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BIAL Foundation
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File160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning2019-042024-11

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-160
Location: BF-GMS
Title:
160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning
Duration: 2019-04 - 2024-11
Researcher(s):
Carmelo Vicario, Michael A Nitsche, Vuk Markovic
Institution(s): Department of Psychology and Neuroscience, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Department of Cognitive Science, University of Messina (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Vicario, C.
Secondary author(s):
Nitsche, M. A., Markovic, V.
Number of reproductions:
1
Keywords:
tDCS / Fear extinction learning / Pre-frontal cortex / Psychophysiology
DocumentEvidence of altered fear extinction learning in individuals with high vaccine hesitancy during COVID-19 pandemic2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-160
Location: BF-GMS
Title:
160 - Exploring the effect of transcranial direct current stimulation during sleep on fear extinction learning
Duration: 2019-04 - 2024-11
Researcher(s):
Carmelo Vicario, Michael A Nitsche, Vuk Markovic
Institution(s): Department of Psychology and Neuroscience, Leibniz Research Centre for Working Environment and Human Factors, Dortmund (Germany); Department of Cognitive Science, University of Messina (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Vicario, C.
Secondary author(s):
Nitsche, M. A., Markovic, V.
Number of reproductions:
1
Keywords:
tDCS / Fear extinction learning / Pre-frontal cortex / Psychophysiology

Reference code: PT/FB/BL-2018-160.11
Location: BF-GMS
Title:
Evidence of altered fear extinction learning in individuals with high vaccine hesitancy during COVID-19 pandemic
Publication year: 2023
URL:
https://www.clinicalneuropsychiatry.org/download/evidence-of-altered-fear-extinction-learning-in-individuals-with-high-vaccine-hesitancy-during-covid-19-pandemic/
Abstract/Results: ABSTRACT:
Objective: A relevance of fear and concerns about vaccine development and its side effects are suggested to explain COVID-19 vaccine hesitancy. However, evidence supporting the phobic origin hypothesis of hesitancy for COVID-19 and other vaccinations remains indirect and elusive.
Method: We addressed this issue by investigating the existence of a relationship between fear conditioning, extinction, and the respective vaccination hesitancy and anxiety scores in a group of 25 individuals.
Results: Overall, we show that the general mechanism of fear extinction learning is impaired in individuals with high vaccine hesitancy. State and trait anxiety scores do not account for this result.
Conclusions: These findings suggest that attitudes against vaccination could be linked to an altered inhibitory learning process
Accessibility: Document exists in file
Language:
eng
Author:
Vicario C. M.
Secondary author(s):
Makris, S., Culicetto, L., Lucifora, C., Falzone, A., Martino, G., Ferraioli, F., Nitsche, M. A., Avenanti, A., Craparo, G. C.
Document type:
Article
Number of reproductions:
1
Reference:
Vicario C. M., Makris, S., Culicetto, L., Lucifora, C., Falzone, A., Martino, G., Ferraioli, F., Nitsche, M. A., Avenanti, A., & Craparo, G. C. (2023). Evidence of altered fear extinction learning in individuals with high vaccine hesitancy during COVID-19 pandemic. Clinical Neuropsychiatry, 20(4), 364-369. https://doi.org/10.36131/cnfioritieditore20230417
2-year Impact Factor: 2|2023
Times cited: N/A
Indexed document: Yes
Quartile: N/A
Keywords: Vaccine hesitancy / Pavlovian fear conditioning / Fear extinction learning / Anxiety / Inhibitory learning process

Evidence of altered fear extinction learning in individuals with high vaccine hesitancy during COVID-19 pandemic

Evidence of altered fear extinction learning in individuals with high vaccine hesitancy during COVID-19 pandemic
DocumentThe amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-085
Location: BF-GMS
Title:
085 - Role of NT3/TrkC in the regulation of fear
Duration: 2019-03 - 2023-07
Researcher(s):
Mónica Santos
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Santos, M.
Number of reproductions:
1
Keywords:
Neurotrophin 3 / Fear conditioning / TrkC / Fear extinction / Psychophysiology

Reference code: PT/FB/BL-2018-085.04
Location: BF-GMS
Title:
The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity
Publication year: 2024
URL:
https://doi.org/10.1038/s41380-024-02412-z
Abstract/Results: ABSTRACT:
Fear-related pathologies are among the most prevalent psychiatric conditions, having inappropriate learned fear and resistance to extinction as cardinal features. Exposure therapy represents a promising therapeutic approach, the efficiency of which depends on inter-individual variation in fear extinction learning, which neurobiological basis is unknown. We characterized a model of extinction learning, whereby fear-conditioned mice were categorized as extinction (EXT)-success or EXT-failure, according to their inherent ability to extinguish fear. In the lateral amygdala, GluN2A-containing NMDAR are required for LTP and stabilization of fear memories, while GluN2B-containing NMDAR are required for LTD and fear extinction. EXT-success mice showed attenuated LTP, strong LTD and higher levels of synaptic GluN2B, while EXT-failure mice showed strong LTP, no LTD and higher levels of synaptic GluN2A. Neurotrophin 3 (NT3) infusion in the lateral amygdala was sufficient to rescue extinction deficits in EXT-failure mice. Mechanistically, activation of tropomyosin receptor kinase C (TrkC) with NT3 in EXT-failure slices attenuated lateral amygdala LTP, in a GluN2B-dependent manner. Conversely, blocking endogenous NT3-TrkC signaling with TrkC-Fc chimera in EXT-success slices strengthened lateral amygdala LTP. Our data support a key role for the NT3-TrkC system in inter-individual differences in fear extinction in rodents, through modulation of amygdalar NMDAR composition and synaptic plasticity.
Accessibility: Document exists in file
Language:
eng
Author:
Masella, G.
Secondary author(s):
Silva, F., Corti, E., Azkona, G., Madeira, M. F., Tomé, Â. R., Ferreira, S. G., Cunha, R. A., Duarte, C. B., Santos, M
Document type:
Article
Number of reproductions:
1
Reference:
Masella, G., Silva, F., Corti, E., Azkona, G., Madeira, M. F., Tomé, Â. R., Ferreira, S. G., Cunha, R. A., Duarte, C. B., & Santos, M. (2024). The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity. Molecular Psychiatry, 29(5), 1322–1337. https://doi.org/10.1038/s41380-024-02412-z
2-year Impact Factor: 9.6|2023
Impact factor notes: Impact factor not available yet for 2024
Times cited: 0|2025-02-19
Indexed document: Yes
Quartile: Q1
Keywords: Fear extinction learning / GluN2B-containing NMDAR / amygdala NT3-TrkC

The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity

The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity