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BIAL Foundation
Selection Description
Type Title Begin End
DocumentPET imaging of dopamine neurotransmission during EEG neurofeedback2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
BIAL Foundation Archive
Start date: 1994
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-442
Location: BF-GMS
442 - Neurochemical Substrates of Neurofeedback
Duration: 2016-04 - 2020-09
Tomas Ros, Nathalie Ginovart
Institution(s): Interfacultary Center for Neuroscience, University of Geneva (Switzerland); Division of Nuclear Medicine, University Hospitals Geneva (Switzerland)
Contents: Contents:
Application form
Progress report
Final report
Language: eng
Ros, T.
Secondary author(s):
Ginovart, N
Number of reproductions:
Neurofeedback / Electroencephalogram / Positron emission tomography / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2014-442.02
Location: BF-GMS
PET imaging of dopamine neurotransmission during EEG neurofeedback
Publication year: 2021
Abstract/Results: ABSTRACT:
Neurofeedback (NFB) is a brain-based training method that enables users to control their own cortical oscillations using real-time feedback from the electroencephalogram (EEG). Importantly, no investigations to date have directly explored the potential impact of NFB on the brain’s key neuromodulatory systems. Our study’s objective was to assess the capacity of NFB to induce dopamine release as revealed by positron emission tomography (PET). Thirty-two healthy volunteers were randomized to either EEG-neurofeedback (NFB) or EEG-electromyography (EMG), and scanned while performing self-regulation during a single session of dynamic PET brain imaging using the high affinity D2/3 receptor radiotracer, [18F]Fallypride. NFB and EMG groups down-regulated cortical alpha power and facial muscle tone, respectively. Task-induced effects on endogenous dopamine release were estimated in the frontal cortex, anterior cingulate cortex, and thalamus, using the linearized simplified reference region model (LSRRM), which accounts for time-dependent changes in radiotracer binding following task initiation. Contrary to our hypothesis of a differential effect for NFB vs. EMG training, significant dopamine release was observed in both training groups in the frontal and anterior cingulate cortex, but not in thalamus. Interestingly, a significant negative correlation was observed between dopamine release in frontal cortex and pre-to-post NFB change in spontaneous alpha power, suggesting that intra-individual changes in brain state (i.e., alpha power) could partly result from changes in neuromodulatory tone. Overall, our findings constitute the first direct investigation of neurofeedback’s effect on the endogenous release of a key neuromodulator, demonstrating its feasibility and paving the way for future studies using this methodology.
Accessibility: Document exists in file
Ros, T.
Secondary author(s):
Kwiek, J., Andriot, T., Michela, A.,, Vuilleumier, P., Garibotto, V., Ginovart, N.
Document type:
Number of reproductions:
Ros, T., Kwiek, J., Andriot, T., Michela, A., Vuilleumier, P., Garibotto, V., & Ginovart, N. (2021). PET imaging of dopamine neurotransmission during EEG neurofeedback. Fronties in Physiology, 11: 590503. doi: 10.3389/fphys.2020.590503
2-year Impact Factor: 4.755|2021
Times cited: 4|2023-08-22
Indexed document: Yes
Quartile: Q1
Keywords: Dopamine / Neurofeedback / Positron emission tomography / Electromyography / Electroencephalography / Fallypride

PET imaging of dopamine neurotransmission during EEG neurofeedback

PET imaging of dopamine neurotransmission during EEG neurofeedback