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Type Title Begin End
DocumentBasal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-094
Location: Arquivo PCA - Pasta 21/2006
Title:
094 - Feedback modulation of visual processing by limbic circuits: A functional connectivity approach to visual face processing
Duration: 2008-01 - 2011-02
Researcher(s):
Miguel Castelo-Branco, Cristina Januário, Solange Silva, Aldina Reis, Catarina Mateus, Miguel Cordeiro
Institution(s): IBILI - Faculdade de Medicina, Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
Language: eng
Author:
Castelo-Branco, M.
Secondary author(s):
Januário, C., Silva, S., Mateus, C., Cordeiro, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Brain structure and function / Emotion / Body structure and function / Vision

Reference code: PT/FB/BL-2006-094.25
Location: Arquivo PCA - Pasta 21/2006
Title:
Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning
Publication year: 2010
URL:
Visitante: / http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder that mainly affects the basal ganglia, although damage to cortical areas is also found. The basal ganglia are a set of subcortical structures that are particularly important for motor functions, action selection, reinforcement learning and implicit learning. However, recent studies have indicated that they might also be involved in implicit learning that does not involve motor functions and is purely based on visual learning (Castelo-Branco, et al. 2009; Van Asselen et al., 2009). To further investigate this, we have used an implicit contextual learning paradigm to test patients with HD.
This is a visual search task, in which subjects need to locate a target as quickly as possible. Importantly, in half of the trials the positions of the distractors and target stimuli are repeated and this spatial information is used as a contextual cue. By memorizing this contextual information, attention is guided to the target stimulus. Since HD is a genetic disease, patients can be diagnosed before the onset of motor and cognitive symptoms. In the current study we tested 9 symptomatic HD patients, 14 presymptomatic HD patients and 21 control subjects.
We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and presymptomatic HD patients. Thus, the HD patients did not learn the repeated contextual information and improve their visual search. Together, this indicates that the basal ganglia are not only involved in implicit motor learning, but also have an important role in purely visually based implicit learning. Furthermore, this impairment is found early in the disease, before the onset of other cognitive and motor impairments.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2006-73.09
Author: Van Asselen, M.
Secondary author(s):
Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., Castelo-Branco, M.
Document type:
Online abstract-d
Number of reproductions:
1
Reference:
Van Asselen, M., Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., & Castelo-Branco, M. (2010, July). Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning. Poster presented at the 7th FENS Forum of European Neuroscience, Amsterdam, Netherlands. Abstract retrieved from http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Indexed document: No
Keywords: Huntington's disease / Basal ganglia dysfunction / Implicit contextual learning
DocumentFinal report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging2011

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.01
Location: Arquivo PCA - Pasta 22/2006
Title:
Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Publication year: 2011
URL:
Visitante: / http://www.bial.com/imagem/Bolsa7306_21022014.pdf
Abstract/Results: RESULTS:
During this research project (73/06) we investigated the mechanism underlying implicit contextual learning as well as its neural correlates. Implicit contextual cueing is a learning mechanism in which visual information from our environment is memorized in order to facilitate visual search.
In the first part of our research project we studied the mechanism underlying implicit contextual cueing using eye movement recording. First, we showed that peripheral vision can be used to memorize the context of a target (Van Asselen et al. 2009), whereas in our following study we demonstrated that object-based contextual cueing is associated with shorter fixation durations (Van Asselen et al., 2010). Finally, we showed that when two contextual cues are presented simultaneously, the contextual cueing effect is much larger than when one cue is presented. This effect is associated with fewer fixations and shorter saccade amplitudes, suggesting that a different search strategy is used.
In the second part of this research project we aimed to look at the neural basis of implicit contextual cueing. Therefore, we tested patients with Huntington’s and Parkinson’s disease with a contextual cueing task and found that these patients are not able to benefit from the repeated contextual information (Van Asselen et al., 2009). Since both of these neurodegenerative diseases affect the basal ganglia, our findings suggest an important role for this brain area. Finally, by using fMRI we demonstrated that the exact neural network that is involved in implicit contextual cueing depends on the type of cues (object or spatial) that are used to guide attention.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Psychophysiology / Implicit contextual learning / Neural correlates / Eye movements / Huntington's disease / Parkinson's disease / Basal ganglia / Perception

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging

Final report - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
DocumentImplicit contextual learning in prodromal and early stage Huntington's disease patients2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.05
Location: Arquivo PCA - Pasta 22/2006
Title:
Implicit contextual learning in prodromal and early stage Huntington's disease patients
Publication year: 2012
URL:
Visitante: / http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8631149
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder affecting the basal ganglia. These subcortical structures are particularly important for motor functions, response selection and implicit learning. In the current study, we have assessed prodromal and symptomatic HD participants with an implicit contextual learning task that is not based on motor learning, but on a purely visual implicit learning mechanism. We used an implicit contextual learning task in which subjects need to locate a target among several distractors. In half of the trials, the positions of the distractors and target stimuli were repeated. By memorizing this contextual information, attention can be guided faster to the target stimulus. Nine symptomatic HD participants, 16 prodromal HD participants and 22 control subjects were included. We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and prodromal HD participants. The results of the current study indicate that both prodromal and symptomatic HD participants are impaired on an implicit contextual learning task.
Accessibility: Document exists in file (previous version submitted for publication)
Copyright/Reproduction:
By permission
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simões, M. R., Castelo-Branco, M.
Document type:
Article
Number of reproductions:
1
Percentiles:
32.88|0.28
Reference:
Van Asselen, M., Almeida, I., Júlio, F., Januário, C., Bobrowicz-Campos, E., Simões, M. R., Castelo-Branco, M. (2012). Implicit contextual learning in prodromal and early stage Huntington's disease patients. Journal of the International Neuropsychological Society, 18(4), 689-696. https://doi.org/10.1017/S1355617712000288
Impact Factor: 2.697|2012
Times cited: 12|2026-02-05
Indexed document: Yes
Quartile: Q2
Keywords: Huntington's disease / Neurodegenerative disorder / Implicit contextual learning / Basal ganglia / Visual search

Implicit contextual learning in prodromal and early stage Huntington's disease patients

Implicit contextual learning in prodromal and early stage Huntington's disease patients
DocumentBasal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning2010

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.09
Location: Arquivo PCA - Pasta 22/2006
Title:
Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning
Publication year: 2010
URL:
Visitante: / http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Abstract/Results: ABSTRACT:
Huntington's disease (HD) is a genetic neurodegenerative disorder that mainly affects the basal ganglia, although damage to cortical areas is also found. The basal ganglia are a set of subcortical structures that are particularly important for motor functions, action selection, reinforcement learning and implicit learning. However, recent studies have indicated that they might also be involved in implicit learning that does not involve motor functions and is purely based on visual learning (Castelo-Branco, et al. 2009; Van Asselen et al., 2009). To further investigate this, we have used an implicit contextual learning paradigm to test patients with HD.
This is a visual search task, in which subjects need to locate a target as quickly as possible. Importantly, in half of the trials the positions of the distractors and target stimuli are repeated and this spatial information is used as a contextual cue. By memorizing this contextual information, attention is guided to the target stimulus. Since HD is a genetic disease, patients can be diagnosed before the onset of motor and cognitive symptoms. In the current study we tested 9 symptomatic HD patients, 14 presymptomatic HD patients and 21 control subjects.
We found that the responses of the control subjects were faster for the repeated trials than for the new trials, indicating that their visual search was facilitated when repeated contextual information was present. In contrast, no difference in response times between the repeated and new trials was found for the symptomatic and presymptomatic HD patients. Thus, the HD patients did not learn the repeated contextual information and improve their visual search. Together, this indicates that the basal ganglia are not only involved in implicit motor learning, but also have an important role in purely visually based implicit learning. Furthermore, this impairment is found early in the disease, before the onset of other cognitive and motor impairments.
Accessibility: Document does not exist in file
Language:
eng
Related objects:
PT/FB/BL-2006-94.25
Author: Van Asselen, M.
Secondary author(s):
Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., Castelo-Branco, M.
Document type:
Online abstract
Number of reproductions:
1
Reference:
Van Asselen, M., Júlio, F., Almeida, I., Januário, C., Bobrowicz-Campos, E., Gonçalves, A., & Castelo-Branco, M. (2010, July). Basal ganglia dysfunction caused by Huntington's disease impairs nonmotor visual learning. Poster presented at the 7th FENS Forum of European Neuroscience, Amsterdam, Netherlands. Abstract retrieved from http://fens2010.neurosciences.asso.fr/abstracts/R4/A114_50.html
Indexed document: No
Keywords: Huntington's disease / Basal ganglia dysfunction / Implicit contextual learning
DocumentThe role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: Visitante: / http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-073
Location: Arquivo PCA - Pasta 22/2006
Title:
073 - The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Duration: 2008-01 - 2011-09
Researcher(s):
Marieke van Asselen, Albert Postma, António Freire Gonçalves, Inês Almeida, José Rebola
Institution(s): IBILI - Faculdade de Medicina, Universidade de Coimbra (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles
Language: eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Learning / Biopsychological problems / Neurodegenerative disorders / Huntington's disease / Parkinson's disease

Reference code: PT/FB/BL-2006-073.13
Location: Arquivo PCA - Pasta 22/2006
Title:
The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging
Publication year: 2012
URL:
Visitante: / http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
OBJECTIVES:
Investigate the mechanism underlying implicit contextual learning and study its neural correlates.
METHODS:
A series of contextual cueing tasks were developed to study different aspects of implicit contextual learning using eye movement recording. Moreover, to define the neural correlates of implicit contextual cueing, several patient and neuroimaging studies were performed.
RESULTS:
We have shown that a snapshot of local contextual information is made using peripheral vision and that different types of contextual information can be used to facilitate visual search through a specific underlying mechanisms. Furthermore, we have demonstrated the importance of the basal ganglia in implicit learning. Finally, distinct neural correlates were found when different types of contextual information were used.
CONCLUSIONS:
Implicit contextual cueing is a complex learning mechanism in which different types of contextual information can be used to facilitate visual search through distinct attention mechanisms. Furthermore, neural correlates of implicit contextual cueing include the basal ganglia, MTL and fronto-parietal networks.
DISCUSSION:
Future research projects should be aimed at further defining the specific role of the basal ganglia and MTL.
Accessibility: Document does not exist in file
Language:
eng
Author:
Van Asselen, M.
Secondary author(s):
Postma, A., Gonçalves, A., Almeida, I., Rebola, J.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Van Asselen, M., Postma, A., Gonçalves, A., Almeida, I., & Rebola, J. (2012). The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging. In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 5/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Implicit contextual learning / Neural correlates / Eye movements

The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging

The role of the cortico-basal ganglia circuit in learning and memory: From patient studies to functional neuroimaging