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BIAL Foundation
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DocumentNeurophysiological examination of the affect–integration–motivation framework of decision-making in the aging brain: A registered report2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-249
Location: BF-GMS
Title:
249 - Healthy aging and economic decision-making: neuropsychophysiological examination of the affect-integration-motivation framework of decision-making in aging brain
Duration: 2018-02 - 2023-04
Researcher(s):
João Marques-Teixeira, Rui Mata, Isabel Martins, Giuseppe Danese, Carina Fernandes, Pasion Rita, Tiago Oliveira Paiva
Institution(s): Laboratory of Neuropsychophysiology, Faculty of Psychology and Education Sciences of the University of Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Marques-Teixeira, J.
Secondary author(s):
Mata, R., Martins, I., Danese, G., Gonçalves, A., Fernandes, C., Pasion, R.
Number of reproductions:
1
Keywords:
Healthy aging / Risk / Economic and social decision-making / Uncertainty / Psychophysiology

Reference code: PT/FB/BL-2016-249.02
Location: BF-GMS
Title:
Neurophysiological examination of the affect–integration–motivation framework of decision-making in the aging brain: A registered report
Publication year: 2022
URL:
https://www.sciencedirect.com/science/article/pii/S1053811922003135
Abstract/Results: The Affect–Integration–Motivation (AIM) framework was proposed to clarify how brain circuits that support
decision-making are altered by aging (Samanez-Larkin & Knutson, 2015). According to this framework, choices
are preceded by affective, integrative, and motivational processes, which may all be affected by aging. The Mon-
etary Incentive Delay (MID) task allows tapping into several mechanisms proposed by the AIM framework, and
the present registered report aimed to explore the temporal resolution of the EEG to find the neural correlates of
age differences in such mechanisms, including gain/loss anticipation, value integration, motivational processes
underlying motor choice, as well as processing of positive/negative rewards. The electrophysiological data were
recorded from 77 participants (20–80 years old), and we analyzed the Cue-P3, Contingent Negative Variation,
target-P3, Feedback-related Negativity, and the Feedback-P3. The results support the AIM framework, suggest-
ing that aging altered affective processes (as shown by a significant reduced cue-P3 in the older group), while
preserved integration and motivation processes. However, despite a general lack of significant group by domain
interactions across the ERPs analyzed, the results of the planned comparisons are suggestive of a preserved pro-
cessing of gains and affected processing of losses during aging. This conclusion requires further replication with
larger samples, but our study shows that future research may profit from decomposing decision processes to
understand how biological aging affects decision making.
Accessibility: Document exists in file
Language:
eng
Author:
Fernandes, C.
Secondary author(s):
Macedo, I., Gonçakves, A. R., Pasion, R., Mata, R., Danese, G., Martins, I. P., Barbosa, F., Marques-Teixeira, J.
Document type:
Article
Number of reproductions:
1
Reference:
Fernandes, C., Macedo, I., Gonçalves, A. R., Pasion, R., Mata, R., Danese, G., Martins, I. P., Barbosa, F. & Marques-Teixeira, J. (2022). Neurophysiological examination of the affect-integration-motivation framework of decision-making in the aging brain: A registered report. NeuroImage, 256, 119189. https://doi.org/10.1016/j.neuroimage.2022.119189
2-year Impact Factor: 5.700|2022
Times cited: 1|2025-09-24
Indexed document: Yes
Quartile: Q1
Keywords: Economic decision-making / Aging / Event-related potentials / Rewards anticipation / feedback processing

Neurophysiological examination of the affect–integration–motivation framework of decision-making in the aging brain: A registered report

Neurophysiological examination of the affect–integration–motivation framework of decision-making in the aging brain: A registered report