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BIAL Foundation
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DE:"Dynamic causal modelling "
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Type Title Begin End
DocumentHow hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-85
Location: BF-GMS
Title:
How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S105381192100118X?via%3Dihub
Abstract/Results: ABSTRACT:
In recent years, specific cortical networks have been proposed to be crucial for sustaining consciousness, including the posterior hot zone and frontoparietal resting state networks (RSN). Here, we computationally evaluate the relative contributions of three RSNs – the default mode network (DMN), the salience network (SAL), and the central executive network (CEN) – to consciousness and its loss during propofol anaesthesia. Specifically, we use dynamic causal modelling (DCM) of 10 min of high-density EEG recordings (N = 10, 4 males) obtained during behavioural responsiveness, unconsciousness and post-anaesthetic recovery to characterise differences in effective connectivity within frontal areas, the posterior ‘hot zone’, frontoparietal connections, and between-RSN connections. We estimate – for the first time – a large DCM model (LAR) of resting EEG, combining the three RSNs into a rich club of interconnectivity. Consistent with the hot zone theory, our findings demonstrate reductions in inter-RSN connectivity in the parietal cortex. Within the DMN itself, the strongest reductions are in feed-forward frontoparietal and parietal connections at the precuneus node. Within the SAL and CEN, loss of consciousness generates small increases in bidirectional connectivity. Using novel DCM leave-one-out cross-validation, we show that the most consistent out-of-sample predictions of the state of consciousness come from a key set of frontoparietal connections. This finding also generalises to unseen data collected during post-anaesthetic recovery. Our findings provide new, computational evidence for the importance of the posterior hot zone in explaining the loss of consciousness, highlighting also the distinct role of frontoparietal connectivity in underpinning conscious responsiveness, and consequently, suggest a dissociation between the mechanisms most prominently associated with explaining the contrast between conscious awareness and unconsciousness, and those maintaining consciousness.
Accessibility: Document exists in file
Language:
eng
Author:
Ihalainen, R.
Secondary author(s):
Gosseries, O., de Steen, F. V., Raimondo, F., Panda, R., Bonhomme, V., Marinazzo, D., Bowman, H., Laureys, S., Chennu, S.
Document type:
Article
Number of reproductions:
3
Reference:
Ihalainen, R., Gosseries, O., de Steen, F. V., Raimondo, F., Panda, R., Bonhomme, V., Marinazzo, D., Bowman, H., Laureys, S., & Chennu, S. (2021). How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness. Neuroimage, 231: 117841. https://doi.org/10.1016/j.neuroimage.2021.117841
2-year Impact Factor: 6.556|2020
Impact factor notes: Impact factor not available yet for 2021
Times cited: 21|2025-09-20
Indexed document: Yes
Quartile: Q1
Keywords: Anaesthesia / Consciousness / EEG / Effective connectivity / Dynamic causal modelling

How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness

How hot is the hot zone? Computational modelling clarifies the role of parietal and frontoparietal connectivity during anaesthetic-induced loss of consciousness
DocumentLateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-147
Location: BF-GMS
Title:
Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness
Publication year: 2024
URL:
https://doi.org/10.1371/journal.pone.0298110
Abstract/Results: ABSTRACT:
Neuroimaging studies have suggested an important role for the default mode network (DMN) in disorders of consciousness (DoC). However, the extent to which DMN connectivity can discriminate DoC states–unresponsive wakefulness syndrome (UWS) and minimally conscious state (MCS)–is less evident. Particularly, it is unclear whether effective DMN connectivity, as measured indirectly with dynamic causal modelling (DCM) of resting EEG can disentangle UWS from healthy controls and from patients considered conscious (MCS+). Crucially, this extends to UWS patients with potentially “covert” awareness (minimally conscious star, MCS*) indexed by voluntary brain activity in conjunction with partially preserved frontoparietal metabolism as measured with positron emission tomography (PET+ diagnosis; in contrast to PET- diagnosis with complete frontoparietal hypometabolism). Here, we address this gap by using DCM of EEG data acquired from patients with traumatic brain injury in 11 UWS (6 PET- and 5 PET+) and in 12 MCS+ (11 PET+ and 1 PET-), alongside with 11 healthy controls. We provide evidence for a key difference in left frontoparietal connectivity when contrasting UWS PET- with MCS+ patients and healthy controls. Next, in a leave-one-subject-out cross-validation, we tested the classification performance of the DCM models demonstrating that connectivity between medial prefrontal and left parietal sources reliably discriminates UWS PET- from MCS+ patients and controls. Finally, we illustrate that these models generalize to an unseen dataset: models trained to discriminate UWS PET- from MCS+ and controls, classify MCS* patients as conscious subjects with high posterior probability (pp > .92). These results identify specific alterations in the DMN after severe brain injury and highlight the clinical utility of EEG-based effective connectivity for identifying patients with potential covert awareness.
Accessibility: Document exists in file
Language:
eng
Author:
Ihalainen, R.
Secondary author(s):
Annen, J., Gosseries, O., Cardone, P., Panda, R., Martial, C., Thibaut, A., Laureys, S., Chennu, S.
Document type:
Article
Number of reproductions:
3
Reference:
Ihalainen, R., Annen, J., Gosseries, O., Cardone, P., Panda, R., Martial, C., Thibaut, A., Laureys, S., & Chennu, S. (2024). Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness. PloS one, 19(7), e0298110. https://doi.org/10.1371/journal.pone.0298110
2-year Impact Factor: 2.6|2024
Times cited: 2|2025-09-27
Indexed document: Yes
Quartile: Q2
Keywords: Default mode network / Disorders of consciousness / Dynamic causal modelling

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness

Lateral frontoparietal effective connectivity differentiates and predicts state of consciousness in a cohort of patients with traumatic disorders of consciousness