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BIAL Foundation
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DocumentTemporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia2013

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2006
Location: Arquivo PCA - Pastas 1 a 22 /2006
Title:
2006 Grants
Start date: 2007-01 - 2013-11
Dimension/support:
22 caixas de arquivo

Reference code: PT/FB/BL-2006-035
Location: Arquivo PCA - Pasta 17/2006
Title:
035 - Development and genetic correlates of brain function in children at high- and low-risk for developing schizophrenia
Duration: 2008-01 - 2011-07
Researcher(s):
Kristin Robyn Laurens, Sheilagh Hodgins, Robin M. Murray, Eric A. Taylor, Collier, Sir Michael Rutter
Institution(s): Department of Forensic Mental Health Science, Institute of Psychiatry, King's College London (UK)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Financial report and expenditure documents
Progress reports
Final report
5 Articles (under review or published)
1 Book chapter
Language: eng
Author:
Laurens, K. R.
Secondary author(s):
Hodgins, S., Murray, R., Taylor, E., Collier, D., Rutter, M.
Number of reproductions:
1
Keywords:
Psychophysiology / Developmental psychology / Assessment tools / Biopsychological problems / Mental health / Psychotic disorders

Reference code: PT/FB/BL-2006-035.20
Location: Arquivo PCA - Pasta 17/2006
Title:
Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia
Publication year: 2013
URL:
http://schizophreniabulletin.oxfordjournals.org/content/39/6/1318
Abstract/Results: ABSTRACT:
Distributed abnormalities of gray matter (GM) and white matter (WM) volume characterize individuals experiencing their first episode of schizophrenia. Regions of abnormality are present already, albeit less extensively, during the prodromal phase of illness. This study aimed to determine whether putatively at-risk children, aged 9–12 years, who present multiple antecedents of schizophrenia (ASz), display GM and WM volume abnormalities relative to typically developing (TD) children presenting no antecedents. Structural magnetic resonance images were acquired for 20 ASz children and 20 TD children matched on age, sex, and IQ. Whole-brain differences in GM and WM volume were determined using voxel-based morphometry. Relative to the TD group, ASz children showed significantly decreased GM volume in the right middle temporal gyrus (MTG) and increased GM volume in the left superior-middle temporal gyri (P < 0.05, cluster correction). WM volume was significantly increased in ASz children relative to TD children in a cluster encompassing the left inferior parietal lobe, occipital lobe, and superior temporal gyrus. Post-hoc analyses indicated that these abnormalities were not limited to ASz children who self-reported auditory hallucinations on questionnaire. Our findings suggest that children aged 9–12 years who present multiple ASz are characterized by abnormalities of GM and WM volume in the temporal lobes, comprising a subset of the regions affected in first-episode schizophrenia and in the prodromal phase of illness. These preliminary findings indicate that structural brain abnormalities associated with schizophrenia may be detected in putatively at-risk, preprodromal children. Prospective studies following the brain development of at-risk children are needed.
Accessibility: Document exists in file
Copyright/Reproduction:
By permission
Language:
eng
Author:
Cullen, A. E.
Secondary author(s):
de Brito, S. A., Gregory, S., Murray, R., Williams, S., Hodgins, S., Laurens, K. R.
Document type:
Article
Number of reproductions:
1
Reference:
Cullen, A. E., de Brito, S. A., Gregory, S., Murray, R., Williams, S., Hodgins, S., & Laurens, K. R. (2013). Temporal lobe volume abnormalities precede the prodrome: A study of children presenting antecedents of schizophrenia. Schizophrenia Bulletin, 39(6), 1318-1327. https://doi.org/10.1093/schbul/sbs128
2-year Impact Factor: 8.607|2013
Times cited: 39|2025-02-10
Indexed document: Yes
Quartile: Q1
Keywords: Psychosis / High-risk / Magnetic resonance imaging (MRI) / Voxel based morphometry (VBM) / Biomarkers / Brain structure

Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia

Temporal lobe volume abnormalities precede the prodrome: a study of children presenting antecedents of schizophrenia

DocumentClassification of first-episode psychosis: a multi-modal multi-feature approach integrating structural and diffusion imaging2015

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2012
Location: SEC PCA
Title:
2012 Grants
Start date: 2013-02

Reference code: PT/FB/BL-2012-262
Location: Arquivo PCA - Pasta 29/2012
Title:
262 - The neural basis of Magical Ideation: A multimodal imaging study in twin subjects
Duration: 2013-08 - 2019-07
Researcher(s):
Paolo Brambilla, Gioia Negri, Sara Piccin, Giuseppe Cabras, Corrado Fagnani
Institution(s): Universitá delgi Studi di Milano and Unit of Epidemiology of the Italian Institute of Health, Rome (Italy)
Contents: Contents:
Bursary agreement
Application form
Correspondence
Progress report
Final report
Articles
Language: eng
Author:
Brambilla, P.
Secondary author(s):
Negri, G., Piccin, S., Cabras, G., Fagnani, C.
Number of reproductions:
3
Keywords:
Psychophysiology and Parapsychology / Paranormal belief / Brain structure and function / Personality

Reference code: PT/FB/BL-2012-262.16
Location: Arquivo PCA - Pasta 29/2012
Title:
Classification of first-episode psychosis: a multi-modal multi-feature approach integrating structural and diffusion imaging
Publication year: 2015
Accessibility:
Document exists in file
Language:
eng
Author:
Peruzzo, D.
Secondary author(s):
Castellani, U., Perlini, C., Bellani, M., Marinelli, V., Rambaldelli, G., Lasalvia, A., Tosato, S., De Santi, K., Murino, V., Ruggeri, M., Brambilla, P., PICOS-Veneto Group
Document type:
Article
Number of reproductions:
3
Reference:
Peruzzo, D., Castellani, U., Perlini, C., Bellani, M., Marinelli, V., Rambaldelli, G., Lasalvia, A., Tosato, S., De Santi, K., Murino, V., Ruggeri, M., Brambilla, P., & PICOS-Veneto Group (2015). Classification of first-episode psychosis: A multi-modal multi-feature approach integrating structural and diffusion imaging. Journal of Neural Transmission, 122(6), 897-905. https://doi.org/10.1007/s00702-014-1324-x
2-year Impact Factor: 2.587|2015
Times cited: 20|2025-02-10
Indexed document: Yes
Quartile: Q2
Keywords: Brain imaging / Machine learning / Multiple kernel learning (MKL) / Support vector machine (SVM) / Magnetic resonance imaging (MRI) / DTI / Schizophrenia