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DocumentHow does cognitive enrichment impact on neuronal networks and behavioral performance?2012

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2008
Location: Arquivo PCA - Pastas 1 a
Title:
2008 Grants
Start date: 2009-01

Reference code: PT/FB/BL-2008-134
Location: Arquivo PCA - Pasta 22/2008
Title:
134 - How does cognitive enrichment impact on neuronal networks and behavioral performance?
Duration: 2010-05 - 2014-11
Researcher(s):
João José Cerqueira, Igor L. M. Spínola, Irene Melo Carvalho, Pedro Ricardo Luís Morgado, Ricardo Jorge Moreira Taipa
Institution(s): Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Final report
Article
Language: eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Cognitive processes / Learning / Brain structure and function / Stress and health / Chronic stress / Intervention

Reference code: PT/FB/BL-2008-134.03
Location: Arquivo PCA - Pasta 22/2008
Title:
How does cognitive enrichment impact on neuronal networks and behavioral performance?
Publication year: 2012
URL:
http://www.bial.com/imagem/Bial%20Sonhos%20Miolo_Total%20Bolsas.pdf
Abstract/Results: ABSTRACT:
Introduction: Several studies in animal models have demonstrated that chronic stress exposure
induces alterations in the structure and function of the hippocampal formation and medial
prefrontal (mPFC). Also relevant, was the finding that such functional and structural changes
partially reverted following cessation of stress exposure; importantly, functional recovery was
correlated with synaptogenesis and dendritic plasticity, at least in the hippocampus.
Objective: The present study aimed to assess the ability of cognitive stimulation to abrogate the
negative effects of chronic stress exposure on learning and memory performances.
Methods: As it is conceivable that specific cognitive stimulation differently enhance brain circuits,
rats free of stress-exposure (CON) and animals previously submitted to chronic unpredictable
stress (CUS) were submitted to spatial reference memory stimulus using the hole board (RM)
paradigm (CON+RM and CUS+RM) while others were trained in a T-maze (WM), a working memory
tasks (CON+WM and CUS+WM).
Results: Behavioral data confirms that stress impairs both reference and working memory.
Importantly, these behavioural underperformances were reverted with cognitive tasks.
Interestingly, however, each individual task ameliorates predominantly that specific cognitive
behaviour, which reinforces the view that neuronal plasticity is circuit-dependent. Structural
analysis of animals submitted chronic stress reveals a trend to recovery of neuropil changes in the
hippocampal formation, but not in the mPFC, after reference memory stimulation (CUS+RM).
Conversely, after working memory stimulation there’s a trend towards recovery of neuropil
changes in the mPFC but not in the hippocampus.
Conclusion and discussion: In conclusion, these preliminary results suggest that reinforcement of
specific cognitive circuits (“cognitive-enrichment”) triggers synaptic plasticity mainly within the
brain circuits implicated in that particular task. These basic experimental procedures provide an
insight on the ability to recover from stress-induced impairments in animal models, which might
prove relevant in the pathogenesis and recovery of several neurological and psychiatric disorders.
Accessibility: Document does not exist in file
Language:
eng
Author:
Cerqueira, J.
Secondary author(s):
Spínola, I., Carvalho, I., Morgado, P., Taipa, R.
Document type:
Conference abstract
Number of reproductions:
1
Reference:
Cerqueira, J., Spínola, I., Carvalho, I., Morgado, P. & Taipa, R. (2012). How does cognitive enrichment impact on neuronal networks and behavioral performance? In Aquém e além do cérebro. Behind and beyond the brain. Proceedings of the 9th Symposium of Fundação Bial (p. 43/63). Porto: Fundação Bial.
Indexed document: No
Keywords: Chronic stress / Plasticity / Long-term potentiation

Novo ficheiro

Novo ficheiro
DocumentEnhanced LTP in aged rats: Detrimental or compensatory?2017

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-057
Location: Arquivo PCA - Pasta 21/2012
Title:
057 - Neurophysiological mechanisms of aging: novel view of old concepts
Duration: 2014-03 - 2017-01
Researcher(s):
Maria José de Oliveira Diógenes Nogueira, Alexandre de Mendoça, Antonina Pereira, Bruno Teixeira da Silva, Raquel Dias
Institution(s): Instituto de Medicina Molecular, Lisboa (Portugal)
Contents: Contents:
Application form
Correspondence
Progress reports
Final report
2 submitted papers
1 poster
1 Article
Language: eng
Author:
Diógenes, M. J.
Secondary author(s):
Mendonça, A., Pereira, A., Silva, B., Lopes, L., Dias, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Neurodegenerative disorders

Reference code: PT/FB/BL-2012-057.03
Location: Arquivo PCA - Pasta 21/2012
Title:
Enhanced LTP in aged rats: Detrimental or compensatory?
Publication year: 2017
URL:
http://www.sciencedirect.com/science/article/pii/S0028390816305147
Abstract/Results: ABSTRACT:
Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats. Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 µM, 4 h), and hippocampal LTP was evaluated. The results show that memantine significantly decreases the larger LTP magnitude recorded in hippocampal slices from aged rats without compromising LTP recorded in slices from young and adult animals. To unveil the impact of in vivo administration of memantine, different doses (1, 5 and 10 mg/kg/day) or saline vehicle solution were intraperitoneally administered, for 15-20 days, to both young and aged animals. Memantine did not significantly affect neither the place learning of young animals, evaluated by Morris Water Maze, nor LTP recorded from hippocampal slices from the same group of animals. However, memantine (5 and 10 mg/kg/day) significantly decreased the large LTP recorded in hippocampal slices from aged animals. Moreover, aged animals treated with memantine (10 mg/kg/day) showed a significantly compromised place learning when compared to aged control animals. Overall, these results suggest that the larger LTP observed in aged animals is a compensatory phenomenon, rather than pathological. The finding that age-dependent blockade of LTP by a NMDAR antagonist leads to learning deficits, implies that the increased LTP observed upon aging may be playing an important role in the learning process.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Pinto, J.
Secondary author(s):
Vale, R., Batalha, V. L., Costenla, A. R., Dias, R., Rombo, D., Sebastião, A., de Mendonça, A., Diógenes, M. J.
Document type:
Article
Number of reproductions:
1
Reference:
Pinto, J., Vale, R., Batalha, V. L., Costenla, A. R., Dias, R., Rombo, D., Sebastião, A., de Mendonça, A., & Diógenes, M. J. (2017). Enhanced LTP in aged rats: Detrimental or compensatory? Neuropharmacology, 114, 12–19. https://doi.org/10.1016/j.neuropharm.2016.11.017
2-year Impact Factor: 4.249|2017
Impact factor notes: Impact factor not available yet for 2019
Times cited: 14|2025-09-16
Indexed document: Yes
Quartile: Q1
Keywords: Aging / Long-term potentiation / Spatial learning / Hippocampus / Watermaze
DocumentCortico-cortical paired associative stimulation (ccPAS) over premotor-motor areas affects local circuitries in the human motor cortex via Hebbian plasticity2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-347
Location: BF-GMS
Title:
347 - Driving synaptic plasticity in motor-to-visual neural pathways to enhance action prediction
Duration: 2019-10 - 2023-06
Researcher(s):
Alessio Avenanti, Marco Zanon
Institution(s): Department of Psychology, Alma Mater Studiorum - Università di Bologna (Italy)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Avenanti, A.
Secondary author(s):
Zanon, M.
Number of reproductions:
1
Keywords:
Action observation / Prediction / Plasticity / Connectivity / Psychophysiology

Reference code: PT/FB/BL-2018-347.26
Location: BF-GMS
Title:
Cortico-cortical paired associative stimulation (ccPAS) over premotor-motor areas affects local circuitries in the human motor cortex via Hebbian plasticity
Publication year: 2023
URL:
https://www.sciencedirect.com/science/article/pii/S1053811923001738?via%3Dihub
Abstract/Results: ABSTRACT:
Transcranial magnetic stimulation (TMS) studies have shown that cortico-cortical paired associative stimulation (ccPAS) can strengthen connectivity between the ventral premotor cortex (PMv) and the primary motor cortex (M1) by modulating convergent input over M1 via Hebbian spike-timing-dependent plasticity (STDP). However, whether ccPAS locally affects M1 activity remains unclear. We tested 60 right-handed young healthy humans in two studies, using a combination of dual coil TMS and ccPAS over the left PMv and M1 to probe and manipulate PMv-to-M1 connectivity, and single- and paired-pulse TMS to assess neural activity within M1. We provide convergent evidence that ccPAS, relying on repeated activations of excitatory PMv-to-M1 connections, acts locally over M1. During ccPAS, motor-evoked potentials (MEPs) induced by paired PMv-M1 stimulation gradually increased. Following ccPAS, the threshold for inducing MEPs of different amplitudes decreased, and the input-output curve (IO) slope increased, highlighting increased M1 corticospinal excitability. Moreover, ccPAS reduced the magnitude of short-interval intracortical inhibition (SICI), reflecting suppression of GABA-ergic interneuronal mechanisms within M1, without affecting intracortical facilitation (ICF). These changes were specific to ccPAS Hebbian strengthening of PMv-to-M1 connectivity, as no modulations were observed when reversing the order of the PMv-M1 stimulation during a control ccPAS protocol. These findings expand prior ccPAS research that focused on the malleability of cortico-cortical connectivity at the network-level, and highlight local changes in the area of convergent activation (i.e., M1) during plasticity induction. These findings provide new mechanistic insights into the physiological basis of ccPAS that are relevant for protocol optimization.
Accessibility: Document exists in file
Language:
eng
Author:
Santarnecchi, E.
Secondary author(s):
Avenanti, A.
Document type:
Article
Number of reproductions:
1
Reference:
Santarnecchi, E., & Avenanti, A. (2023). Cortico-cortical paired associative stimulation (ccPAS) over premotor-motor areas affects local circuitries in the human motor cortex via Hebbian plasticity. NeuroImage, 271, 120027. https://doi.org/10.1016/j.neuroimage.2023.120027
2-year Impact Factor: 4.7|2023
Times cited: 31|2025-09-26
Indexed document: Yes
Quartile: Q1
Keywords: Hebbian plasticity / Cortico-cortical connectivity / Long-term potentiation / Motor cortex / Transcranial magnetic stimulation (TMS) / Intracortical inhibition

Cortico-cortical paired associative stimulation (ccPAS) over premotor-motor areas affects local circuitries in the human motor cortex via Hebbian plasticity

Cortico-cortical paired associative stimulation (ccPAS) over premotor-motor areas affects local circuitries in the human motor cortex via Hebbian plasticity
DocumentThe temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines2023

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2010
Location: Arquivo PCA - Pastas 1 a 23
Title:
2010 Grants
Start date: 2011-01

Reference code: PT/FB/BL-2010-161
Location: Arquivo PCA - Pastas 22/2010
Title:
161 - Investigating the function of synaptic competition in memory formation and mental retardation
Duration: 2011-09 - 2015-09
Researcher(s):
Inbal Israely, Anna Hobbiss, Ana Vaz
Institution(s): Champalimaud Foundation, Lisboa (Portugal)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress report
Language: eng
Author:
Israely, I.
Secondary author(s):
Hobbiss, A., Vaz, A.
Number of reproductions:
1
Keywords:
Psychophysiology / Brain structure and function / Cognitive processes / Memory / Biopsychological problems / Childhood and adolescent disorders / Mental retardation

Reference code: PT/FB/BL-2010-161.06
Location: BF-GMS
Title:
The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines
Publication year: 2023
Abstract/Results:
ABSTRACT:
Learning is thought to involve physiological and structural changes at individual synapses. Synaptic plasticity has predominantly been studied using regular stimulation patterns, but neuronal activity in the brain normally follows a Poisson distribution. We used two-photon imaging and glutamate uncaging to investigate the structural plasticity of single dendritic spines using naturalistic activation patterns sampled from a Poisson distribution. We showed that naturalistic activation patterns elicit structural plasticity that is both NMDAR and protein synthesis-dependent. Furthermore, we uncovered that the longevity of structural plasticity is dependent on the temporal structure of the naturalistic pattern. Finally, we found that during the delivery of the naturalistic activity, spines underwent rapid structural growth that predicted the longevity of plasticity. This was not observed with regularly spaced activity. These data reveal that different temporal organizations of the same number of synaptic stimulations can produce rather distinct short and long-lasting structural plasticity.
Accessibility: Document exists in file
Language:
eng
Author:
Argunsah, A. Ö.
Secondary author(s):
Israely, I.
Document type:
Article
Number of reproductions:
1
Reference:
Argunsah, A. Ö., & Israely, I. (2023). The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines. iScience, 26(6), 106835. https://doi.org/10.1016/j.isci.2023.106835
2-year Impact Factor: 4.6|2023
Times cited: 2|2025-09-26
Indexed document: Yes
Quartile: Q1
Keywords: Long-term potentiation / Protein-synthesis / Natural stimulation / LTP / Transmission / Induction / Mechanism / Synapses / Camkii / Information

The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines

The temporal pattern of synaptic activation determines the longevity of structural plasticity at dendritic spines