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DocumentDifferential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-036
Location: Arquivo PCA - Pasta 18/2006
Title:
036 - The psychophysiology of neurological abnormalities in first episode psychosis and in healthy individuals - A study using multimodal brain imaging
Duration: 2007-03 - 2010-09
Researcher(s):
Paola Dazzan, Philip McGuire, Carmine Pariante, Marta Di Forti, Julia Lappin, Valeria Mondelli
Institution(s): Division of Psychological Medicine, Institute of Psychiatry, London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
1 Article
Language: eng
Author:
Dazzan, P.
Secondary author(s):
McGuire, P., Pariante, C., Di Forti, M., Lappin, J., Mondelli, V.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Biopsychological problems / Mental health / Psychotic disorders / Body structure and function / Audition / Movement / Vision

Reference code: PT/FB/BL-2006-036.22
Location: Arquivo PCA - Pasta 18/2006
Title:
Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals
Publication year: 2012
URL:
https://www.sciencedirect.com/science/article/abs/pii/S0920996412005683?via%3Dihub
Abstract/Results: ABSTRACT:
The minor neurological and cognitive deficits consistently reported in psychoses may reflect the same underlying brain dysfunction. Still, even in healthy individuals minor neurological abnormalities are associated with worse cognitive function. Therefore, establishing which neurological and cognitive deficits are specific to psychosis is essential to inform the pathophysiology of this disorder. We evaluated a large epidemiological sample of patients with first episode psychosis (n = 242) and a population-based sample of healthy individuals (n = 155), as part of the AESOP study. We examined neurological soft signs using the Neurological Evaluation Scale (Buchanan and Heinrichs, 1989), and generalized and specific cognitive deficits (memory; verbal abilities; attention, concentration and mental speed; executive functions and working memory; language; visual constructual/perceptual abilities). In patients, more neurological signs across all subscales were associated with worse general cognitive function, while in controls this was only present for sensory integration and sequencing signs. Furthermore, in patients, but not in healthy individuals, more sensory integrative signs were associated with deficits in specific cognitive domains, such as memory, verbal abilities, language, visual/perceptual, executive function (p ranging <0.001-0.002); sequencing signs with language, executive function, and attention (p<0.001-0.004); and motor signs with poorer verbal abilities (p=0.001). These findings indicate the presence of specific associations between neurological and cognitive deficits in psychosis that are distinct from those of healthy individuals. (C) 2012 Elsevier B.V. All rights reserved.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Mellacqua, Z.
Secondary author(s):
Eyeson, J., Orr, K. D., Morgan, K. D., Zanelli, J., Lloyd, T., Morgan, C., Fearon, P., Hutchinson, G., Doody, G. A., Chan, R. C., Harrison, G., Jones, P. B., Murray, R. M., Reichenberg, A., Dazzan, P.
Document type:
Article
Number of reproductions:
1
Percentiles:
25.26|0.21
Reference:
Mellacqua, Z., Eyeson, J., Orr, K. D., Morgan, K. D., Zanelli, J., Lloyd, T., Morgan, C., Fearon, P., Hutchinson, G., Doody, G. A., Chan, R. C., Harrison, G., Jones, P. B., Murray, R. M., Reichenberg, A., & Dazzan, P. (2012). Differential relationship between neurological and cognitive dysfunction in first episode psychosis patients and in healthy individuals. Schizophrenia Research, 142(1-3), 159-164. https://doi.org/10.1016/j.schres.2012.09.016
2-year Impact Factor: 4.590|2012
Times cited: 8|2026-02-06
Indexed document: Yes
Quartile: Q1
Keywords: Schizophrenia / Neurological signs / IQ / Motor coordination / Executive function / First episode psychosis / Healthy individuals
DocumentGray matter correlates of reading fluency deficits: SES matters, IQ does not2021

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

Reference code: PT/FB/BL-2014-304
Location: BF-GMS
Title:
304 - The impact of music training on reading and mathematical abilities of normal and reading disabled children: a behavioral and neuroimaging longitudinal study
Duration: 2015-10 - 2019-09
Researcher(s):
Maria de São Luís Vasconcelos da Fonseca e Castro Schöner, Christian Gaser, Daniela da Costa Coimbra, Marta Sofia Pinto Martins
Institution(s): Faculty of Psychology and Educational Sciences at University of Porto, FPCEUP / Centre for Psychology at University of Porto (Portugal); Structural Brain Mapping Group/ Department of Psychiatry - Jena University Hospital (Germany)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Castro, S. L.
Secondary author(s):
Gaser, C., Coimbra, D., Martins, M.
Number of reproductions:
1
Keywords:
Longitudinal study / Music training / Reading and mathematical abilities / Brain morphometry / Psychophysiology

Reference code: PT/FB/BL-2014-304.20
Location: BF-GMS
Title:
Gray matter correlates of reading fluency deficits: SES matters, IQ does not
Publication year: 2021
URL:
https://link.springer.com/article/10.1007%2Fs00429-021-02353-1
Abstract/Results: Brain correlates of reading ability have been intensely investigated. Most studies have focused on single-word reading and phonological processing, but the brain basis of reading fluency remains poorly explored to date. Here, in a voxel-based morphometry study with 8-year-old children, we compared fluent readers (n = 18; seven boys) with dysfluent readers with normal IQ (n = 18; six boys) and with low IQ (n = 18; ten boys). Relative to dysfluent readers, fluent readers had larger gray matter volume in the right superior temporal gyrus and the two subgroups of dysfluent readers did not differ from each other, as shown in frequentist and Bayesian analyses. Pairwise comparisons showed that dysfluent readers of normal and low IQ did not differ in core reading regions and that both subgroups had less gray matter volume than fluent readers in occipito-temporal, parieto-temporal and fusiform areas. We also examined gray matter volume in matched subgroups of dysfluent readers differing only in socioeconomic status (SES): lower-SES (n = 14; seven boys) vs. higher-SES (n = 14; seven boys). Higher-SES dysfluent readers had larger gray matter volume in the right angular gyrus than their lower-SES peers, and the volume of this cluster correlated positively with lexico-semantic fluency. Age, sex, IQ, and gray matter volume of the right angular cluster explained 68% of the variance in the reading fluency of higher-SES dysfluent readers. In sum, this study shows that gray matter correlates of dysfluent reading are independent of IQ, and suggests that SES modulates areas sub-serving lexico-semantic processes in dysfluent readers—two findings that may be useful to inform language/reading remediation programs.
Accessibility: Document exists in file
Copyright/Reproduction:
by permission
Language:
eng
Author:
Martins, M.
Secondary author(s):
Reis, A. M., Castro, S. L., Gaser, C.
Document type:
Article
Number of reproductions:
1
Percentiles:
65.81|0.79
Reference:
Martins, M., Reis, A. M., Castro, S. L., & Gaser, C. (2021). Gray matter correlates of reading fluency deficits: SES matters, IQ does not. Brain Structure and Function, 226, 2585-2601. https://doi.org/10.1007/s00429-021-02353-1
2-year Impact Factor: 3.748|2021
Times cited: 9|2026-02-13
Indexed document: Yes
Quartile: Q1
Keywords: Reading fluency deficits / Gray matter / IQ / SES / Children

Gray matter correlates of reading fluency deficits: SES matters, IQ does not

Gray matter correlates of reading fluency deficits: SES matters, IQ does not
DocumentDifferentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.12
Location: BF-GMS
Title:
Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
Publication year: 2025
URL:
https://doi.org/10.1016/j.schres.2025.07.001
Abstract/Results: ABSTRACT:
Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (n = 114) over ages 9–20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents. Both ASz and FHx youth demonstrated early deficits (age ~11 years) in verbal intelligence relative to TD youth, which remained stable into young adulthood. FHx youth additionally showed this stable developmental deficit relative to TD youth in performance intelligence. In exploratory supplementary analyses, verbal intelligence improved with age toward TD performance among ASz children whose psychopathological symptoms remitted during follow-up. Uniquely among FHx youth, those with a low familial loading (one second-degree affected relative only) and none/one of the three antecedents did not evidence the stable developmental deficits in verbal and performance intelligence. These distinct developmental trajectories of verbal and performance intelligence among youth presenting different profiles of schizophrenia risk may signify potential for targeted preventative interventions. Further research is needed to determine whether these trajectories distinguish later transition to schizophrenia from a cognitive vulnerability that normalises among at-risk individuals who do not transition.
Accessibility: Document exists in file
Language:
eng
Author:
Carpendale, E. J.
Secondary author(s):
Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Carpendale, E. J., Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H. L., & Laurens, K. R. (2025). Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence. Schizophrenia Research, 283, 144–151. https://doi.org/10.1016/j.schres.2025.07.001
2-year Impact Factor: 3.5|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2026-02-20
Indexed document: Yes
Quartile: Q1
Keywords: Psychosis / Genetic liability / High-risk / Cognition / IQ / Vocabulary / Matrix reasoning

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
DpcumentDifferentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006.035.34
Location: BF-GMS
Title:
Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence
Publication year: 2015
URL:
https://doi.org/10.1016/j.schres.2025.07.001
Abstract/Results: ABSTRACT:
Distinct patterns in the premorbid development of verbal and performance intelligence might differentiate the propensity for later illness among individuals putatively at risk for schizophrenia. This study applied linear mixed-effects models to four verbal and performance intelligence assessments gathered from a community sample of youth (n = 114) over ages 9–20 years, comparing developmental trajectories for at-risk youth with a triad of well-replicated antecedents of schizophrenia (ASz) and at-risk youth with a family history of schizophrenia (FHx), each relative to low-risk, typically developing peers (TD). Supplementary analyses explored heterogeneity among ASz youth according to persistence of symptoms, and FHx youth according to familial loading and presence of antecedents. Both ASz and FHx youth demonstrated early deficits (age ~11 years) in verbal intelligence relative to TD youth, which remained stable into young adulthood. FHx youth additionally showed this stable developmental deficit relative to TD youth in performance intelligence. In exploratory supplementary analyses, verbal intelligence improved with age toward TD performance among ASz children whose psychopathological symptoms remitted during follow-up. Uniquely among FHx youth, those with a low familial loading (one second-degree affected relative only) and none/one of the three antecedents did not evidence the stable developmental deficits in verbal and performance intelligence. These distinct developmental trajectories of verbal and performance intelligence among youth presenting different profiles of schizophrenia risk may signify potential for targeted preventative interventions. Further research is needed to determine whether these trajectories distinguish later transition to schizophrenia from a cognitive vulnerability that normalises among at-risk individuals who do not transition.
Accessibility: Document exists in file
Language:
eng
Author:
Carpendale, E. J.
Secondary author(s):
Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H., Laurens, K. R.
Document type:
Article-d
Number of reproductions:
1
Percentiles:
0.00|0.00
Reference:
Carpendale, E. J., Bell, M. C., Cullen, A. E., Dickson, H., Roberts, R. E., Fisher, H. L., & Laurens, K. R. (2025). Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence. Schizophrenia Research, 283, 144–151. https://doi.org/10.1016/j.schres.2025.07.001
2-year Impact Factor: 3.5|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2026-02-20
Indexed document: Yes
Quartile: Q1
Keywords: Psychosis / Genetic liability / High-risk / Cognition / IQ / Vocabulary / Matrix reasoning

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence

Differentiation of childhood risk profiles for schizophrenia according to the development of verbal and performance intelligence