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Document

Gamma-rhythm, positive, negative symptoms and cognitive dysfunction in schizophrenia

2010

BIAL Foundation Archive
- BIAL Grants
  - 2002 Grants
    - 020 - Psychophysiological Mechanisms of some aspects of Neurocognitive Deficit in Schizophrenic Patients
      - Gamma-rhythm, positive, negative symptoms and cognitive dysfunction in schizophrenia

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2002
Location:	Arquivo PCA - Pastas 1 a 21/2002
Title:	2002 Grants
Start date:	2003-01 - 2009-11
Dimension/support:	21 caixas de arquivo

Reference code:	PT/FB/BL-2002-020
Location:	Arquivo PCA - Pasta 2/2002
Title:	020 - Psychophysiological Mechanisms of some aspects of Neurocognitive Deficit in Schizophrenic Patients
Duration:	2003-02 - 2004-12
Researcher(s):	Valeria Strelets, Janna Golikova, Vladimir Novototsky-Vlasov, R.A. Magomedov, M.V. Magomedova
Institution(s):	Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences (Russia)
Contents:	Contents: Application form Correspondence Financial report and expenditure documents Progress report Final report
Language:	eng
Author:	Strelets, V.
Secondary author(s):	Golikova, J., Novototsky-Vlasov, V. Y., Magomedov, R., Magomedova, M.
Number of reproductions:	1
Keywords:	Psychophysiology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

Reference code:	PT/FB/BL-2002-020.05
Location:	Arquivo PCA - Pasta 2/2002
Title:	Gamma-rhythm, positive, negative symptoms and cognitive dysfunction in schizophrenia
Publication year:	2010
Contents:	http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=245&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results:	ABSTRACT: We studied characteristics of gamma-band (30-40 Hz) EEG in dependence on the prevalence of positive or negative symptoms of schizophrenia, taking into account the state of cognitive functions. Twenty patients with ICD-10 diagnosis of schizophrenia, with different disease duration (first episode and duration of more than two years) and 38 healthy people were studied. The presence and intensity of positive and negative symptoms were measured by the PANSS scale and cognitive functions were assessed using neuropsychological tests. Compared to the controls, the gamma-rhythm power was higher in patients with the prevalence of positive symptoms and lower in patients with negative symptoms. The reduced number of coherent relations, in particular, interhemispheric ones, and the absence of gamma-band synchronization in different brain areas were found in patients as well.
Accessibility:	Document does not exist in file
Language:	rus
Author:	Magomedov, R.
Secondary author(s):	Garakh, Z. H., Orekhov, Iu. V., Zaitseva, Iu. S., Strelets, V.
Document type:	Article
Number of reproductions:	1
Reference:	Magomedov, R. A., Garakh, Z. V., Orekhov, Y. V., Zaytseva, Y. S., & Strelets, V. B. (2010). Gamma-rhythm, positive, negative symptoms and cognitive dysfunction in schizophrenia. Zhurnal Nevrologii I Psikhiatrii Imeni S S Korsakova, 110(1), 78-83.
2-year Impact Factor:	0.135\|2010
Times cited:	3\|2025-09-09
Indexed document:	Yes
Quartile:	Q4
Keywords:	Schizophrenia / Electroencephalogram (EEG) / Gamma-band / Positive and negative symptoms / Cognitive processes

Document

Stimulus dependent neural oscillatory patterns show reliable statistical identification of Autism Spectrum Disorder in a face perceptual decision task

2018

BIAL Foundation Archive
- BIAL Grants
  - 2014 Grants
    - 373 - Multimodal Mapping of Visual Motion Perceptual Decision: Dissecting the Role of Different Motion Integration Areas in Visual Surface Reconstruction
      - Stimulus dependent neural oscillatory patterns show reliable statistical identification of Autism Spectrum Disorder in a face perceptual decision task

Reference code:	PT/FB
Entity holding:	BIAL Foundation
Location:	S. Mamede do Coronado
Title:	BIAL Foundation Archive
Start date:	1994
History:	The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives. Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge. Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research. The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology. To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world. Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL:	http://www.bial.com/pt/
Accessibility:	By permission

Reference code:	PT/FB/BL
Entity holding:	BIAL Foundation
Title:	BIAL Grants
Start date:	1994
History:	In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology. Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries. The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project. The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665). Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others. The BIAL grants are promoted biannually.

Reference code:	PT/FB/BL-2014
Location:	BF-GMS
Title:	2014 Grants
Start date:	2015-01

Reference code:	PT/FB/BL-2014-373
Location:	BF-GMS
Title:	373 - Multimodal Mapping of Visual Motion Perceptual Decision: Dissecting the Role of Different Motion Integration Areas in Visual Surface Reconstruction
Duration:	2016-02 - 2017-10
Researcher(s):	Miguel de Sá e Sousa de Castelo Branco, Gabriel Nascimento Ferreira da Costa, Gilberto Silva, João Valente Duarte, Ricardo Martins
Institution(s):	ICNAS - Institute for Nuclear Sciences Applied to Health, Coimbra, Portugal; IBILI - Institute for Biomedical Imaging and Life Sciences, Coimbra (Portugal)
Contents:	Contents: Application form Correspondence Progress report Final report Articles
Author:	Castelo-Branco, M.
Secondary author(s):	Costa, G., Silva, G., Duarte, J., Martins, R.
Number of reproductions:	1
Keywords:	Motion perception / Decision-making / Perceptual Ambiguity / Decision Models / Psychophysiology

Reference code:	PT/FB/BL-2014-373.18
Location:	BF-GMS
Title:	Stimulus dependent neural oscillatory patterns show reliable statistical identification of Autism Spectrum Disorder in a face perceptual decision task
Publication year:	2018
URL:	https://www.sciencedirect.com/science/article/pii/S1388245718300981
Abstract/Results:	ABSTRACT: OBJECTIVE Electroencephalographic biomarkers have been widely investigated in autism, in the search for diagnostic, prognostic and therapeutic outcome measures. Here we took advantage of the information available in temporal oscillatory patterns evoked by simple perceptual decisions to investigate whether stimulus dependent oscillatory signatures can be used as potential biomarkers in Autism spectrum disorder (ASD). METHODS We studied an extensive set of stimuli (9 categories of faces) and performed data driven classification (Support vector machine, SVM) of ASD vs. Controls with features based on the EEG power responses. We carried out an extensive time-frequency and synchrony analysis of distinct face categories requiring different processing mechanisms in terms of non-holistic vs. holistic processing. RESULTS We found that the neuronal oscillatory responses of low gamma frequency band, locked to photographic and abstract two-tone (Mooney) face stimulus presentation are decreased in ASD vs. the control group. We also found decreased time-frequency (TF) responses in the beta band in ASD after 350ms, possibly related to motor preparation. On the other hand, synchrony in the 30-45Hz band showed a distinct spatial pattern in ASD. These power changes enabled accurate classification of ASD with an SVM approach. SVM accuracy was approximately 85%. ROC curves showed about 94% AUC (area under the curve). Combination of Mooney and Photographic face stimuli evoked features enabled a better separation between groups, reaching an AUC of 98.6%. CONCLUSIONS We identified a relative decrease in EEG responses to face stimuli in ASD in the beta (15-30Hz; >350ms) and gamma (30-45Hz; 55-80Hz; 50-350ms) frequency ranges. These can be used as input of a machine learning approach to separate between groups with high accuracy. SIGNIFICANCE Future studies can use EEG time-frequency patterns evoked by particular types of faces as a diagnostic biomarker and potentially as outcome measures in therapeutic trials.
Accessibility:	Document exists in file
Copyright/Reproduction:	By permission
Language:	eng
Author:	Castelhano, J.
Secondary author(s):	Tavares, P., Mouga, S., Oliveira, G., Castelo-Branco, M.
Document type:	Article
Number of reproductions:	1
Reference:	Castelhano, J., Tavares, P., Mouga, S., Oliveira, G., & Castelo-Branco, M. (2018). Stimulus dependent neural oscillatory patterns show reliable statistical identification of Autism Spectrum Disorder in a face perceptual decision task. Clinical Neurophysiology, 129(5), 981-989. https://doi.org/10.1016/j.clinph.2018.01.072
2-year Impact Factor:	3.675\|2018
Times cited:	13\|2025-09-17
Indexed document:	Yes
Quartile:	Q2
Keywords:	ASD / Gamma-band / Holistic processing / EEG / Biomarker / SVM classification