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BIAL Foundation
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DE:"Huntington's disease"
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Type Title Begin End
DocumentTask specific contribution of the human striatum to perceptual-motor skill learning2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2002
Location: Arquivo PCA - Pastas 1 a 21/2002
Title:
2002 Grants
Start date: 2003-01 - 2009-11
Dimension/support:
21 caixas de arquivo

Reference code: PT/FB/BL-2002-003
Location: Arquivo PCA - Pasta 8/2002
Title:
003 - The neural structures involved in procedural memory
Duration: 2003-11 - 2006-11
Researcher(s):
Sara Cavaco, Alexandre Lemos de Castro Caldas, Steven Anderson
Institution(s): Centro de Estudos Egas Moniz, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Cavaco, S.
Secondary author(s):
Castro-Caldas, A., Anderson, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Brain dysfunction / Cognitive processes / Learning

Reference code: PT/FB/BL-2002-003.03
Location: Arquivo PCA - Pasta 8/2002
Title:
Task specific contribution of the human striatum to perceptual-motor skill learning
Publication year: 2011
URL:
http://www.tandfonline.com/doi/abs/10.1080/13803395.2010.493144?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed#.Utz4rNGp0q4
Contents: http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=325&SID=Z1T1li1SW9lnlKPlMpq&page=1&doc=1
Abstract/Results: ABSTRACT:
Acquisition of new perceptual-motor skills depends on multiple brain areas, including the striatum. However, the specific contribution of each structure to this type of learning is still poorly understood. Focusing on the striatum, we proposed (a) to replicate the finding of impaired rotary pursuit (RP) and preserved mirror tracing (MT) in Huntington's disease (HD); and (b) to further explore this putative learning dissociation with other human models of striatal dysfunction (i.e., Parkinson's disease and focal vascular damage) and two new paradigms (i.e., Geometric Figures, GF, and Control Stick, CS) of skill learning. Regardless of the etiology, participants with damage to the striatum showed impaired learning of visuomotor tracking skills (i.e., RP and GF), whereas the ability to learn skills that require motor adaptation (i.e., MT and CS) was not affected. These results suggest a task-specific involvement of the striatum in the early stages of skill learning.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cavaco, S.
Secondary author(s):
Anderson, S., Correia, H., Magalhăes, M., Pereira, C., Tuna, A., Taipa, R., Pinto, P., Pinto, C., Cruz, R., Lima, A., Castro-Caldas, A., Martins da Silva, A., Damásio, H.
Document type:
Article
Number of reproductions:
1
Reference:
Cavaco, S., Anderson, S., Correia, M., Magalhăes, M., Pereira, C., Tuna, A. . . . Damásio, H. (2011). Task specific contribution of the human striatum to perceptual-motor skill learning. Journal of Clinical and Experimental Neuropsychology, 33(1), 51-62. https://doi.org/10.1080/13803395.2010.493144
2-year Impact Factor: 2.133|2011
Times cited: 21|2025-09-10
Indexed document: Yes
Quartile: Q2
Keywords: Nondeclarative memory / Skill learning / Striatum / Huntington's disease / Parkinson's disease
DocumentAprendizagem de competęncias perceptivo-motoras na doença de Huntington2007

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2002
Location: Arquivo PCA - Pastas 1 a 21/2002
Title:
2002 Grants
Start date: 2003-01 - 2009-11
Dimension/support:
21 caixas de arquivo

Reference code: PT/FB/BL-2002-003
Location: Arquivo PCA - Pasta 8/2002
Title:
003 - The neural structures involved in procedural memory
Duration: 2003-11 - 2006-11
Researcher(s):
Sara Cavaco, Alexandre Lemos de Castro Caldas, Steven Anderson
Institution(s): Centro de Estudos Egas Moniz, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Cavaco, S.
Secondary author(s):
Castro-Caldas, A., Anderson, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Brain dysfunction / Cognitive processes / Learning

Reference code: PT/FB/BL-2002-003.06
Location: Arquivo PCA - Pasta 8/2002
Title:
Aprendizagem de competęncias perceptivo-motoras na doença de Huntington
Publication year: 2007
URL:
http://cgmdesign.fatcow.com/spn/sinapse.htm
Accessibility: Document does not exist in file
Language:
por
Author:
Cavaco, S.
Secondary author(s):
Magalhăes, M., Tuna, A., Gonçalves, A., Martins da Silva, A.
Document type:
Abstract
Number of reproductions:
1
Reference:
Cavaco, S., Magalhăes, M., Damásio, J., Tuna, A., Gonçalves. A., Martins da Silva, A. (2007). Aprendizagem de competęncias perceptivo-motoras na doença de Huntington. Sinapse, 7(2), 95.
Indexed document: Yes
Keywords: Psychophysiology / Memory / Huntington's disease / Perceptual-motor skill learning
DocumentEmotion recognition in presymptomatic and symptomatic patients with Huntington's disease2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.24
Location: Arquivo PCA - Pasta 21/2006
Title:
Emotion recognition in presymptomatic and symptomatic patients with Huntington's disease
Publication year: 2010
URL:
http://fens2010.neurosciences.asso.fr/abstracts/R1/A023_25.html
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is associated with a loss of the ability to recognize emotions. Recent studies have shown controversial findings regarding a selective impairment for recognition of disgust in presymptomatic HD patients. The current study was aimed at defining the role of visual search behavior in this deficit.
A group of 9 early stage HD patients, 14 presymptomatic HD patients and 21 healthy control subjects were tested. They all did an extensive battery of neuropsychological tests and Huntington's patients were assessed with the UHDRS-motor examination. For the visual tasks, first, we used a forced choice emotion recognition task, in which participants had to indicate whether an image reflected a specific emotion or not. Second, we included a similar emotion recognition task, in which only limited facial information was available to recognize an emotion (i. e. mouth or eye region was masked). These masked tasks were designed to define whether the subject's performance altered when forced to look at a specific component of the face. Finally, a commonly used test of emotion recognition (FEEST) was used, in which participants had to evaluate a face by choosing between six emotions. Each task included the six basic emotion categories: disgust, fear, surprise, anger, sadness and happiness.
Behavioral results demonstrated no difference in the ability to recognize any of the six basic emotions between presymptomatic gene carriers and healthy controls. Thus, the finding that presymptomatic HD patients have a selective impairment of disgust could not be supported. Moreover, an emotion recognition impairment was found in the early stage HD patients for all of the six emotions. Interestingly, even in the masked task conditions, their emotion recognition ability was significantly impaired. This leads to the conclusion that the emotion recognition impairment in symptomatic HD patients is not the result of a deficit in attention guidance to specific features of a face.
Accessibility: Document does not exist in file
Language:
eng
Author:
Júlio, F.
Secondary author(s):
Van Asselen, M., Januário, C., Bobrowicz-Campos, E., Almeida, I., Freire, A., Castelo-Branco, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Júlio, F., Van Asselen, M., Januário, C., Bobrowicz Campos, E., Almeida, I., Freire, A., & Castelo-Branco, M. (2010, July). Emotion recognition in presymptomatic and symptomatic patients with Huntington's disease. Poster presented at the 7th FENS Forum of European Neuroscience, Amsterdam, Netherlands. Abstract retrieved from http://fens2010.neurosciences.asso.fr/abstracts/R1/A023_25.html
Indexed document: No
Keywords: Huntington's disease / Emotion recognition

Emotion recognition in presymptomatic and symptomatic patients with Huntington's disease

Emotion recognition in presymptomatic and symptomatic patients with Huntington's disease
DocumentBasal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.25
Location: Arquivo PCA - Pasta 21/2006
Title:
Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning
Publication year: 2010
URL:
http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder that mainly affects the basal ganglia, although damage to cortical areas is also found. The basal ganglia are a set of subcortical structures that are particularly important for motor functions, action selection, reinforcement learning and implicit learning. However, recent studies have indicated that they might also be involved in implicit learning that does not involve motor functions and is purely based on visual learning (Castelo-Branco, et al. 2009; Van Asselen et al., 2009). To further investigate this, we have used an implicit contextual learning paradigm to test patients with HD.
This is a visual search task, in which subjects need to locate a target as quickly as possible. Importantly, in half of the trials the positions of the distractors and target stimuli are repeated and this spatial information is used as a contextual cue. By memorizing this contextual information, attention is guided to the target stimulus. Since HD is a genetic disease, patients can be diagnosed before the onset of motor and cognitive symptoms. In the current study we tested 9 symptomatic HD patients, 14 presymptomatic HD patients and 21 control subjects.
We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and presymptomatic HD patients. Thus, the HD patients did not learn the repeated contextual information and improve their visual search. Together, this indicates that the basal ganglia are not only involved in implicit motor learning, but also have an important role in purely visually based implicit learning. Furthermore, this impairment is found early in the disease, before the onset of other cognitive and motor impairments.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2006-73.09
Author: Van Asselen, M.
Secondary author(s):
Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., Castelo-Branco, M.
Document type:
Online abstract-d
Number of reproductions:
1
Reference:
Van Asselen, M., Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., & Castelo-Branco, M. (2010, July). Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning. Poster presented at the 7th FENS Forum of European Neuroscience, Amsterdam, Netherlands. Abstract retrieved from http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Indexed document: No
Keywords: Huntington's disease / Basal ganglia dysfunction / Implicit contextual learning
DocumentVisual search patterns during an emotion recognition task in presymptomatic and symptomatic patients with Huntington’s disease2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.29
Location: Arquivo PCA - Pasta 21/2006
Title:
Visual search patterns during an emotion recognition task in presymptomatic and symptomatic patients with Huntington’s disease
Publication year: 2010
URL:
http://eyetracking.ulusofona.pt/images/stories/abstracts/Visual%20search%20patterns%20during%20an%20emotion%20recognition%20task%20in.pdf
Abstract/Results: ABSTRACT:
Huntington’s disease (HD) is associated with a loss of the ability to recognize emotions. Recent studies have highlighted a controversy regarding a selective impairment for disgust recognition in presymptomatic HD patients. The current study was aimed at further investigating this issue and defining the contribution of visual search behavior to the claimed deficit. 9 early HD patients, 14 presymptomatic patients and 22 controls were tested. The visual tasks included an emotion recognition task, in which subjects had to evaluate one of six basic emotions. Eye movements were recorded during this task. There was also a similar task that offered only limited facial information to recognize an emotion (eyes/mouth). The goal of the masked tasks was to define whether the subject’s performance altered when forced to look at a specific face component. Behavioral results showed no differences in the ability to recognize emotions between gene carriers and controls. Thus, the finding of a specific deficit for recognizing disgust in presymptomatic HD could not be supported. An emotion recognition impairment was found in HD patients for all six emotions, even in the masked conditions. Eye movement data reveals a similar visual scanning strategy for gene carriers and controls. Finally, although patients show a global deficit in face emotion recognition, this impairment is not reflected in their visual search pattern. This suggests that their deficits are not a mere consequence of altered visual search but might be caused by an overall impairment in the perceptual domain.
Accessibility: Document does not exist in file
Language:
eng
Author:
Júlio, F.
Secondary author(s):
Van Asselen, M., Januário, C., Bobrowicz-Campos, E., Almeida, I., Freire, A., Castelo-Branco, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Júlio, F., Van Asselen, M., Januário, C., Bobrowicz-Campos, E., Almeida, I., Freire, A., & Castelo-Branco, M. (2010, October). Visual search patterns during an emotion recognition task in presymptomatic and symptomatic patients with Huntington’s disease. Paper presented at the 1st International Conference on Eye Tracking, Visual Cognition and Emotion, Lisbon, Portugal. Abstract retrieved from http://eyetracking.ulusofona.pt/images/stories/abstracts/Visual%20search%20patterns%20during%20an%20emotion%20recognition%20task%20in.pdf
Indexed document: No
Keywords: Huntington's disease / Emotion recognition / Eye tracking

Visual search patterns during an emotion recognition task in presymptomatic and symptomatic patients with Huntington’s disease

Visual search patterns during an emotion recognition task in presymptomatic and symptomatic patients with Huntington’s disease
File073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging2008-012011-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inęs Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease
DocumentFinal report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inęs Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.01
Location: Arquivo PCA - Pasta 22/2006
Title:
Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Publication year: 2011
URL:
http://www.bial.com/imagem/Bolsa7306_21022014.pdf
Abstract/Results: RESULTS:
During this research project (73/06) we investigated the mechanism underlying implicit contextual learning as well as its neural correlates. Implicit contextual cueing is a learning mechanism in which visual information from our environment is memorized in order to facilitate visual search.
In the first part of our research project we studied the mechanism underlying implicit contextual cueing using eye movement recording. First, we showed that peripheral vision can be used to memorize the context of a target (Van Asselen et al. 2009), whereas in our following study we demonstrated that object-based contextual cueing is associated with shorter fixation durations (Van Asselen et al., 2010). Finally, we showed that when two contextual cues are presented simultaneously, the contextual cueing effect is much larger than when one cue is presented. This effect is associated with fewer fixations and shorter saccade amplitudes, suggesting that a different search strategy is used.
In the second part of this research project we aimed to look at the neural basis of implicit contextual cueing. Therefore, we tested patients with Huntington’s and Parkinson’s disease with a contextual cueing task and found that these patients are not able to benefit from the repeated contextual information (Van Asselen et al., 2009). Since both of these neurodegenerative diseases affect the basal ganglia, our findings suggest an important role for this brain area. Finally, by using fMRI we demonstrated that the exact neural network that is involved in implicit contextual cueing depends on the type of cues (object or spatial) that are used to guide attention.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Implicit contextual learning / Neural correlates / Eye movements / Huntington's disease / Parkinson's disease / Basal ganglia / Perception

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
DocumentImplicit contextual learning in prodromal and early stage Huntington's disease patients2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inęs Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.05
Location: Arquivo PCA - Pasta 22/2006
Title:
Implicit contextual learning in prodromal and early stage Huntington's disease patients
Publication year: 2012
URL:
http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8631149
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.
Accessibility: Document exists in file (previous version submitted for publication)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simőes, M. R., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Van Asselen, M., Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simőes, M. R., Castelo-Branco, M. (2012). Implicit contextual learning in prodromal and early stage Huntington's disease patients. Journal of the International Neuropsychological Society, 18(4), 689-696. https://doi.org/10.1017/S1355617712000288
2-year Impact Factor: 2.697|2012
Times cited: 11|2025-09-10
Indexed document: Yes
Quartile: Q2
Keywords: Huntington's disease / Neurodegenerative disorder / Implicit contextual learning / Basal ganglia / Visual search

Implicit contextual learning in prodromal and early stage Huntington's disease patients

Implicit contextual learning in prodromal and early stage Huntington's disease patients
DocumentScanning patterns of faces do not explain impaired emotion recognition in Huntington disease: Evidence for a high level mechanism2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inęs Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.06
Location: Arquivo PCA - Pasta 22/2006
Title:
Scanning patterns of faces do not explain impaired emotion recognition in Huntington disease: Evidence for a high level mechanism
Publication year: 2012
URL:
http://www.ncbi.nlm.nih.gov/pubmed/22355293
Abstract/Results: ABSTRACT:
In the current study, we aimed to investigate the emotion recognition impairment in Huntington’s disease (HD) patients and define whether this deficit is caused by impaired scanning patterns of the face. To achieve this goal, we recorded eye movements during a two-alternative forced-choice emotion recognition task. HD patients in pre-symptomatic (n=16) and symptomatic (n=9) disease stages were tested and their performance was compared to a control group (n=22). In our emotion recognition task, participants had to indicate whether a face reflected one of six basic emotions. In addition, and in order to define whether emotion recognition was altered when the participants were forced to look at a specific component of the face, we used a second task where only limited facial information was provided (eyes/mouth in partially masked faces). Behavioral results showed no differences in the ability to recognize emotions between pre-symptomatic gene carriers and controls. However, an emotion recognition deficit was found for all six basic emotion categories in early stage HD. Analysis of eye movement patterns showed that patient and controls used similar scanning strategies. Patterns of deficits were similar regardless of whether parts of the faces were masked or not, thereby confirming that selective attention to particular face parts is not underlying the deficits. These results suggest that the emotion recognition deficits in symptomatic HD patients cannot be explained by impaired scanning patterns of faces. Furthermore, no selective deficit for recognition of disgust was found in pre-symptomatic HD patients.
Accessibility: Document does not exist in file
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Júlio, F., Januário, C., Bobrowicz-Campos, E., Almeida, I., Cavaco, S., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Van Asselen, M., Júlio, F., Januário, C., Bobrowicz-Campos, E., Almeida, I., Cavaco, S., & Castelo-Branco, M. (2012). Scanning patterns of faces do not explain impaired emotion recognition in Huntington disease: Evidence for a high level mechanism. Frontiers in Psychology, 3, 31. https://doi.org/10.3389/fpsyg.2012.00031
2-year Impact Factor: 2.843|2013
Impact factor notes: Impact factor computed since 2013
Times cited: 21|2025-09-10
Indexed document: Yes
Quartile: Q1
Keywords: Huntington's disease / Emotion recognition / Eye movements / Scanning patterns of faces

Scanning patterns of faces do not explain impaired emotion recognition in Huntington disease: Evidence for a high level mechanism

Scanning patterns of faces do not explain impaired emotion recognition in Huntington disease: Evidence for a high level mechanism
DocumentBasal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inęs Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.09
Location: Arquivo PCA - Pasta 22/2006
Title:
Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning
Publication year: 2010
URL:
http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder that mainly affects the basal ganglia, although damage to cortical areas is also found. The basal ganglia are a set of subcortical structures that are particularly important for motor functions, action selection, reinforcement learning and implicit learning. However, recent studies have indicated that they might also be involved in implicit learning that does not involve motor functions and is purely based on visual learning (Castelo-Branco, et al. 2009; Van Asselen et al., 2009). To further investigate this, we have used an implicit contextual learning paradigm to test patients with HD.
This is a visual search task, in which subjects need to locate a target as quickly as possible. Importantly, in half of the trials the positions of the distractors and target stimuli are repeated and this spatial information is used as a contextual cue. By memorizing this contextual information, attention is guided to the target stimulus. Since HD is a genetic disease, patients can be diagnosed before the onset of motor and cognitive symptoms. In the current study we tested 9 symptomatic HD patients, 14 presymptomatic HD patients and 21 control subjects.
We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and presymptomatic HD patients. Thus, the HD patients did not learn the repeated contextual information and improve their visual search. Together, this indicates that the basal ganglia are not only involved in implicit motor learning, but also have an important role in purely visually based implicit learning. Furthermore, this impairment is found early in the disease, before the onset of other cognitive and motor impairments.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2006-94.25
Author: Van Asselen, M.
Secondary author(s):
Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., Castelo-Branco, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Van Asselen, M., Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., & Castelo-Branco, M. (2010, July). Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning. Poster presented at the 7th FENS Forum of European Neuroscience, Amsterdam, Netherlands. Abstract retrieved from http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Indexed document: No
Keywords: Huntington's disease / Basal ganglia dysfunction / Implicit contextual learning