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BIAL Foundation
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DE:"Longitudinal study"
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File304 - The impact of music training on reading and mathematical abilities of normal and reading disabled children: a behavioral and neuroimaging longitudinal study2015-102019-09

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Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

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Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2014
Location: BF-GMS
Title:
2014 Grants
Start date: 2015-01

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Reference code: PT/FB/BL-2014-304
Location: BF-GMS
Title:
304 - The impact of music training on reading and mathematical abilities of normal and reading disabled children: a behavioral and neuroimaging longitudinal study
Duration: 2015-10 - 2019-09
Researcher(s):
Maria de São Luís Vasconcelos da Fonseca e Castro Schöner, Christian Gaser, Daniela da Costa Coimbra, Marta Sofia Pinto Martins
Institution(s): Faculty of Psychology and Educational Sciences at University of Porto, FPCEUP / Centre for Psychology at University of Porto (Portugal); Structural Brain Mapping Group/ Department of Psychiatry - Jena University Hospital (Germany)
Contents: Contents:
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Castro, S. L.
Secondary author(s):
Gaser, C., Coimbra, D., Martins, M.
Number of reproductions:
1
Keywords:
Longitudinal study / Music training / Reading and mathematical abilities / Brain morphometry / Psychophysiology
DocumentTrajectories of grey and white matter volume in children at elevated risk for schizophrenia2026

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Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

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Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

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Reference code: PT/FB/BL-2012-194
Location: Arquivo PCA - Pasta 25/2012
Title:
194 - Characterising developmental trajectories of brain function from childhood into adolescence
Duration: 2013-04 - 2017-09
Researcher(s):
Kristin Robin Laurens, Ruth E. Roberts
Institution(s): Department of Forensic and Neurodevelopmental Sciences,Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress reports
Final report
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Roberts, R.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Biopsychological problems / Mental health / Psychotic disorders / Brain structure and function

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Reference code: PT/FB/BL-2012-194.19
Location: BF-GMS
Title:
Trajectories of grey and white matter volume in children at elevated risk for schizophrenia
Publication year: 2026
URL:
https://doi.org/10.1017/S1092852926101047
Abstract/Results: ABSTRACT:
Objective: Longitudinal investigation of brain alterations in children putatively at-risk of developing schizophrenia may identify early markers of pathophysiology associated with vulnerability for the disorder.
Methods: Children aged 9-12 years with multiple antecedents of schizophrenia (psychoticlike experiences; speech and/or motor delays; and social, emotional, and/or behavioural difficulties; ASz, n=31), with a family history of schizophrenia/schizoaffective disorder (FHx, n=21), and typically developing children (TD, n=35) were recruited through community screening using questionnaires. T1-weighted structural MRI scans were obtained at baseline, and after approximately 2- and 4-years of follow-up, and processed using the FreeSurfer longitudinal pipeline. Across these three assessment waves, total grey matter (GM) and white matter (WM) volume, and regional GM volumes in twelve regions of interest, were compared among the groups using linear mixed models.
Results: Children from three groups were 11.21 (±1.61) years at baseline and the average lapse-of-time between each assessment was 1.76 (±0.36) years. The ASz group exhibited consistently higher total WM volume (b=29.45) compared to the TD group, with no statistically significant time-related volumetric WM or GM differences in any region. The FHx group also demonstrated higher total WM volume (b=36.49), and time-related total and regional GM volume changes were observed; however, these effects were attenuated after correction.
Conclusion: Global and regionally-specific brain abnormalities distinguished children with different risk profiles for schizophrenia relative to their typically developing peers. Follow-up is required to determine how these changes may relate to later schizophrenia.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2006.035.35
Author: Si, S.
Secondary author(s):
Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Si, S., Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., & Laurens, K. R. (2026). Trajectories of gray and white matter volume in children at elevated risk for schizophrenia. CNS spectrums, 31(1), e23. https://doi.org/10.1017/S1092852926101047
Impact Factor: 4.6|2025
Impact factor notes: Impact factor not available yet for 2026
Times cited: 0|2026-07-24
Indexed document: Yes
Quartile: Q1
Keywords: High-risk / Psychosis / Structural MRI / Community screening / Early detection / Longitudinal study

<!-- mm occ=1 guid=[c5d129cdf565018aed09bf7c4d6f572c] WebBehavior$=[0] -->

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia
DocumentTrajectories of gray and white matter volume in children at elevated risk for schizophrenia2026

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

<!-- vis-dbg web=[web] Visitor=[2] base=[fbial] -->
Reference code: PT/FB/BL-2006.035.35
Location: BF-GMS
Title:
Trajectories of gray and white matter volume in children at elevated risk for schizophrenia
Publication year: 2026
URL:
https://doi.org/10.1017/S1092852926101047
Abstract/Results: ABSTRACT:
Objective: Longitudinal investigation of brain alterations in children putatively at-risk of developing schizophrenia may identify early markers of pathophysiology associated with vulnerability for the disorder.
Methods: Children aged 9-12 years with multiple antecedents of schizophrenia (psychoticlike experiences; speech and/or motor delays; and social, emotional, and/or behavioural difficulties; ASz, n=31), with a family history of schizophrenia/schizoaffective disorder (FHx, n=21), and typically developing children (TD, n=35) were recruited through community screening using questionnaires. T1-weighted structural MRI scans were obtained at baseline, and after approximately 2- and 4-years of follow-up, and processed using the FreeSurfer longitudinal pipeline. Across these three assessment waves, total grey matter (GM) and white matter (WM) volume, and regional GM volumes in twelve regions of interest, were compared among the groups using linear mixed models.
Results: Children from three groups were 11.21 (±1.61) years at baseline and the average lapse-of-time between each assessment was 1.76 (±0.36) years. The ASz group exhibited consistently higher total WM volume (b=29.45) compared to the TD group, with no statistically significant time-related volumetric WM or GM differences in any region. The FHx group also demonstrated higher total WM volume (b=36.49), and time-related total and regional GM volume changes were observed; however, these effects were attenuated after correction.
Conclusion: Global and regionally-specific brain abnormalities distinguished children with different risk profiles for schizophrenia relative to their typically developing peers. Follow-up is required to determine how these changes may relate to later schizophrenia.
Accessibility: Document exists in file
Language:
eng
Related objects:
BL-2012-194.19
Author: Si, S.
Secondary author(s):
Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., Laurens, K. R.
Document type:
Article-d
Number of reproductions:
1
Reference:
Si, S., Kempton, M., Hedges, E., Antoniades, M., Roberts, R. E., Cullen, A. E., & Laurens, K. R. (2026). Trajectories of gray and white matter volume in children at elevated risk for schizophrenia. CNS spectrums, 31(1), e23. https://doi.org/10.1017/S1092852926101047
Impact Factor: 4.6|2025
Impact factor notes: Impact factor not available yet for 2026
Times cited: 0|2026-07-24
Indexed document: Yes
Quartile: Q1
Keywords: High-risk / Psychosis / Structural MRI / Community screening / Early detection / Longitudinal study

<!-- mm occ=1 guid=[c5d129cdf565018aed09bf7c4d6f572c] WebBehavior$=[0] -->

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia

Trajectories of grey and white matter volume in children at elevated risk for schizophrenia