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DocumentAn investigation of effects of dreams on physiological measures of stress2008

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2004
Location: Arquivo PCA - Pastas 1 a 25/2004
Title:
2004 Grants
Start date: 2005-01 - 2012-09
Dimension/support:
25 caixas de arquivo

Reference code: PT/FB/BL-2004-093
Location: Arquivo PCA - Pasta 15/2004
Title:
093 - An investigation of effects of dreams on physiological measures of stress
Duration: 2005-06 - 2007-09
Researcher(s):
Susan Wilson, David Nutt, Stafford L. Lightman
Institution(s): Psychopharmacology Unit, Bristol (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Number of reproductions:
1
Keywords:
Psychophysiology / Sleep and Dreams / Biopsychological problems / Mental health / Sleep disorders / Stress and health / Psychoneuroimmunology / Endocrinology

Reference code: PT/FB/BL-2004-093.05
Location: Arquivo PCA - Pasta 15/2004
Title:
An investigation of effects of dreams on physiological measures of stress
Publication year: 2008
URL:
http://www.bial.com/imagem/Actas_7Simp.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Part 1 - to compare morning salivary cortisol response, sleep questionnaires and dream reports between patients with parasomnias, normal subjects and patients with insomnia.
Part 2 – to pilot the use of automatic blood sampling overnight for cortisol assay synchronized with polysomnography in 6 normal subjects, to assess the minute by minute effect of sleep stage on cortisol measures, and to compare morning dream reports with plasma cortisol and salivary cortisol on awakening.
METHODS:
Part 1 - patients with sleep disorders and healthy good sleepers were provided with a pack containing
cotton swabs for saliva sampling and overnight sleep and dreaming questionnaires. Patients with parasomnias were sent sample kits for 2 nights, 1 with and 1 without an episode (eg night terror). 16 patients and 15 healthy good sleepers returned the packs and salivary cortisol concentration was measured in-house using radio-immunoassay.
Part 2 - 6 healthy volunteers slept in the sleep laboratory. An automated sampling machine has been developed at Bristol University to minimise interference with study subjects when taking blood samples. They were prepared for polysomnography (PSG) and had an indwelling cannula connected ‘through the wall’ to the sampling machine. Blood samples (1ml) were taken every 10 minutes, synchronised with the PSG recording. Samples were later assayed for cortisol. Sleep was scored and the cortisol levels related to different sleep stages.
RESULTS:
Part 1- morning cortisol response was as expected in healthy normal sleepers with a rise between waking
and 30 minutes later. Insomnia patients and parasomnia patients on a ‘good’ night had a similar response with both readings being slightly higher. On the ‘bad’ nights readings were very variable with no consistent rise between the 2 time periods. Waking cortisol levels correlated with complaints of waking too early. Dream report analysis will be presented.
Part 2 – synchronized hypnograms and cortisol profiles will be presented. Cortisol levels fell during the first few hours of sleep and then showed a rise independent of sleep stage about halfway through the night, consistent with the literature. In addition, both awakenings and REM sleep tended to increase cortisol level. Awakening cortisol response occurred from any stage of sleep and at any time of day.
CONCLUSIONS:
Part 1 - Insomnia and parasomnia subjects had higher cortisol levels than controls but this was not
statistically significant. However we demonstrated a significant relationship between cortisol levels and subjective measures of sleep quality and early awakening. Dreaming effects will be discussed.
Part 2 – The automatic sampling method was reliable and effective in obtaining frequent cortisol samples without interfering with sleep. There was evidence of both circadian and sleep-stage-dependent regulation of night-time cortisol level.
Accessibility: Document does not exist in file
Language:
eng
Author:
Wilson, S. J.
Secondary author(s):
Nutt, D. J., Lightman, S.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Wilson, S. J., Nutt, D. J., & Lightman, S. (2008). An investigation of effects of dreams on physiological measures of stress. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 7th Symposium of Fundação Bial. Porto: Fundação Bial.
Indexed document: No
Keywords: Sleep / Parasomnias / Hypothalamic-pituitary-adrenal axis / Cortisol / Stress / Endocrinology

An investigation of effects of dreams on physiological measures of stress

An investigation of effects of dreams on physiological measures of stress
DocumentHigher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.02
Location: Arquivo PCA - Pasta 18/2006
Title:
Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20071148
Abstract/Results: ABSTRACT:
This study investigated the relationship between cortisol secretion and hippocampal volume in first-episode psychosis and healthy controls. Hippocampal volume was measured by magnetic resonance imaging (MRI) in 24 first-episode psychosis patients and in 18 healthy controls, together with diurnal cortisol levels. Twelve patients received a second MRI scan at 3-month follow-up. Diurnal cortisol levels were inversely correlated with left hippocampal volume in patients, both at baseline and at follow-up, while no correlation was found in controls. Our findings suggest that smaller hippocampal volume in first-episode psychosis can partly be explained by stress-related processes in the brain, as measured by cortisol hyper-secretion.
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Pariante, C., Navari, S., Aas, M., D'Albenzio, A., Di Forti, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., Papadopoulos, A., Aitchison, K. J., Murray, R., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Reference:
Mondelli, V., Pariante, C., Navari, S., Aas, M., D'Albenzio, A., ... Dazzan, P. (2010). Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis. Schizophrenia Research, 119(1-3), 75-8. https://doi.org/10.1016/j.schres.2009.12.021
2-year Impact Factor: 4.374|2010
Times cited: 111|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Hippocampus / Psychosis / Hypothalamic-pituitary-adrenal axis / Schizophrenia / Glucocorticoids

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis

Higher cortisol levels are associated with smaller left hippocampal volume in first-episode psychosis
DocumentAbnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.05
Location: Arquivo PCA - Pasta 18/2006
Title:
Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis
Publication year: 2010
URL:
http://www.ncbi.nlm.nih.gov/pubmed/20529412
Abstract/Results: ABSTRACT:
BACKGROUND:
Cognitive impairment, particularly in memory and executive function, is a core feature of psychosis. Moreover, psychosis is characterized by a more prominent history of stress exposure, and by dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis. In turn, stress exposure and abnormal levels of the main HPA axis hormone cortisol are associated with cognitive impairments in a variety of clinical and experimental samples; however, this association has never been examined in first-episode psychosis (FEP).
METHOD:
In this study, 30 FEP patients and 26 controls completed assessment of the HPA axis (cortisol awakening response and cortisol levels during the day), perceived stress, recent life events, history of childhood trauma, and cognitive function. The neuropsychological battery comprised general cognitive function, verbal and non-verbal memory, executive function, perception, visuospatial abilities, processing speed, and general knowledge.
RESULTS:
Patients performed significantly worse on all cognitive domains compared to controls. In patients only, a more blunted cortisol awakening response (that is, more abnormal) was associated with a more severe deficit in verbal memory and processing speed. In controls only, higher levels of perceived stress and more recent life events were associated with a worse performance in executive function and perception and visuospatial abilities.
CONCLUSIONS:
These data support a role for the HPA axis, as measured by cortisol awakening response, in modulating cognitive function in patients with psychosis; however, this association does not seem to be related to the increased exposure to psychosocial stressors described in these patients.
Accessibility: Document does not exist in file
Language:
eng
Author:
Aas, M.
Secondary author(s):
Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A., Di Forti, M., Fisher, H., Handley, R., Hepgul, N., Marques, T. R., Miorelli, A., Taylor, H., Russo, M., Wiffen, B., Papadopoulos, A., Aitchison, K. J., Morgan, C., Murray, R., Pariante, C.
Document type:
Article
Number of reproductions:
1
Reference:
Aas, M., Dazzan, P., Mondelli, V., Toulopoulou, T., Reichenberg, A.,Di Forti, M., . . . Pariante, C. (2010). Abnormal cortisol awakening response predicts worse cognitive function in patients with first-episode psychosis. Psychological Medicine, 41(3), 463-476. https://doi.org/10.1017/S0033291710001170
2-year Impact Factor: 5.200|2010
Times cited: 97|2025-02-07
Indexed document: Yes
Quartile: Q1
Keywords: Cognition / Cortisol / Hypothalamic-pituitary-adrenal axis / Psychosis / Schizophrenia / Stress
DocumentHypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.07
Location: Arquivo PCA - Pasta 18/2006
Title:
Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis
Publication year: 2011
URL:
http://www.psyneuen-journal.com/article/PIIS030645301100268X/abstract?rss=yes
Abstract/Results: ABSTRACT:
BACKGROUND:
Abnormalities in hypothalamic-pituitary-adrenal (HPA) axis activity have been reported in patients with psychosis, but it is still unclear how these are related to the clinical symptomatology. Inconsistent findings have emerged from previous studies on the association between cortisol levels and clinical symptoms. Methodological and/or clinical factors, such as patients' diagnosis or illness phase, might partially account for these inconsistencies. The aim of this study was to investigate the association between HPA axis activity and clinical symptoms in first-episode psychosis, taking into account diagnosis and illness phase.
METHOD:
Saliva samples were collected in 55 subjects with first-episode psychosis to assess the Cortisol Awakening Response (CAR) and diurnal cortisol levels (AUC-DAY). Severity of symptoms was assessed with the Positive and Negative Syndrome Scale (PANSS). Scores for subscales and symptom dimensions were used as predictors in multivariate analyses in different diagnostic subgroups and in clinically remitted patients. In addition, a systematic review of the literature on this topic was conducted.
RESULTS:
In subjects with schizophrenia (n=36), the CAR was predicted by the severity of positive symptoms (beta=0.47, p=0.04); in subjects with depressive psychoses (n=8) the CAR was predicted by excitement (beta=0.58, p=0.005), disorganization (beta=0.39, p=0.007) and depressive symptoms (beta=0.32, p=0.005). In patients with bipolar psychoses (n=11) AUC-DAY was predicted negatively by disorganization (beta=-2.82, p=0.009) and positively by excitement (beta=2.06, p=0.009) and positive symptoms (beta=1.28, p=0.02). In the sample in clinical remission (n=9), the CAR was associated with the severity of positive symptoms (beta=1.34, p=0.009) and, negatively, with excitement (beta=-1.05, p=0.04). The systematic review (on a total of 28 papers, including n=1022 patients), found that in patients with psychosis cortisol levels have been associated with the severity of multiple symptom dimensions.
CONCLUSIONS:
HPA axis activity is associated with the severity of multiple types of symptoms in first-episode psychosis. Patients' diagnosis and clinical phase partially influence these associations.
Accessibility: Document does not exist in file
Language:
eng
Author:
Belvederi Murri, M.
Secondary author(s):
Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., Mondelli, V.
Document type:
Article
Number of reproductions:
1
Reference:
Belvederi Murri, M., Pariante, C., Dazzan, P., Hepgul, N., Papadopoulos, A., Zunszain, P., Di Forti, M., Murray, R., & Mondelli, V. (2011). Hypothalamic-pituitary-adrenal axis and clinical symptoms in first-episode psychosis. Psychoneuroendocrinology, 37(5), 629-644. https://doi.org/10.1016/j.psyneuen.2011.08.013
2-year Impact Factor: 5.809|2011
Times cited: 69|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis / Symptoms / Psychosis / Schizophrenia / Bipolar / Depression / Diagnosis / Remission / Neuroendocrinology
DocumentStress and the hypothalamic pituitary adrenal axis activity in first episode psychosis2009

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.13
Location: Arquivo PCA - Pasta 18/2006
Title:
Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis
Publication year: 2009
URL:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651108/pdf/sbn173.pdf
Abstract/Results: ABSTRACT:
BACKGROUND:
Hypothalamic-pituitary-adrenal (HPA) axis is the main biological system involved in the stress response. The aim of our study was to evaluate objective and subjective stress together with HPA axis activity in first-episode psychosis patients and healthy controls.
METHODS:
We recruited 40 first-episode psychosis patients (mean +/- SEM age: 29.4 +/-1.2 yrs; gender: 35% females) and 30 controls (mean age: 27.4 +/- 1.0 yrs; gender: 23.3% females) as part of the large Genetic And Psychosis (GAP) study, carried out in South London. Information about childhood trauma, recent stressful events and perceived stress were collected using validated schedules. Salivary cortisol was obtained at awakening, at 15, 30, and 60 minutes after awakening, and at 12 pm, and 8 pm. We calculated the Areas Under the Curve to investigate the cortisol levels during the day and the cortisol response to awakening. An independent t-test and was used to analyze differences in the stress variables and cortisol secretion. Correlation analyses were run to investigate the association between stress variables and cortisol secretion.
RESULTS:
First-episode psychosis patients reported more childhood trauma, recent stressful events, and higher perceived stress compared with controls (P < .001). Patients showed no significant difference in cortisol levels during the day compared with controls (P = .2). However, patients showed a significantly lower cortisol awakening response than controls (P = .034). A positive correlation was found between number of recent stressors or perceived stress and cortisol during the day in controls (r = .377, P = .04 and r = .321, P = .08). In contrast, a negative correlation between number of recent stressors or perceived stress and cortisol during the day was found in patients (r = -.413, P = .01 and r = -.356, P = .04).
CONCLUSIONS:
Our data show that first episode psychosis patients have higher number of stressful events but similar cortisol levels during the day when compared with healthy controls. First episode psychosis patients have an impaired HPA axis response to stress as shown by the blunted cortisol response to awakening and by the negative correlation between measures of recent stress and cortisol secretion during the day.
ACKNOWLEDGMENT:
This research is funded by NARSAD Mental Health Research Association, British Academy, and NIHR Biomedical Research Centre Institute of Psychiatry (Kings’ College London).
Accessibility: Document does not exist in file
Language:
eng
Author:
Mondelli, V.
Secondary author(s):
Aas, M., D'Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., Hepgul, N., Marques, T. R., Taylor, H., David, A. S., Dazzan, P., Murray, R., Pariante, C.
Document type:
Abstract
Number of reproductions:
1
Reference:
Mondelli, V., Aas, M., D’Albenzio, A., Di Forti, M., Di Nicola, M., Handley, R., . . . Pariante, C. (2009). Stress and the hypothalamic-pituitary-adrenal axis activity in first episode psychosis. Schizophrenia Bulletin, 35(Suppl. 1), 149-149.
Indexed document: Yes
Keywords: Hypothalamic-pituitary-adrenal axis / Stress / First-episode psychosis / Childhood trauma

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis

Stress and the hypothalamic pituitary adrenal axis activity in first episode psychosis
DocumentState Well-being or Ill-being does not predict cortisol patterns in a young healthy sample2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-096
Location: Arquivo PCA - Pasta 8/2010
Title:
096 - The psychophysiology of positive psychology
Duration: 2011-06 - 2013-09
Researcher(s):
Angela Clow, Lisa Thorn, Nina Smyth, Frank Hucklebridge
Institution(s): Psychophysiology and Stress Research Group, Department of Psychology, University of Westminster, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Language: eng
Author:
Clow, A.
Secondary author(s):
Thorn, L., Smyth, N., Hucklebridge, F.
Number of reproductions:
1
Keywords:
Psychophysiology / Stress and health / Well-being / Psychoneuroimmunology / Endocrinology / Affective and social behavior / Attachment / Developmental psychology

Reference code: PT/FB/BL-2010-096.07
Location: Arquivo PCA - Pasta 8/2010
Title:
State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample
Publication year: 2013
URL:
http://www.psychosomatic.org/anmeeting/PDF/2013abstractBooklet.pdf
Abstract/Results: ABSTRACT:
Many studies have explored the relationship between cortisol secretion and state well-being or ill-being; however, results are inconsistent. This may be explained to some extent by participant non-adherence to the saliva sampling protocol particularly for studies investigating the cortisol awakening response (CAR) as delays (> 5 min) in collecting the first saliva sample lead to misleading measurements of the CAR. Another factor may be the age group of the participants. Consistent associations are found in middle-aged and older populations, whereas relatively weak relationships tend to be found in younger individuals. This study aimed to objectively monitor adherence to the saliva sampling protocol and investigate the relationship between well-being and the CAR and cortisol over the day in a young healthy female sample.
50 healthy female students collected saliva samples on four days at 0, 15, 30, and 45 minutes, 3 and 12 hours post-awakening. State wellbeing and ill-being was assessed by mood ratings throughout each sampling day. Participants rated the extent to which they felt pleased, happy, goal-directed, stressed, out of control, frustrated, and down using electronic devices. Participants were made aware that awakening and sampling times were objectively monitored.
Participants were relatively adherent to the saliva sampling protocol, delays of < 5 min (mean: 1±1 min) was achieved on the majority of sampling days (N=80). Days with delays of over 5 minutes (mean: 13±12 min) were excluded (N=73) from analyses involving the CAR. Mixed modelling showed there was no relationship between well-being or ill-being and the CAR, the diurnal decline and cortisol over the day.
The lack of an association between well-being or ill-being and cortisol on days where saliva samples were collected accurately supports the neurotoxicity hypothesis of HPA axis dysregulation. In young healthy individuals the HPA-axis is resilient and thus associations between well-being or ill-being and cortisol will be absent or weak. We would hypothesise that these associations would be stronger in participants with vulnerability as a result of early life stress (not measured in this study) and in older adults.
Accessibility: Document does not exist in file
Language:
eng
Author:
Smyth, N.
Secondary author(s):
Evans, P., Thorn, L., Hucklebridge, F., Clow, A.
Document type:
Abstract book
Number of reproductions:
1
Reference:
Smyth, N., Evans, P., Thorn, L., Hucklebridge, F., & Clow, A. (2013). State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample. Abstracts of the American Psychosomatic Society 71st Annual Meeting: “Impact and Innovation” (A - 122). Miami, FL.
Indexed document: No
Keywords: Cortisol / Well-being / Cortisol awakening response / Hypothalamic-pituitary-adrenal axis

State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample

State Well-being or Ill-being does not predict cortisol patterns in a young healthy sample
DocumentRelationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-206
Location: BF-GMS
Title:
206 - Developing a neurofunctional intervention for emotion regulation under stress
Duration: 2017-01 - 2023-01
Researcher(s):
Pedro Morgado, Carles Soriano Mas, Paulo Marques, Pedro Moreira, Ricardo Magalhães
Institution(s): Life and Health Sciences Research Institute - ICVS, School of Health Sciences, University of Minho, Braga (Portugal); Department of Psychiatry, Bellvitge Biomedical Research Institute - IDIBELL, Barcelona (Spain)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Author: Morgado, P.
Secondary author(s):
Soriano-Mas, C., Marques, P., Moreira, P., Magalhães, R.
Number of reproductions:
1
Keywords:
Cognitive reappraisal / Stress / Neurofeedback / Electroencephalogram (EEG) / Psychophysiology

Reference code: PT/FB/BL-2016-206.04
Location: BF-GMS
Title:
Relationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis
Publication year: 2019
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0924977X19308752?via%3Dihub
Abstract/Results: ABSTRACT:
Altered stress response and consequent elevated levels of circulating glucocorticoids have been found in neuropsychiatric disorders such as depression or anxiety disorders and proposed to also play a role in the pathophysiology of obsessive-compulsive disorder (OCD). Despite the observation that stressful events may precede the disease onset or even exacerbate its symptoms, studies in this field do not always report consistent results regarding the cortisol profile of OCD patients. As such, a systematic review and meta-analysis was developed to clarify this issue. This systematic review and meta-analysis was elaborated according to the PRISMA method. The analytical procedures were implemented using Metafor package in R software. Nineteen studies were included in the systematic review and 18 were included in the meta-analysis. The meta-analytic results demonstrated that OCD patients had significantly higher cortisol levels compared to controls (d?=?0.76, SE = 0.146, p < 0.001). For studies using the average of multiple assessments, the standardized coefficient was significantly higher when compared to studies focusing on single measurements. Both the systematic review and meta-analysis suggest that cortisol levels are significantly higher in OCD patients than healthy individuals.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Sousa-Lima, J.
Secondary author(s):
Moreira, P. S., Raposo-Lima, C., Sousa, N., Morgado, P.
Document type:
Article
Number of reproductions:
1
Reference:
Sousa-Lima, J., Moreira, P. S., Raposo-Lima, C., Sousa, N., & Morgado, P. (2019). Relationship between obsessive compulsive disorder and cortisol: Systematic review and meta-analysis. European Neuropsychopharmacology. https://doi.org/10.1016/j.euroneuro.2019.09.001
2-year Impact Factor: 3.853|2019
Times cited: 28|2025-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Cortisol / Glucocorticoids / Hypothalamic-pituitary-adrenal axis / OCD / Stress
DocumentPituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.32
Location: BF-GMS
Title:
Pituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia
Publication year: 2015
URL:
https://www.cambridge.org/core/journals/psychological-medicine/article/abs/pituitary-gland-volume-and-psychosocial-stress-among-children-at-elevated-risk-for-schizophrenia/97FDCCD276481C6ED6113D4FE6746FBA
Abstract/Results: Abstract
Background
Pituitary volume enlargements have been observed among individuals with first-episode psychosis. These abnormalities are suggestive of hypothalamic–pituitary–adrenal (HPA) axis hyperactivity, which may contribute to the development of psychosis. However, the extent to which these abnormalities characterize individuals at elevated risk for schizophrenia prior to illness onset is currently unclear, as volume increases, decreases and no volume differences have all been reported relative to controls. The current study aimed to determine whether antipsychotic-naive, putatively at-risk children who present multiple antecedents of schizophrenia (ASz) or a family history of illness (FHx) show pituitary volume abnormalities relative to typically developing (TD) children. An additional aim was to explore the association between pituitary volume and experiences of psychosocial stress.
Method
ASz (n = 30), FHx (n = 22) and TD (n = 32) children were identified at age 9–12 years using a novel community-screening procedure or as relatives of individuals with schizophrenia. Measures of pituitary volume and psychosocial stress were obtained at age 11–14 years.
Results
Neither ASz nor FHx children showed differences in pituitary volume relative to TD children. Among FHx children only, pituitary volume was negatively associated with current distress relating to negative life events and exposure to physical punishment.
Conclusions
The lack of pituitary volume abnormalities among ASz and FHx children is consistent with our previous work demonstrating that these children are not characterized by elevated diurnal cortisol levels. The findings imply that these biological markers of HPA axis hyperactivity, observed in some older samples of high-risk individuals, may emerge later, more proximally to disease onset.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
Day, F. L., Roberts, R. E., Pariante, C. M., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Cullen, A., Day, F., Roberts, R., Pariante, C., & Laurens, K. (2015). Pituitary gland volume and psychosocial stress among children at elevated risk for schizophrenia. Psychological Medicine, 45(15), 3281-3292. https://doi.org/10.1017/S0033291715001282
2-year Impact Factor: 5.491|2015
Times cited: 17|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Childhood trauma / Diathesis-stress model / Genetic high risk / Hypothalamic-pituitary-adrenal axis / Psychosis vulnerability