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DocumentFinal report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.01
Location: Arquivo PCA - Pasta 13/2004
Title:
Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Publication year: 2007
URL:
http://www.bial.com/imagem/Bolsa%2016804.pdf
Abstract/Results: RESULTS:
Using the opportunity to record parahippocampal activity with foramen ovale electrodes in epilepsy patients we examined high-frequency activity and its relation to NREM sleep-slow oscillations and sleep spindles. Parahippocampal high-frequency activity was organized into bursts which were consistently associated with interictal epileptic spikes. Ripple density was higher during Non-REM than REM sleep (p<0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (p<0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (p<0.001). Coordinated occurrence of hippocampal ripples, sleep spindles and slow oscillations have already been reported in animals yet the present results provide first evidence for such a temporal coupling in humans. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Halász, P.
Secondary author(s):
Borbély, C., Fabó, D., Eross, L., Entz, L.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Epilepsy / Sleep / Hippocampus

Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

Final report - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy

DocumentTemporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.02
Location: Arquivo PCA - Pasta 13/2004
Title:
Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans
Publication year: 2007
URL:
http://www.ncbi.nlm.nih.gov/pubmed/17615093
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the depolarized up-state. The temporal coupling between slow oscillations, spindles and ripples has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation during sleep. Here, we examined whether a similar coupling exists between these oscillatory phenomena in humans. In sleep recordings from seven epileptic patients, scalp-recorded slow oscillations and spindles as well as parahippocampal ripples recorded from foramen ovale electrodes were identified by automatic algorithms. Additionally, ripple and spindle root mean square activity was determined for relevant frequency bands. Ripple density was higher during Non-REM than REM sleep (P < 0.001). Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations (P < 0.001), whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak (P < 0.001). Ripples were consistently associated with interictal spikes suggesting that spike-ripple complexes represent an epileptic transformation of sharp wave-ripple complexes in the epileptic hippocampus. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eross, L., Barsi, P., Halász, P., Born, J.
Document type:
Article
Number of reproductions:
1
Reference:
Clemens, Z., Mölle, M., Eross, L., Barsi, P., Halász, P., & Born, J. (2007). Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. Brain, 130, 2868-2878. doi: 10.1093/brain/awm146
2-year Impact Factor: 8.568|2007
Times cited: 285|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Sleep / Hippocampus / Sharp-wave ripples / Slow oscillation / Epilepsy

Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans

DocumentTwenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.03
Location: Arquivo PCA - Pasta 13/2004
Title:
Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles
Publication year: 2006
URL:
http://www.ncbi.nlm.nih.gov/pubmed/16714084
Abstract/Results: ABSTRACT:
Recent evidence suggests that the sleep-dependent consolidation of declarative memories relies on the non-rapid eye movement (NREM) rather than the rapid eye movement (REM) phase of sleep. Moreover, a few studies both at the cellular and the behavioural levels have suggested the involvement of sleep spindles, the most synchronous oscillatory waveforms during NREM sleep stage 2, in this process. Our previous study showed that overnight verbal memory retention correlates with the total number of sleep spindles in left frontocentral areas, while spindling in other regions did not correlate with mnemonic retention. In the present study, we show that retention of visuospatial memories over a 24-h period correlates with the total number of sleep spindles detected over parietal regions during the intervening night-time sleep. This result provides further evidence for the association between sleep spindle activity and declarative memory consolidation, and suggests that visuospatial and verbal memory retention differ in the topographic distribution of the NREM spindle activity with which they are associated.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Fabó, D., Halász, P.
Document type:
Article
Number of reproductions:
1
Reference:
Clemens, Z., Fabó, D., & Halász, P. (2006). Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles. Neuroscience Letters, 403(1-2), 52-56. doi: 10.1016/j.neulet.2006.04.035
2-year Impact Factor: 2.092|2006
Times cited: 106|2022-05-19
Indexed document: Yes
Quartile: Q3
Keywords: Sleep spindles / Rey-Osterrieth complex figure task / Memory consolidation / Oscillations / Hippocampus / Declarative memory

Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles

Twenty-four hours retention of visuospatial memory correlates with the number of parietal sleep spindles

DocumentTemporal coupling of parahippocampal ripples and sleep spindles in humans2006

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.05
Location: Arquivo PCA - Pasta 13/2004
Title:
Temporal coupling of parahippocampal ripples and sleep spindles in humans
Publication year: 2006
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2869.2006.00540_57.x/pdf
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during NREM sleep. In rodents they occur in association with sharp waves and are known to be grouped by the cortical slow oscillation such that their occurrence is maximal during the surface positive, up states. Ripples were also shown to be temporally linked to sleep spindles. Importantly, coordinated spindleripple events have been suggested to provide a framework for information transfer between the hippocampus and the neocortex underlying memory consolidation. Our aim was to examine whether ripples recorded via parahippocampal electrocorticography are also temporally linked with slow oscillations and sleep spindles in epileptic
humans. Whole-night recordings from seven epilepsy patients implanted with foramen ovale (FO) electrodes were analysed. Negative half waves of the slow oscillation and sleep spindles recorded on the scalp as well as ripples in FO recordings were detected by an automatic algorithm. Ripple activity was also measured as root mean square (RMS) of the 80–140 Hz activity. Compared to baseline both ripple measures showed a significant increase time-locked to sleep spindles. In the three patients without temporal structural alterations ripple activity decreased time-locked to slow oscillation negative half waves. In the four other patients exhibiting hippocampal sclerosis, modulation of ripple activity by the negative half waves was much less clear. Ripples significantly increased during NREM sleep and were consistently associated with interictal epileptic spikes. This suggests that ripple/spike complexes represent an epileptic exaggeration of ripple/sharp wave complexes in the human epileptic hippocampus. Whether ripples are epileptically transformed or not, the present data provide first evidence for a temporal coupling between hippocampal ripples and neocortical spindles in humans.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eröss, L., Barsi, P., Halász, P., Born, J.
Document type:
Abstract
Number of reproductions:
1
Reference:
Clemens, Z., Molle, M., Eross, L., Barsi, P., Halasz, P., & Born, J. (2006). Temporal coupling of parahippocampal ripples and sleep spindles in humans. Journal of Sleep Research, 15(Suppl. 1), 242-242. doi: 10.1111/j.1365-2869.2006.00540_57.x
Indexed document: Yes
Keywords: Sleep / Hippocampus / Sharp-wave ripples / Epilepsy

Temporal coupling of parahippocampal ripples and sleep spindles in humans

Temporal coupling of parahippocampal ripples and sleep spindles in humans

DocumentLearning impairments and dopaminergic changes in monoarthritic rats2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-084
Location: Arquivo PCA - Pastas 19 a 20/2004
Title:
084 - A consciência da dor: Alterações induzidas por dor crónica nos mecanismos neurobiológicos de aprendizagem, atenção e recompensa
Duration: 2005-01 - 2008-11
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Miguel Santos Pais-Vieira, Clara Maria Pires Costa Bastos Monteiro
Institution(s): IBMC - Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng / por
Related objects:
PT/FB/BL-2008-126
Author: Galhardo, V.
Secondary author(s):
Lima, D., Pais-Vieira, M., Monteiro, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Decision-making / Memory / Attention / Learning / Brain structure and function / Assessment tools

Reference code: PT/FB/BL-2004-084.11
Location: Arquivo PCA - Pasta 19/2004
Title:
Learning impairments and dopaminergic changes in monoarthritic rats
Publication year: 2008
Accessibility:
Document exists in file (in attachment to the final report)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pais-Vieira, M.
Secondary author(s):
Mendes-Pinto, M., Lima, D., Galhardo, V.
Document type:
Unpublished document
Number of reproductions:
1
Reference:
Pais-Vieira, M., Mendes-Pinto, M., Lima, D., & Galhardo, V. (2008). Learning impairments and dopaminergic changes in monoarthritic rats [Unpublished document].
Indexed document: No
Keywords: Monoarthritis / Complete Freund's adjuvant / Dopamine / Hippocampus / Orbitofrontal cortex / Learning / Working memory / Reference memory

Learning impairments and dopaminergic changes in monoarthritic rats

Learning impairments and dopaminergic changes in monoarthritic rats

DocumentDissociating the neural correlates of verbal and visual episodic memory in normal subjects and in patients with medial temporal lobe pathology2005

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-016
Location: Arquivo PCA - Pasta 24/2004
Title:
016 - Perceptual memory in the human visual system
Duration: 2006-02 - 2010-04
Researcher(s):
Patrícia Margarida Piedade Figueiredo, Mafalda Cavalheiro Gomes Moreira Mendes, Maria Fátima Loureiro da Silva, João Abel Loureiro Marques Xavier, Carlos Gomes
Institution(s): Instituto Biofísico para a Investigação em Luz e Imagem (IBILI), Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Abstracts and posters
Informed consent forms
Review of the final report
Language: eng
Author:
Figueiredo, P.
Secondary author(s):
Mendes, M., Silva, M. F., Xavier, J., Gomes, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Body structure and function / Vision / Cognitive processes / Memory / Learning / Perception / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2004-016.07
Location: Arquivo PCA - Pasta 24/2004
Title:
Dissociating the neural correlates of verbal and visual episodic memory in normal subjects and in patients with medial temporal lobe pathology
Publication year: 2005
URL:
http://www.sfn.org/Annual-Meeting/Past-and-Future-Annual-Meetings/Abstract-Archive/Abstract-Archive-Search
Abstract/Results: ABSTRACT:
Substantial evidence supports the involvement of the human medial temporal lobe (MTL) in episodic memory. Although differential roles have been attributed to left and right MTL in mediating verbal and visual memory, few studies have directly shown a clear material-specific dissociation. This issue becomes particularly relevant in the pre-operative evaluation of temporal lobe epilepsy (TLE) patients with hippocampal sclerosis (HS). Here, we used functional magnetic resonance imaging (fMRI) to compare the neural correlates of verbal and visual episodic memory during both encoding and recognition tasks, in a group of normal subjects and in TLE patients with unilateral right and left HS. Abstract words and line drawings designed so as to separate the verbal and visual components of the material were used [Jones-Gotman, 1997]. Statistical analysis for the control group shows a left-lateralized pattern of activation, including the left anterior hippocampus and the left parahippocampus, for the verbal material. Activity during visual encoding was largely bilateral and included the right posterior hippocampus and both parahippocampi. Results in patients suggest greater MTL activity on the side contralateral to the lesion. These results are consistent with data from neuropsychological tests using the same material. The relative unimpairment of right TLE patients on the visual memory task could be explained by the posterior location of right hippocampal activation relative to the more anterior lesion site. This is in contrast with the impairment of left TLE patients on the verbal memory task, which involves the anterior portion of the left hippocampus. In conclusion, this study supports material-dependent regional dissociations of MTL function which may help explain neuropsychological findings in patients with MTL damage.
Accessibility: Document does not exist in file
Language:
eng
Author:
Figueiredo, P.
Secondary author(s):
Santana, E., Machado, C., Cunha, A., Pinto, M., Castelo-Branco, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Figueiredo, P., Santana, I., Machado, E., Cunha, C., Pinto, A., & Castelo-Branco, M. (2005). Dissociating the neural correlates of verbal and visual episodic memory in normal subjects and in patients with medial temporal lobe pathology. Program No. 191.12. 2005 Abstract Viewer/Itinerary Planner. Washington, DC, USA. Society for Neuroscience, 2005. Online.
Indexed document: No
Keywords: Hippocampus / Functional magnetic resonance imaging (fMRI) / Epilepsy / Lateralization

DocumentTelepathic behaviour associated with biochemical and neuroendocrine parameters2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-128
Location: Arquivo PCA - Pasta 20/2004
Title:
128 - Telepathic behaviour associated with biochemical and neuroendocrine parameters
Duration: 2005-02 - 2008-06
Researcher(s):
Prof. Doutora Maria Carlota Lopes Saldanha, Prof. Doutor Alberto Albino Granado Escalda, Dra. Teresa Raquel Duarte Pacheco, Dra. Ana Rosa Miranda dos Santos Silva
Institution(s): Unidade de Biopatologia Vascular, Instituto de Medicina Molecular, Faculdade de Medicina de Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Related objects:
PT/FB/BL-2002-26
Author: Saldanha, C.
Secondary author(s):
Escalda, A., Pacheco, T., Silva, A. S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Animal psi / Telepathy / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-128.02
Location: Arquivo PCA - Pasta 20/2004
Title:
Telepathic behaviour associated with biochemical and neuroendocrine parameters
Publication year: 2009
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
Animal telepathy experiments with rabbits previously realized have shown maintenance of the erythrocyte
integrity and a bradycardia effect followed by a significant decrease of plasma cortisol levels [1]. A feedback control mechanism by cortisol regulate this own synthesis and in consequence its plasma level is known. The aim of this work was to verify at hippocampus the amount of cortisol binding to glucocorticoid receptors of the rabbits submitted to telepathy.
The telepathy experiments were performed in 2 couples of rabbits with simultaneously arterial plethysmography monitorization for each couple; one scared with blow on the nose and other not scared. The arterial plethysmography monitorization, lactate and cortisol plasma concentrations were determined, as well as AChE erythrocyte activity as a marker of membrane integrity. Imunohistochemical analysis of rabbit hippocampus tissue sections for glucocorticoid receptors was performed in all rabbit’s couples.
The results obtained by plethysmography were analysed by wavelet analysis in which by fast fourier transform we obtain the low frequency (LF) and high frequency (HF), respectively parasympathic and sympathic nervous system information [2, 3]. The telepathy experiments showed that the scare was efficient on the rabbit in which has been done besides no changes in the LF/HF ratio was observed in the respective not scared rabbit .Cortisol and lactate concentrations and AChE erythrocyte activity showed no significant differences between the scared and the not scared rabbit. The imunohistochemical analysis of rabbit hippocampus showed an increased amount of the cortisol receptor binding in the scared rabbits and no differences between the not scared rabbit and the control group.
In conclusion, besides the efficiency of the blowing as a scare, demonstrated by the differences in the LF/HF ratios and also by hippocampus cortisol binding receptor, our results don’t show evidence of telepathy between rabbits in these experimental conditions.
REFERENCES:
[1] Saldanha C, Pacheco T, Silva AS, Martins e Silva J, Peoc’h R. Biochemical characteristics associated to rabbit telepathy. Poster present at 5º Simpósio da Fundação Bial Aquém e Além do Cérebro, 2004. [2] Postolache G, Rocha I, Silva-Carvalho L, Postolache O, Girio P. A wavelet-based approach for monitoring baroreceptors function test in rats. IMTC 2004-Instrumentation and measurements techonology conference; 844-849. [3] Postolache G, Silva-Carvalho L, Postolache O, Girio P, Rocha I. HRV and BPV neural network model with wavelet based algorithm calibration; International Measurements Confederation 2004.
Accessibility: Document does not exist in file
Language:
eng
Author:
Saldanha, C.
Secondary author(s):
Escalda, A., Pacheco, T., Silva, A. S.
Document type:
Conference abstract
Number of reproductions:
3
Reference:
Saldanha, C., Escalda, A., Pacheco, T., & Silva, A. S. (2008). Telepathic behaviour associated with biochemical and neuroendocrine parameters. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Telepathy / Cortisol / Hippocampus / Acetylcholinesterase

Telepathic behaviour associated with biochemical and neuroendocrine parameters

Telepathic behaviour associated with biochemical and neuroendocrine parameters

DocumentElectrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-168
Location: Arquivo PCA - Pasta 13/2004
Title:
168 - Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy
Duration: 2005-02 - 2007-07
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Dániel Fabó
Institution(s): National Institute of Psychiatry and Neurology, Department of Neurology, Epilepsy Center, Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Diseases/Injuries / Epilepsy / Sleep and dreams

Reference code: PT/FB/BL-2004-168.06
Location: Arquivo PCA - Pasta 13/2004
Title:
Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
Ripples are high-frequency oscillation bursts in the mammalian hippocampus mainly present during Non-
REM sleep. In rodents they occur in association with sharp waves and are grouped by the cortical slow oscillation such that, in parallel with sleep spindles, ripple activity is suppressed during the hyperpolarized down-state and enhanced during the depolarized up-state. The temporal coupling between these oscillations has been suggested to serve a hippocampo-neocortical dialogue underlying memory consolidation during sleep. Here we examined whether a similar coupling exists between these oscillatory phenomena in humans. We based our investigations on epilepsy patients undergoing presurgical evaluation implanted with foramen ovale electrodes. Recording with foramen ovale electrodes is a unique technique allowing parahippocampal electrocorticography in a semi-invasive way. In sleep recordings from seven epileptic patients, scalp-recorded slow oscillations and spindles as well as parahippocampal ripples recorded from foramen ovale electrodes were identified by automatic algorithms. Additionally, ripple and spindle root mean square activity was determined for relevant frequency bands. Ripple activity distinctly decreased time-locked to slow oscillation negative half-waves in the three patients without temporal structural alterations, whereas in the four patients with severe mesiotemporal structural alterations this coupling was obscure. Generally, in the patients ripple activity was increased before spindle peaks and distinctly decreased after the peak. Ripples were consistently associated with interictal spikes suggesting that spike/ripple complexes represent an epileptic transformation of sharp wave/ripple complexes in the epileptic hippocampus. Our findings are consistent with the notion of a hippocampo-to-neocortical information transfer during sleep that is linked to coordinate ripple and spindle activity, and that in the intact temporal lobe is synchronized to cortical slow oscillations.
PUBLICATIONS:
Clemens Z, Mölle M, Eross L, Barsi P, Halász P, Born J. Temporal coupling of parahippocampal ripples, sleep spindles and slow oscillations in humans. 2007 Brain, 130:2868-2878.
Accessibility: Document does not exist in file
Language:
eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Halász, P., Clemens, Z., Borbély, C., & Fabó, D. (2008). Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Hippocampus / Oscillations / Memory consolidation

Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain

Electrocortical studies of the hippocampal-parahippocampal (HP) structures in humans: Foramen ovale (FO) electrodes, as a research tool in human cognition and epilepsy. In Aquém e além do cérebro. Behind and beyond the brain

DocumentPhase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.02
Location: Arquivo PCA - Pasta 5/2006
Title:
Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans
Publication year: 2009
URL:
http://www.sciencedirect.com/science/article/pii/S0306452209010690
Abstract/Results: ABSTRACT:
In the human sleep literature there is much controversy regarding the existence and the characteristics of hippocampal rhythmic slow activity (RSA). Generally the human RSA is believed to occur in short bursts of theta activity. An earlier study, however, reported mesiotemporal RSA during rapid-eye-movement (REM) sleep that instead of theta fell in the delta frequency band. We conjectured that if this RSA activity is indeed a human analogue of the animal hippocampal theta then characteristics associated with the animal theta should also be reflected in the human recordings. Here our aim was to examine possible phase coupling between mesiotemporal RSA and gamma activity during REM sleep. The study relied on nine epilepsy surgery candidates implanted with foramen ovale electrodes. Positive half-waves of the 1.5–3 Hz RSA were identified by an automatic algorithm during REM sleep. High-frequency activity was assessed for 11 consecutive 20 Hz–wide frequency bands between 20 and 240 Hz. Increase in high frequency activity was phase coupled with RSA in most frequency bands and patients. Such a phase coupling closely resembles that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding delta rather than theta as the human analogue of RSA in animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Weiss, B., Szucs, A., Eross, L., Rásonyi, G., Halász, P.
Document type:
Article
Number of reproductions:
1
Reference:
Clemens, Z., Weiss, B., Szucs, A., Eross, L., Rásonyi, G., & Halász, P. (2009). Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans. Neuroscience, 163(1), 388-96. doi: 10.1016/j.neuroscience.2009.06.044
2-year Impact Factor: 3.292|2009
Times cited: 24|2022-05-19
Indexed document: Yes
Quartile: Q2
Keywords: Hippocampus / Rhythmic slow activity / Theta / Foramen ovale / Mesial temporal lobe

DocumentInterhemispheric propagation of seizures in mesial temporal lobe epilepsy2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.03
Location: Arquivo PCA - Pasta 5/2006
Title:
Interhemispheric propagation of seizures in mesial temporal lobe epilepsy
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pubmed/19835273
Abstract/Results: ABSTRACT:
OBJECTIVES:
To investigate interhemispheric propagation of mesial temporal lobe epilepsy seizures in patients undergoing long-term video-EEG monitoring with combined scalp and foramen ovale electrodes.
AIM OF THE STUDY:
To reveal possible interhemispheric propagation patterns in mesial temporal lobe epilepsy, to improve presurgical evaluation of temporal epileptic patients.
METHODS:
Sixty-five seizures from 20 patients were analyzed. We defined two contralateral seizure propagation patterns: Type I for those seizures that spread to the contralateral foramen ovale electrodes earlier than to the contralateral scalp electrodes, and type II for the opposite.
PARTICIPANTS:
Twenty drug resistant epileptic patients were investigated in frame of their presurgical evaluation.
RESULTS:
The majority of seizures (80%) were classified as type I. Inter-foramen ovale electrode propagation time was significantly shorter for type I compared to type II seizures. Ninety percent of patients had either type I or type II seizures only. Patients with type I seizures significantly more often had mesiotemporal structural alterations evident on magnetic resonance imaging scans, and became more often seizure-free after surgery compared to patients with type II seizures whose surgical outcome was less favorable or surgery could not be indicated because of independent bilateral ictal seizure-onset.
CONCLUSIONS:
The two types of contralateral propagation patterns we are describing seem to represent two subtypes of mesial temporal lobe epilepsy with different morphological and prognostic features. The predominance of type I over type II seizures together with shorter propagation times for type I seizures indicate a role of a more direct and dominant interhemispheric pathway in mesial temporal lobe epilepsy.
Accessibility: Document does not exist in file
Language:
eng
Author:
Eross, L.
Secondary author(s):
Entz, L., Fabó, D., Jakus, R., Szucs, A., Rásonyi, G., Halász, P.
Document type:
Article
Number of reproductions:
1
Reference:
Eross, L., Entz, L., Fabó, D., Jakus, R., Szucs, A., Rásonyi, G., ... Halász, P. (2009). Interhemispheric propagation of seizures in mesial temporal lobe epilepsy. Ideggyogyaszati Szemle-Clinical Neuroscience, 62(9-10), 319-325.
2-year Impact Factor: 0.236|2010
Impact factor notes: Impact factor computed since 2010
Times cited: 7|2022-05-19
Indexed document: Yes
Quartile: Q4
Keywords: Hippocampus / Epilepsy / Temporal lobe / Hippocampal commissure / Epilepsy surgery

Interhemispheric propagation of seizures in mesial temporal lobe epilepsy

Interhemispheric propagation of seizures in mesial temporal lobe epilepsy

DocumentFine-tuned coupling between human parahippocampal ripples and sleep spindles2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.04
Location: Arquivo PCA - Pasta 5/2006
Title:
Fine-tuned coupling between human parahippocampal ripples and sleep spindles
Publication year: 2011
URL:
http://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.2010.07505.x/pdf
Abstract/Results: ABSTRACT:
Sleep-associated memory consolidation is thought to rely on coordinated information transfer between the hippocampus and neocortex brought about during slow wave sleep (SWS) by distinct local field potential oscillations. Specifically, findings in animals have led to the concept that ripples originating from hippocampus combine with spindles to provide a fine-tuned temporal frame for a persistent transfer of memory-related information to the neocortex. The present study focused on characterizing the temporal relationship between parahippocampal ripple activity (80-140 Hz) and spindles recorded from frontal, parietal and parahippocampal cortices in 12 epilepsy patients implanted with parahippocampal foramen ovale electrodes. Overall, parietal and parahippocampal spindles showed closer relationships to parahippocampal ripple activity than frontal spindles, with the latter following parietal and parahippocampal spindles at a variable delay of up to 0.5 s. On a timescale of seconds, ripple activity showed a continuous increase before the peak of parietal and parahippocampal spindles, and decreased thereafter. At a fine timescale of milliseconds, parahippocampal ripple activity was tightly phase-locked to the troughs of these spindles. The demonstration of spindle phase-locked ripple activity in humans is consistent with the idea of a temporally fine-tuned hippocampus-to-neocortex transfer of information taking place during SWS.
Accessibility: Document does not exist in file
Language:
eng
Author:
Clemens, Z.
Secondary author(s):
Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., Born, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Clemens, Z., Mölle, M., Eross, L., Jakus, R., Rásonyi, G., Halász, P., & Born, J. (2011). Fine-tuned coupling between human parahippocampal ripples and sleep spindles. European Journal of Neuroscience, 33(3), 511-520. doi: 10.1111/j.1460-9568.2010.07505.x
2-year Impact Factor: 3.631|2011
Times cited: 135|2022-05-19
Indexed document: Yes
Quartile: Q2
Keywords: Epilepsy / Hippocampus / Ripples / Sleep / Spindles

Fine-tuned coupling between human parahippocampal ripples and sleep spindles

Fine-tuned coupling between human parahippocampal ripples and sleep spindles

DocumentFinal report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.01
Location: Arquivo PCA - Pasta 10/2006
Title:
Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Publication year: 2010
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Learning / Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning

Final report - How do we learn to associate events separate in time: a study using trace auditory fear conditioning

DocumentTime determines the neural circuit underlying associative fear learning2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.02
Location: Arquivo PCA - Pasta 10/2006
Title:
Time determines the neural circuit underlying associative fear learning
Publication year: 2011
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246300/pdf/fnbeh-05-00089.pdf
Abstract/Results: ABSTRACT:
Ultimately associative learning is a function of the temporal features and relationships between experienced stimuli. Nevertheless how time affects the neural circuit underlying this form of learning remains largely unknown. To address this issue, we used single-trial auditory trace fear conditioning and varied the length of the interval between tone and foot-shock. Through temporary inactivation of the amygdala, medial prefrontal-cortex (mPFC), and dorsal-hippocampus in rats, we tested the hypothesis that different temporal intervals between the tone and the shock influence the neuronal structures necessary for learning. With this study we provide the first experimental evidence showing that temporarily inactivating the amygdala before training impairs auditory fear learning when there is a temporal gap between the tone and the shock. Moreover, imposing a short interval (5 s) between the two stimuli also relies on the mPFC, while learning the association across a longer interval (40 s) becomes additionally dependent on a third structure, the dorsal-hippocampus. Thus, our results suggest that increasing the interval length between tone and shock leads to the involvement of an increasing number of brain areas in order for the association between the two stimuli to be acquired normally. These findings demonstrate that the temporal relationship between events is a key factor in determining the neuronal mechanisms underlying associative fear learning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Guimarãis, M.
Secondary author(s):
Gregório, A., Cruz, A., Guyon, N., Moita, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
6|2022-03-19
Reference:
Guimarãis, M., Gregório, A., Cruz, A., Guyon, N., & Moita, M. (2011). Time determines the neural circuit underlying associative fear learning. Frontiers in Behavioral Neuroscience, 5: 89. doi: 10.3389/fnbeh.2011.00089
2-year Impact Factor: 4.758|2012
Impact factor notes: Impact factor computed since 2012
Times cited: 35|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

Time determines the neural circuit underlying associative fear learning

Time determines the neural circuit underlying associative fear learning

DocumentInvolvement of hippocampus and mPFC in auditory trace fear conditioning is dependent on trace interval length2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.03
Location: Arquivo PCA - Pasta 10/2006
Title:
Involvement of hippocampus and mPFC in auditory trace fear conditioning is dependent on trace interval length
Publication year: 2009
URL:
http://www.abstractsonline.com/Plan/ViewAbstract.aspx?sKey=aaa13b19-300a-4a01-ab65-e4405b9510d8&cKey=0b84d26d-500d-49fa-b507-c467e54e7bbd&mKey=%7b081F7976-E4CD-4F3D-A0AF-E8387992A658%7d
Abstract/Results: ABSTRACT:
During trace auditory fear conditioning (tFC) rats learned to fear a previously neutral tone that is followed by shock after a brief interval. The mechanisms underlying the association between a tone and shock, that occur separate in time, remain elusive.
Several studies have implicated the hippocampus in tFC. Due to it role in spatial and episodic memory, one possibility is that this area is necessary because it links events that occur within the same spatial context. Additionally, previous studies demonstrated that tFC requires the mPFC raising the possibility that this association could be achieved by a working memory-like strategy,. However, it is possible that these two structures work in parallel enabling the animal with the capacity to resolve the same problem using two different neuronal strategies. As a prior study showed the hippocampus is involved in the tFC acquisition only when the two stimuli are separated by a longer intervals. It is possible that the involvement of one more than the other would depend on the length of the trace interval.
To test this hypothesis we performed temporary inactivation, using muscimol, of hippocampus and mPFC during training where the interval between tone a shcok was either short, 5s, or long, 40s. After the infusion all the rats where trained with a trace single tone-shock pairing using a 20s tone, followed by a trace interval (5 or 40 s) at the iend of which a 1.5mA shock of 1.5s duration was delivered. In accordance with previous findings we found that hippocampus inactivation impaired the acquisition of tFC, for the 40s but not the 5s trace interval. In contrast, the involvement of the mPFC was independent of the length of the interval as the muscimol infused animals from either 40s or 5s trace interval groups were both impaired in the acquisition of fear to the tone.
In summary, rats can learn the association between a tone and shock that are separate in time, within a single training trial. However the circuit underlying this learning changes according to the size of the interval between the two stimuli.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Guimarãis, M.
Secondary author(s):
Guyon, N., Cruz, A., Moita, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Guimarães, M., Guyon, N., Cruz, A., & Moita, M. (2009). Involvement of hippocampus and mPFC in auditory trace fear conditioning is dependent on trace interval length. Program No. 384.5/GG44. 2009 Neuroscience Meeting Planner. Chicago, IL: Society for Neuroscience. Online.
Indexed document: No
Keywords: Learning and memory / Trace fear conditioning / Hippocampus / Medial-prefrontal cortex (mPFC)

DocumentHigher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.02
Location: Arquivo PCA - Pasta 18/2006
Title:
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20071148
Abstract/Results: ABSTRACT:
This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Pariante, C., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Reference:
Mondelli, V., Pariante, C., Navari, S., Aas, M., D'Albenzio, A., ... Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75-8. doi: 10.1016/j.schres.2009.12.021
2-year Impact Factor: 4.374|2010
Times cited: 92|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Hippocampus / Psychosis / Hypothalamic-pituitary-adrenal axis / Schizophrenia / Glucocorticoids

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

DocumentThe outcome of elderly patients with cognitive complaints but normal neuropsychological tests2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.07
Location: Arquivo PCA - Pasta 21/2006
Title:
The outcome of elderly patients with cognitive complaints but normal neuropsychological tests
Publication year: 2010
URL:
http://iospress.metapress.com/content/n007j334322x0634/
Abstract/Results: ABSTRACT:
Elderly patients may present with prominent cognitive complaints and have performances in neuropsychological tests within the normal range for the age and education, and thus do not fulfill the criteria for mild cognitive impairment (MCI). There is insufficient evidence to support the clinical decision in these cases ("pre-MCI"). Forty-three subjects, 11 controls, 15 "pre-MCI," and 17 MCI, were followed for about three and half years with neuropsychological testing and magnetic resonance imaging including volumetric measurements of the hippocampus and amygdala. Two of the "pre-MCI" subjects suffered cognitive and functional deterioration and were diagnosed with dementia. Although the "pre-MCI" subjects as a group had no significant deterioration in neuropsychological tests, they suffered a decline in the total hippocampal volume (P=0.04) along the follow-up time. In contrast, all control subjects remained stable and had no volumetric decreases. As expected, MCI patients underwent significant deterioration in several neuropsychological tests, often progressed to Alzheimer's disease, and showed decreases both in total hippocampal and amygdalar volumes. Elderly people presenting with cognitive complaints may be in an initial phase of a degenerative disorder and should be followed clinically, even if they have normal neuropsychological tests.
Accessibility: Document does not exist in file
Language:
eng
Author:
Nunes, T.
Secondary author(s):
Fragata, I., Ribeiro, F., Palma, T., Maroco, J., Cannas, J., Secca, M., Menezes, C., Carmo, I., Cunha, G., Castelo-Branco, M., Guerreiro, M., Mendonça, A.
Document type:
Article
Number of reproductions:
1
Reference:
Nunes, T., Fragata, I., Ribeiro, F., Palma, T., Maroco, J., ... Mendonça, A. (2010). The outcome of elderly patients with cognitive complaints but normal neuropsychological tests. Journal of Alzheimer´s disease, 19(1), 137-145. doi: 10.3233/JAD-2010-1210
2-year Impact Factor: 4.261|2010
Times cited: 27|2022-05-19
Indexed document: Yes
Quartile: Q1
Keywords: Aging / Alzheimer's disease / Amygdala / Dementia / Hippocampus / Magnetic resonance imaging / Mild cognitive impairment (MCI) / Pre-MCI / Volumetry

DocumentImpaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-126
Location: Arquivo PCA - Pastas 16 e 17/2008
Title:
126 - A Experiência da Dor: alterações funcionais induzidas por Dor Crónica nos circuitos neuronais de recompensa e aversão
Duration: 2009-03 - 2013-10
Researcher(s):
Vasco Miguel Clara Lopes Galhardo, Deolinda Maria Valente Alves de Lima Teixeira, Clara Maria Pires Costa Bastos Monteiro, Hélder Cardoso Cruz, Maria Leonor Godinho, Daniela Seixas, Sónia Margarida Dourado
Institution(s): IBMC – Instituto de Biologia Molecular e Celular, Porto (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Articles
Unpublished documents
Language: por / eng
Related objects:
PT/FB/BL-2004-84
Author: Galhardo, V.
Secondary author(s):
Lima, D., Monteiro, C., Cardoso-Cruz, H., Godinho, M., Seixas, D., Dourado, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Pain / Cognitive processes / Brain structure and function

Reference code: PT/FB/BL-2008-126.06
Location: Arquivo PCA - Pastas 16 a 17/2008
Title:
Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity
Publication year: 2013
URL:
http://www.ncbi.nlm.nih.gov/pubmed/23392675
Abstract/Results: ABSTRACT:
Chronic pain patients commonly complain of working memory deficits, but the mechanisms and brain areas underlying this cognitive impairment remain elusive. The neuronal populations of the mPFC and dorsal CA1 (dCA1) are well known to form an interconnected neural circuit that is crucial for correct performance in spatial memory-dependent tasks. In this study, we investigated whether the functional connectivity between these two areas is affected by the onset of an animal model of peripheral neuropathic pain. To address this issue, we implanted two multichannel arrays of electrodes in the mPFC and dCA1 of rats and recorded the neuronal activity during a food-reinforced spatial working memory task in a reward-based alternate trajectory maze. Recordings were performed for 3 weeks, before and after the establishment of the spared nerve injury model of neuropathy. Our results show that the nerve lesion caused an impairment of working memory performance that is temporally associated with changes in the mPFC populational firing activity patterns when the animals navigated between decision points-when memory retention was most needed. Moreover, the activity of both recorded neuronal populations after the nerve injury increased their phase locking with respect to hippocampal theta rhythm. Finally, our data revealed that chronic pain reduces the overall amount of information flowing in the fronto-hippocampal circuit and induces the emergence of different oscillation patterns that are well correlated with the correct/incorrect performance of the animal on a trial-by-trial basis. The present results demonstrate that functional disturbances in the fronto-hippocampal connectivity are a relevant cause for pain-related working memory deficits.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cardoso-Cruz, H.
Secondary author(s):
Lima, D., Galhardo, V.
Document type:
Article
Number of reproductions:
1
Percentiles:
4|2022-03-19
Reference:
Cardoso-Cruz, H., Lima, D., & Galhardo, V. (2013). Impaired spatial memory performance in a rat model of neuropathic pain is associated with reduced hippocampus-prefrontal cortex connectivity. Journal of Neuroscience, 33(6), 2465-2480. doi: 10.1523/JNEUROSCI.5197-12.2013
2-year Impact Factor: 6.747|2013
Times cited: 80|2022-05-20
Indexed document: Yes
Quartile: Q1
Keywords: Neuropathic pain / Rat / Working memory deficit / Medial-prefrontal cortex (mPFC) / Hippocampus

Novo ficheiro

Novo ficheiro

DocumentHigh-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-154
Location: Arquivo PCA - Pasta 5/2006
Title:
154 - High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Duration: 2008-01 - 2009-10
Researcher(s):
Péter Halász, Zsófia Clemens, Csaba Borbély, Daniel Fabó
Institution(s): Budapest-Bethel Epilepsy Center Foundation (BBEC), Budapest (Hungary)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Sleep and dreams / Biopsychological problems / Diseases/Injuries / Epilepsy

Reference code: PT/FB/BL-2006-154.05
Location: Arquivo PCA - Pasta 5/2006
Title:
High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans
Publication year: 2010
URL:
http://www.bial.com/simposio/Livro_de_Actas_8_Simposio.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
To examine possible phase-relation between high-frequency (gamma) and rhythmic slow activity (RSA) during REM sleep in human mesiotemporal EEG recordings. To seek for analogies between the animal hippocampal theta and the human mesiotemporal RSA during REM sleep.
METHODS:
The study relied on nine epilepsy surgery candidates implanted with bilateral semi-invasive foramen ovale electrodes placed beneath the mesiotemporal surface. Positive half-waves of the 1.5–3 Hz RSA were identified by a semi-automatic algorithm during REM sleep. High-frequency activity was assessed for 11 consecutive 20 Hz–wide frequency bands between 20 and 240 Hz. To investigate time relations between RSA
oscillation and high-frequency activity the root mean square of each high-frequency band was averaged for intervals of 0.5 s around all detected RSA oscillation peaks.
RESULTS:
RSA at 1-5-3 Hz was a striking feature of most foramen ovale recordings during REM sleep. Increase in high frequency activity was phase coupled with RSA in most frequency bands and patients. The phase of the highest gamma activity increase was similar across increasing high frequency bands and typically occurred shortly (~0.1 s) before the RSA peak used as trigger. Highest level of modulation was found for the middle high frequency bands (60-80 Hz and 80-100 Hz) which gradually weakened across both decreasing and increasing high-frequency bands.
CONCLUSIONS:
Such a phase coupling closely resembles that seen between theta and gamma in rodents. We consider this commonality to be an additional reason for regarding the 1.5-3 Hz delta rather than theta as the human analogue of RSA in animals.
Accessibility: Document does not exist in file
Language:
eng
Author:
Halász, P.
Secondary author(s):
Clemens, Z., Borbély, C., Fabó, D.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Halász, P., Clemens, Z., Borbély, C., & Fabó, D. (2010). High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 8th Symposium of Fundação Bial (p. 236). Porto: Fundação Bial.
Indexed document: No
Keywords: Hippocampus / Rhythmic slow activity / Theta / Mesial temporal lobe / Epilepsy

High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

High-frequency oscillations and rhythmic slow activity during virtual navigation, REM sleep and wake-sleep transitions: Studies on intracranial recordings in humans

DocumentHow do we learn to associate events separate in time: a study using trace auditory fear conditioning2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-131
Location: Arquivo PCA - Pasta 10/2006
Title:
131 - How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Duration: 2007-01 - 2010-07
Researcher(s):
Marta de Aragão Pacheco Moita, Marta Guimarães
Institution(s): Instituto Gulbenkian de Ciência, Oeiras (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Memory / Emotion

Reference code: PT/FB/BL-2006-131.04
Location: Arquivo PCA - Pasta 10/2006
Title:
How do we learn to associate events separate in time: a study using trace auditory fear conditioning
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Ultimately associative learning is a function of the temporal features and relationships between experienced stimuli. Nevertheless how time affects the neural circuit underlying this form of learning remains largely unknown. To address this issue, we used single-trial auditory trace fear conditioning and varied the length of the interval between tone and foot-shock. Through temporary inactivation of the amygdala, medial-prefrontal cortex (mPFC) and dorsal-hippocampus in rats, we tested the hypothesis that different temporal intervals between the tone and the shock influence the neuronal structures necessary for learning.
METHODS:
Rats were implanted with bilateral cannulae targeting dorsal hippocampus, lateral amygdala or mPFC, under stereotaxic surgery. Muscimol, a GABAa agonist that efficiently shuts down activity, was infused into the targeted region just prior to the trace fear conditioning session. Rats in teh control group received infusions of the vehicle solution. The next day all rats were tested for their fear of the tone in a distinct environment. Freezing was used as a measure of fear.
RESULTS:
We show for the first time that the amygdala is critically involved in the acquisition of auditory fear learning when there is a temporal gap between the tone and the shock. Moreover, imposing a short interval (5 s) between the two stimuli also recruits the medial pre-frontal cortex (mPFC), while learning the association across a longer interval (40 s) becomes additionally dependent on a third structure, the dorsal-hippocampus.
CONCLUSION:
Thus, our results show that increasing the interval length between tone and shock leads to the requirement of an increasing number of brain areas for the association between the two stimuli to be acquired.
Accessibility: Document does not exist in file
Language:
eng
Author:
Moita, M.
Secondary author(s):
Guimarãis, M.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Moita, M., & Guimarães, M. (2012). How do we learn to associate events separate in time: a study using trace auditory fear conditioning. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 9/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Amygdala / Medial-prefrontal cortex (mPFC) / Hippocampus / Trace fear conditioning / Muscimol / Single trial

How do we learn to associate events separate in time: a study using trace auditory fear conditioning

How do we learn to associate events separate in time: a study using trace auditory fear conditioning

DocumentFinal report - Structural and molecular basis of cognitive improvements induced by behavioral training (cognitive enrichment)2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.01
Location: Arquivo PCA - Pasta 22/2008
Title:
Final report - Structural and molecular basis of cognitive improvements induced by behavioral training (cognitive enrichment)
Publication year: 2012
Accessibility:
Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Learning / Cognitive enrichment / Chronic stress / Neuropsychiatric disorders / Prefrontal cortex / Hippocampus