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BIAL Foundation
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DocumentFinal report - The role of astrocytes in complex cognitive processing2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-207
Location: BF-GMS
Title:
207 - The role of astrocytes in complex cognitive processing
Duration: 2015-10
Researcher(s):
João Filipe Pedreira de Oliveira, Joana Correia, Joana Marques, Luísa Pinto, Nuno Dias, Sónia Guerra Gomes, Vanessa Sardinha, Inês Caetano Campos
Institution(s): ICVS/3B's Laboratório Associado - Universidade do Minho, Braga (Portugal)
Contents: Contents:
Application form
Correspondence
Notes: This project is still in progress
Author: Oliveira, J. F.
Secondary author(s):
Correia, J., Marques, J., Pinto, L., Dias, N., Gomes, S., Sardinha, V.
Number of reproductions:
1
Keywords:
Psychophysiology

Reference code: PT/FB/BL-2014-207.01
Location: BF-GMS
Title:
Final report - The role of astrocytes in complex cognitive processing
Publication year: 2019
URL:
https://www.bial.com/media/3019/apoio-20714.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
The importance of glial cells in the brain is rising due to emerging data supporting dynamic neuron-glia interactions, in which astrocyte signaling complements and modulates the communication between pre- and post-synaptic neurons.
AIMS
The main research objective of this project was to assess how astrocyte signaling and calcium-dependent mechanisms underlie cognitive processing in the brain, and to control these pathways to modulate cognitive function.
METHOD
We tested the dnSNARE model that lacks astrocyte signaling via exocytosis and the IP3R2KO model that lacks calcium-dependent signaling in astrocytes. To assess the influence of these mechanisms to cognitive function, we used complementary state-of-the-art techniques such as in vivo electrophysiology, innovative behavior, structural and molecular analysis, to characterize, monitor and rescue cognitive function.
RESULTS
Our results show that neuronal synchrony between the prefrontal cortex and the dorsal hippocampus is dependent on astrocyte signaling. This synchrony supports correct cognitive computation and may be rescued by supplementation of D-serine, a known modulator of glutamatergic excitatory transmission, which is released by astrocytes. We showed also that astrocytic calcium-dependent mechanisms are relevant for cognitive computation in different life stages and may be used to modulate cognitive performance.
CONCLUSIONS
This grant allowed us to explore the potential of astrocyte modulation in brain cells and circuits to allow correct cognitive computation. The results obtained in this project have widened our understanding of astrocyte-specific mechanisms that might mediate cognitive performance.
Accessibility: Document exists in file
Language:
eng
Author:
Oliveira, J. F.
Document type:
Final report
Number of reproductions:
1
Reference:
Oliveira, J. F. (2019). Final report - The role of astrocytes in complex cognitive processing.
Indexed document: No
Keywords: Astrocyte / Gliotransmission / Learning / Prefrontal cortex

Final report - The role of astrocytes in complex cognitive processing

Final report - The role of astrocytes in complex cognitive processing