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DocumentFinal report - Effects of conditional Foxp2 deletion on motor-sequence learning2016

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-192
Location: Arquivo PCA - Pasta 15/2012
Title:
192 - Effects of conditional Foxp2 deletion on motor-sequence learning
Duration: 2013-06 - 2016-07
Researcher(s):
Catherine Ann French
Institution(s): Fundação Champalimaud, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
2 articles (published and submitted)
Language: eng
Author:
French, C.
Number of reproductions:
1
Keywords:
Psychophysiology / Biopsychological problems / Diseases/Injuries / Chromosomal abnormalities / Brain structure and function / Cognitive processes / Learning / Body structure and function / Movement

Reference code: PT/FB/BL-2012-192.01
Location: Arquivo PCA - Pasta 15/2012
Title:
Final report - Effects of conditional Foxp2 deletion on motor-sequence learning
Publication year: 2016
URL:
https://www.bial.com/imagem/Grant19212.pdf
Abstract/Results: ABSTRACT:
Disruptions of FOXP2 cause a speech and language disorder, a core deficit of which are problems in sequencing orofacial movements. The gene encodes a transcription factor that is expressed in cortico-striatal/ -cerebellar circuits which are required for sensorimotor integration and motor-skill learning, and imaging studies of affected individuals have identified structural abnormalities in these regions. FOXP2 is also highly conserved in several other vertebrate species including mice, where expression is seen in comparable brain areas during development and in adulthood. The aims of this study were to 1) establish the contributions of Foxp2 in specific brain regions to motor-sequence learning 2) examine Foxp2 functions in adulthood. We generated conditional mice with selective Foxp2 disruptions in the cortex, striatum or cerebellar Purkinje cells, and assessed effects on motor-sequence learning using an operant lever-pressing task. Foxp2 in each of the circuits contributed differentially to the speed and variability of lever-press sequences. Pronounced deficits were seen in cerebellar Purkinje cell mutants and, in collaboration with Prof. Chris De Zeeuw, we showed that Purkinje cells lacking Foxp2 have increased excitability and are atypically modulated in vivo during locomotion. We also used an inducible Cre to disrupt Foxp2 globally in adulthood. This resulted in the deaths of around one third of mutant mice, although surviving animals appeared healthy and executed lever-press sequences normally. In sum, we found that early Foxp2 expression is critical for motor-sequence learning and model-based decision making, but continued expression in mature animals is important for other behaviours such as sociability.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
French, C.
Document type:
Final report
Number of reproductions:
1
Indexed document:
No
Keywords: Motor-sequence learning / Foxp2 / Speech and language / Conditional gene disruption / in vivo electrophysiology

DocumentThe role of cortico-striatal projections in social hierarchies2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2016
Location: BF-GMS
Title:
2016 Grants
Start date: 2017-01

Reference code: PT/FB/BL-2016-266
Location: BF-GMS
Title:
266 - Early life stress and social hierarchies: The role of cortico-striatal circuits
Duration: 2017-01 - 2021-01
Researcher(s):
João Peça, Joana Guedes, Ana Luísa Cardoso, Mohammed Hussien, Lara Franco, Mário Carvalho
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Author: Peça, J.
Secondary author(s):
Guedes, J., Cardoso, A. L., Hussien, M., Franco, L., Carvalho, M.
Number of reproductions:
1
Keywords:
Animal behavior / Social hierarchy / Stress / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2016-266.03
Location: BF-GMS
Title:
The role of cortico-striatal projections in social hierarchies
Publication year: 2017
Abstract/Results:
ABSTRACT:
In nature, animals in a group will engage in competition for dominance, leading to the formation of a hierarchy. A social hierarchy allows some individuals (of higher rank) to gain priority in accessing food, mate selection and resting places, reducing both the number and intensity of conflicts. Recent neuroimaging studies have begun to elucidate the neurobiological underpinnings of social hierarchy formation, by identifying and characterizing key brain regions involved in behavior repertoire. Furthermore, cortical projections between the mPFC (medial PFC) and Nucleus Accumbens (NAc) have been widely described to guide mice behaviour during non-social and, more recently, during social contexts. However, little is known about their role in social dominance behaviour.
In the course of this work, we found evidence that suggest that these two regions may encode winning information in the tube test setting. Furthermore, we were able to disrupt an already established social hierarchy by optogenetically activating corticostriatal projections, making the subordinate become dominant. Furthermore, we also found evidence that suggest that this change in rank can induce a “winner effect” in the stimulated mouse, winning trials even when not stimulated. However, this change was not long lasting, with the stimulated mouse returning to its initial rank after only a few days. Taken all into account, we provide further insight into the role of these projections and their involvement in social dominance behaviour.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Reis, T.
Document type:
Master's thesis
Number of reproductions:
1
Reference:
Reis, T. (2017). The role of cortico-striatal projections in social hierarchies (Unpublished master´s thesis). Center for Neuroscience and Cell Biology, University of Coimbra, Portugal.
Indexed document: No
Keywords: Social hierarchy / medial prefrontal cortex (mPFC) / nucleus accumbens (NAc) / Corticostriatal projections / Optogenetics / In Vivo Electrophysiology

File074 - The social code in cingulate-hippocampal circuits: The role of memory in social contests2021-02

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-074
Location: BF-GMS
Title:
074 - The social code in cingulate-hippocampal circuits: The role of memory in social contests
Duration: 2021-02
Researcher(s):
Emanuel Fernandes, João Peça, Carolina Kunicki, Joana Guedes, Ana Cardoso
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Fernandes, E.
Secondary author(s):
Peça, J., Kunicki, C., Guedes, J., Cardoso, A. L.
Number of reproductions:
1
Keywords:
Cingulate-hippocampal circuits / Social cognition / In vivo electrophysiology / Optogenetics / Psychophysiology

DocumentIn vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-074
Location: BF-GMS
Title:
074 - The social code in cingulate-hippocampal circuits: The role of memory in social contests
Duration: 2021-02
Researcher(s):
Emanuel Fernandes, João Peça, Carolina Kunicki, Joana Guedes, Ana Cardoso
Institution(s): Center for Neuroscience and Cell Biology, University of Coimbra (Portugal)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Language: eng
Notes:
Ongoing project
Author: Fernandes, E.
Secondary author(s):
Peça, J., Kunicki, C., Guedes, J., Cardoso, A. L.
Number of reproductions:
1
Keywords:
Cingulate-hippocampal circuits / Social cognition / In vivo electrophysiology / Optogenetics / Psychophysiology

Reference code: PT/FB/BL-2020-074.03
Location: BF-GMS
Title:
In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions
Publication year: 2023
URL:
https://www.frontiersin.org/articles/10.3389/fncir.2023.1293620/full
Abstract/Results: ABSTRACT:
In vivo recordings in freely behaving animals are crucial to understand the neuronal circuit basis of behavior. Although current multi-channel silicon probes provide unparalleled sampling density, the study of interacting neuronal populations requires the implantation of multiple probes across different regions of the brain. Ideally, these probes should be independently adjustable, to maximize the yield, and recoverable, to mitigate costs. In this work, we describe the implementation of a miniaturized 3D-printed headgear system for chronic in vivo recordings in mice using independently movable silicon probes targeting multiple brain regions. We successfully demonstrated the performance of the headgear by simultaneously recording the neuronal activity in the prelimbic cortex and dorsal hippocampus. The system proved to be sturdy, ensuring high-quality stable recordings and permitted reuse of the silicon probes, with no observable interference in mouse innate behaviors.
Accessibility: Document exists in file
Language:
eng
Author:
Ferreira-Fernandes, E.
Secondary author(s):
Laranjo, M., Reis, T., Canijo, B., Ferreira, P. A., Martins, P., Vilarinho, J., Tavakoli, M., Kunicki, C., Peça, J.
Document type:
Article
Number of reproductions:
1
Percentiles:
7
Reference:
Ferreira-Fernandes, E., Laranjo, M., Reis, T., Canijo, B., Ferreira, P. A., Martins, P., Vilarinho, J., Tavakoli, M., Kunicki, C., & Peça, J. (2023). In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions. Frontiers in Neural Circuits, 17, 1293620. https://doi.org/10.3389/fncir.2023.1293620
2-year Impact Factor: 3.5|2022
Impact factor notes: Impact factor not available yet for 2023
Times cited: 0|2024-02-16
Indexed document: Yes
Quartile: Q2
Keywords: in vivo electrophysiology / Silicon probes / Methodology / Mouse model / Prefrontal cortex / Hippocampus

In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions

In vivo recordings in freely behaving mice using independent silicon probes targeting multiple brain regions