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DocumentCombining local and global evolutionary trajectories of brain-behaviour relationships through game theory2020

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-195
Location: BF-GMS
Title:
195 - The sense of self: A neuroimaging study of interactions between intrinsic and extrinsic self networks
Duration: 2017-04 - 2019-10
Researcher(s):
Sjoerd Ebisch, Mauro Gianni Perrucci
Institution(s): Department of Neurosciences, Imaging and Clinical Sciences, University "G. D'Annunzio" of Chieti - Pescara (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Ebisch, S.
Secondary author(s):
Perrucci, M. G.
Number of reproductions:
1
Keywords:
Intrinsic self / Extrinsic self / Brain network interactions / Neuroimaging / Psychophysiology

Reference code: PT/FB/BL-2016-195.07
Location: BF-GMS
Title:
Combining local and global evolutionary trajectories of brain-behaviour relationships through game theory
Publication year: 2020
URL:
https://onlinelibrary.wiley.com/doi/10.1111/ejn.14883
Abstract/Results: ABSTRACT:
The study of the evolution of brain-behaviour relationships concerns understanding the causes and repercussions of cross- and within-species variability. Understanding such variability is a main objective of evolutionary and cognitive neuroscience, and it may help explaining the appearance of psychopathological phenotypes. Although brain evolution is related to the progressive action of selection and adaptation through multiple paths (e.g. mosaic vs. concerted evolution, metabolic vs. structural and functional constraints), a coherent, integrative framework is needed to combine evolutionary paths and neuroscientific evidence. Here, we review the literature on evolutionary pressures focusing on structural-functional changes and developmental constraints. Taking advantage of recent progress in neuroimaging and cognitive neuroscience, we propose a twofold hypothetical model of brain evolution. Within this model, global and local trajectories imply rearrangements of neural subunits and subsystems and of behavioural repertoires of a species, respectively. We incorporate these two processes in agamein which the global trajectory shapes the structural-functional neural substrates (i.e. players), while the local trajectory shapes the behavioural repertoires (i.e. stochastic payoffs).
Accessibility: Document does not exist in file
Language:
eng
Author:
Di Plinio, S.
Secondary author(s):
Ebisch, S. J. H.
Document type:
Article
Number of reproductions:
1
Percentiles:
8.08|0.11
Reference:
Di Plinio, S., & Ebisch, S. J. H. (2020). Combining local and global evolutionary trajectories of brain-behaviour relationships through game theory. European Journal of Neuroscience, 52(9), 4198-4213. https://doi.org/10.1111/ejn.14883
2-year Impact Factor: 3.386|2020
Times cited: 5|2026-02-12
Indexed document: Yes
Quartile: Q3
Keywords: Brain networks / Brain systems / Brain-behaviour relationships / Evolution / Game theory / Graph theory / Individual differences / Integrative neuroscience
DocumentConnecting brain and behavior in clinical neuroscience: A network approach2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-284
Location: BF-GMS
Title:
284 - The whole is more than the sum of its parts: Elucidating the link between sleep quality and well-being by integrating cross-modal networks
Duration: 2021-09 - 2023-03
Researcher(s):
Tessa Blanken, Denny Borsboom
Institution(s): Department of Psychology, University of Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Article
Language: eng
Author:
Blanken, T.
Secondary author(s):
Borsboom, D.
Number of reproductions:
1
Keywords:
Sleep / Well-being / Psychophysiology

Reference code: PT/FB/BL-2020-284.02
Location: BF-GMS
Title:
Connecting brain and behavior in clinical neuroscience: A network approach
Publication year: 2021
URL:
https://www.sciencedirect.com/science/article/pii/S0149763421003250
Abstract/Results: ABSTRACT:
In recent years, there has been an increase in applications of network science in many different fields. In clinical neuroscience and psychopathology, the developments and applications of network science have occurred mostly simultaneously, but without much collaboration between the two fields. The promise of integrating these network applications lies in a united framework to tackle one of the fundamental questions of our time: how to understand the link between brain and behavior. In the current overview, we bridge this gap by introducing conventions in both fields, highlighting similarities, and creating a common language that enables the exploitation of synergies. We provide research examples in autism research, as it accurately represents research lines in both network neuroscience and psychological networks. We integrate brain and behavior not only semantically, but also practically, by showcasing three methodological avenues that allow to combine networks of brain and behavioral data. As such, the current paper offers a stepping stone to further develop multi-modal networks and to integrate brain and behavior.
Accessibility: Document exists in file
Language:
eng
Author:
Blanken, T. F.
Secondary author(s):
Bathelt, J., Deserno, M. K., Voge, L., Borsboom, D., Douw, L.
Document type:
Article
Number of reproductions:
1
Percentiles:
96.57|2.90
Reference:
Blanken, T. F., Bathelt, J., Deserno, M. K., Voge, L., Borsboom, D., & Douw, L. (2021). Connecting brain and behavior in clinical neuroscience: A network approach. Neuroscience and Biobehavioral Reviews, 130, 81-90. https://doi.org/10.1016/j.neubiorev.2021.07.027
2-year Impact Factor: 9.052|2021
Times cited: 43|2026-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Brain / Behavior / Network science / Psychopathology / Clinical neuroscience / Graph theory

Connecting brain and behavior in clinical neuroscience: A network approach

Connecting brain and behavior in clinical neuroscience: A network approach
DocumentEarly diagnosis of Alzheimer's disease using machine learning: A multi-diagnostic, generalizable approach2022

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-292
Location: BF-GMS
Title:
292 - Oxytocin: On the psychophysiology of trust and cooperation
Duration: 2017-10 - 2023-11
Researcher(s):
Diana Prata, James Rilling, Manuel Lopes, Duarte Ferreira, Daniel Martins, Pedro Levy
Institution(s): FCiências.ID – Associação para a Investigação e Desenvolvimento de Ciências (Portugal); Emory University, Atlanta (USA)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Prata, D.
Secondary author(s):
Rilling, J., Lopes, M., Ferreira, D. , Martins, D., Levy, P.
Number of reproductions:
1
Keywords:
Oxytocin / Mentalizing / Theory of mind / Dopamine / Psychophysiology

Reference code: PT/FB/BL-2016-292.13
Location: BF-GMS
Title:
Early diagnosis of Alzheimer's disease using machine learning: A multi-diagnostic, generalizable approach
Publication year: 2022
URL:
https://alzres.biomedcentral.com/articles/10.1186/s13195-022-01047-y
Abstract/Results: Abstract
Background
Early and accurate diagnosis of Alzheimer’s disease (AD) is essential for disease management and therapeutic choices that can delay disease progression. Machine learning (ML) approaches have been extensively used in attempts to develop algorithms for reliable early diagnosis of AD, although clinical usefulness, interpretability, and generalizability of the classifiers across datasets and MRI protocols remain limited.
Methods
We report a multi-diagnostic and generalizable approach for mild cognitive impairment (MCI) and AD diagnosis using structural MRI and ML. Classifiers were trained and tested using subjects from the AD Neuroimaging Initiative (ADNI) database (n = 570) and the Open Access Series of Imaging Studies (OASIS) project database (n = 531). Several classifiers are compared and combined using voting for a decision. Additionally, we report tests of generalizability across datasets and protocols (IR-SPGR and MPRAGE), the impact of using graph theory measures on diagnostic classification performance, the relative importance of different brain regions on classification for better interpretability, and an evaluation of the potential for clinical applicability of the classifier.
Results
Our “healthy controls (HC) vs. AD” classifier trained and tested on the combination of ADNI and OASIS datasets obtained a balanced accuracy (BAC) of 90.6% and a Matthew’s correlation coefficient (MCC) of 0.811. Our “HC vs. MCI vs. AD” classifier trained and tested on the ADNI dataset obtained a 62.1% BAC (33.3% being the by-chance cut-off) and 0.438 MCC. Hippocampal features were the strongest contributors to the classification decisions (approx. 25–45%), followed by temporal (approx. 13%), cingulate, and frontal regions (approx. 8–13% each), which is consistent with our current understanding of AD and its progression. Classifiers generalized well across both datasets and protocols. Finally, using graph theory measures did not improve classification performance.
Conclusions
In sum, we present a diagnostic tool for MCI and AD trained using baseline scans and a follow-up diagnosis regardless of progression, which is multi-diagnostic, generalizable across independent data sources and acquisition protocols, and with transparently reported performance. Rated as potentially clinically applicable, our tool may be clinically useful to inform diagnostic decisions in dementia, if successful in real-world prospective clinical trials.
Accessibility: Document exists in file
Language:
eng
Author:
Diogo, V. S.
Secondary author(s):
Ferreira, H. A., Prata, D., Alzheimer's Disease Neuroimaging Initiative
Document type:
Article
Number of reproductions:
1
Percentiles:
98.60|5.69
Reference:
Diogo, V. S., Ferreira, H. A., Prata, D., & Alzheimer's Disease Neuroimaging Initiative (2022). Early diagnosis of Alzheimer's disease using machine learning: A multi-diagnostic, generalizable approach. Alzheimer's Research & Therapy, 14, 17. https://doi.org/10.1186/s13195-022-01047-y
2-year Impact Factor: 9.000|2022
Times cited: 65|2026-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Alzheimer’s disease / Mild cognitive impairment / Dementia / Early diagnosis / Prognosis / Classification / Machine learning / Graph theory

Early diagnosis of Alzheimer's disease using machine learning: A multi-diagnostic, generalizable approach

Early diagnosis of Alzheimer's disease using machine learning: A multi-diagnostic, generalizable approach
DocumentUnravelling brain connectivity patterns in body dysmorphic disorder during decision-making on visual illusions: A graph theoretical approach2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-138
Location: BF-GMS
Title:
138 - The neural signatures of leadership: Two-brain directed synchronization during eye contact
Duration: 2019-07 - 2023-09
Researcher(s):
Caroline Di Bernardi Luft, Isabelle Mareschal
Institution(s): School of Biological and Chemical Sciences, Queen Mary University of London (UK)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Luft, C. D. B.
Secondary author(s):
Mareschal, I.
Number of reproductions:
1
Keywords:
Brain-to-brain synchronization / Electroencephalogram (EEG) / Hyperscanning / Eye-tracking / Psychophysiology

Reference code: PT/FB/BL-2018-138.04
Location: BF-GMS
Title:
Unravelling brain connectivity patterns in body dysmorphic disorder during decision-making on visual illusions: A graph theoretical approach
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S0165178123002068
Abstract/Results: ABSTRACT:
Body dysmorphic disorder (BDD) is characterized by an excessive preoccupation with perceived defects in physical appearance, and is associated with compulsive checking. Visual illusions are illusory or distorted subjective perceptions of visual stimuli, which are induced by specific visual cues or contexts. While previous research has investigated visual processing in BDD, the decision-making processes involved in visual illusion processing remain unknown. The current study addressed this gap by investigating the brain connectivity patterns of BDD patients during decision-making about visual illusions. Thirty-six adults - 18 BDD (9 female) and 18 healthy controls (10 female) - viewed 39 visual illusions while their EEG was recorded. For each image, participants were asked to indicate (1) whether they perceived the illusory features of the images; and (2) their degree of confidence in their response. Our results did not uncover group-level differences in susceptibility to visual illusions, supporting the idea that higher-order differences, as opposed to lower-level visual impairments, can account for the visual processing differences that have previously been reported in BDD. However, the BDD group had lower confidence ratings when they reported illusory percepts, reflecting increased feelings of doubt. At the neural level, individuals with BDD showed greater theta band connectivity while making decisions about the visual illusions, likely reflecting higher intolerance to uncertainty and thus increased performance monitoring. Finally, control participants showed increased left-to-right and front-to-back directed connectivity in the alpha band, which may suggest more efficient top-down modulation of sensory areas in control participants compared to individuals with BDD. Overall, our findings are consistent with the idea that higher-order disruptions in BDD are associated with increased performance monitoring during decision-making, which may be related to constant mental rechecking of responses.
Accessibility: Document exists in file
Language:
eng
Author:
Giannopoulos, A. E.
Secondary author(s):
Zioga, I., Luft, C. D. B., Papageorgiou, P., Papageorgiou, G. N., Kapsali, F., Kontoangelos, K., Capsalis, C. N., Papageorgiou, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
46.06|0.62
Reference:
Giannopoulos, A. E., Zioga, I., Luft, C. D. B., Papageorgiou, P., Papageorgiou, G. N., Kapsali, F., Kontoangelos, K., Capsalis, C. N., & Papageorgiou, C. (2023). Unravelling brain connectivity patterns in body dysmorphic disorder during decision-making on visual illusions: A graph theoretical approach. Psychiatry Research, 325, 115256. https://doi.org/10.1016/j.psychres.2023.115256
2-year Impact Factor: 4.2|2023
Times cited: 4|2026-02-15
Indexed document: Yes
Quartile: Q1
Keywords: Electroencephalogram (EEG) / Body dysmorphic disorder / Visual illusions / Graph theory / Decision-making / Connectivity
DocumentAberrant functional connectivity and brain network organization in high-schizotypy individuals: An electroencephalography study2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-033
Location: BF-GMS
Title:
033 - The influence of emotions on actions: Boosting brain network plasticity to ameliorate action control
Duration: 2023-10 - 2025-05
Researcher(s):
Sara Borgomaneri, Vincenzo Romei
Institution(s): Department of Psychology, University of Bologna (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress Report
Final Report
Articles
Language: eng
Author:
Borgomaneri, S.
Secondary author(s):
Romei, V.
Number of reproductions:
1
Keywords:
Action control / Emotions / Transcranial magnetic stimulation / Unconscious perception / Psychophysiology

Reference code: PT/FB/BL-2022-033.09
Location: BF-GMS
Title:
Aberrant functional connectivity and brain network organization in high-schizotypy individuals: An electroencephalography study
Publication year: 2025
URL:
https://doi.org/10.1093/schbul/sbaf004
Abstract/Results: ABSTRACT:
Background and Hypothesis
Oscillatory synchrony plays a crucial role in establishing functional connectivity across distinct brain regions. Within the realm of schizophrenia, suggested to be a neuropsychiatric disconnection syndrome, discernible aberrations arise in the organization of brain networks. We aim to investigate whether the resting-state functional network is already altered in healthy individuals with high schizotypy traits, highlighting the pivotal influence of brain rhythms in driving brain network alterations.
Study Design
Two-minute resting-state electroencephalography recordings were conducted on healthy participants with low and high schizotypy scores. Subsequently, spectral Granger causality was used to compute functional connectivity in theta, alpha, beta, and gamma frequency bands, and graph theory metrics were employed to assess global and local brain network features.
Study Results
Results highlighted that high-schizotypy individuals exhibit a lower local efficiency in theta and alpha frequencies and a decreased global efficiency across theta, alpha, and beta frequencies. Moreover, high schizotypy is characterized by a lower nodes’ centrality and a frequency-specific decrease of functional connectivity, with a reduced top-down connectivity mostly in slower frequencies and a diminished bottom-up connectivity in faster rhythms.
Conclusions
These results show that healthy individuals with a higher risk of developing psychosis exhibit a less efficient functional brain organization, coupled with a systematic decrease in functional connectivity impacting both bottom-up and top-down processing. These frequency-specific network alterations provide robust support for the dimensional model of schizophrenia, highlighting distinctive neurophysiological signatures in high-schizotypy individuals.
Accessibility: Document exists in file
Language:
eng
Author:
Trajkovic, J.
Secondary author(s):
Ricci, G., Pirazzini, G., Tarasi, L., Di Gregorio, F., Magosso, E., Ursino, M., Romei, V.
Document type:
Article
Number of reproductions:
1
Percentiles:
93.41|4.75
Reference:
Trajkovic, J., Ricci, G., Pirazzini, G., Tarasi, L., Di Gregorio, F., Magosso, E., Ursino, M., & Romei, V. (2025). Aberrant functional connectivity and brain network organization in high-schizotypy individuals: An electroencephalography study. Schizophrenia Bulletin, sbaf004. https://doi.org/10.1093/schbul/sbaf004
2-year Impact Factor: 4.8|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 3|2026-02-16
Indexed document: Yes
Quartile: Q1
Keywords: Schizotypy / Granger causality / Graph theory / Electroencephalography / Resting-state networks / Brain rhythms