| Reference code: | PT/FB/BL-2006-036.02 |
| Location: | Arquivo PCA - Pasta 18/2006
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Title:
| Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
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| Publication year: | 2010
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URL:
| http://www.ncbi.nlm.nih.gov/pubmed/20071148
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| Abstract/Results: | ABSTRACT:
This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.
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| Accessibility: | Document does not exist in file
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Language:
| eng
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Author:
| Mondelli, V.
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Secondary author(s):
| Pariante, C., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R., Dazzan, P.
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Document type:
| Article
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Number of reproductions:
| 1
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Percentiles:
| 91.77|2.60
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Reference:
| Mondelli, V., Pariante, C., Navari, S., Aas, M., D'Albenzio, A., ... Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75-8. https://doi.org/10.1016/j.schres.2009.12.021
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| 2-year Impact Factor: | 4.374|2010
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| Times cited: | 113|2026-02-05
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| Indexed document: | Yes
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| Quartile: | Q1
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| Keywords: | Cortisol / Hippocampus / Psychosis / Hypothalamic-pituitary-adrenal axis / Schizophrenia / Glucocorticoids
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Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis |