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Document

Neurophysiological correlates of excitement in schizophrenia

2013

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 090 - Brain function, creativity, paranormal ideation and risk for psychosis
      - Neurophysiological correlates of excitement in schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-090
Location:	Arquivo PCA - Pasta 5/2002
Title:	090 - Brain function, creativity, paranormal ideation and risk for psychosis
Duration:	2003-03 - 2005-04
Researcher(s):	Alexander Sumich, Michael Brammer, Dominic Ffytch
Institution(s):	Brain Image Analysis Unit, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report Diskette (Reseacrch Bursary 02-03, Alex Sumich: Brain function, creativity, paranormal ideation and risk for psychosis - BIAL)
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Brammer, M., Ffytch, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2002-090.06
Location:	Arquivo PCA - Pasta 5/2002
Title:	Neurophysiological correlates of excitement in schizophrenia
Publication year:	2013
URL:	http://www.sciencedirect.com/science/article/pii/S0278584613001309
Abstract/Results:	ABSTRACT: Objective: The excitement cluster (excitement, hostility, uncooperativeness and impulsivity) may contribute to the risk of violent behaviour, treatment non-adherence, likelihood of discharge and substance use in psychosis. Evidence suggests involvement of frontal executive mechanisms that may show sex differences in their association with symptom severity. The current study tests the association between excitement and the frontal N200 and P300 components of the auditory event-related potential in schizophrenia as a function of sex. Method: Fourteen men and 14 women with schizophrenia (mean illness duration = 20 years) completed a novelty oddball and clinical interview. Results: Men showed higher midline N200 and lower novelty P300 amplitude than women. They had more pronounced differences between midline and lateral N200 amplitude, and did not show the same Novel N Target effect for right frontal P300 as did women. Right frontal N200 amplitude to target stimuli was positively associated with excitement in women and inversely associated with excitement in men. Novelty P300 amplitude was inversely associated with excitement, particularly in women and over the right hemisphere. Conclusion: Results suggest that mechanisms underpinning frontal N200 and P300 subcomponents are differentially involved in excitement depending on sex. Understanding these individual differences may have implications for developing personalised treatment.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Castro, A., Anilkumar, A., Zachariach, E., Kumari, V.
Document type:	Article
Number of reproductions:	1
Reference:	Sumich, A., Castro, A., Anilkumar, A., Zachariach, E., & Kumari, V. (2013). Neurophysiological correlates of excitement in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 46, 132–138. https://doi.org/10.1016/j.pnpbp.2013.06.018
2-year Impact Factor:	4.025\|2013
Times cited:	14\|2025-09-10
Indexed document:	Yes
Quartile:	Q1
Keywords:	Event-related potentials / Excitement / Frontal / N200 / Schizophrenia / Sex differences

Document

Neurophysiological correlates of excitement in men with recent-onset psychosis

2018

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 090 - Brain function, creativity, paranormal ideation and risk for psychosis
      - Neurophysiological correlates of excitement in men with recent-onset psychosis

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-090
Location:	Arquivo PCA - Pasta 5/2002
Title:	090 - Brain function, creativity, paranormal ideation and risk for psychosis
Duration:	2003-03 - 2005-04
Researcher(s):	Alexander Sumich, Michael Brammer, Dominic Ffytch
Institution(s):	Brain Image Analysis Unit, Institute of Psychiatry, King's College London (UK)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress reports Final report Diskette (Reseacrch Bursary 02-03, Alex Sumich: Brain function, creativity, paranormal ideation and risk for psychosis - BIAL)
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Brammer, M., Ffytch, D.
Number of reproductions:	1
Keywords:	Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders

Reference code:	PT/FB/BL-2002-090.07
Location:	Arquivo PCA - Pasta 5/2002
Title:	Neurophysiological correlates of excitement in men with recent-onset psychosis
Publication year:	2018
URL:	http://www.psychiatria-danubina.com/UserDocsImages/pdf/dnb_vol30_no1/dnb_vol30_no1_64.pdf
Abstract/Results:	ABSTRACT: OBJECTIVE: Right frontal function, as indicated by the N200 component of the event-related potential during target detection, has previously been associated with excitement (excitement, impulsivity, hostility, uncooperativeness) in men with a long-term diagnosis of schizophrenia. The current study investigated excitement in relation to N200 in men who had recently experienced their first episode of psychosis. SUBJECTS AND METHODS: Twenty men who had recently suffered their first psychotic episode underwent a clinical interview and auditory oddball task. RESULTS: Multiple linear regression analysis showed that 58% of the variance in the excitement symptom cluster was explained by a positive association with frontal midline N200 amplitude and an inverse association with right frontal N200 amplitude. The latter was not apparent in the initial correlation, suggesting suppression by the midline activity. These associations were not explained by drug use, medication or negative symptoms. However, the correlation between excitement and midline N200 was stronger in drug users, and that between right frontal N200 and excitement was stronger in nonusers. CONCLUSION: Findings support the independent contributions to excitement of mechanisms reflected in midline and right frontal N200 amplitude respectively during the early stages of psychosis.
Accessibility:	Document exists in file
Language:	eng
Author:	Sumich, A.
Secondary author(s):	Harris, A., Whitford, T., Hermens, D., Heym, N., Anderson, J., Bloxsom, C., Kibowski, F., Kumari, V.
Document type:	Article
Number of reproductions:	1
Reference:	Sumich, A., Harris, A., Whitford, T., Hermens, D., Heym, N., ..., Kumari, V. (2018). Neurophysiological correlates of excitement in men with recent-onset psychosis. Psychiatria Danubina, 30(1), 64-71. https://doi.org/10.24869/psyd.2018.64
2-year Impact Factor:	0.683\|2018
Times cited:	2\|2025-09-17
Indexed document:	Yes
Quartile:	Q4
Keywords:	Psychosis / Recent-onset / Event-related potentials / N200 / Excitement / Drug use
Neurophysiological correlates of excitement in men with recent-onset psychosis Neurophysiological correlates of excitement in men with recent-onset psychosis