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DocumentMind the psychedelic hype: Characterizing the risks and benefits of psychedelics for depression2024

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-333
Location: BF-GMS
Title:
333 - Mindfulness and psychedelics: A neurophenomenological approach to the characterization of acute and sustained response to DMT in experienced meditators
Duration: 2021-10 - 2024-05
Researcher(s):
Milan Scheidegger, Daniel Meling, Michael Kometer, Dario Dornbierer
Institution(s): Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich (Switzerland); University Medical Center Freiburg (Germany)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Final report
Language: eng
Author:
Scheidegger, M.
Secondary author(s):
Meling, D., Kometer, M., Dornbierer, D.
Number of reproductions:
3
Keywords:
Meditation / Psychedelics / Neurophenomenology / Brain imaging / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-333.06
Location: BF-GMS
Title:
Mind the psychedelic hype: Characterizing the risks and benefits of psychedelics for depression
Publication year: 2024
URL:
https://doi.org/10.3390/psychoactives3020014
Abstract/Results: ABSTRACT:
Rationale: Psychedelic research re-emerged from a period of suppression into the so-called psychedelic renaissance. In parallel, most media reporting has shifted from the overstatement of the risks of psychedelics to overly positive hype. As the empirical evidence is more equivocal than frequently portrayed, the conclusions about the effectiveness of psychedelics should be considered preliminary. Poor science communication about psychedelics’ therapeutic potential may lead potential participants or patients to feel misled and policy decisions to be misinformed. An evidence-informed characterization of their risks and benefits is needed. Objectives: This article assesses the state of psychedelic research for treating depression and the effect sizes of psychedelics on therapeutic outcomes, the risk of bias, and the prevalence of adverse effects. We review research on the risks and benefits of psychedelics and discuss how the following depression treatments have shown decreasing effect sizes over time: (1) cognitive behavioral therapy, (2) mindfulness interventions, (3) selective serotonin reuptake inhibitors, and (4) ketamine. We speculate that a similar trend may occur for psychedelic treatments. Results and conclusions: It is likely that larger and better-controlled psychedelic trials will demonstrate smaller effect sizes that are more comparable to other conventional and emerging treatments for mood disorders. Clear science communication is critical for setting public expectations and psychedelic policy. With this evidence-based assessment, we aim to cut through the misinformation about the benefits, risks, and future prospects of psychedelic treatments.
Accessibility: Document exists in file
Language:
eng
Author:
Meling, D.
Secondary author(s):
Ehrenkranz, R., Nayak, S. M., Aicher, H. D., Funk, X., van Elk, M., Graziosi, M., Bauer, P. R., Scheidegger, M., Yaden, D. B.
Document type:
Article
Number of reproductions:
3
Reference:
Meling, D., Ehrenkranz, R., Nayak, S. M., Aicher, H. D., Funk, X., van Elk, M., Graziosi, M., Bauer, P. R., Scheidegger, M., & Yaden, D. B. (2024). Mind the psychedelic hype: Characterizing the risks and benefits of psychedelics for depression. Psychoactives, 3(2), 215-234. https://doi.org/10.3390/psychoactives3020014
Indexed document: No
Keywords: Psychedelics / Media hype / Mindfulness / Psychotherapy / Ketamine / Effect size / Adverse effects / Depression

Mind the psychedelic hype: Characterizing the risks and benefits of psychedelics for depression

Mind the psychedelic hype: Characterizing the risks and benefits of psychedelics for depression
DocumentNear-death experience during emergency ketamine use: A case report2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-065
Location: BF-GMS
Title:
065 - Unintended returns of awareness during cardiopulmonary resuscitation
Duration: 2023-02
Researcher(s):
Charlotte Martial, Pauline Fritz, Alice Clerget
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Language: eng
Notes:
Ongoing project
Author: Martial, C.
Secondary author(s):
Fritz, P., Clerget, A.
Number of reproductions:
3
Keywords:
Disconnected consciousness / Connected consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2022-065.12
Location: BF-GMS
Title:
Near-death experience during emergency ketamine use: A case report
Publication year: 2025
URL:
https://doi.org/10.1002/brb3.70939
Abstract/Results: ABSTRACT:
Purpose
Survivors from acute life-threatening conditions occasionally report various alterations in subjective experiences, ranging from visual perceptual changes to multi-faceted phenomena that can be categorized as near-death experiences (NDEs). We report an NDE in a 73-year-old woman with an acute exacerbation of chronic obstructive pulmonary disease, requiring emergency intubation and mechanical ventilation for acute respiratory failure.
Method
The patient suffered from profound hypoxia and hypercapnia with uncompensated respiratory acidosis. Prehospital anesthesia was induced with an intravenous bolus of 500 mg of ketamine administered over 60 s, corresponding to 7 mg/kg of adjusted body weight. The patient eventually recovered and was weaned from ventilator after 24 h. Semi-structured interviews, including several standardized scales assessing potential subjective experience and post-event impact, were conducted at 2 weeks and 2 months post-event.
Finding
Findings revealed a vivid NDE (i.e., meeting the NDE Content scale criteria, with total scores of 34/80 and 32/80 at the first and second interviews, respectively), notably characterized by feelings of peacefulness and well-being, encounters with entities, and the perception of a bright light. Over time, the narrative evolved, with some elements no longer recalled at follow-up, while the patient reported a positive psychological transformation, including improved mood and increased empathy.
Conclusion
This case, set within its medical and pharmacological context, provides a unique opportunity to study NDEs and their precipitating context. The reported transformations underscore the importance of recognizing NDEs for their possible long-term effects on patients and relevance to medical practice.
Accessibility: Document exists in file
Language:
eng
Author:
Fritz, P.
Secondary author(s):
Pichelin, A., Ancion, A., Alnagger, N., Lejeune, N., Ghuysen, A., Gosseries, O., Martial, C.
Document type:
Article
Number of reproductions:
3
Reference:
Fritz, P., Pichelin, A., Ancion, A., Alnagger, N., Lejeune, N., Ghuysen, A., Gosseries, O., & Martial, C. (2025). Near-death experience during emergency ketamine use: A case report. Brain and Behavior, 15(10), e70939. https://doi.org/10.1002/brb3.70939
2-year Impact Factor: 2.7|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 0|2025-11-21
Indexed document: Yes
Quartile: Q2
Keywords: Emergency care / Ketamine / Near-death experience / Psychological transformation

Near-death experience during emergency ketamine use: A case report

Near-death experience during emergency ketamine use: A case report
DocumentNeurophysiological Markers of (Dis)Connectedness: Insights from Ketamine2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2022
Location: BF-GMS
Title:
2022 Grants
Start date: 2023-01

Reference code: PT/FB/BL-2022-065
Location: BF-GMS
Title:
065 - Unintended returns of awareness during cardiopulmonary resuscitation
Duration: 2023-02
Researcher(s):
Charlotte Martial, Pauline Fritz, Alice Clerget
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Articles
Language: eng
Notes:
Ongoing project
Author: Martial, C.
Secondary author(s):
Fritz, P., Clerget, A.
Number of reproductions:
3
Keywords:
Disconnected consciousness / Connected consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2022-065.13
Location: BF-GMS
Title:
Neurophysiological Markers of (Dis)Connectedness: Insights from Ketamine
Publication year: 2025
URL:
https://doi.org/10.1007/978-1-0716-4603-8_8
Abstract/Results: ABSTRACT:
Ketamine is a versatile N-methyl-D-aspartate (NMDA)-antagonist used in various clinical settings. Ketamine dose-dependently induces psychoactive effects: at low, anti-hyperalgesic doses, these are minor or not detectable, but at subanesthetic doses, they may include dissociative, psychotomimetic, and psychedelic events. At an anesthetic dose, ketamine leads to a state of “(full) dissociation” or disconnection rather than unconsciousness, setting it apart from other anesthetics. This unique set of characteristics makes ketamine a particularly interesting substance for studying consciousness in clinical settings. Our chapter reviews ketamine’s neurophysiological effects and neuroimaging data, its potential to inform consciousness research, and its relevance in studying brain disorders involving altered states of consciousness. We trace recent advancements in understanding ketamine’s unique brain effects and report investigations that have developed neurophysiological indexes for consciousness without behavioral output (e.g., disconnected consciousness). Specifically, we discuss the most recent tool, the Explainable Consciousness Indicator (ECI), which uses machine learning to assess the presence of awareness and wakefulness. Finally, we look at future investigations that may utilize ketamine as therapeutic approach to neurological conditions, such as disorders of consciousness.
Accessibility: Document does not exist in file
Language:
Eng
Author:
Alnagger, N.
Secondary author(s):
Cardone, P., Montupil, J., Annen, J., Martial, C., Bonhomme, V., Gosseries, O.
Document type:
Book chapter
Number of reproductions:
3
Reference:
Alnagger, N. L. N., Cardone, P., Montupil, J., Annen, J., Martial, C., Bonhomme, V., & Gosseries, O. (2025). Neurophysiological markers of (dis)connectedness: Insights from ketamine. In S. Himmelseher (Ed.), Ketamine (Neuromethods, Vol. 224). Humana. https://doi.org/10.1007/978-1-0716-4603-8_8
Indexed document: No
Keywords: Ketamine / Neurophysiological markers / Disconnected consciousness / Behavioral responsiveness / Complexity / Machine Learning / Novel approaches to disorders of consciousness