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BIAL Foundation
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Type Title Begin End
DocumentTreating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments2019

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: NDE
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Characterization of “Near-Death Experiences” through the comparison of experiencers and non-experiencers’ particularities: inter-individual differences in cognitive characteristics and susceptibility to false memories
Duration: 2016-03 - 2019-03
Researcher(s):
Steven Laureys, Charlotte Martial, Vanessa Charland-Verville, Héléna Cassol
Institution(s): Coma Science Group, University of Liège (Belgium)
Contents: Application
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Laureys, S.
Number of reproductions:
3
Keywords:
Parapsychology and Psychophysiology / Near-death experience / Functional magnetic resonance imaging (fMRI)

Reference code: NDE-39
Location: Arquivo PCA - Pasta 1/Outros Apoios
Title:
Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments
Publication year: 2019
URL:
https://www.frontiersin.org/articles/10.3389/fneur.2019.00248/full
Abstract/Results: ABSTRACT
BACKGROUND
There are few available therapeutic options to promote recovery among patients with chronic disorders of consciousness (DOC). Among pharmacological treatments, apomorphine, a dopamine agonist, has exhibited promising behavioral effects and safety of use in small-sample pilot studies. The true efficacy of the drug and its neural mechanism are still unclear. Apomorphine may act through a modulation of the anterior forebrain mesocircuit, but neuroimaging and neurophysiological investigations to test this hypothesis are scarce. This clinical trial aims to (1) assess the treatment effect of subcutaneous apomorphine infusions in patients with DOC, (2) better identify the phenotype of responders to treatment, (3) evaluate tolerance and side effects in this population, and (4) examine the neural networks underlying its modulating action on consciousness.
METHODS/DESIGN
This study is a prospective double-blind randomized parallel placebo-controlled trial. Forty-eight patients diagnosed with DOC will be randomized to receive a 30-day regimen of either apomorphine hydrochloride or placebo subcutaneous infusions. Patients will be monitored at baseline 30 days before initiation of therapy, during treatment and for 30 days after treatment washout, using standardized behavioral scales (Coma Recovery Scale-Revised, Nociception Coma Scale-Revised), neurophysiological measures (electroencephalography, body temperature, actigraphy) and brain imaging (magnetic resonance imaging, positron emission tomography). Behavioral follow-up will be performed up to 2 years using structured phone interviews. Analyses will look for changes in behavioral status, circadian rhythmicity, brain metabolism, and functional connectivity at the individual level (comparing before and after treatment) and at the group level (comparing apomorphine and placebo arms, and comparing responder and non-responder groups).
DISCUSSION
This study investigates the use of apomorphine for the recovery of consciousness in the first randomized placebo-controlled double-blind trial using multimodal assessments. The results will contribute to define the role of dopamine agonists for the treatment of these challenging conditions and identify the neural correlates to their action. Results will bring objective evidence to further assess the modulation of the anterior forebrain mesocircuit by pharmacological agents, which may open new therapeutic perspectives.
Accessibility: Document exists in file
Language:
eng
Author:
Sanz, L. R.
Secondary author(s):
Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., Farber, N. M., Zafonte, R. D., Schiff, N. D., Laureys, S., Gosseries, O.
Document type:
Article
Number of reproductions:
3
Reference:
Sanz, L. R., Lejeune, N., Blandiaux, S., Bonin, E., Thibaut, A., Stender, J., ... Gosseries, O. (2019). Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments. Frontiers in Neurology, 10:248. https://doi.org/10.3389/fneur.2019.00248
2-year Impact Factor: 2.889|2019
Times cited: 16|2025-09-17
Indexed document: Yes
Quartile: Q2
Keywords: Disorders of consciousness / Unresponsive wakefulness syndrome / Minimally conscious state / Apomorphine / Dopamine / Mesocircuit / Clinical trial / Protocol

Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments

Treating disorders of consciousness with apomorphine: Protocol for a double-blind randomized controlled trial using multimodal assessments
DocumentPharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2018
Location: BF-GMS
Title:
2018 Grants
Start date: 2019-01

Reference code: PT/FB/BL-2018-261
Location: BF-GMS
Title:
261 - Phenomenological experience and neurophysiological correlates of shamanic trance in healthy individuals
Duration: 2019-07 - 2021-11
Researcher(s):
Olivia Gosseries
Institution(s): GIGA research center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Final report
Articles
Language: eng
Author:
Gosseries, O.
Number of reproductions:
3
Keywords:
Trance / Phenomenology / Electrophysiology / Consciousness / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2018-261.15
Location: BF-GMS
Title:
Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
Publication year: 2025
URL:
https://doi.org/10.1080/14737175.2025.2500757
Abstract/Results: ABSTRACT:
Introduction: Disorders of consciousness (DoC) are characterized by impaired arousal and/or awareness, ranging from coma to unresponsive wakefulness syndrome, minimally conscious state, and cognitive motor dissociation. Pharmacological treatment options remain limited, complicated by the heterogeneity of etiologies, such as traumatic brain injury, stroke, and infections. The lack of rigorous clinical trials has led to off-label use of treatments, often without clear mechanistic understanding, posing challenges for effective patient care.
Areas covered: In this perspective, the authors report on key studies concerning the effectiveness of pharmacological interventions, including dopaminergic and GABAergic agents, antidepressants, statins, and anticonvulsants, in promoting recovery of consciousness in DoC.
Expert opinion: Robust longitudinal clinical trials are needed, with priority given to early subacute phase intervention. Outcomes should be better defined, considering immediate responses to medication while also increasing the emphasis on long-term quality of life. Unified functional and mechanistic frameworks are needed to guide research and foster collaboration. Furthermore, a shift toward personalized medicine would benefit this heterogeneous population. Moving forward, assessing the efficacy of more unconventional or 'paradoxical' pharmacological options in treatment plans will be essential. The authors also expect an increased use of AI tools to identify factors that best predict treatment responses.
Accessibility: Document exists in file
Language:
eng
Author:
Girard Pepin, R.
Secondary author(s):
Seyfzadeh, F., Williamson, D., Gosseries, O., Duclos, C.
Document type:
Article
Number of reproductions:
3
Reference:
Girard Pepin, R., Seyfzadeh, F., Williamson, D., Gosseries, O., & Duclos, C. (2025). Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues. Expert Review of Neurotherapeutics, 25(6), 613–633. https://doi.org/10.1080/14737175.2025.2500757
2-year Impact Factor: 3.4|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 1|2025-09-27
Indexed document: Yes
Quartile: Q2
Keywords: Pharmacotherapy / Coma / Criticality / Disorders of consciousness / Mesocircuit / Minimally conscious state / Personalized medicine / Unresponsive wakefulness syndrome

Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues

Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
DoccumentPharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues2025

Reference code: PT/FB
Entity holding: BIAL Foundation
Location: S. Mamede do Coronado
Title:
BIAL Foundation Archive
Start date: 1994
History:
The BIAL Foundation was created in 1994 by Laboratórios BIAL in conjunction with the Council of Rectors of Portuguese Universities. BIAL’s Foundation mission is to foster the scientific study of Man from both the physical and spiritual perspectives.
Along the years the BIAL Foundation has developed an important relationship with the scientific community, first in Portugal and after worldwide. Today it is an institution of reference which aims to stimulate new researches that may help people, promote more health and contribute to new milestones to gain access to knowledge.
Among its activities the BIAL Foundation manages the BIAL Award, created in 1984, one of the most important awards in the Health field in Europe. The BIAL Award rewards both the basic and the clinical research distinguishing works of major impact in medical research.
The BIAL Foundation also assigns Scientific Research Scholarships for the study of neurophysiological and mental health in people, arousing the interest of researchers in the areas of Psychophysiology and Parapsychology.
To date the BIAL Foundation has supported 461 projects, more than 1000 researchers, with research groups in twenty-seven countries, resulting, until April 2013, in about 600 full papers, out of which 172 published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Since 1996 the BIAL Foundation organizes the Symposia entitled "Behind and Beyond the Brain", a Forum that gathers well renowned neurosciences speakers and the BIAL Foundation Fellows which are spread around the world.
Classified as an institution of public utility, the BIAL Foundation includes among its patrons the Portuguese President, the Portuguese Universities Rectors' Council and the Portuguese Medical Association.
URL: http://www.bial.com/pt/
Accessibility: By permission

Reference code: PT/FB/BL
Entity holding: BIAL Foundation
Title: BIAL Grants
Start date: 1994
History:
In 1994 the BIAL Foundation launched a programme of science research grants with the aim of encouraging the research into Man’s physical and mental processes, namely in fields still largely unexplored but which warrant further scientific analysis, as Psychophysiology and Parapsychology.
Since its launch, applications to the BIAL grants have been increasing. Up to now 461 projects have been supported, involving more than 1000 researchers from 27 countries.
The approved applications have benefited from grants in amounts comprised between €5,000 and €50, 000. The amount to be granted is fixed by the Scientific board according to the needs of each project.
The supported projects have originated, until April 2013, in about 600 full papers, 172 out of which were published in indexed international journals with an average impact factor of 3.6 and a substantial number of citations (1665).
Among the BIAL Foundation fellows is worth highlighting the presence of scientists from prestigious universities from the United States, United Kingdom, Australia, Russia, Germany, Japan, France, Canada, and many others.
The BIAL grants are promoted biannually.

Reference code: PT/FB/BL-2020
Location: BF-GMS
Title:
2020 Grants
Start date: 2021-01

Reference code: PT/FB/BL-2020-344
Location: BF-GMS
Title:
344 - Evaluation of psychological traits, pain perception and muscular strength in trance experts
Duration: 2022-01
Researcher(s):
Olivia Gosseries, Paul Hollanders, Yannick Lafon
Institution(s): GIGA Research Center, GIGA-Consciousness, University of Liège (Belgium)
Contents: Contents:
Application form
Correspondence
Research Funding Agreement
Progress report
Language: eng
Notes:
Ongoing project
Author: Gosseries, O.
Secondary author(s):
Hollanders, P., Lafon, Y.
Number of reproductions:
3
Keywords:
Trance / Personality traits / Pain perception / Muscular strenght / Psychophysiology and Parapsychology

Reference code: PT/FB/BL-2020-344.06
Location: BF-GMS
Title:
Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues
Publication year: 2025
URL:
https://doi.org/10.1080/14737175.2025.2500757
Abstract/Results: ABSTRACT:
Introduction: Disorders of consciousness (DoC) are characterized by impaired arousal and/or awareness, ranging from coma to unresponsive wakefulness syndrome, minimally conscious state, and cognitive motor dissociation. Pharmacological treatment options remain limited, complicated by the heterogeneity of etiologies, such as traumatic brain injury, stroke, and infections. The lack of rigorous clinical trials has led to off-label use of treatments, often without clear mechanistic understanding, posing challenges for effective patient care.
Areas covered: In this perspective, the authors report on key studies concerning the effectiveness of pharmacological interventions, including dopaminergic and GABAergic agents, antidepressants, statins, and anticonvulsants, in promoting recovery of consciousness in DoC.
Expert opinion: Robust longitudinal clinical trials are needed, with priority given to early subacute phase intervention. Outcomes should be better defined, considering immediate responses to medication while also increasing the emphasis on long-term quality of life. Unified functional and mechanistic frameworks are needed to guide research and foster collaboration. Furthermore, a shift toward personalized medicine would benefit this heterogeneous population. Moving forward, assessing the efficacy of more unconventional or 'paradoxical' pharmacological options in treatment plans will be essential. The authors also expect an increased use of AI tools to identify factors that best predict treatment responses.
Accessibility: Document does not exist in file
Language:
eng
Author:
Girard Pepin, R.
Secondary author(s):
Seyfzadeh, F., Williamson, D., Gosseries, O., Duclos, C.
Document type:
Article
Number of reproductions:
1
Reference:
Girard Pepin, R., Seyfzadeh, F., Williamson, D., Gosseries, O., & Duclos, C. (2025). Pharmacological therapies for early and long-term recovery in disorders of consciousness: Current knowledge and promising avenues. Expert Review of Neurotherapeutics, 25(6), 613–633. https://doi.org/10.1080/14737175.2025.2500757
2-year Impact Factor: 3.4|2024
Impact factor notes: Impact factor not available yet for 2025
Times cited: 1|2025-09-27
Indexed document: Yes
Quartile: Q2
Keywords: Pharmacotherapy / Coma / Criticality / Disorders of consciousness / Mesocircuit / Minimally conscious state / Personalized medicine / Unresponsive wakefulness syndrome