Reference code: | PT/FB/BL-2012-084.05 |
Location: | Arquivo PCA - Pasta 13/2012
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Title:
| Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials
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Publication year: | 2014
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URL:
| http://www.sciencedirect.com/science/article/pii/S1053811914003450
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Abstract/Results: | ABSTRACT:
The neuromodulatory effects of repetitive transcranial magnetic stimulation (rTMS) have been mostly investigated by peripheral motor-evoked potentials (MEPs). New TMS-compatible EEG systems allow a direct investigation of the stimulation effects through the analysis of TMS-evoked potentials (TEPs). We investigated the effects of 1-Hz rTMS over the primary motor cortex (M1) of 15 healthy volunteers on TEP evoked by single pulse TMS over the same area. A second experiment in which rTMS was delivered over the primary visual cortex (V1) of 15 healthy volunteers was conducted to examine the spatial specificity of the effects. Single-pulse TMS evoked four main components: P30, N45, P60 and N100. M1-rTMS resulted in a significant decrease of MEP amplitude and in a significant increase of P60 and N100 amplitude. There was no effect after V1-rTMS. 1-Hz rTMS appears to increase the amount of inhibition following a TMS pulse, as demonstrated by the higher N100 and P60, which are thought to originate from GABAb-mediated inhibitory post-synaptic potentials. Our results confirm the reliability of the TMS-evoked N100 as a marker of cortical inhibition and provide insight into the neuromodulatory effects of 1-Hz rTMS. The present finding could be of relevance for therapeutic and diagnostic purposes.
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Accessibility: | Document exists in file
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Copyright/Reproduction:
| By permission
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Language:
| eng
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Author:
| Casula, E.
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Secondary author(s):
| Tarantino, V., Basso, D., Arcara, G., Marino, G., Toffolo, G., Rothwell, J. C., Bisiacchi, P.
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Document type:
| Article
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Number of reproductions:
| 1
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Reference:
| Casula, E., Tarantino, V., Basso, D., Arcara, G., Marino, G., Toffolo, G., Rothwell, J. C., & Bisiacchi, P. (2014). Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials. NeuroImage, 98, 225-232. https://doi.org/10.1016/j.neuroimage.2014.04.065
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2-year Impact Factor: | 6.357|2014
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Times cited: | 79|2025-02-10
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Indexed document: | Yes
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Quartile: | Q1
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Keywords: | TMS / EEG / Inhibition / TEPs / N100 / GABAb
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Low-frequency rTMS inhibitory effects in the primary motor cortex: Insights from TMS-evoked potentials |