| Reference code: | PT/FB/BL-2020-333.12 |
| Location: | BF-GMS
|
Title:
| Mixed-methods analysis on psychedelic-augmented meditation experiences from a randomized controlled mindfulness retreat
|
| Publication year: | 2026
|
URL:
| https://www.nature.com/articles/s41598-026-39261-5
|
| Abstract/Results: | ABSTRACT:
The acute subjective effects (ASEs) of psychedelic substances are assumed to play a critical role for their therapeutic and well-being enhancing benefits. However, recent work voiced critique regarding the validity and adequacy of conventional measures and modalities utilized to study ASEs of psychedelics, and call for data-driven, unbiased, and experience-based research approaches. The emergence of advanced Natural Language Processing techniques as an enabler of data-driven qualitative research holds promise for addressing the current biases and limitations in the investigation of ASEs of psychedelics. In the present study, we employed an NLP-driven, multi-method analytical paradigm to study the subjective experiences of participants in an ecologically valid RCT examining the effect of DMT/harmine on meditative states in experienced meditators using phenomenological interviews. Our analysis showed differences in the thematic landscape and experiential diversity of meditation under placebo and meditation under DMT-harmine while showing overlap in their semantic topographies. The mixed-modal analysis successfully identified a wide range of well-established primary subjective effects while also detecting subtle, patterned regularities in language that traditional hypothesis-driven approaches alone may overlook. It revealed a pronounced use of Buddhist concepts and spiritual jargon to describe and integrate the subjective experience, independent of the experimental condition. Findings suggested shared experiential features between meditative and psychedelic states, a strong drug-context interconnection and potential synergistic effects of meditation and psychedelics. We advocate for using NLP-augmented, data-driven paradigms to deepen the understanding of psychedelic subjectivity and emphasize the importance of extra-pharmacological factors in shaping therapeutic outcomes.
|
| Accessibility: | Document exists in file
|
Language:
| eng
|
Author:
| Schlomberg, J. T. T.
|
Secondary author(s):
| Meling, D., Grylka, R., Vasella, E. A., Augustinovic, D., Scheidegger, M.
|
Document type:
| Article
|
Number of reproductions:
| 3
|
Reference:
| Schlomberg, J. T. T., Meling, D., Grylka, R., Vasella, E. A., Augustinovic, D., & Scheidegger, M. (2026). Mixed-methods analysis on psychedelic-augmented meditation experiences from a randomized controlled mindfulness retreat. Scientific Reports, 16(1), 14236. https://doi.org/10.1038/s41598-026-39261-5 |
| Impact Factor: | 4.9|2025
|
| Impact factor notes: | Impact factor not available yet for 2026
|
| Times cited: | 0|2026-07-23
|
| Indexed document: | Yes
|
| Quartile: | Q1
|
| Keywords: | Psychedelics / Meditation / Natural Language Processing / Subjective Effects / Multi-Modal / Synergistic effects
|
<!-- mm occ=1 guid=[91e6fae8a0e8929dc0433f07b55bc240] WebBehavior$=[0] --> Mixed-methods analysis on psychedelic-augmented meditation experiences from a randomized controlled mindfulness retreat |