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File253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia2015-112017-09

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep
DocumentI keep a close watch on this heart of mine: increased interoception in insomnia2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-252
Location: SEC PCA 252/12
Title:
252 - Sleep state misperception mispercieved
Duration: 2014-06 - 2017-01
Researcher(s):
Eus J. W. Van Someren, J. Ramautar
Institution(s): Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Progress reports
Final reports
2 Articles
Language: eng
Author:
Van Someren, E.
Secondary author(s):
Ramautar, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and dreams / Biopsychological problems / Mental health / Sleep disorders / Brain structure and function / Cognitive processes / Memory / Consciousness

Reference code: PT/FB/BL-2012-252.03
Location: SEC PCA 252/12
Title:
I keep a close watch on this heart of mine: increased interoception in insomnia
Publication year: 2016
URL:
https://www.ncbi.nlm.nih.gov/pubmed/27634787
Abstract/Results: ABSTRACT:
STUDY OBJECTIVES:
Whereas both insomnia and altered interoception are core symptoms in affective disorders, their neural mechanisms remain insufficiently understood and have not previously been linked. Insomnia Disorder (ID) is characterized by sensory hypersensitivity during wakefulness and sleep. Previous studies on sensory processing in ID addressed external stimuli only, but not interoception. Interoceptive sensitivity can be studied quantitatively by measuring the cerebral cortical response to one's heartbeat (heartbeat-evoked potential, HEP). We here investigated whether insomnia is associated with increased interoceptive sensitivity as indexed by the HEP amplitude.
METHODS:
Sixty-four participants aged 21-70 years were recruited through www.sleepregistry.nl including 32 people suffering from ID and 32 age- and sex-matched controls without sleep complaints. HEPs were obtained from resting-state high-density electroencephalography (HD-EEG) recorded during evening wakeful rest in eyes-open (EO) and eyes-closed (EC) conditions of 5-minute duration each. Significance of group differences in HEP amplitude and their topographical distribution over the scalp were assessed by means of cluster-based permutation tests.
RESULTS:
In particular during EC, and to a lesser extent during EO, people with ID had a larger amplitude late HEP component than controls at frontal electrodes 376-500 ms after the R-wave peak. Source localization suggested increased neural activity time-locked to heartbeats in people with ID mainly in anterior cingulate/medial frontal cortices.
CONCLUSIONS:
People with insomnia show insufficient adaptation of their brain responses to the ever-present heartbeats. Abnormalities in the neural circuits involved in interoceptive awareness including the salience network may be of key importance to the pathophysiology of insomnia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Wei, Y.
Secondary author(s):
Ramautar, J., Colombo, M., Stoffers, D., Gomez-Herrero, G., van der Meijden, W. P., Te Lindert, B. H., van der Werf, Y., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Wei, Y., Ramautar, J., Colombo, M., Stoffers, D., Gomez-Herrero, G., van der Meijden, W. P., Te Lindert, B. H., van der Werf, Y., & Van Someren, E. (2016). I keep a close watch on this heart of mine: increased interoception in insomnia. Sleep, 39(12), 2113-2124. https://doi.org/10.5665/sleep.6308
2-year Impact Factor: 4.923|2016
Times cited: 68|2025-09-16
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia disorder / Interoception / Heartbeat-evoked potential / Event-related potential / High-density EEG / Hyperarousal / Resting state / Salience network
DocumentSlow dissolving of emotional distress contributes to hyperarousal2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.02
Location: Arquivo PCA - Pasta 25/2012
Title:
Slow dissolving of emotional distress contributes to hyperarousal
Publication year: 2016
URL:
http://www.pnas.org/content/113/9/2538.abstract
Abstract/Results: ABSTRACT:
The mechanisms underlying hyperarousal, the key symptom of insomnia, have remained elusive, hampering cause-targeted treatment. Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal. Participants (n = 1,199) completed questionnaires on insomnia severity, hyperarousal, self-conscious emotional distress, and thought-like nocturnal mentation that was validated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0.57, P < 0.001; eye movement density: R = 0.46, P < 0.01) in 32 polysomnographically assessed participants. The experience of distress lasting overnight increased with insomnia severity (ß = 0.29, P < 10-23), whereas short-lasting distress did not (ß = -0.02, P = 0.41). Insomnia severity was associated with hyperarousal (ß = 0.47, P < 10-63) and with the thought-like nocturnal mentation that is specifically associated with restless REM sleep (ß = 0.31, P < 10-26). Structural equation modeling showed that 62.4% of the association between these key characteristics of insomnia was mediated specifically by reduced overnight resolution of emotional distress. The model outperformed all alternative mediation pathways. The findings suggest that restless REM sleep reflects a process that interferes with the overnight resolution of distress. Its accumulation may promote the development of chronic hyperarousal, giving clinical relevance to the role of REM sleep in emotion regulation in insomnia, depression, and posttraumatic stress disorder.
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., Van Der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., Van Someren, E.
Document type:
Article
Number of reproductions:
1
Reference:
Wassing, R., Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., Van Der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., & Van Someren, E. (2016). Slow dissolving of emotional distress contributes to hyperarousal. Proceedings of the National Academy of Sciences of the United States of America, 113(9), 2538–2543. https://doi.org/10.1073/pnas.1522520113
2-year Impact Factor: 9.661|2016
Times cited: 127|2025-09-16
Indexed document: Yes
Quartile: Q1
Keywords: Insomnia / REM sleep / Hyperarousal / Self-conscious emotion / Shame

Slow dissolving of emotional distress contributes to hyperarousal

Slow dissolving of emotional distress contributes to hyperarousal
DocumentFinal report - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.01
Location: Arquivo PCA - Pasta 25/2012
Title:
Final report - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Publication year: 2017
URL:
https://www.bial.com/imagem/Grant_25312.pdf
Abstract/Results: ABSTRACT:
BACKGROUND
The mechanisms of hyperarousal, the key symptom of insomnia, have remained elusive. Recently, restless REM sleep emerged as a robust signature of insomnia. Given the role of REM sleep in emotion regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution of emotional distress, thus contributing to accumulation of arousal.
AIMS
We aimed to investigate whether restless REM sleep impedes overnight distress resolution, and accumulates as hyperarousal.
METHOD
Observational and experimental studies employed psychometrics, EEG and fMRI. We first validated a proxy measure for restless REM sleep, and assessed it in a large sample along with measures of distress dissolving and hyperarousal. We then implemented an internet-protocol to induce self-conscious distress and assessed distress dissipation across 5 consecutive days. The same distress-inducing protocol was used in a MRI scanner while conditioning it to a simultaneously provided odor. The odor was again given during part of the subsequent sleep period, to induce targeted memory reactivation. A second MRI scan of distress induction evaluated how neural correlates of its impact changed overnight.
RESULTS
Of the association between restless REM sleep and hyperarousal, 62.4% was mediated specifically by reduced overnight resolution of emotional distress in insomnia. In people with insomnia, a night's sleep could even increase distress, rather than resolve it. MRI findings indicated activation of the salience network during the induction self-conscious emotions, that ameliorated with sleep but not with a similar interval of being awake.
CONCLUSION
Restless REM sleep interferes with overnight maintenance of balanced salience network activation.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
enG
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: REM-sleep / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion
DocumentInsomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress2017

Reference code: PT/FB/BL-2012-253.03
Location: Arquivo PCA - Pasta 25/2012
Title:
Insomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress
Publication year: 2017
URL:
http://onlinelibrary.wiley.com/doi/10.1111/jsr.12446/epdf
Accessibility: Document exists in file
Language:
eng
Author:
Wassing, R.
Secondary author(s):
Benjamins, J. S., Dekker, K., Moens, S., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., van der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., Van Someren, E.
Document type:
Abstract
Number of reproductions:
1
Reference:
Wassing, R., Spiegelhalder, K., Feige, B., Riemann, D., van der Sluis, S., van der Werf, Y., Talamini, L., Walkerg, M., Schalkwijkh, F., & Van Someren, E. (2017). Insomnia: Restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress. Journal of Sleep Research, 25(Suppl. 1), 31.
Indexed document: Yes
Keywords: Insomnia / Hyperarousal / REM sleep

Insomnia: restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress

Insomnia: restless REM sleep promotes nocturnal mentation and hyperarousal by interfering with the resolution of emotional distress
DocumentSelf-referential dysfunction and default-mode hyperactivation in psychophysiological insomnia patients: A case-control fMRI study2018

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-170
Location: Arquivo PCA - Pasta 10/2010
Title:
170 - The role of fusion of multisensory percepts in dynamic facial/body expressions: an fMRI study
Duration: 2011-04 - 2013-11
Researcher(s):
Gina Maria Costa Caetano, Miguel Castelo-Branco, Beatrice de Gelder, Gregor Philipak
Institution(s): Instituto Biomédico de Investigaçăo de Luz e Imagem - IBILI-, Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
1 Master's thesis
Language: eng
Author:
Caetano, G.
Secondary author(s):
Castelo-Branco, M., Gelder, B., Philipiak, G.
Number of reproductions:
1
Keywords:
Psychophysiology / Emotion / Cognitive processes / Perception / Brain structure and function

Reference code: PT/FB/BL-2010-170.04
Location: Arquivo PCA - Pasta 9/2010
Title:
Self-referential dysfunction and default-mode hyperactivation in psychophysiological insomnia patients: A case-control fMRI study
Publication year: 2018
URL:
http://econtent.hogrefe.com/doi/abs/10.1027/0269-8803/a000194
Abstract/Results: ABSTRACT:
Psychophysiological insomnia (PI) is one of the most frequent sleep disorders. In this study we tested whether differences in terms of neural activation are present between a group of PI patients and a healthy-control group while they are exposed to idiosyncratic ruminations and worries, evoked visually by words, so as to explore their hypothetical link with default-mode network (DMN) dysfunction in PI. We recruited five PI patients diagnosed according to the International Classification of Sleep Disorders, version 2 (ICSD-2) of American Academy of Sleep Medicine (AASM) and five age- and sex-matched healthy controls. Patients were recruited at the outpatient Sleep Medicine Centre of the Coimbra University Hospital Centre. We used a functional magnetic resonance imaging (fMRI) block-design paradigm where the participants visualized lists of words related to past/present and future concerns and also emotionally neutral words. The results suggested that the PI patients showed a failure of the DMN to deactivate. Moreover, when these patients were exposed to words concerning both past/present ruminations and future worries, there was a pronounced and significant over-recruitment of brain areas related to DMN and self-referential processing when they were compared to healthy volunteers. The differences between the patient and control groups were also evident in self-report measures. In sum, despite the relatively small sample size, our study clearly suggests that in PI there is a dysfunction in brain regions pertaining to self-referential processing, which is corroborated by an overall pattern of hyperarousal in brain regions comprising the DMN. These data may be useful in the improvement of pathophysiological models, diagnostic and therapeutic interventions for insomnia.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Marques, D.
Secondary author(s):
Gomes, A., Clemente, V., dos Santos, J. M., Duarte, I. C., Caetano, G., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Reference:
Marques, D. R., Gomes, A. A., Clemente, V., dos Santos, J. M., Duarte, I. C., Caetano, G., & Castelo-Branco, M. (2018). Self-referential dysfunction and default-mode hyperactivation in psychophysiological insomnia patients: A case-control fMRI study. Journal of Psychophysiology, 32(3), 140-155. https://doi.org/10.1027/0269-8803/a000194
2-year Impact Factor: 1.000|2018
Times cited: 12|2025-09-17
Indexed document: Yes
Quartile: Q4
Keywords: Psychophysiological insomnia / Hyperarousal / Rumination / Worry / Default-mode network
File253 - Uncovering the dynamics of hyperarousal and restless sleep2023-10

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-253
Location: BF-GMS
Title:
253 - Uncovering the dynamics of hyperarousal and restless sleep
Duration: 2023-10
Researcher(s):
Lara Rösler, Roy Cox, Eus Van Someren
Institution(s): Netherlands Institute for Neuroscience, Royal Netherlands Academy of Arts and Sciences, Amsterdam (The Netherlands)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Language: eng
Notes:
Ongoing project
Author: Rösler, L.
Secondary author(s):
Cox, R., van Someren, E. J. W,
Number of reproductions:
1
Keywords:
Hyperarousal / Restless sleep / Rapid eye movement (REM) / Headband EEG / Psychophysiology
DocumentFrom childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-253
Location: Arquivo PCA - Pasta 25/2012
Title:
253 - REM-sleep, the regulation of self-conscious emotion and hyperarousal in psychophysiological insomnia
Duration: 2015-11 - 2017-09
Researcher(s):
Lucia Talamini, Ekaterini Georgopoulou, Eus Van Someren
Institution(s): University of Amsterdam, Psychology, Dept. Brain and Cognition (The Netherlands) and Netherlands Institute for Neuroscience, Dept. Sleep & Cognition, Amsterdam (The Netherlands)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Language: eng
Author:
Talamini, L.
Secondary author(s):
Georgopoulou, E., Van Someren, E.
Number of reproductions:
1
Keywords:
Psychophysiology / Psychophysiological insomnia / Hyperarousal / Self-conscious emotion / REM-sleep

Reference code: PT/FB/BL-2012-253.05
Location: BF-GMS
Title:
From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia
Publication year: 2023
URL:
https://www.frontiersin.org/articles/10.3389/fnhum.2023.990581/full
Abstract/Results: ABSTRACT:
Introduction:
A new line of insomnia research focuses on the developmental trajectories from early live stress to insomnia in adulthood. Adverse childhood experiences (ACE's) might create a vulnerability for later maladaptive coping with distress, as seen in chronic hyperarousal or insomnia. In an functional magnetic resonance imaging (fMRI) study, failure to dissociate the neurobiological components of shame from autobiographical shameful memories in insomnia was reflected by continued activation of the dorsal anterior cingulate cortex (dACC), which may be a result of maladaptive coping in the wake of ACE's. Following up on that study, the current pilot study explores the relation between ACE's, shame coping-styles, adult insomnia, hyperarousal, and neurobiology of autobiographical memory.
Methods:
We used existing data (N = 57) from individuals with insomnia (N = 27) and controls (N = 30), and asked these participants to complete the childhood trauma questionnaire (CTQ). Two structural equation models were used to test the hypotheses that shame-coping styles and insomnia symptom severity mediate the association between ACE's and (1) self-rated hyperarousal symptoms and (2) dACC activation to recall of autobiographical memories.
Results:
For the association between ACE's and hyperarousal, there was a significant mediation of shame-coping style (p < 0.05). This model also indicated worse shame coping with more ACE's (p < 0.05) and worse insomnia symptoms with more ACES's (p < 0.05), but no association between shame coping and insomnia symptoms (p = 0.154). In contrast, dACC activation to recall of autobiographical memories could only be explained by its direct association with ACE's (p < 0.05), albeit that in this model more ACE's were also associated with worse insomnia symptoms.
Discussion:
These findings could have an implication for the approach of treatment for insomnia. It could be focused more on trauma and emotional processing instead of conventional sleep interventions. Future studies are recommended to investigate the relationship mechanism between childhood trauma and insomnia, with additional factors of attachment styles, personality, and temperament.
Accessibility: Document exists in file
Language:
eng
Author:
Schalkwijk, F.
Secondary author(s):
Van Someren, E. J. W., Nicolai, N. J., Uijttewaal, J. L., Wassing, R.
Document type:
Article
Number of reproductions:
1
Reference:
Schalkwijk, F., Van Someren, E. J. W., Nicolai, N. J., Uijttewaal, J. L., & Wassing, R. (2023). From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia. Frontiers in Human Neuroscience, 17, 990581. https://doi.org/10.3389/fnhum.2023.990581
2-year Impact Factor: 2.4|2023
Times cited: 4|2025-09-26
Indexed document: Yes
Quartile: Q2
Keywords: Adverse childhood experiences (ACEs) / Childhood trauma / dorsal anterior cingulate cortex (dACC) / Hyperarousal / Insomnia / Shame

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia

From childhood trauma to hyperarousal in adults: The mediating effect of maladaptive shame coping and insomnia