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BIAL Foundation
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DocumentThe medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat2003

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.02
Location: Arquivo PCA - Pasta 10/2000
Title:
The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat
Publication year: 2003
URL:
http://onlinelibrary.wiley.com/doi/10.1046/j.1460-9568.2003.02782.x/abstract
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=213&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Single-unit spinal recordings combined with application of glutamate into the medullary dorsal reticular nucleus were used to assess the action of this nucleus upon deep dorsal horn neurons in rats. Injection of high glutamate concentrations (10 and 100 mm) induced a dramatic and long-lasting increase of the responses of wide-dynamic range neurons to electrical stimulation of the sciatic nerve in the noxious range, without affecting ongoing discharges. Post-stimulus time histograms revealed that this increase concerned the post-discharge, but not A- or C-fibre-mediated responses, which remained unchanged independently of the stimulation frequency applied. The onset of the glutamate-induced response enhancement occurred with a concentration-dependent time delay and developed slowly until its maximum. These data indicate that the medullary dorsal reticular nucleus exerts a facilitating action upon deep dorsal horn wide-dynamic range neurons by enhancing their capacity to respond to peripheral stimulation through prolongation of their discharge. This action is accompanied by the strengthening of wind-up of deep dorsal horn wide-dynamic range neurons, hence providing a plausible substrate for chronic pain states. These results are in agreement with previous behavioural studies suggesting a pronociceptive role for the dorsal reticular nucleus [Almeida et al. (1996) Brain Res. Bull., 39, 7-15; Almeida et al. (1999) Eur. J. Neurosci., 11, 110-122], and support the involvement of a reverberating circuit, previously described in morphological studies [Almeida et al. (1993) Neuroscience, 55, 1093-1106; Almeida et al. (2000) Eur. J. Pain, 4, 373-387], which probably operates only at a certain threshold of activation.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dugast, C.
Secondary author(s):
Almeida, A., Lima, D.
Document type:
Article
Number of reproductions:
1
Reference:
Dugast, C., Almeida, A., & Lima, D. (2003). The medullary dorsal reticular nucleus enhances the responsiveness of spinal nociceptive neurons to peripheral stimulation in the rat. European Journal of Neuroscience, 18(3), 580-588. doi: 10.1046/j.1460-9568.2003.02782.x
2-year Impact Factor: 3.872|2003
Times cited: 28|2022-05-18
Indexed document: Yes
Quartile: Q1
Keywords: Electrophysiology / Facilitation / Pain / Wide-dynamic range / Wind-up

DocumentWind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus2001

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2000
Location: Arquivo PCA - Pastas 1 a 13/2000
Title:
2000 Grants
Start date: 2001-01 - 2014-02
Dimension/support:
13 caixas de arquivo

Reference code: PT/FB/BL-2000-067
Location: Arquivo PCA - Pasta 10/2000
Title:
067 - Pain control from the brain. Novel approaches of chronic pain treatment through manipulation of supraspinal areas
Duration: 2000-12 - 2003-12
Researcher(s):
Deolinda Lima, Isaura Ferreira Tavares, Armando Alberto da Nova Pinto de Almeida, Christophe Dugast, Vasco Miguel Clara Lopes Galhardo, Marta Sofia Carvalho Teixeira Pinto
Institution(s): Instituto de Histologia e Embriologia da Faculdade de Medicina do Porto (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Lima, D.
Secondary author(s):
Tavares, I., Almeida, A., Dugast, C., Galhardo, V., Pinto, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain

Reference code: PT/FB/BL-2000-067.05
Location: Arquivo PCA - Pasta 10/2000
Title:
Wind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus
Publication year: 2001
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Description: Spinal cord wide-dynamic-range (WDR) neurons have been shown to display wind-up, a gradual frequency-dependent increase of their responses to repeated stimulation of primary afferent C-fibers. This phenomenon affects only C-fiber mediated responses and the post-discharge, and may involve a reverberatory activity. Recent electrophysiological studies have reported an increase in C-fiber evoked responses and post-discharge of lumbar WDR neurons following activation of the medullary dorsal reticular nucleus (DRt), while behavioral and morphological data suggest the existence of a putative reverberating loop between the DRt and the spinal nociceptive cells it innervates. The present study was aimed at evaluating the role of the DRt in spinal WDR neurons wind-up. The responses of spinal WDR neurons to sciatic nerve electrical stimulation with various frequencies and duration were recorded in L4-L5 spinal cord segments before, during and after glutamate injections into the DRt. Whatever the stimulation applied, glutamate injection increased the number of C-fiber evoked responses and the post-discharge. In addition, DRt glutamate-activation reduced the stimulation frequency and/or the number of stimulation pulses needed to trigger wind-up. Our results show that the DRt exerts a facilitatory action upon spinal WDR neurons and, therefore, contributes to the wind-up of these neurons.
Accessibility: Document does not exist in file
Language:
eng
Author:
Dugast, C.
Secondary author(s):
Almeida, A., Lima, D.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Dugast, C., Almeida, A., & Lima, D. (2001). Wind-up of spinal cord wide-dynamic-range neurons is influenced by the medullary reticular nucleus. Program No. 161.1. Neuroscience Abstracts. San Diego, USA: Society for Neuroscience. Online
Indexed document: No
Keywords: Glutamate / Nociception / Facilitation / Spinal