria on the selection of nutrients and have developed a new approach using genome information for designing diets optimizing both aging and reproductive output.
We have therefore achieved the main goals of the project which aimed at identifying and characterizing circuits regulating nutrient homeostasis and exploring the impact of nutrients on lifespan with a special focus on amino acids.
Accessibility: Document exists in file
Language:
eng
Author:
Ribeiro, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Nutrition / Diet / Circuits / Drosophila / Brain

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging

Final report - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging

DocumentCommensal bacteria and essential amino acids control food choice behavior and reproduction2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-283
Location: BF-GMS
Title:
283 - Identifying and characterizing the neuronal circuits required for nutrient choice and their effects on aging
Duration: 2015-05 - 2017-07
Researcher(s):
Carlos Ribeiro, Ana Paula Elias, Matthew D. W. Piper, Samantha Herbert, Samuel Walker
Institution(s): Champalimaud Centre for the Unknown, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
Articles
Language: eng
Author:
Ribeiro, C.
Secondary author(s):
Elias, A., Piper, M. D., Herbert, S., Walker, S.
Number of reproductions:
1
Keywords:
Drosophila / Feeding Behavior / Aging / Neuronal Circuits / Psychophysiology

Reference code: PT/FB/BL-2014-283.02
Location: BF-GMS
Title:
Commensal bacteria and essential amino acids control food choice behavior and reproduction
Publication year: 2017
URL:
http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2000862
Abstract/Results: ABSTRACT:
Choosing the right nutrients to consume is essential to health and wellbeing across species. However, the factors that influence these decisions are poorly understood. This is particularly true for dietary proteins, which are important determinants of lifespan and reproduction. We show that in Drosophila melanogaster, essential amino acids (eAAs) and the concerted action of the commensal bacteria Acetobacter pomorum and Lactobacilli are critical modulators of food choice. Using a chemically defined diet, we show that the absence of any single eAA from the diet is sufficient to elicit specific appetites for amino acid (AA)-rich food. Furthermore, commensal bacteria buffer the animal from the lack of dietary eAAs: both increased yeast appetite and decreased reproduction induced by eAA deprivation are rescued by the presence of commensals. Surprisingly, these effects do not seem to be due to changes in AA titers, suggesting that gut bacteria act through a different mechanism to change behavior and reproduction. Thus, eAAs and commensal bacteria are potent modulators of feeding decisions and reproductive output. This demonstrates how the interaction of specific nutrients with the microbiome can shape behavioral decisions and life history traits.
Accessibility: Document exists in file
Language:
eng
Author:
Leitão-Gonçalves, R.
Secondary author(s):
Francisco, A., Carvalho-Santos, Z., Fioreze, G., Anjos, M., Baltazar, C., Elias, A., Itskov, P. M., Piper, M. D., Ribeiro, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
4
Reference:
Leitão-Gonçalves, R., Francisco, A. P., Carvalho-Santos, Z., Fioreze, G. T., Anjos, M., Baltazar, C., Elias, A. P., Itskov, P. M., Piper, M. D., & Ribeiro, C. (2017). Commensal bacteria and essential amino acids control food choice behavior and reproduction. PLoS Biology, 15(4): e2000862. https://doi.org/10.1371/journal.pbio.2000862
2-year Impact Factor: 9.163|2017
Times cited: 184|2024-02-08
Indexed document: Yes
Quartile: Q1
Keywords: Nutrition / Drosophila