Reference code: | PT/FB/BL-2006-036.12 |
Location: | Arquivo PCA - Pasta 18/2006
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Title:
| Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode
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Publication year: | 2009
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URL:
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
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Abstract/Results: | ABSTRACT:
Introduction: An excess of neurological signs is present in psychosis, particularly in primary and motor coordination signs. It remains unclear whether these signs progress over the course of the illness, and it has never been investigated whether any progression is associated with changes in brain structure. Methods: We evaluated 49 individuals (mean age 27 years 68; 59% males; 45% DSM IV schizophrenia) at the time of the first psychotic episode and 6 years later. We investigated neurological function using the Neurological Evaluation Scale, and grey matter volume using Magnetic Resonance Imaging, with a 1.5 T GE scanner. We estimated grey matter volume with automated segmentation methods. Results: Rates of primary and motor coordination signs remained stable over the follow up period, as did motor sequencing signs. In contrast, sensory integration signs increased over the follow up period (P = .007). Higher rates of primary signs (at baseline) and higher rates of motor coordination signs (at follow up) were correlated with more grey matter loss over follow up (P = .05 and P = .07 respectively). Conclusions: Primary and motor coordination deficits
may represent trait markers of psychosis and their presence may be predictive of a more progressive illness course. Further work will investigate whether these signs are also associated with regional brain changes.
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Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Dazzan, P.
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Secondary author(s):
| Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., Hutchinson, G., McGuire, P., Jones, P., Leff, J., Fearon, P., Murray, R., Lappin, J.
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Document type:
| Abstract
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Number of reproductions:
| 1
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Reference:
| Dazzan, P., Morgan, K., Morgan, C., Reinders, S., Zanelli, J., Orr, K., . . . Lappin, J. (2009). Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode. Schizophrenia Bulletin, 35(Suppl. 1), 207-207.
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Indexed document: | Yes
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Keywords: | Neurological signs / Psychosis / Schizophrenia / Functional magnetic resonance imaging (fMRI) / Trait markers
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Changes in neurological signs and their anatomical correlates, over 6 years after the first psychotic episode |